PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS
    8.
    发明申请
    PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS 审中-公开
    哌啶和哌嗪衍生物作为SMO拮抗剂

    公开(公告)号:US20130053396A1

    公开(公告)日:2013-02-28

    申请号:US13496958

    申请日:2010-09-21

    CPC分类号: C07D413/04 C07D417/04

    摘要: The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smo antagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.

    摘要翻译: 本发明涉及作为Sonic Hedgehog途径的抑制剂,特别是Smo拮抗剂的式(I)化合物及其药学上可接受的盐或互变异构体。 因此,本发明的化合物可用于治疗与异常hedgehog途径活化相关的疾病,包括癌症,例如基底细胞癌,成神经管细胞瘤,前列腺,胰腺癌,乳腺癌,结肠癌,骨细胞和小细胞肺癌,以及癌症 上胃肠道