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公开(公告)号:US10898421B2
公开(公告)日:2021-01-26
申请号:US15580018
申请日:2016-06-08
IPC分类号: A61K8/35 , A61K8/49 , A61Q5/00 , A61K31/352 , A61K31/60 , A61K31/194 , A61K31/496 , A61K31/4412 , A61Q5/02 , A61Q5/12 , C12P17/06 , C12P17/18
摘要: Use of pycnidione, epolone A, and epolone B as anti-dandruff actives either alone or in combination in anti-dandruff compositions, particularly shampoos and conditioners. The actives are particularly effective against Malassezia yeasts and Malassezia furfur. A method of obtaining pycnidione, epolone A, and epolone B from culturing of Neosetophoma samarorum is also described.
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公开(公告)号:US20190127411A1
公开(公告)日:2019-05-02
申请号:US16090888
申请日:2017-04-06
摘要: Surfactants based on a newly discovered class of compounds include a hydrophobic lipid oligomer covalently linked to a peptide or peptide-like chain and a carbohydrate moiety, and a serine-leucinol dipeptide linked to the lipid oligomer. Such surfactants can be used to create an oil-in-water or water-in-oil emulsion by mixing together a polar component; a non-polar component; and the surfactant. Biosurfactants of the newly discovered class can be made by isolating and culturing a microorganism which produces the biosurfactant, and then isolating the biosurfactant from the culture. A microorganism can be engineered to produce biosurfactant of this newly discovered class by expressing a set of heterologous genes involved in the biosynthesis of the biosurfactant in the microorganism.
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公开(公告)号:US10821064B2
公开(公告)日:2020-11-03
申请号:US15580019
申请日:2016-06-08
摘要: A novel anti-dandruff agent being a fumagillin derivative according to formula (I), and use of said agent as an anti-dandruff actives in anti-dandruff compositions, particularly shampoos and conditioners. The active is particularly effective against Malassezia yeasts and Malassezia furfur which may cause dandruff. A method of obtaining the fumagillin derivative from culturing of Peyronellaea sp. strain RKDO347 is also described.
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公开(公告)号:US20190110973A1
公开(公告)日:2019-04-18
申请号:US15580019
申请日:2016-06-08
CPC分类号: A61K8/4973 , A61K8/49 , A61P31/10 , A61Q5/006 , C12P17/162 , C12R1/645
摘要: A novel anti-dandruff agent being a fumagillin derivative according to formula (I), and use of said agent as an anti-dandruff actives in anti-dandruff compositions, particularly shampoos and conditioners. The active is particularly effective against Malassezia yeasts and Malassezia furfur which may cause dandruff. A method of obtaining the fumagillin derivative from culturing of Peyronellaea sp. strain RKDO347 is also described.
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公开(公告)号:US20230227489A1
公开(公告)日:2023-07-20
申请号:US18099723
申请日:2023-01-20
IPC分类号: C07H15/04 , C11D3/38 , C02F3/34 , C07H1/08 , C12N15/52 , C12N1/20 , C11D1/00 , C12P19/44 , C11D1/66 , C11D1/10 , C12R1/01
CPC分类号: C07H15/04 , C11D3/381 , C02F3/34 , C07H1/08 , C12N15/52 , C12N1/205 , C11D1/008 , C12P19/44 , C11D1/662 , C11D1/10 , C12R2001/01
摘要: Surfactants based on a newly discovered class of compounds include a hydrophobic lipid oligomer covalently linked to a peptide or peptide-like chain and a carbohydrate moiety, and a serine-leucinol dipeptide linked to the lipid oligomer. Such surfactants can be used to create an oil-in-water or water-in-oil emulsion by mixing together a polar component; a non-polar component; and the surfactant. Biosurfactants of the newly discovered class can be made by isolating and culturing a microorganism which produces the biosurfactant, and then isolating the biosurfactant from the culture. A microorganism can be engineered to produce biosurfactant of this newly discovered class by expressing a set of heterologous genes involved in the biosynthesis of the biosurfactant in the microorganism.
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公开(公告)号:US10888548B2
公开(公告)日:2021-01-12
申请号:US15580017
申请日:2016-06-08
IPC分类号: A61K31/407 , A61K31/336 , A61Q5/00 , A61K31/4025 , A61K8/49 , C12P17/16 , C12P17/18 , C12R1/645
摘要: Anti-Dandruff Agents A novel anti-dandruff composition comprising spirofuranone-lactam tetramic acid or derivatives thereof, and optionally at least one biologically derivable meroterpene. The spirofuranone-lactam tetramic acid is preferably a bio-active heterospirocyclic secondary metabolite of Aspergillus, such as pseurotin A. The biologically derivable meroterpene may be selected from fumagillin, fumagillin derivative, chlovalicin, or ovalicin. Use of said agents as anti-dandruff actives in anti-dandruff compositions, particularly shampoos and conditioners is also provided. The active is particularly effective against Malassezia yeasts and Malassezia furfur which may cause dandruff. A method of obtaining the anti-dandruff actives from culturing of Peyronellaea sp. strain RKDO347 is also described.
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公开(公告)号:US20180177762A1
公开(公告)日:2018-06-28
申请号:US15580017
申请日:2016-06-08
IPC分类号: A61K31/407 , A61K31/336 , A61K8/49 , A61Q5/00 , C12P17/16 , C12P17/18 , C12R1/645
CPC分类号: A61K31/407 , A61K8/4973 , A61K31/336 , A61K31/4025 , A61Q5/006 , C12P17/162 , C12P17/182 , C12R1/645 , A61K2300/00
摘要: Anti-Dandruff Agents A novel anti-dandruff composition comprising spirofuranone-lactam tetramic acid or derivatives thereof, and optionally at least one biologically derivable meroterpene. The spirofuranone-lactam tetramic acid is preferably a bio-active heterospirocyclic secondary metabolite of Aspergillus, such as pseurotin A. The biologically derivable meroterpene may be selected from fumagillin, fumagillin derivative, chlovalicin, or ovalicin. Use of said agents as anti-dandruff actives in anti-dandruff compositions, particularly shampoos and conditioners is also provided. The active is particularly effective against Malassezia yeasts and Malassezia furfur which may cause dandruff. A method of obtaining the anti-dandruff actives from culturing of Peyronellaea sp. strain RKDO347 is also described.
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公开(公告)号:US20180168979A1
公开(公告)日:2018-06-21
申请号:US15580018
申请日:2016-06-08
CPC分类号: A61K8/498 , A61K8/35 , A61K31/194 , A61K31/352 , A61K31/4412 , A61K31/496 , A61K31/60 , A61Q5/006 , A61Q5/02 , A61Q5/12 , C12P17/06 , C12P17/181 , A61K2300/00
摘要: Use of pycnidione, epolone A, and epolone B as anti-dandruff actives either alone or in combination in anti-dandruff compositions, particularly shampoos and conditioners. The actives are particularly effective against Malassezia yeasts and Malassezia furfur. A method of obtaining pycnidione, epolone A, and epolone B from culturing of Neosetophoma samarorum is also described.
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