公开(公告)号：US09676714B2

公开(公告)日：2017-06-13

申请号：US15026471

申请日：2014-10-02

Applicant: Daewoong Pharmaceutical Co., Ltd.

Inventor： Kyung A Yu ,  Ji Sung Yoon ,  Deok Ki Eom ,  Yeon Im Lee ,  Hye Ryun Shin ,  Jun Hee Lee ,  Ha Nee Seo ,  Ji Duck Kim ,  Sang Ho Lee ,  Chun Ho Lee

IPC: C07D209/30 ,  C07D403/12 ,  C07D401/14 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D471/04 ,  C07D209/14 ,  C07D405/14

CPC classification number: C07D209/30 ,  C07D209/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/14 ,  C07D471/04

Abstract: Disclosed are a sulfonylindole derivative useful for the prevention or treatment of peptic ulcer, gastritis or reflux esophagitis, a method of preparing the same, and a pharmaceutical composition containing the same.

公开(公告)号：US10039747B2

公开(公告)日：2018-08-07

申请号：US14913696

申请日：2014-08-29

Applicant: Daewoong Pharmaceutical Co., Ltd.

Inventor： Kyung A Yu ,  Ji Sung Yoon ,  Deok Ki Eom ,  Yeon Im Lee ,  Mi Ryeong Han ,  Jun Hee Lee ,  Ha Nee Seo ,  Ji Duck Kim ,  Sang Ho Lee

IPC: A61K31/4035 ,  A61K31/4439 ,  C07D209/44 ,  C07D209/52 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D471/04 ,  C07D487/04 ,  C07D405/10 ,  C07D409/12 ,  C07D409/14 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D498/04

Abstract: The present invention provides tetrahydrocyclopentapyrrole derivatives that can be used for preventing or treating peptic ulcer, gastritis or reflux esophagitis, a method for preparing the same, and a pharmaceutical composition containing the same.

公开(公告)号：US10100010B1

公开(公告)日：2018-10-16

申请号：US15520518

申请日：2016-04-27

Applicant: Daewoong Pharmaceutical Co., Ltd.

Inventor： Chun Ho Lee ,  Seung Chul Lee ,  Yeon Im Lee ,  Deok Ki Eom ,  Mi Ryeong Han ,  Eun Ji Koh

IPC: C07D207/48 ,  A61P31/04 ,  A61P1/16

Abstract: The present invention provides a 4-methoxy pyrrole derivative or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition containing the same. The 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof according to the present invention have not only excellent proton pump inhibitory activity, gastric damage-inhibiting activity and defensive factor-enhancing effects, but also excellent eradication activity against H. pylori. Therefore, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof can be effectively used for the prevention and treatment of gastrointestinal damage due to gastrointestinal tract ulcer, gastritis, reflux esophagitis or H. pylori. Moreover, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof, have inhibitory activities against GPCR and thus can be effectively used for the prevention and treatment of 5-HT receptor-mediated or muscarinic acetylcholine receptor-mediated diseases.

公开(公告)号：US20160200681A1

公开(公告)日：2016-07-14

申请号：US14913696

申请日：2014-08-29

Applicant: DAEWOONG PHARMACEUTICAL CO., LTD.

Inventor： Kyung A Yu ,  Ji Sung Yoon ,  Deok Ki Eom ,  Yeon Im Lee ,  Mi Ryeong Han ,  Jun Hee Lee ,  Ha Nee Seo ,  Ji Duck Kim ,  Sang Ho Lee

IPC: C07D209/52 ,  C07D403/04 ,  C07D409/04 ,  C07D471/04 ,  C07D409/12 ,  C07D401/12 ,  C07D409/14 ,  C07D498/04 ,  C07D405/10 ,  C07D401/04

CPC classification number: A61K31/4035 ,  A61K31/4439 ,  C07D209/44 ,  C07D209/52 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

Abstract: The present invention provides tetrahydrocyclopentapyrrole derivatives that can be used for preventing or treating peptic ulcer, gastritis or reflux esophagitis, a method for preparing the same, and a pharmaceutical composition containing the same.

Abstract translation: 本发明提供可用于预防或治疗消化性溃疡，胃炎或反流性食管炎的四氢环戊吡咯衍生物及其制备方法，以及含有该四氢环戊并吡咯衍生物的药物组合物。

公开(公告)号：US12227498B2

公开(公告)日：2025-02-18

申请号：US17269325

申请日：2019-08-27

Applicant: Daewoong Pharmaceutical Co., Ltd.

Inventor： Wol Young Kim ,  Yeon Im Lee ,  Youn Jung Yoon ,  Joon Seok Park ,  Deok Ki Eom ,  Keuk-Chan Bang ,  Jaehyun Jung

IPC: C07D417/14 ,  C07D413/04 ,  C07D471/04 ,  A61K31/4427 ,  A61K31/4523 ,  A61K31/496 ,  A61K31/506 ,  A61P35/00 ,  A61P37/00 ,  C07D401/14 ,  C07D403/14 ,  C07D417/12 ,  C07D487/04

Abstract: The present disclosure relates to a novel heterocyclic amine derivative represented by the following Chemical Formula 1 and a pharmaceutical composition comprising the same, and the compound according to the present disclosure can be usefully used for the prevention or treatment of autoimmune diseases or cancers. wherein, in Chemical Formula 1, R1, R2, X1, X2, L, Y, A and B are the same as defined in the specification.

公开(公告)号：US20220064155A1

公开(公告)日：2022-03-03

申请号：US17269325

申请日：2019-08-27

Applicant: Daewoong Pharmaceutical Co., Ltd.

Inventor： Wol Young Kim ,  Yeon Im Lee ,  Youn Jung Yoon ,  Joon Seok Park ,  Deok Ki Eom ,  Keuk-Chan Bang ,  Jaehyun Jung

IPC: C07D417/14 ,  C07D471/04 ,  C07D413/04

Abstract: The present disclosure relates to a novel heterocyclic amine derivative represented by the following Chemical Formula 1 and a pharmaceutical composition comprising the same, and the compound according to the present disclosure can be usefully used for the prevention or treatment of autoimmune diseases or cancers. wherein, in Chemical Formula 1, R1, R2, X1, X2, L, Y, A and B are the same as defined in the specification.