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公开(公告)号：US08962571B2
公开(公告)日：2015-02-24
申请号：US13452415
申请日：2012-04-20
申请人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
发明人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
IPC分类号： A61K38/06
CPC分类号： A61K38/06 , A61K8/645 , A61K8/66 , A61K8/97 , A61K38/08 , A61K38/10 , A61Q19/00 , A61K2300/00
摘要： A method for repairing DNA damage in human keratinocytes by applying to the keratinocytes a composition comprising at least one CLOCK or PER1 gene activator and at least one DNA repair enzyme.
摘要翻译： 一种通过向角化细胞施用包含至少一种CLOCK或PER1基因激活剂和至少一种DNA修复酶的组合物来修复人角质形成细胞中的DNA损伤的方法。
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公开(公告)号：US20120219537A1
公开(公告)日：2012-08-30
申请号：US13452415
申请日：2012-04-20
申请人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
发明人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
CPC分类号： A61K38/06 , A61K8/645 , A61K8/66 , A61K8/97 , A61K38/08 , A61K38/10 , A61Q19/00 , A61K2300/00
摘要： A method for repairing DNA damage in human keratinocytes by applying to the keratinocytes a composition comprising at least one CLOCK or PER1 gene activator and at least one DNA repair enzyme.
摘要翻译： 一种通过向角化细胞施用包含至少一种CLOCK或PER1基因激活剂和至少一种DNA修复酶的组合物来修复人角质形成细胞中的DNA损伤的方法。
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公开(公告)号：US08193155B2
公开(公告)日：2012-06-05
申请号：US12367705
申请日：2009-02-09
申请人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
发明人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
CPC分类号： A61K38/06 , A61K8/645 , A61K8/66 , A61K8/97 , A61K38/08 , A61K38/10 , A61Q19/00 , A61K2300/00
摘要： A skin care composition comprising at least one keratinocyte CLOCK or PER1 gene activator and at least one DNA repair enzyme; a method for inhibiting damage to human keratinocytes due to environmental aggressors by applying a composition comprising at least one keratinocyte CLOCK or PER1 gene activator and at least one DNA repair enzyme; and a method for repairing DNA damage in human keratinocytes.
摘要翻译： 一种皮肤护理组合物，其包含至少一种角质形成细胞CLOCK或PER1基因激活剂和至少一种DNA修复酶; 通过施用包含至少一种角质形成细胞CLOCK或PER1基因激活剂和至少一种DNA修复酶的组合物来抑制由于环境侵袭者对人角质形成细胞的损伤的方法; 以及修复人角质形成细胞DNA损伤的方法。
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4.发明申请Skin Repair Compositions Comprising Circadian Gene Activators And A Synergistic Combination Of Sirt1 Gene Activators 有权皮肤修复组合包含昼夜节律基因激活剂和Sirt1基因激活子的协同组合公开(公告)号：US20100028317A1
公开(公告)日：2010-02-04
申请号：US12489619
申请日：2009-06-23
申请人： Daniel H. Maes , Nadine A. Pernodet , Thomas Mammone , Edward Pelle , Donald F. Collins , Lenny Slutsky , Kerri Goldgraben , James Timothy McCarthy
发明人： Daniel H. Maes , Nadine A. Pernodet , Thomas Mammone , Edward Pelle , Donald F. Collins , Lenny Slutsky , Kerri Goldgraben , James Timothy McCarthy
CPC分类号： A61K8/347 , A61K8/37 , A61K8/55 , A61K8/64 , A61K8/66 , A61K31/70 , A61K35/74 , A61K36/31 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/10 , A61K38/43 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： Compositions and methods for enhancing repair of damaged DNA in skin cells. Topical compositions comprising at least one agent that upregulates circadian gene expression in skin cells and at least one non-circadian agent that delays mitosis in skin cells. Preferably, such compositions comprise one or more keratinocyte clock and per1 gene activators, along with SIRT1 or one or more sirt1 activators. More preferably, the sirt1 activator is a synergistic combination of specific peptidic sirt1 activators and resveratrol. Preferably, such compositions are easy to use, efficacious, cosmetically acceptable, chemically, thermodynamically and light stable, safe for topical use, have little or no side effects, and commercially feasible in a personal care marketplace.
摘要翻译： 增强皮肤细胞损伤的DNA修复的组合物和方法。 包含至少一种上调皮肤细胞中的昼夜节律基因表达的试剂和至少一种延缓皮肤细胞中的有丝分裂的非昼夜节律作用的局部组合物。 优选地，这样的组合物包含一种或多种角质形成细胞时钟和per1基因激活剂，连同SIRT1或一种或多种sirt1激活剂。 更优选地，sirt1激活剂是特定肽sirt1激活剂和白藜芦醇的协同组合。 优选地，这样的组合物易于使用，有效，化妆品可接受，化学，热力学和光稳定性，对于局部使用安全，几乎没有或没有副作用，并且在个人护理市场中是商业上可行的。
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公开(公告)号：US20090220481A1
公开(公告)日：2009-09-03
申请号：US12367705
申请日：2009-02-09
申请人： DANIEL H. MAES , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
发明人： DANIEL H. MAES , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
IPC分类号： A61K38/43
CPC分类号： A61K38/06 , A61K8/645 , A61K8/66 , A61K8/97 , A61K38/08 , A61K38/10 , A61Q19/00 , A61K2300/00
摘要： A skin care composition comprising at least one keratinocyte CLOCK or PER1 gene activator and at least one DNA repair enzyme; a method for inhibiting damage to human keratinocytes due to environmental aggressors by applying a composition comprising at least one keratinocyte CLOCK or PER1 gene activator and at least one DNA repair enzyme; and a method for repairing DNA damage in human keratinocytes.
摘要翻译： 一种皮肤护理组合物，其包含至少一种角质形成细胞CLOCK或PER1基因激活剂和至少一种DNA修复酶; 通过施用包含至少一种角质形成细胞CLOCK或PER1基因激活剂和至少一种DNA修复酶的组合物来抑制由于环境侵袭者对人角质形成细胞的损伤的方法; 以及修复人角质形成细胞DNA损伤的方法。
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6.发明授权Skin repair compositions comprising circadian gene activators and a synergistic combination of Sirt1 gene activators 有权皮肤修复组合物包含昼夜节律基因激活剂和Sirt1基因激活剂的协同组合公开(公告)号：US08703161B2
公开(公告)日：2014-04-22
申请号：US12489619
申请日：2009-06-23
申请人： Daniel H. Maes , Nadine A. Pernodet , Thomas Mammone , Edward Pelle , Donald F. Collins , Lenny Slutsky , Kerri Goldgraben
发明人： Daniel H. Maes , Nadine A. Pernodet , Thomas Mammone , Edward Pelle , Donald F. Collins , Lenny Slutsky , Kerri Goldgraben
CPC分类号： A61K8/347 , A61K8/37 , A61K8/55 , A61K8/64 , A61K8/66 , A61K31/70 , A61K35/74 , A61K36/31 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/10 , A61K38/43 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： Compositions and methods for enhancing repair of damaged DNA in skin cells. Topical compositions comprising at least one agent that upregulates circadian gene expression in skin cells and at least one non-circadian agent that delays mitosis in skin cells. Preferably, such compositions comprise one or more keratinocyte clock and per1 gene activators, along with SIRT1 or one or more sirt1 activators. More preferably, the sirt1 activator is a synergistic combination of specific peptidic sirt1 activators and resveratrol. Preferably, such compositions are easy to use, efficacious, cosmetically acceptable, chemically, thermodynamically and light stable, safe for topical use, have little or no side effects, and commercially feasible in a personal care marketplace.
摘要翻译： 增强皮肤细胞损伤的DNA修复的组合物和方法。 包含至少一种上调皮肤细胞中的昼夜节律基因表达的试剂和至少一种延缓皮肤细胞中的有丝分裂的非昼夜节律作用的局部组合物。 优选地，这样的组合物包含一种或多种角质形成细胞时钟和per1基因激活剂，连同SIRT1或一种或多种sirt1激活剂。 更优选地，sirt1激活剂是特定肽sirt1激活剂和白藜芦醇的协同组合。 优选地，这样的组合物易于使用，有效，化妆品可接受，化学，热力学和光稳定性，对于局部使用安全，几乎没有或没有副作用，并且在个人护理市场中是商业上可行的。
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公开(公告)号：US20110250251A1
公开(公告)日：2011-10-13
申请号：US13101430
申请日：2011-05-05
申请人： Daniel H. Maes , Thomas Mammone , Kerri Goldgraben
发明人： Daniel H. Maes , Thomas Mammone , Kerri Goldgraben
CPC分类号： A61K31/70 , A61K8/347 , A61K8/37 , A61K8/55 , A61K8/66 , A61K38/465 , A61K38/47 , A61Q19/00 , A61Q19/08
摘要： The present invention relates to methods and compositions for repairing adverse effects of the environment, daily stress, sun exposure, or pre-mature aging on human skin, comprising applying to the skin, prior to a period of bodily rest, a topical composition that contains resveratrol or a derivative thereof and at least one DNA repair enzyme.
摘要翻译： 本发明涉及用于修复环境，日常压力，日晒暴露或对人皮肤的熟化前衰老的不利影响的方法和组合物，其包括在身体休息期之前将皮肤施用于含有 白藜芦醇或其衍生物和至少一种DNA修复酶。
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公开(公告)号：US20090047309A1
公开(公告)日：2009-02-19
申请号：US11837658
申请日：2007-08-13
申请人： Daniel H. Maes , Thomas Mammone , Kerri Goldgraben
发明人： Daniel H. Maes , Thomas Mammone , Kerri Goldgraben
CPC分类号： A61K31/70 , A61K8/347 , A61K8/37 , A61K8/55 , A61K8/66 , A61K38/465 , A61K38/47 , A61Q19/00 , A61Q19/08
摘要： The present invention relates to methods and compositions for repairing adverse effects of the environment, daily stress, sun exposure, or pre-mature aging on human skin, comprising applying to the skin, prior to a period of bodily rest, a topical composition that contains resveratrol or a derivative thereof and at least one DNA repair enzyme.
摘要翻译： 本发明涉及用于修复环境，日常压力，日晒暴露或对人皮肤的熟化前衰老的不利影响的方法和组合物，其包括在身体休息期之前将皮肤施用于含有 白藜芦醇或其衍生物和至少一种DNA修复酶。
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公开(公告)号：US20100080845A1
公开(公告)日：2010-04-01
申请号：US12631585
申请日：2009-12-04
申请人： Daniel H. Maes , Thomas Mammone , Kerri Goldgraben
发明人： Daniel H. Maes , Thomas Mammone , Kerri Goldgraben
CPC分类号： A61K31/70 , A61K8/347 , A61K8/37 , A61K8/55 , A61K8/66 , A61K38/465 , A61K38/47 , A61Q19/00 , A61Q19/08
摘要： The present invention relates to methods and compositions for repairing adverse effects of the environment, daily stress, sun exposure, or pre-mature aging on human skin, comprising applying to the skin, prior to a period of bodily rest, a topical composition that contains resveratrol or a derivative thereof and at least one DNA repair enzyme.
摘要翻译： 本发明涉及用于修复环境，日常压力，日晒暴露或对人皮肤的熟化前衰老的不利影响的方法和组合物，其包括在身体休息期之前将皮肤施用于含有 白藜芦醇或其衍生物和至少一种DNA修复酶。
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