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公开(公告)号：US08962571B2
公开(公告)日：2015-02-24
申请号：US13452415
申请日：2012-04-20
申请人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
发明人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
IPC分类号： A61K38/06
CPC分类号： A61K38/06 , A61K8/645 , A61K8/66 , A61K8/97 , A61K38/08 , A61K38/10 , A61Q19/00 , A61K2300/00
摘要： A method for repairing DNA damage in human keratinocytes by applying to the keratinocytes a composition comprising at least one CLOCK or PER1 gene activator and at least one DNA repair enzyme.
摘要翻译： 一种通过向角化细胞施用包含至少一种CLOCK或PER1基因激活剂和至少一种DNA修复酶的组合物来修复人角质形成细胞中的DNA损伤的方法。
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公开(公告)号：US20120219537A1
公开(公告)日：2012-08-30
申请号：US13452415
申请日：2012-04-20
申请人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
发明人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
CPC分类号： A61K38/06 , A61K8/645 , A61K8/66 , A61K8/97 , A61K38/08 , A61K38/10 , A61Q19/00 , A61K2300/00
摘要： A method for repairing DNA damage in human keratinocytes by applying to the keratinocytes a composition comprising at least one CLOCK or PER1 gene activator and at least one DNA repair enzyme.
摘要翻译： 一种通过向角化细胞施用包含至少一种CLOCK或PER1基因激活剂和至少一种DNA修复酶的组合物来修复人角质形成细胞中的DNA损伤的方法。
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公开(公告)号：US08193155B2
公开(公告)日：2012-06-05
申请号：US12367705
申请日：2009-02-09
申请人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
发明人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
CPC分类号： A61K38/06 , A61K8/645 , A61K8/66 , A61K8/97 , A61K38/08 , A61K38/10 , A61Q19/00 , A61K2300/00
摘要： A skin care composition comprising at least one keratinocyte CLOCK or PER1 gene activator and at least one DNA repair enzyme; a method for inhibiting damage to human keratinocytes due to environmental aggressors by applying a composition comprising at least one keratinocyte CLOCK or PER1 gene activator and at least one DNA repair enzyme; and a method for repairing DNA damage in human keratinocytes.
摘要翻译： 一种皮肤护理组合物，其包含至少一种角质形成细胞CLOCK或PER1基因激活剂和至少一种DNA修复酶; 通过施用包含至少一种角质形成细胞CLOCK或PER1基因激活剂和至少一种DNA修复酶的组合物来抑制由于环境侵袭者对人角质形成细胞的损伤的方法; 以及修复人角质形成细胞DNA损伤的方法。
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4.发明申请Skin Repair Compositions Comprising Circadian Gene Activators And A Synergistic Combination Of Sirt1 Gene Activators 有权皮肤修复组合包含昼夜节律基因激活剂和Sirt1基因激活子的协同组合公开(公告)号：US20100028317A1
公开(公告)日：2010-02-04
申请号：US12489619
申请日：2009-06-23
申请人： Daniel H. Maes , Nadine A. Pernodet , Thomas Mammone , Edward Pelle , Donald F. Collins , Lenny Slutsky , Kerri Goldgraben , James Timothy McCarthy
发明人： Daniel H. Maes , Nadine A. Pernodet , Thomas Mammone , Edward Pelle , Donald F. Collins , Lenny Slutsky , Kerri Goldgraben , James Timothy McCarthy
CPC分类号： A61K8/347 , A61K8/37 , A61K8/55 , A61K8/64 , A61K8/66 , A61K31/70 , A61K35/74 , A61K36/31 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/10 , A61K38/43 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： Compositions and methods for enhancing repair of damaged DNA in skin cells. Topical compositions comprising at least one agent that upregulates circadian gene expression in skin cells and at least one non-circadian agent that delays mitosis in skin cells. Preferably, such compositions comprise one or more keratinocyte clock and per1 gene activators, along with SIRT1 or one or more sirt1 activators. More preferably, the sirt1 activator is a synergistic combination of specific peptidic sirt1 activators and resveratrol. Preferably, such compositions are easy to use, efficacious, cosmetically acceptable, chemically, thermodynamically and light stable, safe for topical use, have little or no side effects, and commercially feasible in a personal care marketplace.
摘要翻译： 增强皮肤细胞损伤的DNA修复的组合物和方法。 包含至少一种上调皮肤细胞中的昼夜节律基因表达的试剂和至少一种延缓皮肤细胞中的有丝分裂的非昼夜节律作用的局部组合物。 优选地，这样的组合物包含一种或多种角质形成细胞时钟和per1基因激活剂，连同SIRT1或一种或多种sirt1激活剂。 更优选地，sirt1激活剂是特定肽sirt1激活剂和白藜芦醇的协同组合。 优选地，这样的组合物易于使用，有效，化妆品可接受，化学，热力学和光稳定性，对于局部使用安全，几乎没有或没有副作用，并且在个人护理市场中是商业上可行的。
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公开(公告)号：US20090220481A1
公开(公告)日：2009-09-03
申请号：US12367705
申请日：2009-02-09
申请人： DANIEL H. MAES , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
发明人： DANIEL H. MAES , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
IPC分类号： A61K38/43
CPC分类号： A61K38/06 , A61K8/645 , A61K8/66 , A61K8/97 , A61K38/08 , A61K38/10 , A61Q19/00 , A61K2300/00
摘要： A skin care composition comprising at least one keratinocyte CLOCK or PER1 gene activator and at least one DNA repair enzyme; a method for inhibiting damage to human keratinocytes due to environmental aggressors by applying a composition comprising at least one keratinocyte CLOCK or PER1 gene activator and at least one DNA repair enzyme; and a method for repairing DNA damage in human keratinocytes.
摘要翻译： 一种皮肤护理组合物，其包含至少一种角质形成细胞CLOCK或PER1基因激活剂和至少一种DNA修复酶; 通过施用包含至少一种角质形成细胞CLOCK或PER1基因激活剂和至少一种DNA修复酶的组合物来抑制由于环境侵袭者对人角质形成细胞的损伤的方法; 以及修复人角质形成细胞DNA损伤的方法。
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6.发明授权Skin repair compositions comprising circadian gene activators and a synergistic combination of Sirt1 gene activators 有权皮肤修复组合物包含昼夜节律基因激活剂和Sirt1基因激活剂的协同组合公开(公告)号：US08703161B2
公开(公告)日：2014-04-22
申请号：US12489619
申请日：2009-06-23
申请人： Daniel H. Maes , Nadine A. Pernodet , Thomas Mammone , Edward Pelle , Donald F. Collins , Lenny Slutsky , Kerri Goldgraben
发明人： Daniel H. Maes , Nadine A. Pernodet , Thomas Mammone , Edward Pelle , Donald F. Collins , Lenny Slutsky , Kerri Goldgraben
CPC分类号： A61K8/347 , A61K8/37 , A61K8/55 , A61K8/64 , A61K8/66 , A61K31/70 , A61K35/74 , A61K36/31 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/10 , A61K38/43 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： Compositions and methods for enhancing repair of damaged DNA in skin cells. Topical compositions comprising at least one agent that upregulates circadian gene expression in skin cells and at least one non-circadian agent that delays mitosis in skin cells. Preferably, such compositions comprise one or more keratinocyte clock and per1 gene activators, along with SIRT1 or one or more sirt1 activators. More preferably, the sirt1 activator is a synergistic combination of specific peptidic sirt1 activators and resveratrol. Preferably, such compositions are easy to use, efficacious, cosmetically acceptable, chemically, thermodynamically and light stable, safe for topical use, have little or no side effects, and commercially feasible in a personal care marketplace.
摘要翻译： 增强皮肤细胞损伤的DNA修复的组合物和方法。 包含至少一种上调皮肤细胞中的昼夜节律基因表达的试剂和至少一种延缓皮肤细胞中的有丝分裂的非昼夜节律作用的局部组合物。 优选地，这样的组合物包含一种或多种角质形成细胞时钟和per1基因激活剂，连同SIRT1或一种或多种sirt1激活剂。 更优选地，sirt1激活剂是特定肽sirt1激活剂和白藜芦醇的协同组合。 优选地，这样的组合物易于使用，有效，化妆品可接受，化学，热力学和光稳定性，对于局部使用安全，几乎没有或没有副作用，并且在个人护理市场中是商业上可行的。
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公开(公告)号：US20110268688A1
公开(公告)日：2011-11-03
申请号：US12993549
申请日：2009-06-17
CPC分类号： A61K9/0014 , A61K8/347 , A61K8/361 , A61K8/375 , A61K8/498 , A61K8/55 , A61K8/894 , A61K47/14 , A61K47/24 , A61Q19/06
摘要： A topical composition comprising at least one adipogenesis inhibitor and at least one adipocyte lipolytic agent and, optionally, at least one skin tightening agent; a method for improving the appearance of facial or body skin, treating the appearance of cellulite, or treating the face or body to improve the appearance of skin and uneven skin surfaces.
摘要翻译： 一种局部组合物，其包含至少一种脂肪形成抑制剂和至少一种脂肪细胞脂肪分解剂和任选的至少一种皮肤紧固剂; 改善面部或身体皮肤外观，治疗脂肪团的外观，或治疗面部或身体以改善皮肤外观和不均匀皮肤表面的方法。
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8.发明申请Bio-Mechanical Stimulation Of Collagen Synthesis In Skin Cells And Reduction Of Appearance Of Fine Lines And Wrinkles On The Skin 审中-公开皮肤细胞中胶原合成的生物机械刺激和皮肤上细纹和皱纹的外观减少公开(公告)号：US20120087888A1
公开(公告)日：2012-04-12
申请号：US13082889
申请日：2011-04-08
申请人： Nadine A. Pernodet , Donald F. Collins , Jean Harry Xavier , Phillip Cummins , Christina G. Fthenakis , William Robert Bickford , Lenny Slutsky
发明人： Nadine A. Pernodet , Donald F. Collins , Jean Harry Xavier , Phillip Cummins , Christina G. Fthenakis , William Robert Bickford , Lenny Slutsky
CPC分类号： A61Q19/08 , A61K8/02 , A61K8/64 , A61K8/67 , A61K8/72 , A61K8/8117 , A61K8/8152 , A61K8/899 , A61K2800/87 , A61Q19/00
摘要： The present invention achieves bio-mechanical stimulation of collagen synthesis in skin cells and reduction of the appearance of fine lines and wrinkles on the skin by applying a polymeric composition onto the skin in a manner so as to create surface tension that mimics the natural mechanical tension found in youthful skin.
摘要翻译： 本发明通过将聚合物组合物施加到皮肤上以便产生模拟天然机械张力的表面张力来实现皮肤细胞中胶原合成的生物机械刺激，并减少皮肤细纹和皱纹的外观 发现在年轻的皮肤。
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9.发明申请Composite Particles Having An Antioxidant-Based Protective System, And Topical Compositions Comprising The Same 审中-公开具有抗氧化剂的保护系统的复合颗粒和包含它的局部组合物公开(公告)号：US20100040696A1
公开(公告)日：2010-02-18
申请号：US12507145
申请日：2009-07-22
申请人： Ilse Sente , Lleve Declercq , Daniel H. Maes , Milan Franz Sojka , Phillip Cummins , Christina G. Fthenakis , Nadine A. Pernodet , Wilson A. Lee , Linda Najdek , MaryAnn McKeever-Alfieri , Lawrence P. Teta
发明人： Ilse Sente , Lleve Declercq , Daniel H. Maes , Milan Franz Sojka , Phillip Cummins , Christina G. Fthenakis , Nadine A. Pernodet , Wilson A. Lee , Linda Najdek , MaryAnn McKeever-Alfieri , Lawrence P. Teta
IPC分类号： A61K9/16 , A61K36/899
CPC分类号： A61K8/27 , A61K8/11 , A61K8/29 , A61K8/347 , A61K8/365 , A61K8/447 , A61K8/498 , A61K8/63 , A61K8/676 , A61K8/678 , A61K8/97 , A61K8/9706 , A61K2800/522 , A61K2800/56 , A61Q17/04 , A61Q19/001
摘要： The present invention relates to topical compositions containing a dispersion of composite particles. Each of such composite particles contains one or more core particles encapsulated or entrapped in a polymeric shell. At least some of the core particles are formed of a material capable of causing generation of reactive oxygen species (ROS). Each of the composite particles further contains: (1) a first antioxidant co-encapsulated or co-entrapped with the core particles inside the polymeric shell for quenching or scavenging ROS generated in the vicinity of the core particles, and (2) a second antioxidant coated over the polymeric shell for preventing or reducing oxidative damage to the skin, such as lipid peroxidation. The particle dispersion of the present invention therefore can be readily formulated into topical sunscreen compositions with organic sunscreen agents susceptible to oxidative decomposition or degradation to provide improved protection against skin damage caused by exposure to UV light.
摘要翻译： 本发明涉及含有复合颗粒分散体的局部组合物。 这些复合颗粒中的每一个都包含一个或多个包封或截留在聚合物壳中的芯颗粒。 至少一些核心颗粒由能够产生活性氧（ROS）的材料形成。 每个复合颗粒还包含：（1）与聚合物壳体内的核心颗粒共同包封或共截留的第一抗氧化剂，用于淬灭或清除在核心颗粒附近产生的ROS，和（2）第二抗氧化剂 涂覆在聚合物壳上以防止或减少对皮肤的氧化损伤，例如脂质过氧化。 因此，本发明的颗粒分散体可以容易地配制成具有易于氧化分解或降解的有机防晒剂的局部防晒组合物，以提供改善的防止由于暴露于UV光引起的皮肤损伤的保护。
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公开(公告)号：US09125843B2
公开(公告)日：2015-09-08
申请号：US14045075
申请日：2013-10-03
CPC分类号： A61K8/975 , A61K8/64 , A61K8/97 , A61K8/9706 , A61Q19/08
摘要： A method for stimulating collagen synthesis in aging skin cells in need of treatment by topically applying a composition comprising at least one extract from Laminaria genus, at least one extract from the Narcissus genus, and at least one peptide that stimulates sirtuin 6 activity in the form of a peptide or a yeast extract where the peptide is component of the extract; and a treatment composition comprising at least one extract from Laminaria genus, at least one extract from the Narcissus genus; and at least one peptide that stimulates sirtuin 6 activity.
摘要翻译： 用于刺激衰老皮肤细胞中的胶原合成的方法，需要通过局部施用包含至少一种来自水aria属提取物的组合物，至少一种来自水仙属的提取物的组合物和至少一种刺激沉默调节蛋白6活性的肽 肽或酵母提取物，其中肽是提取物的组分; 以及包含至少一种来自地衣属的提取物，至少一种来自所述水仙属的提取物的处理组合物; 和至少一种刺激沉默调节蛋白6活性的肽。
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