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1.发明申请Skin Repair Compositions Comprising Circadian Gene Activators And A Synergistic Combination Of Sirt1 Gene Activators 有权皮肤修复组合包含昼夜节律基因激活剂和Sirt1基因激活子的协同组合公开(公告)号：US20100028317A1
公开(公告)日：2010-02-04
申请号：US12489619
申请日：2009-06-23
申请人： Daniel H. Maes , Nadine A. Pernodet , Thomas Mammone , Edward Pelle , Donald F. Collins , Lenny Slutsky , Kerri Goldgraben , James Timothy McCarthy
发明人： Daniel H. Maes , Nadine A. Pernodet , Thomas Mammone , Edward Pelle , Donald F. Collins , Lenny Slutsky , Kerri Goldgraben , James Timothy McCarthy
CPC分类号： A61K8/347 , A61K8/37 , A61K8/55 , A61K8/64 , A61K8/66 , A61K31/70 , A61K35/74 , A61K36/31 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/10 , A61K38/43 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： Compositions and methods for enhancing repair of damaged DNA in skin cells. Topical compositions comprising at least one agent that upregulates circadian gene expression in skin cells and at least one non-circadian agent that delays mitosis in skin cells. Preferably, such compositions comprise one or more keratinocyte clock and per1 gene activators, along with SIRT1 or one or more sirt1 activators. More preferably, the sirt1 activator is a synergistic combination of specific peptidic sirt1 activators and resveratrol. Preferably, such compositions are easy to use, efficacious, cosmetically acceptable, chemically, thermodynamically and light stable, safe for topical use, have little or no side effects, and commercially feasible in a personal care marketplace.
摘要翻译： 增强皮肤细胞损伤的DNA修复的组合物和方法。 包含至少一种上调皮肤细胞中的昼夜节律基因表达的试剂和至少一种延缓皮肤细胞中的有丝分裂的非昼夜节律作用的局部组合物。 优选地，这样的组合物包含一种或多种角质形成细胞时钟和per1基因激活剂，连同SIRT1或一种或多种sirt1激活剂。 更优选地，sirt1激活剂是特定肽sirt1激活剂和白藜芦醇的协同组合。 优选地，这样的组合物易于使用，有效，化妆品可接受，化学，热力学和光稳定性，对于局部使用安全，几乎没有或没有副作用，并且在个人护理市场中是商业上可行的。
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公开(公告)号：US08962571B2
公开(公告)日：2015-02-24
申请号：US13452415
申请日：2012-04-20
申请人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
发明人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
IPC分类号： A61K38/06
CPC分类号： A61K38/06 , A61K8/645 , A61K8/66 , A61K8/97 , A61K38/08 , A61K38/10 , A61Q19/00 , A61K2300/00
摘要： A method for repairing DNA damage in human keratinocytes by applying to the keratinocytes a composition comprising at least one CLOCK or PER1 gene activator and at least one DNA repair enzyme.
摘要翻译： 一种通过向角化细胞施用包含至少一种CLOCK或PER1基因激活剂和至少一种DNA修复酶的组合物来修复人角质形成细胞中的DNA损伤的方法。
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公开(公告)号：US20120219537A1
公开(公告)日：2012-08-30
申请号：US13452415
申请日：2012-04-20
申请人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
发明人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
CPC分类号： A61K38/06 , A61K8/645 , A61K8/66 , A61K8/97 , A61K38/08 , A61K38/10 , A61Q19/00 , A61K2300/00
摘要： A method for repairing DNA damage in human keratinocytes by applying to the keratinocytes a composition comprising at least one CLOCK or PER1 gene activator and at least one DNA repair enzyme.
摘要翻译： 一种通过向角化细胞施用包含至少一种CLOCK或PER1基因激活剂和至少一种DNA修复酶的组合物来修复人角质形成细胞中的DNA损伤的方法。
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公开(公告)号：US08193155B2
公开(公告)日：2012-06-05
申请号：US12367705
申请日：2009-02-09
申请人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
发明人： Daniel H. Maes , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
CPC分类号： A61K38/06 , A61K8/645 , A61K8/66 , A61K8/97 , A61K38/08 , A61K38/10 , A61Q19/00 , A61K2300/00
摘要： A skin care composition comprising at least one keratinocyte CLOCK or PER1 gene activator and at least one DNA repair enzyme; a method for inhibiting damage to human keratinocytes due to environmental aggressors by applying a composition comprising at least one keratinocyte CLOCK or PER1 gene activator and at least one DNA repair enzyme; and a method for repairing DNA damage in human keratinocytes.
摘要翻译： 一种皮肤护理组合物，其包含至少一种角质形成细胞CLOCK或PER1基因激活剂和至少一种DNA修复酶; 通过施用包含至少一种角质形成细胞CLOCK或PER1基因激活剂和至少一种DNA修复酶的组合物来抑制由于环境侵袭者对人角质形成细胞的损伤的方法; 以及修复人角质形成细胞DNA损伤的方法。
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公开(公告)号：US20090220481A1
公开(公告)日：2009-09-03
申请号：US12367705
申请日：2009-02-09
申请人： DANIEL H. MAES , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
发明人： DANIEL H. MAES , Nadine A. Pernodet , Lenny Slutsky , Donald F. Collins , Kerri Goldgraben , Edward Pelle , James Timothy McCarthy
IPC分类号： A61K38/43
CPC分类号： A61K38/06 , A61K8/645 , A61K8/66 , A61K8/97 , A61K38/08 , A61K38/10 , A61Q19/00 , A61K2300/00
摘要： A skin care composition comprising at least one keratinocyte CLOCK or PER1 gene activator and at least one DNA repair enzyme; a method for inhibiting damage to human keratinocytes due to environmental aggressors by applying a composition comprising at least one keratinocyte CLOCK or PER1 gene activator and at least one DNA repair enzyme; and a method for repairing DNA damage in human keratinocytes.
摘要翻译： 一种皮肤护理组合物，其包含至少一种角质形成细胞CLOCK或PER1基因激活剂和至少一种DNA修复酶; 通过施用包含至少一种角质形成细胞CLOCK或PER1基因激活剂和至少一种DNA修复酶的组合物来抑制由于环境侵袭者对人角质形成细胞的损伤的方法; 以及修复人角质形成细胞DNA损伤的方法。
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6.发明授权Skin repair compositions comprising circadian gene activators and a synergistic combination of Sirt1 gene activators 有权皮肤修复组合物包含昼夜节律基因激活剂和Sirt1基因激活剂的协同组合公开(公告)号：US08703161B2
公开(公告)日：2014-04-22
申请号：US12489619
申请日：2009-06-23
申请人： Daniel H. Maes , Nadine A. Pernodet , Thomas Mammone , Edward Pelle , Donald F. Collins , Lenny Slutsky , Kerri Goldgraben
发明人： Daniel H. Maes , Nadine A. Pernodet , Thomas Mammone , Edward Pelle , Donald F. Collins , Lenny Slutsky , Kerri Goldgraben
CPC分类号： A61K8/347 , A61K8/37 , A61K8/55 , A61K8/64 , A61K8/66 , A61K31/70 , A61K35/74 , A61K36/31 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/10 , A61K38/43 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： Compositions and methods for enhancing repair of damaged DNA in skin cells. Topical compositions comprising at least one agent that upregulates circadian gene expression in skin cells and at least one non-circadian agent that delays mitosis in skin cells. Preferably, such compositions comprise one or more keratinocyte clock and per1 gene activators, along with SIRT1 or one or more sirt1 activators. More preferably, the sirt1 activator is a synergistic combination of specific peptidic sirt1 activators and resveratrol. Preferably, such compositions are easy to use, efficacious, cosmetically acceptable, chemically, thermodynamically and light stable, safe for topical use, have little or no side effects, and commercially feasible in a personal care marketplace.
摘要翻译： 增强皮肤细胞损伤的DNA修复的组合物和方法。 包含至少一种上调皮肤细胞中的昼夜节律基因表达的试剂和至少一种延缓皮肤细胞中的有丝分裂的非昼夜节律作用的局部组合物。 优选地，这样的组合物包含一种或多种角质形成细胞时钟和per1基因激活剂，连同SIRT1或一种或多种sirt1激活剂。 更优选地，sirt1激活剂是特定肽sirt1激活剂和白藜芦醇的协同组合。 优选地，这样的组合物易于使用，有效，化妆品可接受，化学，热力学和光稳定性，对于局部使用安全，几乎没有或没有副作用，并且在个人护理市场中是商业上可行的。
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7.发明申请Bio-Mechanical Stimulation Of Collagen Synthesis In Skin Cells And Reduction Of Appearance Of Fine Lines And Wrinkles On The Skin 审中-公开皮肤细胞中胶原合成的生物机械刺激和皮肤上细纹和皱纹的外观减少公开(公告)号：US20120087888A1
公开(公告)日：2012-04-12
申请号：US13082889
申请日：2011-04-08
申请人： Nadine A. Pernodet , Donald F. Collins , Jean Harry Xavier , Phillip Cummins , Christina G. Fthenakis , William Robert Bickford , Lenny Slutsky
发明人： Nadine A. Pernodet , Donald F. Collins , Jean Harry Xavier , Phillip Cummins , Christina G. Fthenakis , William Robert Bickford , Lenny Slutsky
CPC分类号： A61Q19/08 , A61K8/02 , A61K8/64 , A61K8/67 , A61K8/72 , A61K8/8117 , A61K8/8152 , A61K8/899 , A61K2800/87 , A61Q19/00
摘要： The present invention achieves bio-mechanical stimulation of collagen synthesis in skin cells and reduction of the appearance of fine lines and wrinkles on the skin by applying a polymeric composition onto the skin in a manner so as to create surface tension that mimics the natural mechanical tension found in youthful skin.
摘要翻译： 本发明通过将聚合物组合物施加到皮肤上以便产生模拟天然机械张力的表面张力来实现皮肤细胞中胶原合成的生物机械刺激，并减少皮肤细纹和皱纹的外观 发现在年轻的皮肤。
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公开(公告)号：US20110223262A1
公开(公告)日：2011-09-15
申请号：US13114505
申请日：2011-05-24
申请人： George Cioca , Vasile Ionita-Manzatu , Liliana George , Paolo U. Giacomoni , Andrew J. Bevacqua , Harvey Gedeon , Charles Craig Tadlock , Donald F. Collins , Thomas Mammone , Daniel H. Maes , Christina G. Fthenakis
发明人： George Cioca , Vasile Ionita-Manzatu , Liliana George , Paolo U. Giacomoni , Andrew J. Bevacqua , Harvey Gedeon , Charles Craig Tadlock , Donald F. Collins , Thomas Mammone , Daniel H. Maes , Christina G. Fthenakis
CPC分类号： A61Q19/00 , A61K8/97 , A61K8/99 , A61K35/32 , A61K36/064 , A61K36/14 , A61K36/185 , A61K36/21 , A61K36/23 , A61K36/28 , A61K36/38 , A61K36/48 , A61K36/484 , A61K36/53 , A61K36/54 , A61K36/58 , A61K36/738 , A61K36/82 , A61K36/87 , A61K36/886 , A61K36/896 , A61K36/9068 , A61K38/39 , A61K2800/28 , A61K2800/85 , A61K2300/00
摘要： The present invention relates to a method of modulating a selected biological activity of a naturally occurring material having one or more biological activities in an extract of the naturally occurring material, the method comprising incubating the extract in a medium in the presence of an aerobically metabolizing microorganism, under suitable aerobic conditions, for a period of time sufficient to modulate the selected activity with respect to baseline activity of the unincubated extract. The invention also relates to the bioconverted material so prepared, and the use of same in cosmetic or pharmaceutical compositions.
摘要翻译： 本发明涉及在天然存在的材料的提取物中调节具有一种或多种生物活性的天然存在物质的选定生物活性的方法，所述方法包括在有氧代谢微生物存在下将培养基中的提取物 在合适的有氧条件下，足以调节相对于未温育的提取物的基线活性的选定活性的时间。 本发明还涉及如此制备的生物转化材料及其在化妆品或药物组合物中的用途。
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公开(公告)号：US20090156689A1
公开(公告)日：2009-06-18
申请号：US12369230
申请日：2009-02-11
申请人： George Cioca , Vasile Ionita-Manzatu , Liliana George , Paolo U. Giacomoni , Andrew J. Bevacqua , Harvey Gedeon , Charles Craig Tadlock , Donald F. Collins , Thomas Mammone , Daniel H. Maes , Christina G. Fthenakis
发明人： George Cioca , Vasile Ionita-Manzatu , Liliana George , Paolo U. Giacomoni , Andrew J. Bevacqua , Harvey Gedeon , Charles Craig Tadlock , Donald F. Collins , Thomas Mammone , Daniel H. Maes , Christina G. Fthenakis
CPC分类号： A61Q19/00 , A61K8/97 , A61K8/99 , A61K35/32 , A61K36/064 , A61K36/14 , A61K36/185 , A61K36/21 , A61K36/23 , A61K36/28 , A61K36/38 , A61K36/48 , A61K36/484 , A61K36/53 , A61K36/54 , A61K36/58 , A61K36/738 , A61K36/82 , A61K36/87 , A61K36/886 , A61K36/896 , A61K36/9068 , A61K38/39 , A61K2800/28 , A61K2800/85 , A61K2300/00
摘要： The present invention relates to a method of modulating a selected biological activity of a naturally occurring material having one or more biological activities in an extract of the naturally occurring material, the method comprising incubating the extract in a medium in the presence of an aerobically metabolizing microorganism, under suitable aerobic conditions, for a period of time sufficient to modulate the selected activity with respect to baseline activity of the unincubated extract. The invention also relates to the bioconverted material so prepared, and the use of same in cosmetic or pharmaceutical compositions.
摘要翻译： 本发明涉及在天然存在的材料的提取物中调节具有一种或多种生物活性的天然存在物质的选定生物活性的方法，所述方法包括在有氧代谢微生物存在下将培养基中的提取物 在合适的有氧条件下，足以调节相对于未温育的提取物的基线活性的选定活性的时间。 本发明还涉及如此制备的生物转化材料及其在化妆品或药物组合物中的用途。
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公开(公告)号：US09125843B2
公开(公告)日：2015-09-08
申请号：US14045075
申请日：2013-10-03
CPC分类号： A61K8/975 , A61K8/64 , A61K8/97 , A61K8/9706 , A61Q19/08
摘要： A method for stimulating collagen synthesis in aging skin cells in need of treatment by topically applying a composition comprising at least one extract from Laminaria genus, at least one extract from the Narcissus genus, and at least one peptide that stimulates sirtuin 6 activity in the form of a peptide or a yeast extract where the peptide is component of the extract; and a treatment composition comprising at least one extract from Laminaria genus, at least one extract from the Narcissus genus; and at least one peptide that stimulates sirtuin 6 activity.
摘要翻译： 用于刺激衰老皮肤细胞中的胶原合成的方法，需要通过局部施用包含至少一种来自水aria属提取物的组合物，至少一种来自水仙属的提取物的组合物和至少一种刺激沉默调节蛋白6活性的肽 肽或酵母提取物，其中肽是提取物的组分; 以及包含至少一种来自地衣属的提取物，至少一种来自所述水仙属的提取物的处理组合物; 和至少一种刺激沉默调节蛋白6活性的肽。
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