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    Nucleotide sequences which code for the metF gene
    1.
    发明申请
    Nucleotide sequences which code for the metF gene 审中-公开
    编码metF基因的核苷酸序列

    公开(公告)号：US20020049305A1

    公开(公告)日：2002-04-25

    申请号：US09919935

    申请日：2001-08-02

    申请人： DEGUSSA AG

    发明人： Brigitte Bathe ,  Bettina Moeckel ,  Walter Pfefferle ,  Klaus Huthmacher ,  Michael Binder ,  Dieter Greissinger ,  Georg Thierbach

    IPC分类号： C07K014/435 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06

    CPC分类号： C12N9/0044 ,  A23K10/12 ,  A23K20/142 ,  C12P13/12

    摘要： An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of a) polynucleotide which is at least 70% identical to a polynucleotide that codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide that comprises an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the metF gene is present in enhanced form, and the use of the polynucleotide sequences as hybridization probes.

    摘要翻译： 一种分离的多核苷酸，其包含选自以下的多核苷酸序列：a）与编码包含SEQ ID No.2的氨基酸序列的多肽的多核苷酸至少70％相同的多核苷酸，b）编码 包含与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列的多肽，c）与a）或b）的多核苷酸互补的多核苷酸，以及d）至少包含至少 a），b）或c）的多核苷酸序列的15个连续核苷酸，以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少metF基因以增强形式存在，以及使用多核苷酸 序列作为杂交探针。

    Nucleotide sequences which code for the metR and metZ genes
    3.
    发明申请
    Nucleotide sequences which code for the metR and metZ genes 有权
    编码metR和metZ基因的核苷酸序列

    公开(公告)号：US20020102664A1

    公开(公告)日：2002-08-01

    申请号：US09919831

    申请日：2001-08-02

    申请人： DEGUSSA AG

    发明人： Brigitte Bathe ,  Walter Pfefferle ,  Klaus Huthmacher ,  Christian Rueckert ,  Joern Kalinowski ,  Alfred Puehler ,  Michael Binder ,  Dieter Greissinger ,  Georg Thierbach

    IPC分类号： C12P013/04 ,  C12N009/10 ,  C07H021/04 ,  C12P021/02 ,  C12N001/21 ,  C12N015/74

    CPC分类号： C12N9/88 ,  C07K14/34 ,  C12P13/08 ,  C12P13/12

    摘要： Polynucleotides from coryneform bacteria which code for the metR and/or metZ genes and comprise polynucleotide sequences, selected from the group consisting of a) polynucleotide which is at least 70% identical to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which is at least 70% identical to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 3, c) polynucleotide which codes for a polypeptide that comprises an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, d) polynucleotide which codes for a polypeptide that comprises an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 3, e) polynucleotide which is complementary to the polynucleotides of a) b), c) or d), and f) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequences of a), b), c), d) or e) and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the metR gene and/or the metZ gene is present in attenuated form, and use of polynucleotides which comprise the sequences according to the invention as hybridization probes.

    摘要翻译： 编码metR和/或metZ基因的棒状细菌的多核苷酸，并且包含多核苷酸序列，其选自a）与编码多肽的多核苷酸至少70％相同的多核苷酸，所述多核苷酸包含氨基酸序列 SEQ ID No.2，b）与编码包含SEQ ID No.3的氨基酸序列的多肽的多核苷酸至少70％相同的多核苷酸，c）编码包含氨基酸的多肽的多核苷酸 与SEQ ID No.2的氨基酸序列至少70％相同的序列，d）编码多肽的多核苷酸，其包含与SEQ ID No的氨基酸序列至少70％相同的氨基酸序列 3）e）与a）b），c）或d）的多核苷酸互补的多核苷酸，和f）包含a），b），c），d）的多核苷酸序列的至少15个连续核苷酸的多核苷酸， 或e）和使用棒状细菌发酵制备L-氨基酸的方法，其中至少metR基因和/或metZ基因以减毒形式存在，以及使用包含根据本发明的序列的多核苷酸作为 杂交探针。

    Nucleotide sequences which code for the metE gene
    6.
    发明申请
    Nucleotide sequences which code for the metE gene 有权
    编码metE基因的核苷酸序列

    公开(公告)号：US20020110877A1

    公开(公告)日：2002-08-15

    申请号：US09919835

    申请日：2001-08-02

    申请人： DEGUSSA AG

    发明人： Brigitte Bathe ,  Bettina Moeckel ,  Walter Pfefferle ,  Klaus Huthmacher ,  Christian Rueckert ,  Joern Kalinowski ,  Alfred Puehler ,  Michael Binder ,  Dieter Greissinger ,  Georg Thierbach

    IPC分类号： C12P013/12 ,  C12P013/04 ,  A61K031/70

    CPC分类号： C12N9/1007 ,  A23K20/142 ,  C07K14/34 ,  C12P13/12

    摘要： An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of a) polynucleotide which is at least 70% identical to a polynucleotide that codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide that comprises an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the metE gene is present in enhanced form, and the use of the polynucleotide sequences as hybridization probes.

    摘要翻译： 一种分离的多核苷酸，其包含选自以下的多核苷酸序列：a）与编码包含SEQ ID No.2的氨基酸序列的多肽的多核苷酸至少70％相同的多核苷酸，b）编码 包含与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列的多肽，c）与a）或b）的多核苷酸互补的多核苷酸，以及d）至少包含至少 a），b）或c）的多核苷酸序列的15个连续核苷酸，以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少metE基因以增强形式存在，以及使用多核苷酸 序列作为杂交探针。

    Nucleotide sequence which code for the metH gene
    7.
    发明申请
    Nucleotide sequence which code for the metH gene 有权
    编码metH基因的核苷酸序列

    公开(公告)号：US20020048793A1

    公开(公告)日：2002-04-25

    申请号：US09919891

    申请日：2001-08-02

    申请人： DEGUSSA AG

    发明人： Brigitte Bathe ,  Bettina Moeckel ,  Walter Pfefferle ,  Klaus Huthmacher ,  Christian Rueckert ,  Joern Kalinowski ,  Alfred Puehler ,  Michael Binder ,  Dieter Greissinger ,  Georg Thierbach

    IPC分类号： C12P021/02 ,  C07H021/04 ,  C12N001/21 ,  C12N015/74

    CPC分类号： C12N9/1007 ,  A23K20/142 ,  C12P13/12 ,  C12R1/15

    摘要： An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of a) polynucleotide which is at least 70% identical to a polynucleotide that codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide that comprises an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the metH gene is present in enhanced form, and use of the polynucleotide sequences as hybridization probes.

    摘要翻译： 一种分离的多核苷酸，其包含选自以下的多核苷酸序列：a）与编码包含SEQ ID No.2的氨基酸序列的多肽的多核苷酸至少70％相同的多核苷酸，b）编码 包含与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列的多肽，c）与a）或b）的多核苷酸互补的多核苷酸，以及d）至少包含至少 a），b）或c）的多核苷酸序列的15个连续核苷酸，以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少metH基因以增强形式存在，以及使用多核苷酸序列 作为杂交探针。

    Nucleotide sequences which code for the sahH gene
    8.
    发明申请
    Nucleotide sequences which code for the sahH gene 有权
    编码sahH基因的核苷酸序列

    公开(公告)号：US20030100080A1

    公开(公告)日：2003-05-29

    申请号：US09919854

    申请日：2001-08-02

    申请人： DEGUSSA AG

    发明人： Mike Farwick ,  Klaus Huthmacher ,  Jennifer Brehme ,  Walter Pfefferle ,  Michael Binder ,  Dieter Greissinger ,  Georg Thierbach

    IPC分类号： C12P013/04 ,  C07H021/04 ,  C12P021/02 ,  C12N001/21 ,  C12N015/74

    CPC分类号： C12N9/88 ,  A23K10/12 ,  A23K20/142 ,  A23K40/35 ,  A23K50/10 ,  C12P13/08 ,  C12P13/12

    摘要： An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of a) polynucleotide which is at least 70% identical to a polynucleotide that codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide that comprises an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria, in which at least the sahH gene is present in enhanced form, and the use of polynucleotides which contain the sequences according to the invention as hybridization probes.

    摘要翻译： 一种分离的多核苷酸，其包含选自以下的多核苷酸序列：a）与编码包含SEQ ID No.2的氨基酸序列的多肽的多核苷酸至少70％相同的多核苷酸，b）编码 包含与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列的多肽，c）与a）或b）的多核苷酸互补的多核苷酸，以及d）至少包含至少 a），b）或c）的多核苷酸序列的15个连续核苷酸，以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少sahH基因以增强形式存在，以及使用 含有根据本发明的序列的多核苷酸作为杂交探针。

    Nucleotide sequences which code for the metY gene
    9.
    发明申请
    Nucleotide sequences which code for the metY gene 有权
    编码metY基因的核苷酸序列

    公开(公告)号：US20020110878A1

    公开(公告)日：2002-08-15

    申请号：US09919932

    申请日：2001-08-02

    申请人： DEGUSSA AG

    发明人： Bettina Moeckel ,  Walter Pfefferle ,  Klaus Huthmacher ,  Christian Rueckert ,  Joern Kalinowski ,  Alfred Puehler ,  Michael Binder ,  Dieter Greissinger ,  Georg Thierbach

    IPC分类号： C12P013/08 ,  C12N009/10 ,  C07H021/04 ,  C12N015/74 ,  C12P021/02 ,  C12N001/21

    CPC分类号： C12P13/12 ,  C12N9/88 ,  C12P13/08

    摘要： An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of a) polynucleotide which is at least 70% identical to a polynucleotide that codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide that comprises an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the metY gene is present in enhanced form, and use of the polynucleotides as hybridization probes.

    摘要翻译： 一种分离的多核苷酸，其包含选自以下的多核苷酸序列：a）与编码包含SEQ ID No.2的氨基酸序列的多肽的多核苷酸至少70％相同的多核苷酸，b）编码 包含与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列的多肽，c）与a）或b）的多核苷酸互补的多核苷酸，以及d）至少包含至少 a），b）或c）的多核苷酸序列的15个连续核苷酸，以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少metY基因以增强形式存在，以及使用多核苷酸 作为杂交探针。