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1.发明授权Systems and methods for identifying precursor ions from product ions using arbitrary transmission windowing 有权使用任意透射窗口从产物离子中鉴定前体离子的系统和方法公开(公告)号：US09472387B2
公开(公告)日：2016-10-18
申请号：US15089529
申请日：2016-04-02
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Nic G. Bloomfield , Frank Londry
CPC classification number: H01J49/0036 , H01J49/0027 , H01J49/004 , H01J49/061 , H01J49/40 , H01J49/4215 , H01J49/427
Abstract: Ions are separated from a sample over time and filtered. The precursor ions produced at each step are fragmented. Resulting product ions are analyzed using a mass analyzer, producing a product ion spectrum for each step of the transmission window and a plurality of product ion spectra for the mass range for the each scan. The plurality of product ion spectra are received, producing a plurality of multi-scan product ion spectra. At least one product ion is selected from the plurality of multi-scan product ion spectra that is present at least two or more times in product ion spectra from each of two or more scans. A known separation profile of a precursor ion is fit to intensities from the at least one product ion in the plurality of multi-scan product ion spectra to reconstruct a separation profile of a precursor ion of the at least one product ion.
Abstract translation: 离子与样品随时间分离并过滤。 在每个步骤产生的前体离子是碎裂的。 使用质量分析仪分析所得产物离子，产生用于传输窗口的每个步骤的产物离子谱和用于每次扫描的质量范围的多个产物离子光谱。 接收多个产物离子光谱，产生多个多扫描产物离子光谱。 从多个多扫描产物离子光谱中选择至少一个产物离子，所述离子谱在两次或更多次扫描中的每一次的产物离子谱中至少存在两次或更多次。 前体离子的已知分离曲线适合于多个多扫描产物离子光谱中的至少一种产物离子的强度，以重建至少一种产物离子的前体离子的分离曲线。
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公开(公告)号：US20160233077A1
公开(公告)日：2016-08-11
申请号：US15026236
申请日：2014-10-07
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： James Walter Hager , Frank Londry , Nic G. Bloomfield
CPC classification number: H01J49/4215 , H01J49/0027 , H01J49/004 , H01J49/04 , H01J49/427
Abstract: Systems and methods are provided for shaping an effective transmission window used to select precursor ions for a precursor mass range of a sequential windowed acquisition experiment. For at least one precursor mass range, an ion transfer function is selected that is a function of mass using a processor. A quadrupole mass filter that transmits ions from a sample is instructed to produce two or more transmission windows over time using the processor. The two or more transmission windows are produced to cumulatively create an effective transmission window for the at least one precursor mass range with a shape described by the ion transfer function.
Abstract translation: 提供了系统和方法，用于形成用于选择前体离子的有效传输窗口用于顺序窗口采集实验的前体质量范围。 对于至少一个前体质量范围，选择使用处理器作为质量的函数的离子传递函数。 指示从样品传输离子的四极质量过滤器使用处理器随时间产生两个或更多个传输窗口。 产生两个或更多个传输窗口以累积地产生具有由离子传递函数描述的形状的至少一个前体质量范围的有效传播窗口。
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Patent Agency Ranking
公开(公告)号：US09768009B2
公开(公告)日：2017-09-19
申请号：US15026236
申请日：2014-10-07
Applicant: DH Technologies Development Pte. Ltd.
Inventor： James Walter Hager , Frank Londry , Nic G. Bloomfield
CPC classification number: H01J49/4215 , H01J49/0027 , H01J49/004 , H01J49/04 , H01J49/427
Abstract: Systems and methods are provided for shaping an effective transmission window used to select precursor ions for a precursor mass range of a sequential windowed acquisition experiment. For at least one precursor mass range, an ion transfer function is selected that is a function of mass using a processor. A quadrupole mass filter that transmits ions from a sample is instructed to produce two or more transmission windows over time using the processor. The two or more transmission windows are produced to cumulatively create an effective transmission window for the at least one precursor mass range with a shape described by the ion transfer function.
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公开(公告)号：US10068753B2
公开(公告)日：2018-09-04
申请号：US15026237
申请日：2014-10-07
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Nic G. Bloomfield , Frank Londry
Abstract: A transmission window that has a constant rate of precursor ion transmission for each precursor ion is stepped across a mass range, producing a series of overlapping transmission windows across the mass range. The precursor ions produced at each step are fragmented. Resulting product ions are analyzed, producing a product ion spectrum for each step of the transmission window and a plurality of product ion spectra for the mass range. For at least one product ion of the plurality of product ion spectra, a function that describes how an intensity of the at least one product ion from the plurality of product ion spectra varies with precursor ion mass as the transmission window is stepped across the mass range is calculated. A precursor ion of the at least one product ion is identified from the function. An elution profile can also be determined from the function.
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5.发明申请公开(公告)号：US20170336356A1
公开(公告)日：2017-11-23
申请号：US15520867
申请日：2015-10-21
Applicant: DH Technologies Development PTE Ltd.
Inventor： Thomas R Covey , Yang Kang , Frank Londry , Bradley B Schneider
CPC classification number: G01N27/624 , H01J49/0031 , H01J49/004 , H01J49/04 , H01J49/06 , H01J49/24
Abstract: A sample analysis system having a continuous beam ion mobility filter incorporates an ion removal mechanism for removing residual ions from the ion mobility filter to reduce cross-talk. A sample to be analyzed by the sample analysis system can be entered into the continuous beam ion mobility filter, which filters the ions of the sample and passes the filtered group of ions to a detector or a mass analyzer (e.g., via an ion optics assembly disposed between the mass analyzer and the ion mobility filter), where some or all of the ions in the group are detected. The ion removal mechanism then removes all or a substantial portion of the residual ions from the ion mobility filter that are left over from the first filtered group before a second filtered group is passed through. In some aspects, the ion removal mechanism can be operated concurrent with an ion removal mechanism for removing residual ions from an ion optics assembly.
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6.发明申请Systems and Methods for Identifying Precursor ions from Product Ions Using Arbitrary Transmission Windowing 审中-公开使用任意传输窗口识别来自产物离子的前体离子的系统和方法公开(公告)号：US20160268111A1
公开(公告)日：2016-09-15
申请号：US15026237
申请日：2014-10-07
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE., LTD.
Inventor： Nic G. Bloomfield , Frank Londry
CPC classification number: H01J49/0036 , H01J49/0027 , H01J49/004 , H01J49/061 , H01J49/40 , H01J49/4215 , H01J49/427
Abstract: A transmission window that has a constant rate of precursor ion transmission for each precursor ion is stepped across a mass range, producing a series of overlapping transmission windows across the mass range. The precursor ions produced at each step are fragmented. Resulting product ions are analyzed, producing a product ion spectrum for each step of the transmission window and a plurality of product ion spectra for the mass range. For at least one product ion of the plurality of product ion spectra, a function that describes how an intensity of the at least one product ion from the plurality of product ion spectra varies with precursor ion mass as the transmission window is stepped across the mass range is calculated. A precursor ion of the at least one product ion is identified from the function. An elution profile can also be determined from the function.
Abstract translation: 对于每个前体离子具有恒定速率的前体离子传输的传输窗口跨越质量范围，在质量范围内产生一系列重叠的传输窗口。 在每个步骤产生的前体离子是碎裂的。 分析得到的产物离子，产生透射窗的每个步骤的产物离子光谱和质量范围的多个产物离子光谱。 对于多个产物离子光谱中的至少一个产物离子，描述了当多个产物离子谱中的至少一个产物离子的强度随前驱离子质量而变化的函数，随着透射窗跨越质量范围 被计算。 根据该功能鉴定至少一种产物离子的前体离子。 也可以从功能中确定洗脱曲线。
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7.发明申请Systems and Methods for Identifying Precursor ions from Product Ions Using Arbitrary Transmission Windowing 有权使用任意传输窗口识别来自产物离子的前体离子的系统和方法公开(公告)号：US20160217988A1
公开(公告)日：2016-07-28
申请号：US15089529
申请日：2016-04-02
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Nic G. Bloomfield , Frank Londry
CPC classification number: H01J49/0036 , H01J49/0027 , H01J49/004 , H01J49/061 , H01J49/40 , H01J49/4215 , H01J49/427
Abstract: Ions are separated from a sample over time and filtered. The precursor ions produced at each step are fragmented. Resulting product ions are analyzed using a mass analyzer, producing a product ion spectrum for each step of the transmission window and a plurality of product ion spectra for the mass range for the each scan. The plurality of product ion spectra are received, producing a plurality of multi-scan product ion spectra. At least one product ion is selected from the plurality of multi-scan product ion spectra that is present at least two or more times in product ion spectra from each of two or more scans. A known separation profile of a precursor ion is fit to intensities from the at least one product ion in the plurality of multi-scan product ion spectra to reconstruct a separation profile of a precursor ion of the at least one product ion.
Abstract translation: 离子与样品随时间分离并过滤。 在每个步骤产生的前体离子是碎裂的。 使用质量分析仪分析所得产物离子，产生用于传输窗口的每个步骤的产物离子谱和用于每次扫描的质量范围的多个产物离子光谱。 接收多个产物离子光谱，产生多个多扫描产物离子光谱。 从多个多扫描产物离子光谱中选择至少一个产物离子，所述离子谱在两次或更多次扫描中的每一次的产物离子谱中至少存在两次或更多次。 前体离子的已知分离曲线适合于多个多扫描产物离子光谱中的至少一种产物离子的强度，以重建至少一种产物离子的前体离子的分离曲线。
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