公开(公告)号：US20240222104A1

公开(公告)日：2024-07-04

申请号：US18684195

申请日：2022-08-16

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Stanislaw POTYRALA ,  Bradley B. SCHNEIDER ,  Leigh BEDFORD

IPC: H01J49/04 ,  H01J49/06 ,  H01J49/16

CPC classification number: H01J49/044 ,  H01J49/045 ,  H01J49/067 ,  H01J49/165

Abstract: A curtain chamber includes an orifice plate defining an orifice plate bore. A curtain plate is disposed adjacent to the orifice plate and defines a curtain plate bore. The orifice plate bore is disposed adjacent the curtain plate bore. A biasing element includes a first portion disposed in the orifice plate bore and a second portion disposed in the curtain plate bore. The biasing element biases the curtain plate towards the orifice plate. A race is defined by at least one of the orifice plate and the curtain plate. The race defines a race depth. A seal is disposed in the race. The seal includes an uncompressed seal depth greater than the race depth and a compressed seal depth less than the uncompressed seal depth.

公开(公告)号：US20240255467A1

公开(公告)日：2024-08-01

申请号：US18561031

申请日：2022-05-18

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Leigh BEDFORD ,  Bradley B. SCHNEIDER ,  Eva DUCHOSLAV ,  Stephen TATE

IPC: G01N27/623 ,  G01N27/624 ,  H01J49/16

CPC classification number: G01N27/623 ,  G01N27/624 ,  H01J49/165

Abstract: A method of operating a system including a differential mobility spectrometer (DMS) and a mass spectrometer. A sample is introduced to the DMS. The sample is analyzed with the DMS. Data is generated based at least in part on an analyte ion generated from the sample and at least one transport gas composition. Library data of the analyte ion is accessed from a library. The generated data is compared to the library data. A signal is sent when the generated data deviates from the library data by more than a predetermined threshold.

公开(公告)号：US20240272121A1

公开(公告)日：2024-08-15

申请号：US18569701

申请日：2022-06-16

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Bradley B. SCHNEIDER ,  Leigh BEDFORD ,  Yves LE BLANC ,  Eva DUCHOSLAV

IPC: G01N27/623 ,  G01N27/624 ,  H01J49/00

CPC classification number: G01N27/623 ,  G01N27/624 ,  H01J49/0031

Abstract: An automated method of operating a mass spectrometer (MS) comprising a differential mobility spectrometer (DMS) includes: introducing a first compound to the DMS; calculating a first alpha function for the first compound; introducing a second compound to the DMS; calculating a second alpha function for the second compound; and determining operation parameters of the DMS to achieve sufficient separation of the first compound and the second compound, based on the first alpha function and the second alpha function.

公开(公告)号：US20230288372A1

公开(公告)日：2023-09-14

申请号：US18019546

申请日：2021-02-03

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Leigh BEDFORD ,  Bradley SCHNEIDER

IPC: G01N27/624 ,  G01N27/623

CPC classification number: G01N27/624 ,  G01N27/623

Abstract: A method and apparatus are provided for separating and distinguishing between isotopic or isobaric opioid and/or benzodiazepine species within a sample. The method comprises introducing ions of the sample to an inlet of a differential mobility spectrometer (DMS), introducing a transport gas to carry the ions through the DMS, supplying an acetate modifier to the transport gas to modify the differential mobility of the ions, transporting the ions through the DMS in the presences of the acetate modifier and selectively transporting each of the species by selectively applying a corresponding compensation voltage for that species to allow that species to transport through and exit from the DMS.

公开(公告)号：US20240282564A1

公开(公告)日：2024-08-22

申请号：US18571482

申请日：2022-06-22

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Leigh BEDFORD ,  Bradley B. SCHNEIDER

IPC: H01J49/04 ,  G01N27/623 ,  G01N27/624

CPC classification number: H01J49/0422 ,  G01N27/623 ,  G01N27/624 ,  H01J49/0431 ,  H01J49/0468

Abstract: A gas introduction system for a differential mobility spectrometer (DMS) includes a manifold including a gas inlet and a gas outlet. A mixing channel fluidically couples the gas inlet to the gas outlet. A plurality of modifier liquid supply inlets is coupled to the mixing channel and a plurality of selectively operable valves. One of the plurality of selectively operable valves is coupled to one of the plurality of modifier liquid supply inlets. A control system is in communication with each of the plurality of the selectively operable valves. The control system is configured to actuate each of the plurality of selectively operable valves.

公开(公告)号：US20240177987A1

公开(公告)日：2024-05-30

申请号：US18282841

申请日：2021-11-18

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Leigh BEDFORD ,  Thomas R. COVEY ,  James HAGER ,  Bradley B. SCHNEIDER

IPC: H01J49/42 ,  G01N33/02 ,  G01N33/483 ,  H01J49/24

CPC classification number: H01J49/4215 ,  G01N33/02 ,  G01N33/4833 ,  H01J49/24

Abstract: In one aspect, a method of performing mass spectrometric analysis of a sample, e.g. a food-based sample, is disclosed, which comprises ionizing the sample to generate a plurality of ions, introducing the plurality of ions into a mass filter configured to provide a high m/z cutoff greater than a maximum m/z ratio of ions associated with one or more analytes of interest in the sample so as to allow passage of the analyte ions while inhibiting passage of ions having m/z ratios above said high m/z cutoff, and performing a mass analysis of ions passing through said mass filter. In a related aspect, a mass spectrometer is disclosed, which comprises an atmospheric pressure ion source, a first mass filter, a user interface and a controller.

公开(公告)号：US20240087870A1

公开(公告)日：2024-03-14

申请号：US18273914

申请日：2022-01-21

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Leigh BEDFORD ,  Hassan JAVAHERI ,  Yang KANG ,  Bradley B. SCHNEIDER

IPC: H01J49/24

CPC classification number: H01J49/24

Abstract: In one aspect, an ion guide for use in a mass spectrometry system is disclosed, which comprises an inlet for receiving a plurality of ions entrained in a gas flow, and a plurality of rods arranged in a multipole configuration so as to provide a passageway through which the received ions can traverse. At least one of the rods is configured for application of a DC and/or an RF voltage thereto for generating an electromagnetic field within the passageway suitable for focusing the ions, and a controller configured to maintain an operational pressure of the ion guide within a predefined range.