公开(公告)号：US20240177987A1

公开(公告)日：2024-05-30

申请号：US18282841

申请日：2021-11-18

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Leigh BEDFORD ,  Thomas R. COVEY ,  James HAGER ,  Bradley B. SCHNEIDER

IPC: H01J49/42 ,  G01N33/02 ,  G01N33/483 ,  H01J49/24

CPC classification number: H01J49/4215 ,  G01N33/02 ,  G01N33/4833 ,  H01J49/24

Abstract: In one aspect, a method of performing mass spectrometric analysis of a sample, e.g. a food-based sample, is disclosed, which comprises ionizing the sample to generate a plurality of ions, introducing the plurality of ions into a mass filter configured to provide a high m/z cutoff greater than a maximum m/z ratio of ions associated with one or more analytes of interest in the sample so as to allow passage of the analyte ions while inhibiting passage of ions having m/z ratios above said high m/z cutoff, and performing a mass analysis of ions passing through said mass filter. In a related aspect, a mass spectrometer is disclosed, which comprises an atmospheric pressure ion source, a first mass filter, a user interface and a controller.

公开(公告)号：US20240203719A1

公开(公告)日：2024-06-20

申请号：US18285715

申请日：2022-04-04

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Aaron Timothy BOOY ,  James HAGER

IPC: H01J49/06

CPC classification number: H01J49/066 ,  H01J49/061

Abstract: In one aspect, an ion guide for use in a mass spectrometer is disclosed, which comprises a pair of printed circuit boards (PCBs) having an inlet for receiving a plurality of ions from an upstream ion source and outlet through which the ions exit the ion guide. The ion guide includes at least two ion paths provided in the space between the two PCBs for transmission of ions from the inlet to the outlet. The ion guide can further include at least one ion-routing device that can be coupled to the ions paths for selecting a propagation path of the ions between those ion paths. In some embodiments, the two ion paths can have at least one segment in common.

公开(公告)号：US20240162027A1

公开(公告)日：2024-05-16

申请号：US18281722

申请日：2022-03-17

Applicant: DH Technologies Development Pte. Ltd.

Inventor： James HAGER

IPC: H01J49/42 ,  H01J49/06

CPC classification number: H01J49/42 ,  H01J49/063

Abstract: In one aspect, a mass spectrometer is disclosed, which comprises an ion source for receiving a sample and ionizing at least a portion of the sample to generate a plurality of ions, and a Fourier Transform (FT) mass analyzer that is configured to receive at least a portion of said plurality of ions at an inlet thereof. The ions exiting the FT are detected by an ion detector, which generates a transient oscillating ion detection signal. The analyzer processes the ion detection signal via application of an FT thereto, where the FT window width is selected to optimize a mass signal associated with at least one target ion of interest.

公开(公告)号：US20240290600A1

公开(公告)日：2024-08-29

申请号：US18278544

申请日：2022-02-23

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Aaron Timothy BOOY ,  James HAGER

IPC: H01J49/06

CPC classification number: H01J49/062

Abstract: In one aspect, an ion guide for use in a mass spectrometer is disclosed, which comprises a first plurality of conductive electrodes disposed on a first surface, a second plurality of conductive electrodes disposed on a second surface, wherein the two surfaces are positioned relative to one another and shaped so as to provide a passageway having an inlet for receiving an ion beam and an outlet through which target ions of interest exit the passageway. The ion guide further includes an orifice formed in at least one of those surfaces through which neutral species and/or large ion clusters, when present in the ion beam, exit the ion guide.

公开(公告)号：US20240234123A1

公开(公告)日：2024-07-11

申请号：US18037582

申请日：2021-11-17

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Bruce COLLINGS ,  James HAGER ,  Yang KANG ,  Bradley B. SCHNEIDER

IPC: H01J49/42 ,  H01J49/00 ,  H01J49/24

CPC classification number: H01J49/4215 ,  H01J49/0031 ,  H01J49/24 ,  H01J49/0086

Abstract: A mass spectrometer comprises a first mass filter for receiving a plurality of ions and having a transmission bandwidth configured to allow transmission of ions having m/z ratios within a desired range, and a second mass filter that is disposed downstream of the first mass filter for selecting ions having a target m/z value within a transmission window thereof for mass analysis. The transmission bandwidth of the first mass filter encompasses at least two m/z ratios of interest such that one of said m/z ratios corresponds to said target m/z value within the transmission window of said second mass filter.

公开(公告)号：US20230027201A1

公开(公告)日：2023-01-26

申请号：US17792656

申请日：2021-01-14

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： James HAGER

IPC: H01J49/00 ,  H01J49/06

Abstract: In one aspect, a mass spectrometer is disclosed, which comprises a Fourier Transform (FT) mass analyzer having an input port for receiving ions and an exit port through which the ions exit the FT mass analyzer, a detector disposed downstream of said FT analyzer for detecting ions exiting the FT analyzer, and a multi-segment ion guide having a plurality of segments, said multi-segment ion guide being disposed upstream of said FT mass analyzer and having an input port for receiving ions and an output port through which ions exit the FT mass analyzer. The segments of the ion guide are configured to be independently activated via application of a DC offset voltage thereto so as to adjust a length through which ions passing through the ion guide experience collisional cooling.