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公开(公告)号：US09592294B2
公开(公告)日：2017-03-14
申请号：US14649721
申请日：2014-01-13
Applicant: Dow Global Technologies LLC
Inventor： Mladen Ladika , Jin Zhao , Michael L. Tulchinsky , Thomas H. Kalantar , J. Keith Harris
IPC: A61K47/10 , A61K31/095 , A61K31/10 , A61K9/48 , A61K31/192 , A61K31/58 , C08G65/20 , A61K31/343 , C08L71/02
CPC classification number: A61K47/10 , A61K9/4866 , A61K31/095 , A61K31/10 , A61K31/192 , A61K31/343 , A61K31/58 , C08G65/20 , C08L71/02
Abstract: The present invention relates to the use of polyalkoxylated alcohols of the formula R—O-(AO)—H, wherein R is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl or heterocyclic group having 7 to 25 carbon atoms, (AO) is a polyoxyalkylene moiety of the composition (BO)m(EO)n(DO)r with random or blockwise arrangement of the constituting oxyalkylene units, wherein m, n and r represent the average number of oxybutylene (BO) units, oxyethylene (EO) units and oxyalkylene units derived from at least one epoxide selected from styrene oxide and alkylene oxides having from 5 to 10 carbon atoms (DO) per molecule of the polyalkoxylated alcohol, respectively, m being a number greater than or equal to 1, n being a number greater than or equal to 1 and r being a number in the range from 0 to 50 under the proviso that (m+n+r) is less than or equal to 200 and the ratio n/(m+r) is in the range of 1 to 20, as excipients in pharmaceutical compositions. Said polyalkoxylated alcohols enable very effective solubilization of poorly soluble active pharmaceutical ingredients in aqueous media. Solid or semi-solid pharmaceutical compositions comprising one or more such polyalkoxylated alcohol combined with at least one active pharmaceutical ingredient are further long term stable under typical storage conditions and can be readily provided in various dosage forms such as tablets and filled capsules.
Abstract translation: 本发明涉及式R-O-（AO）-H的聚烷氧基化醇的用途，其中R是具有7至25个碳原子的取代或未取代的烷基，烯基，炔基，芳基，芳烷基或杂环基，（ AO）是组成（BO）m（EO）n（DO）r的聚氧化烯部分，其具有构成的氧化烯单元的无规或块状排列，其中m，n和r表示氧化丁烯（BO）单元的平均数，氧化乙烯 （EO）单元和衍生自至少一种选自氧化苯乙烯和每分子聚烷氧基化醇具有5至10个碳原子的氧化烯（DO）的环氧化物的氧化烯单元，m分别大于或等于1， n是大于或等于1的数，r是0至50的数，条件是（m + n + r）小于或等于200，并且比率n /（m + r） 在1至20的范围内，作为药物组合物中的赋形剂。 所述聚烷氧基化的醇使得难溶性活性药物成分非常有效地溶解在水性介质中。 包含一种或多种这样的多烷氧基化醇与至少一种活性药物成分组合的固体或半固体药物组合物在典型的储存条件下进一步长期稳定，并且可以容易地以各种剂型例如片剂和填充的胶囊提供。
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公开(公告)号：US20170354586A1
公开(公告)日：2017-12-14
申请号：US15527427
申请日：2015-11-17
Applicant: Dow Global Technologies LLC
Inventor： Tatiana V. Drovetskaya , Susan L. Jordan , Thomas H. Kalantar , Mladen Ladika
Abstract: Provided are compositions and methods that are useful for personal care compositions. The compositions comprise (a) a cationic polymer comprising polymerized units derived from (i) 30 to 80 weight % of cationic monomers, (ii) 10 to 65 weight % of (meth)acrylamide monomers, and (iii) 0 to 30 weight % of polar non-ionic derivatives of acrylic monomers, and (b) at least one cosmetically acceptable surfactant, rheology modifier, or cosmetic active. Also provided are methods of treating hair with such compositions.
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3.发明授权公开(公告)号：US09212280B2
公开(公告)日：2015-12-15
申请号：US14431454
申请日：2013-09-13
Applicant: Dow Global Technologies LLC , Rohm and Haas Company
Inventor： Linda Kim-Habermehl , Mark D. Westmeyer , Liang Chen , Liang Hong , Mladen Ladika
IPC: C08L31/04 , C08L25/08 , C04B28/04 , C04B28/06 , C04B40/00 , C08L23/08 , C04B111/00 , C04B111/70
CPC classification number: C08L31/04 , C04B28/04 , C04B28/06 , C04B40/0042 , C04B2111/00672 , C04B2111/70 , C08L23/0853 , C08L23/0869 , C08L25/08 , C04B2103/0057 , C04B24/2623 , C04B24/2676 , C04B14/06 , C04B22/10 , C04B22/143 , C04B24/06 , C04B24/383 , C04B2103/0065 , C04B40/0608
Abstract: A mixture of first and second redispersible polymer powders where the first redispersible polymer powder has a copolymer having a glass transition temperature of 60 degrees Celsius or higher and an acid level in a range of 0.1 to 8 weight-percent percent as determined by potentiometric titration according to ASTM D664 and the second redispersible polymer powder is selected from vinyl acetate ethylene copolymer redispersible polymer powders and polymer powders of a blend of vinyl acetate ethylene copolymer and vinyl ester of versatic acid copolymer is useful as a component in a dry-mix formulation that further contains Portland cement, alumina rich cement and calcium sulfate.
Abstract translation: 第一和第二可再分散聚合物粉末的混合物，其中第一可再分散聚合物粉末具有玻璃化转变温度为60摄氏度或更高的共聚物，并且通过电位滴定测定的酸度在0.1至8重量％的范围内， 根据ASTM D664，第二种可再分散聚合物粉末选自乙酸乙烯酯乙烯共聚物可再分散聚合物粉末，乙酸乙烯酯乙烯共聚物和叔碳酸共聚物的乙烯基酯共混物的聚合物粉末可用作干混配方中的组分，其进一步 含有波特兰水泥，富含氧化铝的水泥和硫酸钙。
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Patent Agency Ranking
公开(公告)号：US10507176B2
公开(公告)日：2019-12-17
申请号：US15527427
申请日：2015-11-17
Applicant: Dow Global Technologies LLC
Inventor： Tatiana V. Drovetskaya , Susan L. Jordan , Thomas H. Kalantar , Mladen Ladika
Abstract: Provided are compositions and methods that are useful for personal care compositions. The compositions comprise (a) a cationic polymer comprising polymerized units derived from (i) 30 to 80 weight % of cationic monomers, (ii) 10 to 65 weight % of (meth)acrylamide monomers, and (iii) 0 to 30 weight % of polar non-ionic derivatives of acrylic monomers, and (b) at least one cosmetically acceptable surfactant, rheology modifier, or cosmetic active. Also provided are methods of treating hair with such compositions.
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公开(公告)号：US20170360686A1
公开(公告)日：2017-12-21
申请号：US15527062
申请日：2015-11-17
Inventor： Tatiana V. Drovetskaya , Susan L. Jordan , Thomas H. Kalantar , Mladen Ladika
CPC classification number: A61K8/8158 , A61K8/416 , A61K8/891 , A61K2800/5426 , A61K2800/596 , A61Q5/02 , A61Q5/12 , A61Q19/10
Abstract: Provided are compositions and methods that are useful for personal care compositions. The compositions comprise (a) a cationic polymer comprising polymerized units derived from (i) 30 to 80 weight % of cationic monomers, (ii) 10 to 65 weight % of (meth)acrylamide monomers, and (iii) 0 to 30 weight % of polar non-ionic derivatives of acrylic monomers, and (b) silicone. Also provided are methods of treating hair with such compositions.
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公开(公告)号：US10195134B2
公开(公告)日：2019-02-05
申请号：US15527062
申请日：2015-11-17
Inventor： Tatiana V. Drovetskaya , Susan L. Jordan , Thomas H. Kalantar , Mladen Ladika
Abstract: Provided are compositions and methods that are useful for personal care compositions. The compositions comprise (a) a cationic polymer comprising polymerized units derived from (i) 30 to 80 weight % of cationic monomers, (ii) 10 to 65 weight % of (meth)acrylamide monomers, and (iii) 0 to 30 weight % of polar non-ionic derivatives of acrylic monomers, and (b) silicone. Also provided are methods of treating hair with such compositions.
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公开(公告)号：US20150374823A1
公开(公告)日：2015-12-31
申请号：US14649721
申请日：2014-01-13
Applicant: DOW GLOBAL TECHNOLOGIES LLC
Inventor： Mladen Ladika , Jin Zhao , Michael L. Tulchinsky , Thomas H. Kalantar , J. Keith Harris
IPC: A61K47/10 , A61K31/095 , A61K31/343 , A61K31/192 , A61K31/58
CPC classification number: A61K47/10 , A61K9/4866 , A61K31/095 , A61K31/10 , A61K31/192 , A61K31/343 , A61K31/58 , C08G65/20 , C08L71/02
Abstract: The present invention relates to the use of polyalkoxylated alcohols of the formula R—O-(AO)—H, wherein R is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl or heterocyclic group having 7 to 25 carbon atoms, (AO) is a polyoxyalkylene moiety of the composition (BO)m(EO)n(DO)r with random or blockwise arrangement of the constituting oxyalkylene units, wherein m, n and r represent the average number of oxybutylene (BO) units, oxyethylene (EO) units and oxyalkylene units derived from at least one epoxide selected from styrene oxide and alkylene oxides having from 5 to 10 carbon atoms (DO) per molecule of the polyalkoxylated alcohol, respectively, m being a number greater than or equal to 1, n being a number greater than or equal to 1 and r being a number in the range from 0 to 50 under the proviso that (m+n+r) is less than or equal to 200 and the ratio n/(m+r) is in the range of 1 to 20, as excipients in pharmaceutical compositions. Said polyalkoxylated alcohols enable very effective solubilisation of poorly soluble active pharmaceutical ingredients in aqueous media. Solid or semi-solid pharmaceutical compositions comprising one or more such polyalkoxylated alcohol combined with at least one active pharmaceutical ingredient are further long term stable under typical storage conditions and can be readily provided in various dosage forms such as tablets and filled capsules.
Abstract translation: 本发明涉及式R-O-（AO）-H的聚烷氧基化醇的用途，其中R是具有7至25个碳原子的取代或未取代的烷基，烯基，炔基，芳基，芳烷基或杂环基，（ AO）是组成（BO）m（EO）n（DO）r的聚氧化烯部分，其具有构成的氧化烯单元的无规或阻塞排列，其中m，n和r表示氧丁烯（BO）单元的平均数，氧化乙烯 （EO）单元和衍生自至少一种选自氧化苯乙烯和每分子聚烷氧基化醇具有5至10个碳原子的氧化烯（DO）的环氧化物的氧化烯单元，m分别大于或等于1， n是大于或等于1的数，r是0至50的数，条件是（m + n + r）小于或等于200，并且比率n /（m + r） 在1至20的范围内，作为药物组合物中的赋形剂。 所述聚烷氧基化的醇使得难溶性活性药物成分在水性介质中非常有效地溶解。 包含一种或多种这样的多烷氧基化醇与至少一种活性药物成分组合的固体或半固体药物组合物在典型的储存条件下进一步长期稳定，并且可以容易地以各种剂型例如片剂和填充的胶囊提供。
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8.发明申请公开(公告)号：US20150247029A1
公开(公告)日：2015-09-03
申请号：US14431454
申请日：2013-09-13
Applicant: ROHM AND HAAS COMPANY , DOW GLOBAL TECHNOLOGIES LLC
Inventor： Linda Kim-Habermehl , Mark D. Westmeyer , Liang Chen , Liang Hong , Mladen Ladika
CPC classification number: C08L31/04 , C04B28/04 , C04B28/06 , C04B40/0042 , C04B2111/00672 , C04B2111/70 , C08L23/0853 , C08L23/0869 , C08L25/08 , C04B2103/0057 , C04B24/2623 , C04B24/2676 , C04B14/06 , C04B22/10 , C04B22/143 , C04B24/06 , C04B24/383 , C04B2103/0065 , C04B40/0608
Abstract: A mixture of first and second redispersible polymer powders where the first redispersible polymer powder has a copolymer having a glass transition temperature of 60 degrees Celsius or higher and an acid level in a range of 0.1 to 8 weight-percent percent as determined by potentiometric titration according to ASTM D664 and the second redispersible polymer powder is selected from vinyl acetate ethylene copolymer redispersible polymer powders and polymer powders of a blend of vinyl acetate ethylene copolymer and vinyl ester of versatic acid copolymer is useful as a component in a dry-mix formulation that further contains Portland cement, alumina rich cement and calcium sulfate.
Abstract translation: 第一和第二可再分散聚合物粉末的混合物，其中第一可再分散聚合物粉末具有玻璃化转变温度为60摄氏度或更高的共聚物，并且通过电位滴定测定的酸度在0.1至8重量％的范围内， 根据ASTM D664，第二种可再分散聚合物粉末选自乙酸乙烯酯乙烯共聚物可再分散聚合物粉末，乙酸乙烯酯乙烯共聚物和叔碳酸共聚物的乙烯基酯共混物的聚合物粉末可用作干混配方中的组分，其进一步 含有波特兰水泥，富含氧化铝的水泥和硫酸钙。
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