公开(公告)号：US20170349563A1

公开(公告)日：2017-12-07

申请号：US15535477

申请日：2015-12-09

Applicant: DSM IP ASSETS B.V.

Inventor： Ulla LETINOIS ,  Thomas NETSCHER

IPC: C07D311/04 ,  C07C37/14 ,  C07C1/32 ,  C07C37/00 ,  C07F7/08 ,  C07C45/00

CPC classification number: C07D311/04 ,  C07C1/321 ,  C07C37/00 ,  C07C37/14 ,  C07C45/00 ,  C07F7/0805 ,  C07C39/19

Abstract: The present invention relates to a method of preparing chromanes from 2,5-dimethylfuran and substituted alkynes comprising an long chain unsaturated alkyl group as substituent in the alpha position of a substituted phenol followed by oxidation, reduction and acid ring closure. It is particularly advantageous to use 2,5-dimethylfuran as this offers an ecological beneficial synthesis of β-tocopherol.

公开(公告)号：US20160168110A1

公开(公告)日：2016-06-16

申请号：US14902661

申请日：2014-07-03

Applicant: DSM IP ASSETS B.V.

Inventor： Jonthan Alan MEDLOCK ,  Ulla LETINOIS ,  Thomas NETSCHER ,  Wemer BONRATH

IPC: C07D311/22

CPC classification number: C07D311/22 ,  C07B2200/09

Abstract: The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of a specific type and of at least one Bransted acid or in the presence a specific chiral compound having a Bransted acid functional group in the molecule.

Abstract translation: 本发明涉及在苯并二氢吡喃酮或苯并二氢吡喃环中2-位的立体特异性物质中的色满酮或色烷的合成。 已经发现，该合成在特定类型的手性化合物和至少一种布氏酸的存在下或在分子中存在具有布朗斯台酸官能团的特定手性化合物的情况下是特别有可能的。

公开(公告)号：US20240228426A1

公开(公告)日：2024-07-11

申请号：US18597843

申请日：2024-03-06

Applicant: DSM IP Assets B.V.

Inventor： Stefan Karl LAEUGER ,  Ulla LETINOIS ,  Peter RIEBEL

IPC: C07C203/04 ,  A23K20/105 ,  A23K20/158 ,  A23K50/10

CPC classification number: C07C203/04 ,  A23K20/105 ,  A23K20/158 ,  A23K50/10

Abstract: Dicarboxylic diesters are disclosed having the formula (I):




wherein n is 3, and X is a C2 alkylene or a C2 alkenylene group. Such dicarboxylic diesters are useful for inhibiting the methane production in ruminants.

公开(公告)号：US20240207200A1

公开(公告)日：2024-06-27

申请号：US18555329

申请日：2022-04-12

Applicant: DSM IP Assets B.V.

Inventor： Maik KINDERMANN ,  Ulla LETINOIS ,  Luis Fernando MONTEIRO TAMASSIA ,  René Tobias STEMMLER ,  Nicola WALKER

IPC: A61K31/045 ,  A23K20/105 ,  A23K50/10 ,  A61K9/00 ,  A61K31/015 ,  A61P1/14

CPC classification number: A61K31/045 ,  A23K20/105 ,  A23K50/10 ,  A61K9/0056 ,  A61K31/015 ,  A61P1/14

Abstract: The present invention relates to the field of reduction of methane emission in ruminants. Particularly, it relates to the administration of limonene and propanediol mononitrate to a ruminant for reducing the production of methane emanating from the digestive activities of said ruminant.

公开(公告)号：US20240207203A1

公开(公告)日：2024-06-27

申请号：US18555095

申请日：2022-04-12

Applicant: DSM IP Assets B.V.

Inventor： Maik KINDERMANN ,  Ulla LETINOIS ,  Luis Fernando MONTEIRO TAMASSIA ,  René Tobias STEMMLER ,  Nicola WALKER

IPC: A61K31/11 ,  A61K31/045 ,  A61K47/02 ,  A61K47/10 ,  A61P1/14

CPC classification number: A61K31/11 ,  A61K31/045 ,  A61K47/02 ,  A61K47/10 ,  A61P1/14

Abstract: The present invention relates to the field of reduction of methane emission in ruminants. Particularly, it relates to the administration of gossypol and propanediol mononitrate to a ruminant for reducing the production of methane emanating from the digestive activities of said ruminant.

公开(公告)号：US20200123087A1

公开(公告)日：2020-04-23

申请号：US16720580

申请日：2019-12-19

Applicant: DSM IP Assets B.V.

Inventor： Ulla LETINOIS ,  Stephan ACKERMANN ,  Jonathan Alan MEDLOCK ,  Hajo LEHMANN

IPC: C07C41/30 ,  C07C39/08 ,  C07C39/07 ,  B01J31/24 ,  B01J31/22 ,  B01J31/18 ,  C07C43/178 ,  C07C37/50 ,  C07C37/07 ,  C07C41/36 ,  C07C46/08 ,  C07D311/72

Abstract: The present invention relates to a method of preparing ortho substituted phenols from 2,5-dimethylfuran and propargyl ethers in the presence of a gold(I) complex. It is particularly advantageous to use 2,5-dimethylfuran as this offers an ecological beneficial synthesis of said ortho substituted phenols.

公开(公告)号：US20160145228A1

公开(公告)日：2016-05-26

申请号：US14902871

申请日：2014-07-03

Applicant: DSM IP ASSETS B.V.

Inventor： Ulla LETINOIS ,  Thomas NETSCHER ,  Stephan ACKERMANN

IPC: C07D311/22

CPC classification number: C07D311/22

Abstract: The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of formula of a specific type and of at least one urea or thiourea.

Abstract translation: 本发明涉及在苯并二氢吡喃酮或苯并二氢吡喃环中2-位的立体特异性物质中的色满酮或色烷的合成。 已经发现，在具有特定类型的式的手性化合物和至少一种脲或硫脲的存在下，这种合成是特别有可能的。

公开(公告)号：US20240196933A1

公开(公告)日：2024-06-20

申请号：US18554927

申请日：2022-04-12

Applicant: DSM IP ASSETS B.V.

Inventor： Maik KINDERMANN ,  Ulla LETINOIS ,  René Tobias STEMMLER ,  Nicola WALKER ,  Luis Fernando MONTEIRO TAMASSIA

IPC: A23K20/111 ,  A23K20/105 ,  A23K50/10

CPC classification number: A23K20/111 ,  A23K20/105 ,  A23K50/10

Abstract: The present invention relates to the field of reduction of methane emission in ruminants. Particularly, it relates to the administration of gossypol and a methane inhibitor to a ruminant for reducing the production of methane emanating from the digestive activities of said ruminant.

公开(公告)号：US20210163397A1

公开(公告)日：2021-06-03

申请号：US17047883

申请日：2019-04-23

Applicant: DSM IP ASSETS B.V.

Inventor： Stefan Karl LAEUGER ,  Ulla LETINOIS ,  Peter RIEBEL

IPC: C07C203/04 ,  A23K20/105 ,  A23K20/158 ,  A23K50/10

Abstract: The present invention relates to novel dicarboxylic diesters as well as the use thereof as for inhibiting the methane production in ruminants

公开(公告)号：US20180370887A1

公开(公告)日：2018-12-27

申请号：US16063481

申请日：2016-11-28

Applicant: DSM IP Assets B.V.

Inventor： Ulla LETINOIS ,  Stephan ACKERMANN ,  Jonathan Alan MEDLOCK ,  Hajo LEHMANN

IPC: C07C41/30 ,  C07C43/178 ,  C07C37/07 ,  C07C37/50 ,  C07C39/07 ,  C07C39/08 ,  B01J31/24 ,  B01J31/22 ,  B01J31/18

Abstract: The present invention relates to a method of preparing ortho substituted phenols from 2,5-dimethylfuran and propargyl ethers in the presence of a gold(I) complex. It is particularly advantageous to use 2,5-dimethylfuran as this offers an ecological beneficial synthesis of said ortho substituted phenols.