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    Process for enzymatic hydrolysis of lignocellulosic material and fermentation of sugars
    1.
    发明授权
    Process for enzymatic hydrolysis of lignocellulosic material and fermentation of sugars 有权

    公开(公告)号：US11091784B2

    公开(公告)日：2021-08-17

    申请号：US16557256

    申请日：2019-08-30

    Applicant: DSM IP ASSETS B.V.

    Inventor： Bertus Noordam

    IPC: C12P19/14 ,  C12P19/02 ,  C12P7/10 ,  C12P7/14 ,  C12N9/30

    Abstract: A method of treating a patient who has melanoma includes administering to said patient a composition containing a population of activated T cells that selectively recognize cells in the patient that aberrantly express a peptide. A pharmaceutical composition contains activated T cells that selectively recognize cells in a patient that aberrantly express a peptide, and a pharmaceutically acceptable carrier, in which the T cells bind to the peptide in a complex with an MHC class I molecule, and the composition is for treating the patient who has melanoma. A method of treating a patient who has melanoma includes administering to said patient a composition comprising a peptide in the form of a pharmaceutically acceptable salt, thereby inducing a T-cell response to the melanoma.

    Process for enzymatic hydrolysis of lignocellulosic material and fermentation of sugars
    2.
    发明授权
    Process for enzymatic hydrolysis of lignocellulosic material and fermentation of sugars 有权

    公开(公告)号：US10947573B2

    公开(公告)日：2021-03-16

    申请号：US16408062

    申请日：2019-05-09

    Applicant: DSM IP ASSETS B.V.

    Inventor： Bertus Noordam ,  Loes Elizabeth Bevers ,  Rudy Francois Maria Jozef Parton ,  Michael Petrus Jozef Berkhout

    IPC: C12P19/02 ,  C13K1/02 ,  D21C3/26 ,  C13K13/00 ,  C12P19/14

    Abstract: The invention relates to a process for the preparation of a fermentation product from lignocellulosic material, comprising the following steps: a) optionally, pretreatment of the lignocellulosic material, b) optionally, washing of the optionally pretreated lignocellulosic material, c) enzymatic hydrolysis of the optionally washed and/or optionally pretreated lignocellulosic material using an enzyme composition comprising at least two cellulases and whereby the enzyme composition at least comprises LPMO, and optionally purifying the hydrolysed lignocellulosic material, d) fermentation of the hydrolysed lignocellulosic material to produce a fermentation product, and e) optionally, recovery of a fermentation product, wherein the amounts of formed hydrolysed oxidation products at the end of the enzymatic hydrolysis by the oxidation by LPMO of the lignocellulosic material containing cellulose and/or cello-oligosaccharides is kept between 3 to 80 g/kg glucan present in the lignocellulosic material by adding a suitable amount of oxygen after the pre-treatment and before and/or during the enzymatic hydrolysis to the lignocellulosic material, preferably the formed hydrolysed oxidation product is gluconic acid, an aldonic acid and/or geminal diol, more preferably the hydrolysed oxidation product is gluconic acid.

    Process for enzymatic hydrolysis of lignocellulosic material and fermentation of sugars
    3.
    发明授权
    Process for enzymatic hydrolysis of lignocellulosic material and fermentation of sugars 有权

    公开(公告)号：US10907183B2

    公开(公告)日：2021-02-02

    申请号：US16528191

    申请日：2019-07-31

    Applicant: DSM IP ASSETS B.V.

    Inventor： Bertus Noordam ,  Michael Petrus Jozef Berkhout

    IPC: C12P19/02 ,  C13K1/02 ,  D21C3/26 ,  C13K13/00 ,  C12P19/14

    Abstract: The invention relates to a process for the preparation of a fermentation product from lignocellulosic material, comprising the following steps: a) optionally, pre-treatment of the lignocellulosic material, b) optionally, washing of the optionally pretreated lignocellulosic material, c) enzymatic hydrolysis of the optionally washed and/or optionally pretreated lignocellulosic material using an enzyme composition comprising at least two cellulases and whereby the enzyme composition at least comprises LPMO, and optionally purifying the hydrolysed lignocellulosic material, d) fermentation of the hydrolysed lignocellulosic material to produce a fermentation product, and e) optionally, recovery of a fermentation product, wherein oxygen is consumed in amounts corresponding to between 20 and 5000 mmol molecular oxygen per kg glucan present in the lignocellulosic material, the oxygen is added after the pretreatment and before and/or during the enzymatic hydrolysis of the lignocellulosic material, preferably in an amount corresponding to at least 30 mmol molecular oxygen per kg glucan present in the lignocellulosic material, more preferably in an amount corresponding to at least 40 mmol molecular oxygen per kg glucan present in the lignocellulosic material, and most preferably in an amount corresponding to at least 50 mmol molecular oxygen per kg glucan present in the lignocellulosic material is consumed.

    PROCESS FOR ENZYMATIC HYDROLYSIS OF LIGNOCELLULOSIC MATERIAL AND FERMENTATION OF SUGARS
    5.
    发明申请
    PROCESS FOR ENZYMATIC HYDROLYSIS OF LIGNOCELLULOSIC MATERIAL AND FERMENTATION OF SUGARS 审中-公开
    木质纤维素材料的酶解水解和糖的发酵工艺

    公开(公告)号：US20150203885A1

    公开(公告)日：2015-07-23

    申请号：US14420765

    申请日：2013-11-07

    Applicant: DSM IP ASSETS B.V.

    Inventor： Bertus Noordam

    IPC: C12P19/14 ,  C12P19/02

    CPC classification number: C12P19/14 ,  C12P19/02 ,  Y02E50/16

    Abstract: The invention relates to a process for the preparation of a fermentation product from ligno-cellulosic material, comprising the following steps: a) optionally pre-treatment of the ligno-cellulosic material; b) optionally washing of the optionally pre-treated ligno-cellulosic material; c) enzymatic hydrolysis of the optionally washed and/or optionally pre-treated ligno-cellulosic material using an enzyme composition comprising at least two cellulase and whereby the enzyme composition at least comprises GH61; d) fermentation of the hydrolysed ligno-cellulosic material to produce a fermentation product; and e) optionally recovery of a fermentation product; wherein before and/or during the enzymatic hydrolysis oxygen is added to the ligno-cellulosic material.

    Abstract translation: 本发明涉及一种从木质纤维素材料制备发酵产物的方法，包括以下步骤：a）任选地预处理木素纤维素材料; b）任选地洗涤任选预处理的木质纤维素材料; c）使用包含至少两种纤维素酶的酶组合物对任选洗涤和/或任选预处理的木质纤维素材料进行酶水解，由此所述酶组合物至少包含GH61; d）水解的木质纤维素材料的发酵以产生发酵产物; 和e）任选地回收发酵产物; 其中在酶水解之前和/或期间，向木质纤维素材料中加入氧气。

    Process for enzymatic hydrolysis of lignocellulosic material and fermentation of sugars
    7.
    发明授权
    Process for enzymatic hydrolysis of lignocellulosic material and fermentation of sugars 有权

    公开(公告)号：US10337040B2

    公开(公告)日：2019-07-02

    申请号：US15307241

    申请日：2015-04-29

    Applicant: DSM IP Assets B.V.

    Inventor： Bertus Noordam ,  Loes Elizabeth Bevers ,  Rudy Francois Maria Jozef Parton ,  Michael Petrus Jozef Berkhout

    IPC: C13K1/02 ,  D21C3/26 ,  C12P19/02 ,  C12P19/14 ,  C13K13/00

    Abstract: The invention relates to a process for the preparation of a fermentation product from lignocellulosic material, comprising the following steps: a) optionally, pretreatment of the lignocellulosic material, b) optionally, washing of the optionally pretreated lignocellulosic material, c) enzymatic hydrolysis of the optionally washed and/or optionally pretreated lignocellulosic material using an enzyme composition comprising at least two cellulases and whereby the enzyme composition at least comprises LPMO, and optionally purifying the hydrolysed lignocellulosic material, d) fermentation of the hydrolysed lignocellulosic material to produce a fermentation product, and e) optionally, recovery of a fermentation product, wherein the amounts of formed hydrolysed oxidation products at the end of the enzymatic hydrolysis by the oxidation by LPMO of the lignocellulosic material containing cellulose and/or cello-oligosaccharides is kept between 3 to 80 g/kg glucan present in the lignocellulosic material by adding a suitable amount of oxygen after the pre-treatment and before and/or during the enzymatic hydrolysis to the lignocellulosic material, preferably the formed hydrolysed oxidation product is gluconic acid, an aldonic acid and/or geminal diol, more preferably the hydrolysed oxidation product is gluconic acid.

    PROCESS FOR ENZYMATIC HYDROLYSIS OF LIGNOCELLULOSIC MATERIAL AND FERMENTATION OF SUGARS
    9.
    发明申请
    PROCESS FOR ENZYMATIC HYDROLYSIS OF LIGNOCELLULOSIC MATERIAL AND FERMENTATION OF SUGARS 有权
    木质纤维素材料的酶解水解和糖的发酵工艺

    公开(公告)号：US20150299749A1

    公开(公告)日：2015-10-22

    申请号：US14440658

    申请日：2013-11-07

    Applicant: DSM IP ASSETS B.V.

    Inventor： Bertus Noordam ,  Michael Petrus Jozef Berkhout ,  Aida Hiseni

    IPC: C12P19/02 ,  C12P19/14

    CPC classification number: C12P7/10 ,  C12P5/026 ,  C12P7/16 ,  C12P7/18 ,  C12P7/20 ,  C12P7/40 ,  C12P7/42 ,  C12P7/46 ,  C12P7/48 ,  C12P7/54 ,  C12P7/56 ,  C12P17/10 ,  C12P19/02 ,  C12P19/14 ,  C12P35/00 ,  C12P2203/00 ,  Y02E50/16 ,  Y02E50/343

    Abstract: The invention relates to a process for the preparation of a sugar product from ligno-cellulosic material, comprising the following steps: a) optionally pre-treatment of the ligno-cellulosic material; b) optionally washing of the optionally pre-treated ligno-cellulosic material; c) enzymatic hydrolysis of the optionally washed and/or optionally pre-treated ligno-cellulosic material using an enzyme composition comprising at least two cellulase and whereby the enzyme composition at least comprises GH61; and d) optionally recovery of a sugar product; wherein during part of the time of the enzymatic hydrolysis, oxygen is added to the ligno-cellulosic material and during part of the time of the enzymatic hydrolysis less oxygen is added to the ligno-cellulosic material compared to the other part of the time of the enzymatic hydrolysis, preferably no oxygen is added to the ligno-cellulosic material.

    Abstract translation: 本发明涉及一种从木质纤维素材料制备糖产品的方法，包括以下步骤：a）任选预处理木素纤维素材料; b）任选地洗涤任选预处理的木质纤维素材料; c）使用包含至少两种纤维素酶的酶组合物对任选洗涤和/或任选预处理的木质纤维素材料进行酶水解，由此所述酶组合物至少包含GH61; 和d）任选地回收糖产品; 其中在酶水解的部分时间期间，将氧添加到木质纤维素材料中，并且在酶水解的部分时间期间，与木质纤维素材料的另一部分相比，较少的氧被加入到木质纤维素材料中 酶水解，优选不向木质纤维素材料中加入氧。

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