公开(公告)号：US10561702B2

公开(公告)日：2020-02-18

申请号：US16060096

申请日：2016-12-09

Applicant: DSM IP ASSETS B.V.

Inventor： Remo Campiche ,  Dominik Imfeld ,  Eileen Jackson ,  Eliane Ursula Wandeler

IPC: A61K38/05 ,  A61K8/64 ,  A61Q19/00 ,  A61P17/10 ,  A61P17/08 ,  A61K8/06 ,  A61K8/55 ,  A61K9/107 ,  A61K47/24

Abstract: The present invention relates to a novel use of proline containing dipeptides for the prevention and/or treatment of skin conditions associated with altered, damaged or malfunctioning sebaceous glands.

公开(公告)号：US09060945B2

公开(公告)日：2015-06-23

申请号：US14369850

申请日：2012-12-28

Applicant: DSM IP Assets B.V.

Inventor： Remo Campiche ,  Piero Geotti-Bianchini ,  Hugo Ziegler ,  Stefan Martin Stoeckli

IPC: A61K8/35 ,  A61Q19/02 ,  A61K8/97 ,  A61Q17/04

CPC classification number: A61K8/35 ,  A61K8/97 ,  A61K2800/10 ,  A61Q17/04 ,  A61Q19/02

Abstract: The present invention relates to a novel composition comprising danielone and derivatives thereof as well as to the use of such compositions in skin lightening. More particularly, the present invention relates to danielone and derivatives thereof for use in topical compositions for smoothening skin color irregularities, for reducing melanin formation in the human skin, for lightening/brightening human skin and/or for treatment of pigmentation disorders which comprises topically administering an effective amount of danielone and derivatives thereof to the appropriate skin area of a person in need of such beautifying agent, or treatment.

Abstract translation: 本发明涉及一种包含丹尼酮及其衍生物的新型组合物，以及这些组合物在减轻皮肤中的用途。 更具体地说，本发明涉及用于局部用于平滑皮肤颜色不规则的局部组合物的丹尼酮及其衍生物，用于减少人皮肤黑色素的形成，减轻/增亮人体皮肤和/或治疗色素沉着病，其包括局部施用 有效量的丹尼酮及其衍生物可用于需要这种美容剂的人的适当皮肤区域或治疗。

公开(公告)号：US10328011B2

公开(公告)日：2019-06-25

申请号：US16060571

申请日：2016-12-09

Applicant: DSM IP ASSETS B.V.

Inventor： Remo Campiche ,  Dominik Imfeld ,  Alexandre Rio

IPC: A61K8/06 ,  A61K8/55 ,  A61K8/64 ,  A61Q19/00 ,  A61Q19/08

Abstract: Proline containing dipeptides are disclosed for up-regulating of genes involved in collagen fiber maturation and thus for revitalizing, strengthening and increasing the integrity of collagen fibers. These proline containing dipeptides are furthermore particularly suitable for improving the skin firmness, texture and elasticity as well as reducing the pore size and increasing skin moisturization.

公开(公告)号：US20150174021A1

公开(公告)日：2015-06-25

申请号：US14414004

申请日：2013-07-08

Applicant: DSM IP ASSETS B.V.

Inventor： Remo Campiche ,  Rainer Voegeli ,  Peter Wikstroem

IPC: A61K8/34 ,  A61Q19/00 ,  A61K8/64 ,  A61Q5/00

CPC classification number: A61K8/345 ,  A61K8/64 ,  A61K2800/5922 ,  A61K2800/782 ,  A61Q5/006 ,  A61Q19/00 ,  A61Q19/007

Abstract: The present invention relates to the field of active compositions for use in cosmetic products for humans. More particularly, the present invention relates to a cosmetic composition comprising benzylsulfonyl-D-Ser-homoPhe-(4-amidino-benzylamide), or a salt thereof, and a polyalcohol. Moreover, it relates to the use of said composition for maintaining, restoring, and/or improving the skin hydration, and/or the transepidermal water loss level in human skin. The present invention further relates to the use of benzylsulfonyl-D-Ser-homoPhe-(4-amidino-benzylamide), or a salt thereof, in combination with a polyalcohol for the co-inhibition of both plasmin and urokinase activity in the skin and/or the scalp.

Abstract translation: 本发明涉及用于人类化妆品的活性组合物领域。 更具体地，本发明涉及包含苄基磺酰基-D-Ser-高 - （4-脒基 - 苄基酰胺）或其盐和多元醇的化妆品组合物。 此外，它涉及所述组合物在人皮肤中维持，恢复和/或改善皮肤水合和/或经表皮水分损失水平的用途。 本发明还涉及苄基磺酰基-D-Ser-高 - （4-脒基 - 苄基酰胺）或其盐与多元醇的组合在皮肤中共同抑制纤溶酶和尿激酶活性的用途，以及 /或头皮。