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公开(公告)号：US11660100B2
公开(公告)日：2023-05-30
申请号：US16962464
申请日：2019-01-25
Applicant: DSM IP Assets B.V.
Inventor： William T. Fisher , Timothy Ringeisen , Gino Bradica
CPC classification number: A61B17/1615 , A61B17/164 , A61B17/1633 , A61B17/1659 , A61B2017/00867
Abstract: Disclosed are radially expanding debridement tools configured to pass through an access channel present in a first tissue of a living being, expand radially, and create a void in a second tissue of the living being upon being advanced distally through the access channel and into the second tissue while being rotated, wherein the shape of the void comprises at least one step. Further disclosed are debridement systems and methods of treating tissue defects in living beings.
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公开(公告)号：US20180230418A1
公开(公告)日：2018-08-16
申请号：US15949714
申请日：2018-04-10
Applicant: DSM IP ASSETS, B.V.
Inventor： John E. Nash , William T. Fisher , Gino Bradica
IPC: C12M1/00 , B04B7/12 , B04B3/00 , C12N5/0775
Abstract: A centrifuge device is provided for the sizing and separation of constituents of a biologic mixture, e.g., adipose tissue. The device provides for the mechanical breaking down of the fibrous structure in the tissue by centrifugation causing the tissue to pass through a mesh element, or a sizing helix, or an extrusion element, whereupon the material is reduced to a slurry. This processed material may then be separated by centrifugation into its constituents, in order to harvest the fraction containing the multipotent cells. These multipotent cells may be utilized for various medical procedures to stimulate healing and tissue regeneration.
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公开(公告)号：US12018244B2
公开(公告)日：2024-06-25
申请号：US18094446
申请日：2023-01-09
Applicant: DSM IP Assets B.V.
Inventor： John E. Nash , William T. Fisher , Gino Bradica
IPC: C12M1/00 , B04B3/00 , B04B7/12 , C12N5/0775
CPC classification number: C12M47/04 , C12M47/02 , B04B3/00 , B04B7/12 , C12N5/0667
Abstract: A centrifuge device is provided for the sizing and separation of constituents of a biologic mixture, e.g., adipose tissue. The device provides for the mechanical breaking down of the fibrous structure in the tissue by centrifugation causing the tissue to pass through a mesh element, or a sizing helix, or an extrusion element, whereupon the material is reduced to a slurry. This processed material may then be separated by centrifugation into its constituents, in order to harvest the fraction containing the multipotent cells. These multipotent cells may be utilized for various medical procedures to stimulate healing and tissue regeneration.
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公开(公告)号：US10711239B2
公开(公告)日：2020-07-14
申请号：US15949714
申请日：2018-04-10
Applicant: DSM IP ASSETS, B.V.
Inventor： John E. Nash , William T. Fisher , Gino Bradica
Abstract: A centrifuge device is provided for the sizing and separation of constituents of a biologic mixture, e.g., adipose tissue. The device provides for the mechanical breaking down of the fibrous structure in the tissue by centrifugation causing the tissue to pass through a mesh element, or a sizing helix, or an extrusion element, whereupon the material is reduced to a slurry. This processed material may then be separated by centrifugation into its constituents, in order to harvest the fraction containing the multipotent cells. These multipotent cells may be utilized for various medical procedures to stimulate healing and tissue regeneration.
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Patent Agency Ranking
公开(公告)号：US10646884B2
公开(公告)日：2020-05-12
申请号：US15841435
申请日：2017-12-14
Applicant: DSM IP Assets, B.V.
Inventor： John E. Nash , William T. Fisher , Douglas G. Evans
IPC: B04B11/04 , B01D21/26 , B01D21/34 , B04B1/02 , B04B5/04 , B04B7/08 , A61M1/36 , B04B1/18 , B04B1/14
Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.
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公开(公告)号：US20180104703A1
公开(公告)日：2018-04-19
申请号：US15841435
申请日：2017-12-14
Applicant: DSM IP Assets, B.V.
Inventor： John E. Nash , William T. Fisher , Douglas G. Evans
IPC: B04B11/04 , A61M1/36 , B01D21/26 , B04B5/04 , B01D21/34 , B04B1/02 , B04B7/08 , B04B1/18 , B04B1/14
CPC classification number: B04B11/04 , A61M1/3693 , A61M1/3696 , B01D21/262 , B01D21/34 , B01D2221/10 , B04B1/02 , B04B1/14 , B04B1/18 , B04B5/0407 , B04B5/0442 , B04B7/08 , B04B2005/0485
Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.
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公开(公告)号：US10125345B2
公开(公告)日：2018-11-13
申请号：US14610613
申请日：2015-01-30
Applicant: DSM IP ASSETS B.V.
Inventor： John E. Nash , William T. Fisher , Gino Bradica
IPC: C12M1/00 , C12N5/0775 , B04B3/00 , B04B7/12
Abstract: A centrifuge device is provided for the sizing and separation of constituents of a biologic mixture, e.g., adipose tissue. The device provides for the mechanical breaking down of the fibrous structure in the tissue by centrifugation causing the tissue to pass through a mesh element, or a sizing helix, or an extrusion element, whereupon the material is reduced to a slurry. This processed material may then be separated by centrifugation into its constituents, in order to harvest the fraction containing the multipotent cells. These multipotent cells may be utilized for various medical procedures to stimulate healing and tissue regeneration.
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公开(公告)号：US11549094B2
公开(公告)日：2023-01-10
申请号：US16893464
申请日：2020-06-05
Applicant: DSM IP Assets B.V.
Inventor： John E. Nash , William T. Fisher , Gino Bradica
IPC: C12M1/00 , C12N5/0775 , B04B3/00 , B04B7/12
Abstract: A centrifuge device is provided for the sizing and separation of constituents of a biologic mixture, e.g., adipose tissue. The device provides for the mechanical breaking down of the fibrous structure in the tissue by centrifugation causing the tissue to pass through a mesh element, or a sizing helix, or an extrusion element, whereupon the material is reduced to a slurry. This processed material may then be separated by centrifugation into its constituents, in order to harvest the fraction containing the multipotent cells. These multipotent cells may be utilized for various medical procedures to stimulate healing and tissue regeneration.
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公开(公告)号：US11167292B2
公开(公告)日：2021-11-09
申请号：US16833743
申请日：2020-03-30
Applicant: DSM IP Assets B.V.
Inventor： John E. Nash , William T. Fisher , Douglas G. Evans
IPC: B04B11/04 , B01D21/26 , B01D21/34 , B04B1/02 , B04B5/04 , B04B7/08 , A61M1/36 , B04B1/18 , B04B1/14
Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.
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