公开(公告)号：US09572812B2

公开(公告)日：2017-02-21

申请号：US14995658

申请日：2016-01-14

申请人： DURECT CORPORATION ,  ZOGENIX INC.

发明人： Jeremy C. Wright ,  Wilma Tamraz ,  John J. Leonard ,  John W. Gibson ,  Keith E. Branham ,  Stefania Sjobeck ,  Brooks Boyd ,  Christopher M. Rubino

IPC分类号： A61K9/19 ,  A61M5/30 ,  A61K31/519 ,  A61K9/00 ,  A61K47/22 ,  A61K47/26 ,  A61K47/34 ,  A61K9/10 ,  A61K9/16 ,  A61K47/10 ,  A61K47/14 ,  A61K47/20 ,  A61K47/44 ,  A61K9/14 ,  A61M5/20 ,  A61M5/31

CPC分类号： A61K31/519 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1623 ,  A61K9/1647 ,  A61K9/19 ,  A61K41/0019 ,  A61K47/10 ,  A61K47/14 ,  A61K47/20 ,  A61K47/22 ,  A61K47/26 ,  A61K47/34 ,  A61K47/44 ,  A61M5/30 ,  A61M2005/2013 ,  A61M2005/2073 ,  A61M2005/312 ,  C08G63/08 ,  C08G63/912

摘要： Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed.

摘要翻译： 组合物可以包括药物活性剂，高粘度液体载体材料（HVLCM），乳酸基聚合物和有机溶剂。 还公开了相关的组合物和方法。

公开(公告)号：US09737605B2

公开(公告)日：2017-08-22

申请号：US14773642

申请日：2014-03-11

申请人： DURECT CORPORATION ,  ZOGENIX, INC.

发明人： Jeremy C. Wright ,  Wilma Tamraz ,  John J. Leonard ,  John W. Gibson ,  Keith E. Branham ,  Stefania Sjobeck ,  Brooks Boyd ,  Christopher M. Rubino

IPC分类号： A61K47/22 ,  A61K9/00 ,  A61K31/519 ,  A61K47/20 ,  A61K47/26 ,  A61M5/20 ,  A61M5/24 ,  A61M5/30 ,  A61M5/315

CPC分类号： A61K47/22 ,  A61K9/0019 ,  A61K9/0021 ,  A61K31/519 ,  A61K47/20 ,  A61K47/26 ,  A61M5/2033 ,  A61M5/2046 ,  A61M5/2053 ,  A61M5/24 ,  A61M5/30 ,  A61M5/315 ,  A61M2205/8206

摘要： Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed. For instance, a carrier formulation for controlled release of injectable drugs is disclosed. The formulation may include a non-water soluble high viscosity liquid which may be sucrose acetate isobutyrate, a lactic-acid based polymer which may be a poly(lactic acid)(glycolic acid), and an organic solvent which maintains the composition in a monophasic form at 25° C. in one atmosphere. Drug in the formulation may be released upon administration such that less than 10% (e.g. 2-8%) of drug is released in the first 5 hours; 10% to 80% of the drug is released during a period of 5 hours to 7 days after administration; and 10% to 40% of the drug is released gradually over a period of 7 days to 28 days from initial administration. The drug may be an anti-schizophrenia agent delivered by injection.

公开(公告)号：US20220257619A1

公开(公告)日：2022-08-18

申请号：US17627000

申请日：2020-07-17

申请人： Gilead Sciences, Inc. ,  Durect Corporation

发明人： Susan Autio ,  Keith Edward Branham ,  James A. Filice ,  John W. Gibson ,  John J. Leonard ,  James Matriano ,  Whitney Moro ,  Michael Sekar ,  Chelsea Alexandra Snyder ,  Robert G. Strickley ,  Raju Subramanian ,  Felix Theeuwes ,  Monica Tijerina ,  Jeremy C. Wright ,  Su Il Yum ,  Faye Xu

IPC分类号： A61K31/675 ,  A61K47/26 ,  A61K47/34 ,  A61K47/22 ,  A61P31/18

摘要： The present disclosure provides long-acting formulations of tenofovir alafenamide, methods of making the same and methods of using the same.

公开(公告)号：US20180289696A1

公开(公告)日：2018-10-11

申请号：US15887797

申请日：2018-02-02

申请人： Durect Corporation

发明人： Su Il Yum ,  Grant Schoenhard ,  Arthur J. Tipton ,  John W. Gibson ,  John C. Middleton ,  Roger Fu ,  Michael S. Zamloot

IPC分类号： A61K31/485 ,  A61K47/14 ,  A61K31/4458 ,  A61K47/26 ,  A61K9/48 ,  A61K9/00 ,  A61K47/38

摘要： Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.

公开(公告)号：US20170189547A1

公开(公告)日：2017-07-06

申请号：US15356488

申请日：2016-11-18

申请人： Durect Corporation

发明人： William W. van Osdol ,  Su Il Yum ,  Felix Theeuwes ,  Michael Sekar ,  John W. Gibson ,  Keith E. Branham ,  Huey-Ching Su

IPC分类号： A61K48/00 ,  A61K47/14 ,  A61K47/10 ,  A61K9/00 ,  A61K38/27 ,  A61K38/21 ,  A61K31/7052 ,  A61K38/26 ,  A61K47/26 ,  A61K47/34 ,  A61K47/48

CPC分类号： A61K38/212 ,  A61K9/0019 ,  A61K31/7052 ,  A61K38/26 ,  A61K38/27 ,  A61K47/14 ,  A61K47/26 ,  A61K47/34 ,  A61K47/52 ,  A61K47/541 ,  A61K47/64

摘要： The present disclosure provides a biodegradable drug delivery composition including a vehicle and an insoluble component comprising beneficial agent dispersed in the vehicle. Typically, the composition is not an emulsion, but has a low viscosity and further provides for minimized initial burst and sustained release of the beneficial agent over time. Also provided, are kits including the biodegradable drug delivery composition or components thereof, as well as methods of making and using the biodegradable drug delivery composition.

公开(公告)号：US20210038731A1

公开(公告)日：2021-02-11

申请号：US16935110

申请日：2020-07-21

申请人： Durect Corporation

发明人： Michael Sekar ,  Felix Theeuwes ,  Keith Edward Branham ,  John W. Gibson ,  James Matriano ,  Whitney Moro ,  John Tipton ,  William Van Osdol ,  Su Il Yum

IPC分类号： A61K47/54 ,  A61K9/16 ,  A61K9/19 ,  A61K9/00 ,  A61K47/59 ,  A61K38/26 ,  A61K31/352 ,  A61K31/706 ,  A61K31/785 ,  A61K38/27 ,  A61K38/28 ,  A61K38/31 ,  A61K39/395

摘要： The present disclosure generally provides complexes including a pharmaceutically active agent and a functionalized polymer, wherein the functionalized polymer includes repeat units, the repeat units including ionizable repeat units having at least one ionizable side group and/or ionizable end group, a plurality of the at least one ionizable groups forming non-covalent bonds with the pharmaceutically active agent. Polymers which may be used to form such complexes as well as methods of making and using the complexes and related compositions are also provided.

公开(公告)号：US10226532B2

公开(公告)日：2019-03-12

申请号：US15652655

申请日：2017-07-18

申请人： DURECT CORPORATION

发明人： Jeremy C. Wright ,  Wilma Tamraz ,  John J. Leonard ,  John W. Gibson ,  Keith E. Branham ,  Stefania Sjobeck ,  Brooks Boyd ,  Christopher M. Rubino

IPC分类号： A61K9/00 ,  A61M5/20 ,  A61M5/24 ,  A61M5/30 ,  A61K47/20 ,  A61K47/22 ,  A61K47/26 ,  A61M5/315 ,  A61K31/519

摘要： Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed. For instance, a carrier formulation for controlled release of injectable drugs is disclosed. The formulation may include a non-water soluble high viscosity liquid which may be sucrose acetate isobutyrate, a lactic-acid based polymer which may be a poly(lactic acid)(glycolic acid), and an organic solvent which maintains the composition in a monophasic form at 25° C. in one atmosphere. Drug in the formulation may be released upon administration such that less than 10% (e.g. 2-8%) of drug is released in the first 5 hours; 10% to 80% of the drug is released during a period of 5 hours to 7 days after administration; and 10% to 40% of the drug is released gradually over a period of 7 days to 28 days from initial administration. The drug may be an anti-schizophrenia agent delivered by injection.

公开(公告)号：US20140193365A1

公开(公告)日：2014-07-10

申请号：US14102453

申请日：2013-12-10

申请人： Durect Corporation

发明人： William W. van Osdol ,  Su Il Yum ,  Felix Theeuwes ,  Michael Sekar ,  John W. Gibson ,  Keith E. Branham ,  Huey-Ching Su

IPC分类号： A61K9/00 ,  A61K38/27 ,  A61K47/14 ,  A61K38/21 ,  A61K47/34 ,  A61K47/10 ,  A61K38/26 ,  A61K31/7052

CPC分类号： A61K38/212 ,  A61K9/0019 ,  A61K31/7052 ,  A61K38/26 ,  A61K38/27 ,  A61K47/14 ,  A61K47/26 ,  A61K47/34 ,  A61K47/52 ,  A61K47/541 ,  A61K47/64

摘要： The present disclosure provides a biodegradable drug delivery composition including a vehicle and an insoluble component comprising beneficial agent dispersed in the vehicle. Typically, the composition is not an emulsion, but has a low viscosity and further provides for minimized initial burst and sustained release of the beneficial agent over time. Also provided, are kits including the biodegradable drug delivery composition or components thereof, as well as methods of making and using the biodegradable drug delivery composition.

摘要翻译： 本公开提供了包含载体和包含分散在载体中的有益剂的不溶性组分的生物可降解药物递送组合物。 通常，组合物不是乳液，而是具有低粘度，并进一步提供有益剂随时间的最小化的初始爆发和持续释放。 还提供了包括可生物降解的药物递送组合物或其组分的试剂盒，以及制备和使用可生物降解的药物递送组合物的方法。

公开(公告)号：US11285217B2

公开(公告)日：2022-03-29

申请号：US16889115

申请日：2020-06-01

申请人： DURECT CORPORATION

发明人： Jeremy C. Wright ,  Wilma Tamraz ,  John J. Leonard ,  John W. Gibson ,  Keith E. Branham ,  Stefania Sjobeck ,  Brooks Boyd ,  Christopher M. Rubino

IPC分类号： A61K47/22 ,  A61K9/00 ,  A61K31/519 ,  A61K47/20 ,  A61K47/26 ,  A61M5/20 ,  A61M5/24 ,  A61M5/30 ,  A61M5/315

摘要： Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed. For instance, a carrier formulation for controlled release of injectable drugs is disclosed. The formulation may include a non-water soluble high viscosity liquid which may be sucrose acetate isobutyrate, a lactic-acid based polymer which may be a poly(lactic acid)(glycolic acid), and an organic solvent which maintains the composition in a monophasic form at 25° C. in one atmosphere. Drug in the formulation may be released upon administration such that less than 10% (e.g. 2-8%) of drug is released in the first 5 hours; 10% to 80% of the drug is released during a period of 5 hours to 7 days after administration; and 10% to 40% of the drug is released gradually over a period of 7 days to 28 days from initial administration. The drug may be an anti-schizophrenia agent delivered by injection.

公开(公告)号：US09517271B2

公开(公告)日：2016-12-13

申请号：US14957148

申请日：2015-12-02

申请人： Durect Corporation

发明人： Su Il Yum ,  Grant Schoenhard ,  Arthur J. Tipton ,  John W. Gibson ,  John C. Middleton ,  Roger Fu ,  Michael S. Zamloot

IPC分类号： A61K47/38 ,  A61K9/48 ,  A61K47/26 ,  A61K47/14 ,  A61K31/485 ,  A61K31/4458

CPC分类号： A61K31/485 ,  A61K9/0053 ,  A61K9/48 ,  A61K9/4825 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/4458 ,  A61K47/14 ,  A61K47/26 ,  A61K47/38 ,  Y10S514/96

摘要： Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.