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公开(公告)号：US5612215A
公开(公告)日：1997-03-18
申请号：US390850
申请日：1995-02-17
IPC分类号： A61K38/00 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07K14/47 , C12N9/64 , C12N15/113 , C12N15/85 , A61K48/00 , C12Q1/68
CPC分类号： C12N15/113 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07K14/4702 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N9/6491 , C12Y304/24017 , A61K38/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/126 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/332 , C12N2310/346
摘要： An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of an arthritic condition.
摘要翻译： 一种酶切RNA分子，其切割与发育或维持关节炎病症相关的mRNA。
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2.发明授权Ribozyme treatment of diseases or conditions related to levels of intercellular adhesion molecule-1 (CAM-1) 失效与细胞间粘附分子-1（CAM-1）水平相关的疾病或病症的核酶治疗公开(公告)号：US06436644B1
公开(公告)日：2002-08-20
申请号：US09589628
申请日：2000-06-07
IPC分类号： C07H2104
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C07K14/4702 , C12N9/6491 , C12N15/101 , C12N15/1131 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/32 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3523 , C12N2310/3527 , C12N2310/3533 , C12N2310/3535
摘要： The present invention relates to enzymatic RNA molecules which cleave ICAM-1 mRNA.
摘要翻译： 本发明涉及切割ICAM-1mRNA的酶RNA分子
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3.发明授权Ribozyme treatment of diseases or conditions related to levels of intercellular adhesion molecule-1 (ICAM-1) 失效与细胞间粘附分子-1（ICAM-1）水平相关的疾病或病症的核酶治疗
公开(公告)号：US6132967A
公开(公告)日：2000-10-17
申请号：US71845
申请日：1998-05-01
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N9/64 , C12N15/10 , C12N15/113 , C12Q1/68 , C07H21/04 , C12N15/63 , C12N15/85
CPC分类号： C12N15/113 , C07K14/4702 , C12N15/101 , C12N15/1131 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N9/6491 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/32 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3523 , C12N2310/3527 , C12N2310/3533 , C12N2310/3535
摘要： Enzymatic RNA molecules which cleave ICAM-1 mRNA.
摘要翻译： 切割ICAM-1 mRNA的酶RNA分子。
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4.发明授权
公开(公告)号：US6159692A
公开(公告)日：2000-12-12
申请号：US249215
申请日：1999-02-12
IPC分类号： A61K38/00 , C07K14/08 , C12N15/113 , C12N15/85 , C12N15/86 , C12Q1/70 , C12Q1/68 , C07H21/04 , C12N15/63
CPC分类号： C12N15/1132 , A61K38/00 , C07K14/005 , C12N15/85 , C12N15/86 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3531 , C12N2310/3533 , C12N2310/3535 , C12N2740/16022 , C12Q1/701 , C12Q1/703
摘要： An enzymatic nucleic acid molecule which cleaves an immunodeficiency virus RNA in a gene required for viral replication, e.g., the nef or tat gene regions.
摘要翻译： 在病毒复制所需的基因中切割免疫缺陷病毒RNA的酶学核酸分子，例如nef或tat基因区域。
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公开(公告)号：US5837542A
公开(公告)日：1998-11-17
申请号：US292620
申请日：1994-08-17
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N9/64 , C12N15/10 , C12N15/113 , C12Q1/68 , C12N15/85
CPC分类号： C12N15/113 , C07K14/4702 , C12N15/101 , C12N15/1131 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N9/6491 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/32 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3523 , C12N2310/3527 , C12N2310/3533 , C12N2310/3535
摘要： Enzymatic RNA molecules which cleave ICAM-1 mRNA.
摘要翻译： 切割ICAM-1 mRNA的酶RNA分子。
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公开(公告)号：US5731295A
公开(公告)日：1998-03-24
申请号：US435634
申请日：1995-05-05
IPC分类号： A61K38/00 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07K14/47 , C12N9/64 , C12N15/113 , A61K48/00 , C12Q1/68
CPC分类号： C12N15/113 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07K14/4702 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N9/6491 , C12Y304/24017 , A61K38/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/126 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/332 , C12N2310/346
摘要： An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of an arthritic condition.
摘要翻译： 一种酶切RNA分子，其切割与发育或维持关节炎病症相关的mRNA。
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公开(公告)号：US5616488A
公开(公告)日：1997-04-01
申请号：US319492
申请日：1994-10-07
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N9/64 , C12N15/10 , C12N15/113 , C12N15/05 , C12Q1/68
CPC分类号： C07K14/4702 , C12N15/101 , C12N15/113 , C12N15/1131 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N9/6491 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/32 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3523 , C12N2310/3527 , C12N2310/3533 , C12N2310/3535
摘要： Enzymatic RNA molecules which cleave IL-5 mRNA.
摘要翻译： 酶切RNA分子IL-5 mRNA。
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8.发明授权Ribozyme treatment of diseases or conditions related to levels of NF-&kgr;B 失效与NF-κB水平相关的疾病或病症的核酶治疗公开(公告)号：US06410224B1
公开(公告)日：2002-06-25
申请号：US08777916
申请日：1996-12-23
IPC分类号： C07H2104
CPC分类号： C12N15/101 , A61K38/00 , A61K48/00 , C07K14/4702 , C12N9/6491 , C12N15/113 , C12N15/1131 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/315 , C12N2310/317 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3517 , C12N2310/3523 , C12N2310/3527 , C12N2310/3533 , C12N2310/3535 , C12N2310/3521
摘要： Enzymatic RNA molecules which cleave rel A mRNA.
摘要翻译： 分解相关A mRNA的酶RNA分子
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公开(公告)号：US5972704A
公开(公告)日：1999-10-26
申请号：US910408
申请日：1997-08-13
IPC分类号： A61K38/00 , C07K14/08 , C12N15/113 , C12N15/85 , C12N15/86 , C12Q1/70 , C12Q1/68 , C07H21/04
CPC分类号： C12N15/1132 , C07K14/005 , C12N15/85 , C12N15/86 , C12Q1/701 , C12Q1/703 , A61K38/00 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3531 , C12N2310/3533 , C12N2310/3535 , C12N2740/16022
摘要： An enzymatic nucleic acid molecule which cleaves an immunodeficiency virus RNA in a gene required for viral replication, e.g., the nef or tat gene regions.
摘要翻译： 在病毒复制所需的基因中切割免疫缺陷病毒RNA的酶学核酸分子，例如nef或tat基因区域。
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公开(公告)号：US5693535A
公开(公告)日：1997-12-02
申请号：US271880
申请日：1994-07-07
IPC分类号： A61K38/00 , C07K14/08 , C12N15/113 , C12N15/85 , C12N15/86 , C12Q1/70 , C12N15/83 , C12Q1/68
CPC分类号： C12N15/1132 , C07K14/005 , C12N15/85 , C12N15/86 , C12Q1/701 , C12Q1/703 , A61K38/00 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3531 , C12N2310/3533 , C12N2310/3535 , C12N2740/16022
摘要： An enzymatic nucleic acid molecule which cleaves an immunodeficiency virus RNA in a gene required for viral replication, e.g., the nef or tat gene regions.
摘要翻译： 在病毒复制所需的基因中切割免疫缺陷病毒RNA的酶学核酸分子，例如nef或tat基因区域。
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