-
公开(公告)号：US20130296378A1
公开(公告)日：2013-11-07
申请号：US13857665
申请日：2013-04-05
申请人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Prezewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Paul Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
发明人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Prezewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Paul Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号： C07D401/04 , A61K45/06 , A61K31/4439 , C07D401/14
CPC分类号： C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
-
公开(公告)号：US08329736B2
公开(公告)日：2012-12-11
申请号：US13452200
申请日：2012-04-20
申请人： Dinesh U. Chimmanamada , Weiwen Ying , Teresa Kowalczyk Przewloka , Shijie Zhang , Kevin Foley , Zhenjian Du , Dan Zhou , Shuzhen Qin
发明人： Dinesh U. Chimmanamada , Weiwen Ying , Teresa Kowalczyk Przewloka , Shijie Zhang , Kevin Foley , Zhenjian Du , Dan Zhou , Shuzhen Qin
IPC分类号： A61K31/4196 , C07D249/12
CPC分类号： C07D249/12 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D407/10 , C07D413/10 , C07F9/6518
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
-
公开(公告)号：US08927548B2
公开(公告)日：2015-01-06
申请号：US13350296
申请日：2012-01-13
申请人： Weiwen Ying , David James , Shijie Zhang , Junghyun Chae , Teresa Kowalczyk-Przewloka , Howard P. Ng , Hao Li , Zachary Demko , Dinesh U. Chimmanamada , Chi-wan Lee , Zhenjian Du , Kevin Foley , Minghu Song , Lijun Sun , Keizo Koya , Dan Zhou , Shuzhen Qin
发明人： Weiwen Ying , David James , Shijie Zhang , Junghyun Chae , Teresa Kowalczyk-Przewloka , Howard P. Ng , Hao Li , Zachary Demko , Dinesh U. Chimmanamada , Chi-wan Lee , Zhenjian Du , Kevin Foley , Minghu Song , Lijun Sun , Keizo Koya , Dan Zhou , Shuzhen Qin
IPC分类号： C07D249/12 , C07D401/04 , C07D405/10 , C07D417/04 , C07D405/14 , C07D409/04 , A61K31/5377 , A61P35/00 , C07D405/04 , C07D403/04 , C07D403/14
CPC分类号： C07D417/04 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/10 , C07D405/14 , C07D409/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
-
公开(公告)号：US20140141511A1
公开(公告)日：2014-05-22
申请号：US14055398
申请日：2013-10-16
申请人： Dan Zhou , Shuzhen Qin , Weiwen Ying
发明人： Dan Zhou , Shuzhen Qin , Weiwen Ying
IPC分类号： C07D249/12 , C07D403/10
CPC分类号： C07D249/12 , A61K31/4196 , C07D403/10 , Y02A50/422
摘要： The present invention relates to a method for suppressing the immune system in a subject in need thereof, and a method for treating an inflammatory or immune disorder in a subject in need thereof.
摘要翻译： 本发明涉及在有需要的受试者中抑制免疫系统的方法，以及在有需要的受试者中治疗炎性或免疫疾病的方法。
-
公开(公告)号：US08415377B2
公开(公告)日：2013-04-09
申请号：US13229178
申请日：2011-09-09
申请人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
发明人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号： C07D401/14 , C07D403/04 , A61K31/4196 , A61K31/4709
CPC分类号： C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
-
公开(公告)号：US20120202813A1
公开(公告)日：2012-08-09
申请号：US13452200
申请日：2012-04-20
申请人： Dinesh U. Chimmanamada , Weiwen Ying , Teresa Kowalczyk Przewloka , Shijie Zhang , Kevin Foley , Zhenjian Du , Dan Zhou , Shuzhen Qin
发明人： Dinesh U. Chimmanamada , Weiwen Ying , Teresa Kowalczyk Przewloka , Shijie Zhang , Kevin Foley , Zhenjian Du , Dan Zhou , Shuzhen Qin
IPC分类号： A61K31/4196 , A61P35/00 , A61P35/02 , A61K31/4439 , A61K31/5377
CPC分类号： C07D249/12 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D407/10 , C07D413/10 , C07F9/6518
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
-
公开(公告)号：US20100280032A1
公开(公告)日：2010-11-04
申请号：US12312106
申请日：2007-10-25
申请人： Dan Zhou , Shuzhen Qin , Weiwen Ying
发明人： Dan Zhou , Shuzhen Qin , Weiwen Ying
IPC分类号： A61K31/4196 , A61K31/5377 , A61K31/4709 , A61K31/428 , A61P1/00 , A61P11/06 , A61P29/00 , A61P11/00 , A61P19/00 , A61P37/06 , A61P27/02 , A61P25/28 , A61P9/10 , C12N5/00
CPC分类号： C07D249/12 , A61K31/4196 , C07D403/10 , Y02A50/422
摘要： The present invention relates to a method for suppressing the immune system in a subject in need thereof, and a method for treating an inflammatory or immune disorder in a subject in need thereof.
摘要翻译： 本发明涉及在有需要的受试者中抑制免疫系统的方法，以及在有需要的受试者中治疗炎性或免疫疾病的方法。
-
公开(公告)号：US08524712B2
公开(公告)日：2013-09-03
申请号：US12593147
申请日：2008-03-24
申请人： Chi-Wan Lee , Teresa Przewloka , Weiwen Ying , Minghu Song , Zhenjian Du , Kevin Foley , Dan Zhou , Shuzhen Qin
发明人： Chi-Wan Lee , Teresa Przewloka , Weiwen Ying , Minghu Song , Zhenjian Du , Kevin Foley , Dan Zhou , Shuzhen Qin
IPC分类号： A61K31/53 , A61K31/519 , A61K31/47 , C07D401/04 , C07D253/06 , C07D471/02 , C07D487/02
CPC分类号： C07D239/36 , C07D209/40 , C07D239/10 , C07D239/20 , C07D253/06 , C07D403/04 , C07D405/04 , C07D487/04 , C07D491/048
摘要： The present invention relates to compounds according to formulae (IA) to (ID) and compositions that inhibit the activity of Hsp90. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及根据式（IA）至（ID）的化合物和抑制Hsp90活性的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法以及在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明化合物或 包含这种化合物的组合物。
-
公开(公告)号：US20120122869A1
公开(公告)日：2012-05-17
申请号：US13350296
申请日：2012-01-13
申请人： Weiwen Ying , David James , Shijie Zhang , Junghyun Chae , Teresa Przewloka , Howard P. Ng , Hao Li , Zachary Demko , Dinesh U. Chimmanamada , Chi-wan Lee , Zhenjian Du , Kevin Foley , Minghu Song , Lijun Sun , Keizo Koya , Dan Zhou , Shuzhen Qin
发明人： Weiwen Ying , David James , Shijie Zhang , Junghyun Chae , Teresa Przewloka , Howard P. Ng , Hao Li , Zachary Demko , Dinesh U. Chimmanamada , Chi-wan Lee , Zhenjian Du , Kevin Foley , Minghu Song , Lijun Sun , Keizo Koya , Dan Zhou , Shuzhen Qin
IPC分类号： A61K31/5377 , A61K31/4196 , A61P35/00 , C07D403/00 , A61K31/4709 , C07D249/12 , C07D413/10
CPC分类号： C07D417/04 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/10 , C07D405/14 , C07D409/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
-
公开(公告)号：US08053456B2
公开(公告)日：2011-11-08
申请号：US11807327
申请日：2007-05-25
申请人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
发明人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号： A61K31/4196 , C07D249/12
CPC分类号： C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
-
-
-
-
-
-
-
-
-
搜索结果
36 条记录 (耗时 0.061 秒)
