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1.发明申请INTRAVENOUS AND ORAL DOSING OF A DIRECT-ACTING AND REVERSIBLE P2Y12 INHIBITOR 审中-公开直接作用和可逆的P2Y12抑制剂的口服和口服剂量公开(公告)号：US20090048216A1
公开(公告)日：2009-02-19
申请号：US12114630
申请日：2008-05-02
申请人： Daniel D. Gretler , Pamela B. Conley , Patrick Andre , Athiwat Hutchaleelaha , David R. Phillips , Anjali Pandey , Robert M. Scarborough , Caroll Scarborough , Wolin Huang
发明人： Daniel D. Gretler , Pamela B. Conley , Patrick Andre , Athiwat Hutchaleelaha , David R. Phillips , Anjali Pandey , Robert M. Scarborough , Caroll Scarborough , Wolin Huang
IPC分类号： A61K31/517 , A61K31/60 , A61P9/00
CPC分类号： A61K31/517 , A61K31/216 , A61K2300/00
摘要： The invention provides methods and compositions for rapid and reversible inhibition of platelet aggregation in human subjects in need thereof by administering compounds of the formula: alone or in combination with a second agent which can be aspirin or a thrombolytic agent.
摘要翻译： 本发明提供了通过施用下式的化合物单独或与可以是阿司匹林或溶栓剂的第二药剂组合来快速和可逆地抑制有需要的人受试者血小板聚集的方法和组合物。
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2.发明申请INTRAVENOUS AND ORAL DOSING OF A DIRECT-ACTING AND REVERSIBLE P2Y12 INHIBITOR 审中-公开直接作用和可逆的P2Y12抑制剂的口服和口服剂量公开(公告)号：US20120009172A1
公开(公告)日：2012-01-12
申请号：US13235305
申请日：2011-09-16
申请人： Daniel D. Gretler , Pamela B. Conley , Patrick Andre , Athiwat Hutchaleelaha , David R. Phillips , Anjali Pandey , Robert M. Scarborough , Carroll Anna Crew Scarborough , Wolin Huang
发明人： Daniel D. Gretler , Pamela B. Conley , Patrick Andre , Athiwat Hutchaleelaha , David R. Phillips , Anjali Pandey , Robert M. Scarborough , Carroll Anna Crew Scarborough , Wolin Huang
IPC分类号： A61K38/45 , A61K38/48 , A61P9/00 , A61K31/517 , C07D409/12 , A61P7/00 , A61K38/46 , A61K31/60
CPC分类号： A61K31/517 , A61K31/216 , A61K2300/00
摘要： The invention provides methods and compositions for rapid and reversible inhibition of platelet aggregation in human subjects in need thereof by administering compounds of the formula: alone or in combination with a second agent which can be aspirin or a thrombolytic agent.
摘要翻译： 本发明提供了通过施用下式的化合物单独或与可以是阿司匹林或溶栓剂的第二药剂组合来快速和可逆地抑制有需要的人受试者血小板聚集的方法和组合物。
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公开(公告)号：US20080241233A1
公开(公告)日：2008-10-02
申请号：US12057100
申请日：2008-03-27
申请人： Peter J. Sims , Pamela B. Conley , Peng Luan , David R. Phillips
发明人： Peter J. Sims , Pamela B. Conley , Peng Luan , David R. Phillips
IPC分类号： A61K9/127 , A61K38/02 , A61K39/395 , A61K38/17 , A61K38/43
CPC分类号： A61K9/1271 , A61K9/1272 , A61K31/685 , A61K38/177 , A61K38/46 , A61K47/6843 , A61K47/6913 , A61K2300/00
摘要： A platelet substitute consisting of large unilamellar lipid vesicles that contain phosphatidylserine or another procoagulant (clot-promoting) phospholipid, a protein that has binding affinity for collagen or other component of the vessel wall that becomes exposed upon vessel injury, and/or a phospholipid scramblase, has been developed. This platelet substitute provides a means for selectively delivering procoagulant phospholipids and/or fatty acids to the site of vessel injury through targeted adherence to collagen or other component exposed upon vessel injury. These are particularly effective due to the combination of targeting procoagulant vesicles to a site of injury, and triggered exposure of phosphatidylserine (PS) on the surface.
摘要翻译： 包含含有磷脂酰丝氨酸或另一促凝血素（促凝血素）磷脂的大单层脂质囊泡的血小板替代物，对血管损伤时暴露于血管壁的胶原蛋白或其他成分具有结合亲和力的蛋白质和/或磷脂类 ，已经开发。 该血小板替代物提供了通过靶向粘附到血管损伤时暴露于胶原或其它组分的选择性地将促凝血磷脂和/或脂肪酸输送到血管损伤部位的手段。 由于靶向促凝血小泡与损伤部位的结合，并且触发表面上的磷脂酰丝氨酸（PS）的暴露，这些是特别有效的。
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公开(公告)号：US08153590B2
公开(公告)日：2012-04-10
申请号：US12239651
申请日：2008-09-26
申请人： Genmin Lu , David R. Phillips , Patrick Andre , Uma Sinha
发明人： Genmin Lu , David R. Phillips , Patrick Andre , Uma Sinha
IPC分类号： A61K35/14
CPC分类号： A61K38/4846 , A61K38/00 , A61K38/4826 , A61K38/4833 , A61K38/4853 , A61K39/00 , A61K47/60 , C07K14/435 , C12N9/6432 , C12Y304/21006
摘要： The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
摘要翻译： 本发明涉及靶向因子Xa的抗凝剂的解毒剂。 解毒剂是与因子Xa抑制剂结合的因子Xa蛋白衍生物，从而基本上中和它们，但不组装到凝血酶原酶复合物中。 本文所述的衍生物缺乏或具有降低的内在凝结剂活性。 本文公开了在目前正在进行使用因子Xa抑制剂进行抗凝治疗的患者中停止或预防出血的方法。
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5.发明授权Device and methods for identifying and treating aspirin non-responsive patients 失效用于鉴定和治疗阿司匹林非反应性患者的装置和方法公开(公告)号：US07785891B2
公开(公告)日：2010-08-31
申请号：US12037012
申请日：2008-02-25
CPC分类号： G01N33/9486 , G01N33/86
摘要： The present invention relates to methods and compositions for identifying and treating subjects in need of antithrombotic therapies but who are not responsive to aspirin.
摘要翻译： 本发明涉及用于鉴定和治疗需要抗血栓治疗但是对阿司匹林不敏感的受试者的方法和组合物。
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公开(公告)号：US08455441B2
公开(公告)日：2013-06-04
申请号：US13414499
申请日：2012-03-07
申请人： Genmin Lu , David R. Phillips , Patrick Andre , Uma Sinha
发明人： Genmin Lu , David R. Phillips , Patrick Andre , Uma Sinha
IPC分类号： A61K39/00
CPC分类号： A61K38/4846 , A61K38/00 , A61K38/4826 , A61K38/4833 , A61K38/4853 , A61K39/00 , A61K47/60 , C07K14/435 , C12N9/6432 , C12Y304/21006
摘要： The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
摘要翻译： 本发明涉及靶向因子Xa的抗凝剂的解毒剂。 解毒剂是与因子Xa抑制剂结合的因子Xa蛋白衍生物，从而基本上中和它们，但不组装到凝血酶原酶复合物中。 本文所述的衍生物缺乏或具有降低的内在凝结剂活性。 本文公开了在目前正在进行使用因子Xa抑制剂进行抗凝治疗的患者中停止或预防出血的方法。
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公开(公告)号：US20120269788A1
公开(公告)日：2012-10-25
申请号：US13414499
申请日：2012-03-07
申请人： Genmin Lu , David R. Phillips , Patrick Andre , Uma Sinha
发明人： Genmin Lu , David R. Phillips , Patrick Andre , Uma Sinha
IPC分类号： A61K38/48 , C12N9/96 , C12N15/57 , A61P7/04 , C12N5/10 , C12N1/19 , A61K48/00 , A61P39/02 , C12N9/64 , C12N1/21
CPC分类号： A61K38/4846 , A61K38/00 , A61K38/4826 , A61K38/4833 , A61K38/4853 , A61K39/00 , A61K47/60 , C07K14/435 , C12N9/6432 , C12Y304/21006
摘要： The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
摘要翻译： 本发明涉及靶向因子Xa的抗凝剂的解毒剂。 解毒剂是与因子Xa抑制剂结合的因子Xa蛋白衍生物，从而基本上中和它们，但不组装到凝血酶原酶复合物中。 本文所述的衍生物缺乏或具有降低的内在凝结剂活性。 本文公开了在目前正在进行使用因子Xa抑制剂进行抗凝治疗的患者中停止或预防出血的方法。
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公开(公告)号：US20120027834A1
公开(公告)日：2012-02-02
申请号：US13253899
申请日：2011-10-05
申请人： Patrick Andre , David R. Phillips , Charles Homcy
发明人： Patrick Andre , David R. Phillips , Charles Homcy
IPC分类号： A61F2/82 , A61P7/00 , A61P7/06 , A61L27/54 , A61P9/00 , A61L31/16 , A61L29/16 , A61K31/52 , A61P29/00
CPC分类号： A61K31/473 , A61K31/4745 , A61K31/52 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L2300/434
摘要： The present invention provides novel compositions and methods for inhibiting restenosis, thrombosis, and/or inflammation in a patient undergoing a vascular intervention. More particularly, the present invention provides intravascular devices coated with one or more spleen tyrosine kinase (Syk) inhibitors. Methods for inhibiting restenosis, thrombosis, and/or inflammation in a patient by treatment with such intravascular devices are also provided. In addition, the present invention provides methods for treating sickle cell disease using Syk inhibitors.
摘要翻译： 本发明提供了用于在经历血管干预的患者中抑制再狭窄，血栓形成和/或炎症的新型组合物和方法。 更具体地，本发明提供涂覆有一种或多种脾脏酪氨酸激酶（Syk）抑制剂的血管内装置。 还提供了通过用这种血管内装置治疗来抑制患者再狭窄，血栓形成和/或炎症的方法。 此外，本发明提供了使用Syk抑制剂治疗镰状细胞病的方法。
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9.发明申请UNIT DOSE FORMULATIONS AND METHODS OF TREATING AND PREVENTING THROMBOSIS WITH THROMBOXANE RECEPTOR ANTAGONISTS 审中-公开单位剂量配方和治疗和预防与血栓形成受体拮抗剂相关的血栓形成的方法公开(公告)号：US20090012136A1
公开(公告)日：2009-01-08
申请号：US12114646
申请日：2008-05-02
申请人： Gillian Stephens , Dacao Gao , Patrick Andre , David R. Phillips
发明人： Gillian Stephens , Dacao Gao , Patrick Andre , David R. Phillips
IPC分类号： A61K31/421 , C12N5/00 , C12Q1/02 , A61P7/02
CPC分类号： A61K31/422 , A61K31/20 , A61K31/405 , A61K31/4406 , A61K31/444 , A61K45/06
摘要： The present invention provides new methods of treating thrombosis and cardiovascular diseases using of antithrombotic agents, as well as methods of determining therapeutically effective amounts of antithrombotic agents and unit dose formulations thereof.
摘要翻译： 本发明提供使用抗血栓形成剂治疗血栓形成和心血管疾病的新方法，以及确定治疗有效量的抗血栓形成剂及其单位剂量制剂的方法。
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10.发明申请DEVICE AND METHODS FOR IDENTIFYING AND TREATING ASPIRIN NON-RESPONSIVE PATIENTS 失效鉴定和治疗ASPIRIN非反应性患者的装置和方法公开(公告)号：US20080207681A1
公开(公告)日：2008-08-28
申请号：US12037012
申请日：2008-02-25
IPC分类号： A61K31/4365 , A61P9/00
CPC分类号： G01N33/9486 , G01N33/86
摘要： The present invention relates to methods and compositions for identifying and treating subjects in need of antithrombotic therapies but who are not responsive to aspirin.
摘要翻译： 本发明涉及用于鉴定和治疗需要抗血栓治疗但是对阿司匹林不敏感的受试者的方法和组合物。
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