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115 条记录 (耗时 0.032 秒)

    Macrophage stimulation by homologs or analogs of quadrol
    1.
    发明授权
    Macrophage stimulation by homologs or analogs of quadrol 失效
    巨噬细胞刺激由同系物或类似物的四联体

    公开(公告)号：US4937269A

    公开(公告)日：1990-06-26

    申请号：US258173

    申请日：1988-10-14

    申请人： Daniel J. Smith ,  Sanjay R. Patel ,  Edwin C. Rowland

    发明人： Daniel J. Smith ,  Sanjay R. Patel ,  Edwin C. Rowland

    IPC分类号： A61K31/13 ,  A61L15/20 ,  A61L15/44 ,  C07C215/14

    CPC分类号： A61K31/13

    摘要： Quadrol and homologs and analogs thereof have been found to stimulate macrophage activity in warm blooded animals. As a consequence, these compounds may be used to combat bacterial infection, remove degenerated tissue, and promote new tissue growth. Quadrol or a homolog or analog thereof may be applied topically, e.g., as the active agent in a wound dressing. The active compounds may be represented by the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 are substituted alkyl (C.sub.2 -C.sub.6) in which the substituents include one or more hydroxyl groups attached to carbon atoms other than the alpha carbon atom, R.sub.3 and R.sub.4 are alkyl or substituted alkyl (C.sub.1 -C.sub.6), and n=2 to about 6. Preferably R.sub.1 through R.sub.4 are the same and are 2-hydroxyalkyl.

    摘要翻译： 已经发现其对映体及其同源物及其类似物可刺激温血动物中的巨噬细胞活性。 因此，这些化合物可用于对抗细菌感染，去除退化的组织并促进新的组织生长。 四环或其同系物或类似物可以局部施用，例如作为伤口敷料中的活性剂。 活性化合物可以由式（I）表示，其中R 1和R 2是取代的烷基（C 2 -C 6），其中取代基包括与α碳原子以外的碳原子连接的一个或多个羟基，R 3和 R 4是烷基或取代的烷基（C 1 -C 6），n = 2至约6.优选R 1至R 4相同且为2-羟基烷基。

    Macrophage stimulation by quadrol
    2.
    发明授权
    Macrophage stimulation by quadrol 失效
    巨噬细胞刺激通过四联体

    公开(公告)号：US4778825A

    公开(公告)日：1988-10-18

    申请号：US901927

    申请日：1986-08-29

    申请人： Daniel J. Smith ,  Sanjay R. Patel ,  Edwin C. Rowland

    发明人： Daniel J. Smith ,  Sanjay R. Patel ,  Edwin C. Rowland

    IPC分类号： A61K31/13 ,  A61L15/20 ,  A61L15/44 ,  C07C215/14

    CPC分类号： A61K31/13

    摘要： Quadrol has been found to stimulate macrophage activity in warm blooded animals. As a consequence, Quadrol may be used to combat bacterial infection, remove degenerated tissue, and promote new tissue growth. Quadrol may be applied topically, e.g., as the active agent in a wound dressing.

    摘要翻译： 已经发现Quadrol在温血动物中刺激巨噬细胞活动。 因此，Quadrol可用于对抗细菌感染，去除退化的组织，并促进新的组织生长。 可以局部应用Quadrol，例如作为伤口敷料中的活性剂。

    Hydrogels of quadrol methacrylate polymers
    3.
    发明授权
    Hydrogels of quadrol methacrylate polymers 失效
    四甲基甲基丙烯酸酯聚合物的水凝胶

    公开(公告)号：US4781921A

    公开(公告)日：1988-11-01

    申请号：US915545

    申请日：1986-10-06

    申请人： Daniel J. Smith ,  Sanjay R. Patel

    发明人： Daniel J. Smith ,  Sanjay R. Patel

    IPC分类号： A61L26/00 ,  C08F20/36 ,  A61K31/78 ,  C08L39/00

    CPC分类号： C08F20/36 ,  A61L26/0014 ,  A61L26/008

    摘要： Acrylate and methacrylate monoesters and diesters having the following formula (I) ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 are as defined in the specification, are disclosed. These monomers are polymerizable into hydrogel polymers which are extremely hydrophilic. These hydrogel polymers are useful in the preparation of wound dressings. These polymers form complexes with polyvalent metal ions such as Ca, Mg, Mn and Cu, and possess macrophage stimulating activity in addition to the useful properties possessed by other acrylate and methacrylate hydrogel polymers.

    摘要翻译： 公开了具有下式（I）的丙烯酸酯和甲基丙烯酸酯单酯和二酯：其中R1，R2，R3如说明书中所定义。 这些单体可聚合成非常亲水的水凝胶聚合物。 这些水凝胶聚合物可用于制备伤口敷料。 这些聚合物与多价金属离子如Ca，Mg，Mn和Cu形成络合物，除了其它丙烯酸酯和甲基丙烯酸酯水凝胶聚合物具有的有用特性之外，还具有巨噬细胞刺激活性。

    Wound dressing containing acrylate or methacrylate hydrogel polymer
    4.
    发明授权
    Wound dressing containing acrylate or methacrylate hydrogel polymer 失效
    含有丙烯酸酯或甲基丙烯酸酯水凝胶聚合物的伤口敷料

    公开(公告)号：US4889530A

    公开(公告)日：1989-12-26

    申请号：US223086

    申请日：1988-07-22

    申请人： Daniel J. Smith ,  Sanjay R. Patel

    发明人： Daniel J. Smith ,  Sanjay R. Patel

    IPC分类号： A61L26/00 ,  C08F20/36

    CPC分类号： C08F20/36 ,  A61L26/0014 ,  A61L26/008

    摘要： Acrylate and methacrylate monoesters and diesters having the following formula (I) ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 are as defined in the specification, are disclosed. These monomers are polymerizable into hydrogen polymers which are extremely hydrophilic. These hydrogel polymers are useful in the preparation of wound dressings. These polymers form complexes with polyvalent metal ions such as Ca, Mg, Mn and Cu, and possess macrophage stimulating activity in addition to the useful properties possessed by other acrylate and methacrylate hydrogel polymers.

    摘要翻译： 公开了具有下式（I）的丙烯酸酯和甲基丙烯酸酯单酯和二酯：其中R1，R2，R3如说明书中所定义。 这些单体可聚合成非常亲水的氢聚合物。 这些水凝胶聚合物可用于制备伤口敷料。 这些聚合物与多价金属离子如Ca，Mg，Mn和Cu形成络合物，除了其它丙烯酸酯和甲基丙烯酸酯水凝胶聚合物具有的有用特性之外，还具有巨噬细胞刺激活性。

    Stabilization and ionic triggering of nitric oxide release
    6.
    发明授权
    Stabilization and ionic triggering of nitric oxide release 有权
    一氧化氮释放的稳定和离子触发

    公开(公告)号：US08518362B2

    公开(公告)日：2013-08-27

    申请号：US13234495

    申请日：2011-09-16

    申请人： Daniel J. Smith

    发明人： Daniel J. Smith

    IPC分类号： C01B21/24

    CPC分类号： C01B21/24 ,  A61K9/0014 ,  A61K9/145 ,  A61K33/00 ,  A61K47/585 ,  B01J39/04 ,  B01J41/04

    摘要： Provided is a method for producing nitric oxide that employs an ion exchange resin. Also provided is a method for producing nitric oxide that combines a salt with a gel or cream. A method is provided for producing nitric oxide that combines a pH adjuster with a diazeniumdiolate-containing compound or composition.

    摘要翻译： 提供采用离子交换树脂的一氧化氮的制造方法。 还提供了一种将盐与凝胶或奶油组合的产生一氧化氮的方法。 提供了一种用于生产一氧化氮的方法，其将pH调节剂与含二氮化萘二醇化合物或组合物结合。

    Self-locating, multiple application, and multiple location medical patch systems and methods therefor
    7.
    发明授权
    Self-locating, multiple application, and multiple location medical patch systems and methods therefor 有权
    自定位，多应用和多位置医疗补丁系统及其方法

    公开(公告)号：US08303982B2

    公开(公告)日：2012-11-06

    申请号：US12407840

    申请日：2009-03-20

    申请人： Daniel J. Smith ,  Jessica Liberatore

    发明人： Daniel J. Smith ,  Jessica Liberatore

    IPC分类号： A61F13/02 ,  A61F13/00 ,  A61F15/00

    CPC分类号： A61F13/00063 ,  A61F13/023 ,  A61F13/025 ,  A61F2013/00553 ,  A61F2013/00646

    摘要： A medical patch system has a first medical patch including an outer locating ring securable to a surface and an inner patch, separable from the outer locating ring, disposed within the outer locating ring. The medical patch system includes a second medical patch adapted for insertion into the central area bounded by the outer locating ring after the inner patch is separated from the outer locating ring. The second medical patch includes a second outer locating ring securable to the surface, and a second inner patch section, separable from the second outer locating ring, disposed within a second central area bounded by the second outer locating ring. The first and second outer locating rings have adhesive layers for securing the outer locating rings to a surface. The adhesive layers on the respective outer locating rings have different sizes, shapes or patterns to minimize skin irritation.

    摘要翻译： 医疗补片系统具有第一医疗补片，其包括可安装到表面的外定位环和设置在外定位环内的与外定位环可分离的内补片。 医疗贴片系统包括第二医疗贴片，其适于在内贴片与外定位环分离之后插入到由外定位环限定的中心区域。 第二医疗补片包括可固定到表面的第二外定位环和与第二外定位环分离的第二内补片部分，其设置在由第二外定位环限定的第二中心区域内。 第一和第二外定位环具有用于将外定位环固定到表面的粘合剂层。 相应的外定位环上的粘合剂层具有不同的尺寸，形状或图案以最小化皮肤刺激。

    Guitar body reinforcement
    8.
    再颁专利
    Guitar body reinforcement 有权
    吉他体增强

    公开(公告)号：USRE42769E1

    公开(公告)日：2011-10-04

    申请号：US12893803

    申请日：2010-09-29

    申请人： Kevin M. Kroeger ,  Meaulnes Laberge ,  Timothy P. Shaw ,  Daniel J. Smith ,  Donald Scott Wade, Jr.

    发明人： Kevin M. Kroeger ,  Meaulnes Laberge ,  Timothy P. Shaw ,  Daniel J. Smith ,  Donald Scott Wade, Jr.

    IPC分类号： G10D3/00

    CPC分类号： G10D3/02

    摘要： A support for a body of a stringed instrument includes a brace structure having a plurality of legs radially disposed about a central body. The brace structure has a substantially flat first surface. A portion of the plurality of legs conforms to a soundhole opening which is integrated into the body of the stringed instrument. A brace for a body of a guitar includes a unitary structure adapted to mount to a soundboard of the guitar. The unitary structure has a plurality of arms radially disposed about a central body. A method of assembling a guitar includes mounting a brace structure to a soundboard of the guitar. Again, the brace structure has a plurality of legs radially disposed about a central body.

    摘要翻译： 用于弦乐器的主体的支撑件包括具有绕中心体径向设置的多个腿的支撑结构。 支架结构具有基本平坦的第一表面。 所述多个腿部的一部分符合整合到弦乐器的主体中的声孔开口。 用于吉他身体的支架包括适于安装到吉他的音板的单一结构。 单一结构具有围绕中心体径向设置的多个臂。 一种组装吉他的方法包括将支架结构安装到吉他的音板上。 同样，支架结构具有围绕中心体径向设置的多个腿。

    Non-woven fiber assemblies
    9.
    发明授权
    Non-woven fiber assemblies 有权
    无纺布纤维集合体

    公开(公告)号：US07765647B2

    公开(公告)日：2010-08-03

    申请号：US10510457

    申请日：2003-04-04

    申请人： Daniel J. Smith ,  Darrell H. Reneker

    发明人： Daniel J. Smith ,  Darrell H. Reneker

    IPC分类号： D01G13/00

    CPC分类号： D04H3/16 ,  A61F13/0206 ,  A61F13/0209 ,  A61F13/0223 ,  A61F13/0226 ,  A61F13/0253 ,  A61L15/225 ,  A61L15/58 ,  A61L26/0052 ,  D04H1/728 ,  Y10T442/608 ,  Y10T442/642

    摘要： In one embodiment, the present invention relates to a non-woven fiber assembly comprising one or more fibers wherein each fiber contains: a hydrophilic component; and an elastomeric component, and wherein the non-woven fiber assembly further comprises an adhesive component. In still another embodiment, the present invention relates to a non-woven fiber assembly comprising one or more fibers wherein each fiber contains: a hydrophilic component; an elastomeric component; and an adhesive component, wherein the hydrophilic component, the elastomeric component and the adhesive component are all contained within each fiber. Also disclosed is a method of making the afore-mentioned non-woven fiber assemblies. Additionally, a medical dressing made from the non-woven fiber assemblies of the present invention is disclosed.

    摘要翻译： 在一个实施方案中，本发明涉及包含一种或多种纤维的无纺纤维组合物，其中每种纤维包含：亲水性组分; 和弹性体组分，并且其中所述无纺纤维组合件还包含粘合剂组分。 在另一个实施方案中，本发明涉及一种包含一种或多种纤维的无纺纤维组合物，其中每种纤维包含：亲水组分; 弹性体组分; 和粘合剂组分，其中亲水组分，弹性体组分和粘合剂组分都包含在每个纤维内。 还公开了制造上述无纺纤维组件的方法。 此外，公开了由本发明的无纺纤维组件制成的医用敷料。