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    Self-expanding stent with enhanced delivery precision and stent delivery system
    2.
    发明授权
    Self-expanding stent with enhanced delivery precision and stent delivery system 有权
    自扩张支架具有增强的输送精度和支架输送系统

    公开(公告)号：US06695862B2

    公开(公告)日：2004-02-24

    申请号：US09919083

    申请日：2001-07-31

    申请人： Daniel L. Cox ,  Matthew J. Fitz ,  William James Harrison ,  Michael D. Schultz ,  Joseph A. Ventura

    发明人： Daniel L. Cox ,  Matthew J. Fitz ,  William James Harrison ,  Michael D. Schultz ,  Joseph A. Ventura

    IPC分类号： A61M2900

    CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2/95 ,  A61F2002/91516 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2002/9517 ,  A61F2230/0013

    摘要： The invention is directed to a self-expanding stent for implantation into a body lumen, such as an artery. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by a plurality of interconnecting members placed on the stent in a collinear arrangement such as to create at least one continuous spine which extends along the length of the stent. The invention is also directed to a stent delivery system for implantation of a stent in a vessel which includes an outer tubular member having a restraining sheath and an inner tubular member having a distal end which has a compressed stent mounted thereto. The proximal end of the inner tubular member is connected to a housing assembly which prevents the inner tubular member from moving when the outer tubular member is retracted to deploy the stent. The proximal end of the outer tubular member is attached to a pull-back handle which is slidably mounted on the base of the housing assembly. When the pull-back handle is retracted, the restraining sheath is retracted to deploy the sheath, while the inner tubular member remains stationary.

    摘要翻译： 本发明涉及用于植入体腔如动脉的自扩张支架。 支架由多个可径向扩张的圆柱形元件组成，通常在共同的纵向支架轴线上对准并且通过以共线布置放置在支架上的多个互连构件相互连接，以产生至少一个连续的脊柱，其沿着 支架 本发明还涉及用于将支架植入容器中的支架输送系统，该支架包括具有约束护套的外管状构件和具有安装在其上的压缩支架的远端的内管状构件。 内部管状构件的近端连接到壳体组件，当外部管状构件缩回以展开支架时，壳体组件防止内部管状构件移动。 外管状构件的近端附接到可滑动地安装在壳体组件的基部上的拉回手柄。 当拉回手柄缩回时，约束护套被缩回以展开护套，同时内部管状构件保持静止。

    SELF-EXPANDING STENT WITH ENHANCED DELIVERY PRECISION AND STENT DELIVERY SYSTEM
    3.
    发明申请
    SELF-EXPANDING STENT WITH ENHANCED DELIVERY PRECISION AND STENT DELIVERY SYSTEM 有权
    具有增强的交付精度和STENT交付系统的自我扩张

    公开(公告)号：US20090082843A1

    公开(公告)日：2009-03-26

    申请号：US12238219

    申请日：2008-09-25

    申请人： Daniel L. Cox ,  Matthew J. Fitz ,  William James Harrison ,  Michael D. Schultz ,  Joseph A. Ventura

    发明人： Daniel L. Cox ,  Matthew J. Fitz ,  William James Harrison ,  Michael D. Schultz ,  Joseph A. Ventura

    IPC分类号： A61F2/06

    CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2/95 ,  A61F2002/91516 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2002/9517 ,  A61F2230/0013

    摘要： The invention is directed to a self-expanding stent for implantation into a body lumen, such as an artery. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by a plurality of interconnecting members placed on the stent in a collinear arrangement such as to create at least one continuous spine which extends along the length of the stent. The invention is also directed to a stent delivery system for implantation of a stent in a vessel which includes an outer tubular member having a restraining sheath and an inner tubular member having a distal end which has a compressed stent mounted thereto. The proximal end of the inner tubular member is connected to a housing assembly which prevents the inner tubular member from moving when the outer tubular member is retracted to deploy the stent. The proximal end of the outer tubular member is attached to a pull-back handle which is slidably mounted on the base of the housing assembly. When the pull-back handle is retracted, the restraining sheath is retracted to deploy the sheath, while the inner tubular member remains stationary.

    摘要翻译： 本发明涉及用于植入体腔如动脉的自扩张支架。 支架由多个可径向扩张的圆柱形元件组成，通常在共同的纵向支架轴线上对准并且通过以共线布置放置在支架上的多个互连构件相互连接，以产生至少一个连续的脊柱，其沿着 支架 本发明还涉及用于将支架植入容器中的支架输送系统，该支架包括具有约束护套的外管状构件和具有安装在其上的压缩支架的远端的内管状构件。 内部管状构件的近端连接到壳体组件，当外部管状构件缩回以展开支架时，壳体组件防止内部管状构件移动。 外管状构件的近端附接到可滑动地安装在壳体组件的基部上的拉回手柄。 当拉回手柄缩回时，约束护套被缩回以展开护套，同时内部管状构件保持静止。

    Radiopaque catheter tip for enhanced delivery precision of a stent using a guidewire
    4.
    发明授权
    Radiopaque catheter tip for enhanced delivery precision of a stent using a guidewire 有权
    不透射线导管尖端，用于提高使用导丝的支架的输送精度

    公开(公告)号：US07491224B2

    公开(公告)日：2009-02-17

    申请号：US10748947

    申请日：2003-12-29

    申请人： Daniel L. Cox ,  Matthew J. Fitz ,  William James Harrison ,  Michael D. Schultz ,  Joseph A. Ventura

    发明人： Daniel L. Cox ,  Matthew J. Fitz ,  William James Harrison ,  Michael D. Schultz ,  Joseph A. Ventura

    IPC分类号： A61F2/06

    CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2/95 ,  A61F2002/91516 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2002/9517 ,  A61F2230/0013

    摘要： The invention is directed to a self-expanding stent for implantation into a body lumen, such as an artery. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by a plurality of interconnecting members placed on the stent in a collinear arrangement such as to create at least one continuous spine which extends along the length of the stent. The invention is also directed to a stent delivery system for implantation of a stent in a vessel which includes an outer tubular member having a restraining sheath and an inner tubular member having a distal end which has a compressed stent mounted thereto. The proximal end of the inner tubular member is connected to a housing assembly which prevents the inner tubular member from moving when the outer tubular member is retracted to deploy the stent. The proximal end of the outer tubular member is attached to a pull-back handle which is slidably mounted on the base of the housing assembly. When the pull-back handle is retracted, the restraining sheath is retracted to deploy the sheath, while the inner tubular member remains stationary.

    摘要翻译： 本发明涉及用于植入体腔如动脉的自扩张支架。 支架由多个可径向扩张的圆柱形元件组成，通常在共同的纵向支架轴线上对准并且通过以共线布置放置在支架上的多个互连构件相互连接，以产生至少一个连续的脊柱，其沿着 支架 本发明还涉及用于将支架植入容器中的支架输送系统，该支架包括具有约束护套的外管状构件和具有安装在其上的压缩支架的远端的内管状构件。 内部管状构件的近端连接到壳体组件，当外部管状构件缩回以展开支架时，壳体组件防止内部管状构件移动。 外管状构件的近端附接到可滑动地安装在壳体组件的基部上的拉回手柄。 当拉回手柄缩回时，约束护套被缩回以展开护套，同时内部管状构件保持静止。

    Self-expanding stent with enhanced delivery precision and stent delivery system
    5.
    发明授权
    Self-expanding stent with enhanced delivery precision and stent delivery system 有权
    自扩张支架具有增强的输送精度和支架输送系统

    公开(公告)号：US06709454B1

    公开(公告)日：2004-03-23

    申请号：US09495395

    申请日：2000-01-31

    申请人： Daniel L. Cox ,  William James Harrison

    发明人： Daniel L. Cox ,  William James Harrison

    IPC分类号： A61F206

    CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2/95 ,  A61F2002/91516 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2002/9517 ,  A61F2230/0013

    摘要： A self-expanding stent for implantation into a body lumen, such as an artery, includes a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by a plurality of interconnecting members placed on the stent in a collinear arrangement such as to create at least one continuous spine which extends along the length of the stent. The stent has cylindrical elements at each end of the stent which includes a plurality of double curved portions.

    摘要翻译： 用于植入体腔（例如动脉）中的自扩张支架包括多个径向可扩张的圆柱形元件，其大致对准在共同的纵向支架轴线上并且通过布置在支架上的多个互连构件以共线布置 以便产生沿支架长度延伸的至少一个连续脊柱。 支架在支架的每个端部具有圆柱形元件，其包括多个双弯曲部分。

    Molecular imaging probes based on loaded reactive nano-scale latex
    7.
    发明申请
    Molecular imaging probes based on loaded reactive nano-scale latex 审中-公开
    基于负载的反应性纳米级胶乳的分子成像探针

    公开(公告)号：US20100034748A1

    公开(公告)日：2010-02-11

    申请号：US12221839

    申请日：2008-08-07

    申请人： Guizhi Li ,  John William Harder ,  William James Harrison

    发明人： Guizhi Li ,  John William Harder ,  William James Harrison

    IPC分类号： A61K49/18 ,  C08K5/3417 ,  B32B1/00 ,  A61K49/04

    CPC分类号： A61K49/0032 ,  A61K49/0093 ,  C08K5/34 ,  C08K5/55 ,  Y10T428/2982 ,  C08L33/14

    摘要： The present invention relates to a loaded reactive nanoscale latex particle synthesized from mixture of monomers containing water insoluble monomers, at least two ethylenically functionalities monomers, halo-aromatic-polyethyleneglycol-methacrylate, polyethyleneglycolacrylate containing macromonomers, and up to 10 wt % other ethylenic monomers different from above monomers. The reactive halo-aromatic groups on the surface of latex particle are servable as linkers to react with peptides, antibodies, nucleic acids, ligands or other biomolecules.

    摘要翻译： 本发明涉及由含有水不溶性单体，至少两种烯键式官能团单体，卤代芳族聚乙二醇 - 甲基丙烯酸酯，含聚乙二醇丙烯酸酯的大分子单体和至多10重量％的其它乙烯单体的混合物的混合物合成的负载的反应性纳米尺寸胶乳颗粒 从上述单体。 胶乳颗粒表面上的反应性卤代芳族基团可作为接头与肽，抗体，核酸，配体或其他生物分子反应。