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    NOVEL USE OF ORGANIC COMPOUNDS
    3.
    发明申请
    NOVEL USE OF ORGANIC COMPOUNDS 审中-公开
    有机化合物的新用途

    公开(公告)号：US20100041746A1

    公开(公告)日：2010-02-18

    申请号：US12301505

    申请日：2007-05-24

    申请人： Daniel D'Orazio ,  Daniel Raederstorff ,  Goede Schueler ,  Ying Wang-Schmidt ,  Karin Wertz ,  Swen Wolfram

    发明人： Daniel D'Orazio ,  Daniel Raederstorff ,  Goede Schueler ,  Ying Wang-Schmidt ,  Karin Wertz ,  Swen Wolfram

    IPC分类号： A61K31/352 ,  A61K31/12 ,  A61K31/36 ,  C07C49/255 ,  C07D317/46 ,  C07D311/02 ,  A61P21/00

    CPC分类号： A23K20/111 ,  A23L2/52 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/12 ,  A61K31/166 ,  A61K31/352 ,  A23V2200/316 ,  A23V2200/328 ,  A23V2200/326 ,  A23V2200/318 ,  A23V2200/32

    摘要： The present invention refers to compounds of the general formulae Ia to Ie as defined above for use as/in a composition (especially foods and dietary supplements, cosmetic, as well as pharmaceutical compositions) for the prevention and improvement of muscular disorders and for the improvement of muscle function. Other fields of use are disorders connected to impaired lipid metabolism, impaired glucose metabolism and impaired insulin action, obesity, overweight conditions, eating disorders such as bulimia and anorexia nervosa, cardiovascular diseases, atherosclerosis, vascular diseases, heart failure, inflammatory disorders such as arthritis, rheumatoid arthritis, osteoarthritis, gout, gastrointestinal disorders such as inflammatory bowel syndrome, Crohn's disease, gastritis, irritable bowel syndrome and ulcerative colitis, skin related conditions such as psoriasis, eczema, burns, dermatitis, and allergy, respiratory disorders such as asthma, chronic obstructive pulmonary disease (COPD), allergic diseases, and/or bone disorders such as osteoporosis and osteopenia. The compounds may also be used for bodyshaping, for improving the muscle:fat ratio or for accelerating skin wound healing. The present invention is also directed to dietary compositions such as (fortified) food, beverages, (fortified) feed, food additives, beverage additives, feed additives, clinical nutrition, dietary supplements, functional food, functional feed and nutraceuticals and to pharmaceutical compositions containing such compounds, to methods of treating the above mentioned disorders/diseases in mammals including humans and to the compounds of the formula I themselves. Another object of the present invention is the use of such compounds for the manufacture of a composition for the treatment of such disorders/diseases as mentioned above.

    摘要翻译： 本发明涉及如上定义的用于预防和改善肌肉疾病和改善的组合物（特别是食品和膳食补充剂，化妆品以及药物组合物）中的上述通式Ia至Ie的化合物 的肌肉功能。 其他使用领域是与脂质代谢受损，葡萄糖代谢受损和胰岛素作用受损，肥胖症，超重症状，进食障碍如贪食症和神经性厌食症，心血管疾病，动脉粥样硬化，血管疾病，心力衰竭，炎症性疾病如关节炎相关的疾病 类风湿性关节炎，骨关节炎，痛风，胃肠道疾病如炎性肠综合征，克罗恩病，胃炎，肠易激综合征和溃疡性结肠炎，皮肤相关病症如牛皮癣，湿疹，烧伤，皮炎和过敏，呼吸系统疾病如哮喘， 慢性阻塞性肺疾病（COPD），过敏性疾病和/或骨骼疾病如骨质疏松症和骨质减少。 这些化合物也可用于体脂整形，用于改善肌肉：脂肪比例或用于加速皮肤伤口愈合。 本发明还涉及饮食组合物，例如（强化）食品，饮料，（强化）饲料，食品添加剂，饮料添加剂，饲料添加剂，临床营养，膳食补充剂，功能性食品，功能性饲料和营养食品，以及含有 这些化合物，涉及治疗哺乳动物（包括人）和式I本身化合物的上述疾病/疾病的方法。 本发明的另一个目的是使用这些化合物来制备用于治疗如上所述的这种疾病/疾病的组合物。

    NOVEL USE OF ORGANIC COMPOUNDS
    5.
    发明申请
    NOVEL USE OF ORGANIC COMPOUNDS 审中-公开
    有机化合物的新用途

    公开(公告)号：US20090221693A1

    公开(公告)日：2009-09-03

    申请号：US12299644

    申请日：2007-05-02

    申请人： Daniel D'Orazio ,  Daniel Raederstorff ,  Goede Schueler ,  Ying Wang-Schmidt ,  Swen Wolfram

    发明人： Daniel D'Orazio ,  Daniel Raederstorff ,  Goede Schueler ,  Ying Wang-Schmidt ,  Swen Wolfram

    IPC分类号： A61K31/352 ,  C07D311/82 ,  A61P21/00

    CPC分类号： A61K31/352

    摘要： The present invention refers to compounds of the general formulae I as defined above, preferably α-mangostin, for use as/in a composition (especially foods and dietary supplements, cosmetic, as well as pharmaceutical compositions) for the prevention and improvement of muscular disorders and for the improvement of muscle function and endurance. Other fields of use are eating disorders such as bulimia and anorexia nervosa, use for accelerating wound healing, and/or use for the treatment/prevention of bone disorders such as osteoporosis and osteopenia. The present invention is also directed to dietary compositions such as (fortified) food, beverages, (fortified) feed, food additives, beverage additives, feed additives, clinical nutrition, dietary supplements, functional food, functional feed and nutraceuticals and to pharmaceutical compositions containing such compounds, to methods of preventing and/or treating the above mentioned disorders/diseases, as well as to methods of maintaining the healthy state and/or improving the baseline conditions in mammals including humans and to the compounds of the formula I themselves. Another object of the present invention is the use of such compounds for the manufacture of a composition for the prevention and/or treatment of such disorders/diseases as mentioned above.

    摘要翻译： 本发明涉及用于预防和改善肌肉疾病的组合物（特别是食品和膳食补充剂，化妆品以及药物组合物）中用作/组合物的上述通式I的化合物，优选α-谷歌蛋白 并改善肌肉功能和耐力。 其他使用领域是进食障碍，例如贪食症和神经性厌食症，用于加速伤口愈合，和/或用于治疗/预防骨病，如骨质疏松症和骨质减少症。 本发明还涉及饮食组合物，例如（强化）食品，饮料，（强化）饲料，食品添加剂，饮料添加剂，饲料添加剂，临床营养，膳食补充剂，功能性食品，功能性饲料和营养食品，以及含有 这些化合物，预防和/或治疗上述疾病/疾病的方法，以及维持健康状态和/或改善哺乳动物包括人类和式I本身化合物的基线条件的方法。 本发明的另一个目的是这些化合物在制备用于预防和/或治疗上述疾病/疾病的组合物中的用途。

    Novel Use of Nutraceutical Compositions Comprising Resveratrol
    8.
    发明申请
    Novel Use of Nutraceutical Compositions Comprising Resveratrol 审中-公开
    包含白藜芦醇的营养组合物的新用途

    公开(公告)号：US20080262081A1

    公开(公告)日：2008-10-23

    申请号：US12089584

    申请日：2006-10-11

    申请人： Daniel Raederstorff ,  Ying Wang-Schmidt ,  Swen Wolfram

    发明人： Daniel Raederstorff ,  Ying Wang-Schmidt ,  Swen Wolfram

    IPC分类号： A61K31/05 ,  A61K31/366

    CPC分类号： A61K31/353 ,  A23L33/10 ,  A23L33/12 ,  A23L33/15 ,  A61K31/05 ,  A61K2300/00

    摘要： The use of resveratrol, a derivative, metabolite or analogue thereof, in combination with at least one additional component selected from EGCG, coenzyme Q-IO, genistein, lycopene, hydroxytyrosol and polyunsaturated fatty acids in the manufacture of a nutraceutical composition for delaying aging and/or for the treatment or prevention of age-related diseases in animals, in particular in mammals including humans.

    摘要翻译： 在制备用于延缓衰老的营养药物组合物中使用白藜芦醇，其衍生物，代谢产物或类似物与至少一种选自EGCG，辅酶Q-10，染料木素，番茄红素，羟基酪醇和多不饱和脂肪酸的其它组分的组合，以及 /或用于治疗或预防动物，特别是包括人在内的哺乳动物中的年龄相关疾病。

    Novel use of nutraceutical compositions
    9.
    发明申请
    Novel use of nutraceutical compositions 审中-公开
    新型使用营养组合物

    公开(公告)号：US20090163579A1

    公开(公告)日：2009-06-25

    申请号：US11990395

    申请日：2006-10-11

    申请人： Daniel Raederstorff ,  Ying Wang-Schmidt ,  Swen Wolfram

    发明人： Daniel Raederstorff ,  Ying Wang-Schmidt ,  Swen Wolfram

    IPC分类号： A61K31/353 ,  A61K31/05 ,  A61P21/00

    CPC分类号： A61K31/05 ,  A61K31/353

    摘要： The use of at least one component selected from the group consisting of EGCG, hydroxytyrosol, resveratrol and derivatives, metabolites or analogues thereof in the manufacture of a nutraceutical composition for the prevention and treatment of muscle wasting leading to muscle loss, atrophy and other associated muscle disorders in animals, in particular mammals including humans.

    摘要翻译： 使用至少一种选自EGCG，羟基酪醇，白藜芦醇及其衍生物，代谢物或类似物的组分在制备营养组合物中用于预防和治疗导致肌肉损失的肌肉消瘦，萎缩和其它相关肌肉 动物，特别是哺乳动物，包括人类的疾病。