公开(公告)号：US07022982B2

公开(公告)日：2006-04-04

申请号：US10896981

申请日：2004-07-23

申请人： Daniel Sobek ,  Jing Cai ,  Kevin Killeen ,  Hongfeng Yin

发明人： Daniel Sobek ,  Jing Cai ,  Kevin Killeen ,  Hongfeng Yin

IPC分类号： H01J49/10

CPC分类号： H01J49/165

摘要： An ion source for an analytical instrument is described. The ion source comprises a capillary tip and counter-electrode interface and a feedback loop control device connected to the capillary tip and counter-electrode interface. The feedback loop control device comprises a transimpedance amplifier, a DC de-coupler, a frequency to voltage converter, a controller, and a voltage-controlled high-voltage power supply that provides a tip to counter-electrode voltage to the capillary tip and counter-electrode interface. The feedback loop control device measures the modulation frequency of ionization currents and provides a feedback adjustment of the tip-to-counter-electrode voltage to maintain ionization efficiency.

摘要翻译： 描述了用于分析仪器的离子源。 离子源包括毛细管尖端和对电极界面以及连接到毛细管尖端和对电极界面的反馈回路控制装置。 反馈回路控制装置包括跨阻抗放大器，直流去耦合器，频率 - 电压转换器，控制器和电压控制的高压电源，其提供针对毛细管尖端和计数器的对电极电压的尖端 电极接口。 反馈回路控制装置测量电离电流的调制频率，并提供端对电极电压的反馈调整，以维持电离效率。

公开(公告)号：US07372023B2

公开(公告)日：2008-05-13

申请号：US11333213

申请日：2006-01-18

申请人： Daniel Sobek ,  Jing Cai ,  Kevin Killeen ,  Hongfeng Yin

发明人： Daniel Sobek ,  Jing Cai ,  Kevin Killeen ,  Hongfeng Yin

IPC分类号： H01J49/10

CPC分类号： H01J49/165

摘要： An ion source for an analytical instrument is described. The ion source comprises a capillary tip and counter-electrode interface and a feedback loop control device connected to the capillary tip and counter-electrode interface. The feedback loop control device comprises a transimpedance amplifier, a DC de-coupler, a frequency to voltage converter, a controller, and a voltage-controlled high-voltage power supply that provides a tip to counter-electrode voltage to the capillary tip and counter-electrode interface. The feedback loop control device measures the modulation frequency of ionization currents and provides a feedback adjustment of the tip-to-counter-electrode voltage to maintain ionization efficiency.

摘要翻译： 描述了用于分析仪器的离子源。 离子源包括毛细管尖端和对电极界面以及连接到毛细管尖端和对电极界面的反馈回路控制装置。 反馈回路控制装置包括跨阻抗放大器，直流去耦合器，频率 - 电压转换器，控制器和电压控制的高压电源，其提供针对毛细管尖端和计数器的对电极电压的尖端 电极接口。 反馈回路控制装置测量电离电流的调制频率，并提供端对电极电压的反馈调整，以维持电离效率。

公开(公告)号：US20050178974A1

公开(公告)日：2005-08-18

申请号：US10896981

申请日：2004-07-23

申请人： Daniel Sobek ,  Jing Cai ,  Kevin Killeen ,  Hongfeng Yin

发明人： Daniel Sobek ,  Jing Cai ,  Kevin Killeen ,  Hongfeng Yin

IPC分类号： H01J27/02 ,  H01J49/04 ,  H01J49/10 ,  H01J49/16 ,  H01J27/00

CPC分类号： H01J49/165

摘要： An ion source for an analytical instrument is described. The ion source comprises a capillary tip and counter-electrode interface and a feedback loop control device connected to the capillary tip and counter-electrode interface. The feedback loop control device comprises a transimpedance amplifier, a DC de-coupler, a frequency to voltage converter, a controller, and a voltage-controlled high-voltage power supply that provides a tip to counter-electrode voltage to the capillary tip and counter-electrode interface. The feedback loop control device measures the modulation frequency of ionization currents and provides a feedback adjustment of the tip-to-counter-electrode voltage to maintain ionization efficiency.

摘要翻译： 描述了用于分析仪器的离子源。 离子源包括毛细管尖端和对电极界面以及连接到毛细管尖端和对电极界面的反馈回路控制装置。 反馈回路控制装置包括跨阻抗放大器，直流去耦合器，频率 - 电压转换器，控制器和电压控制的高压电源，其提供针对毛细管尖端和计数器的对电极电压的尖端 电极接口。 反馈回路控制装置测量电离电流的调制频率，并提供端对电极电压的反馈调整，以维持电离效率。

公开(公告)号：US20060118714A1

公开(公告)日：2006-06-08

申请号：US11333213

申请日：2006-01-18

申请人： Daniel Sobek ,  Jing Cai ,  Kevin Killeen ,  Hongfeng Yin

发明人： Daniel Sobek ,  Jing Cai ,  Kevin Killeen ,  Hongfeng Yin

IPC分类号： H01J49/00

CPC分类号： H01J49/165

摘要： An ion source for an analytical instrument is described. The ion source comprises a capillary tip and counter-electrode interface and a feedback loop control device connected to the capillary tip and counter-electrode interface. The feedback loop control device comprises a transimpedance amplifier, a DC de-coupler, a frequency to voltage converter, a controller, and a voltage-controlled high-voltage power supply that provides a tip to counter-electrode voltage to the capillary tip and counter-electrode interface. The feedback loop control device measures the modulation frequency of ionization currents and provides a feedback adjustment of the tip-to-counter-electrode voltage to maintain ionization efficiency.

公开(公告)号：US20060011548A1

公开(公告)日：2006-01-19

申请号：US11224904

申请日：2005-09-12

申请人： Hongfeng Yin ,  Kevin Killeen ,  Daniel Sobek

发明人： Hongfeng Yin ,  Kevin Killeen ,  Daniel Sobek

IPC分类号： B01D15/08

CPC分类号： G01N30/34 ,  G01N30/6095 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/285

摘要： The present invention relates to a microfluidic device for separating the components of a fluid sample. A cover plate is arranged over the first surface of a substrate, which, in combination with a microchannel formed in the first surface, defines a separation conduit for separating the components of the fluid sample. An inlet port in fluid communication with the separation conduit allows a mobile phase containing a gradient of a selected mobile-phase component to be introduced from an integrated gradient-generation means to the separation conduit. A method is also provided for separating the components of a fluid sample using a mobile phase containing a gradient of a selected mobile-phase component, wherein the gradient is generated within a small volume of mobile phase.

公开(公告)号：US20060097153A1

公开(公告)日：2006-05-11

申请号：US11001268

申请日：2004-11-30

申请人： Karen Seaward ,  Hongfeng Yin ,  Kevin Killeen ,  Daniel Sobek ,  Daniel Roitman

发明人： Karen Seaward ,  Hongfeng Yin ,  Kevin Killeen ,  Daniel Sobek ,  Daniel Roitman

IPC分类号： H01J49/10

CPC分类号： H01J49/167 ,  G01N30/7266

摘要： An electrospray device for a mass spectrometry system is described. The electrospray device comprises a body portion and a tip portion extending from the body portion. The tip portion comprises a polymeric material. The electrospray device also comprises a hydrophobic coating substantially selectively covering the tip portion.

摘要翻译： 描述了用于质谱系统的电喷雾装置。 电喷雾装置包括主体部分和从主体部分延伸的尖端部分。 尖端部分包括聚合材料。 电喷雾装置还包括基本上选择性地覆盖尖端部分的疏水涂层。

公开(公告)号：US07138062B2

公开(公告)日：2006-11-21

申请号：US11224904

申请日：2005-09-12

申请人： Hongfeng Yin ,  Kevin Killeen ,  Daniel Sobek

发明人： Hongfeng Yin ,  Kevin Killeen ,  Daniel Sobek

IPC分类号： B01D15/08

CPC分类号： G01N30/34 ,  G01N30/6095 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/285

摘要： The present invention relates to a microfluidic device for separating the components of a fluid sample. A cover plate is arranged over the first surface of a substrate, which, in combination with a microchannel formed in the first surface, defines a separation conduit for separating the components of the fluid sample. An inlet port in fluid communication with the separation conduit allows a mobile phase containing a gradient of a selected mobile-phase component to be introduced from an integrated gradient-generation means to the separation conduit. A method is also provided for separating the components of a fluid sample using a mobile phase containing a gradient of a selected mobile-phase component, wherein the gradient is generated within a small volume of mobile phase.

公开(公告)号：US20050066747A1

公开(公告)日：2005-03-31

申请号：US10675037

申请日：2003-09-30

申请人： Daniel Sobek ,  Hongfeng Yin ,  Roy Rocklin ,  Kevin Killeen

发明人： Daniel Sobek ,  Hongfeng Yin ,  Roy Rocklin ,  Kevin Killeen

IPC分类号： G01F1/708

CPC分类号： G01F1/7084

摘要： The fluid flow rate within a microfluidic passageway of a microfabricated device is determined by measuring the time-of-flight of a heat pulse coupled into the fluid. Since the propagation velocity of the heat trace is generally slower than the mean flow rate of the flow, additional processing provides the appropriate scaling needed to obtain an accurate fluid flow rate measurement. The scaling factor is based on the geometry of the structure and the thermal properties of the fluid and the materials used for the device.

摘要翻译： 通过测量耦合到流体中的热脉冲的飞行时间来确定微加工装置的微流体通道内的流体流速。 由于热迹线的传播速度通常比流动的平均流速慢，所以额外的处理提供了获得准确的流体流量测量所需的适当的缩放比例。 缩放因子基于结构的几何形状和流体和用于该装置的材料的热性质。

公开(公告)号：US06958119B2

公开(公告)日：2005-10-25

申请号：US10085598

申请日：2002-02-26

申请人： Hongfeng Yin ,  Kevin Killeen ,  Daniel Sobek

发明人： Hongfeng Yin ,  Kevin Killeen ,  Daniel Sobek

IPC分类号： G01N30/20 ,  G01N30/28 ,  G01N30/34 ,  G01N30/60 ,  B01D15/08

CPC分类号： G01N30/34 ,  G01N30/6095 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/285

摘要： The present invention relates to a microfluidic device for separating the components of a fluid sample. A cover plate is arranged over the first surface of a substrate, which, in combination with a microchannel formed in the first surface, defines a separation conduit for separating the components of the fluid sample. An inlet port in fluid communication with the separation conduit allows a mobile phase containing a gradient of a selected mobile-phase component to be introduced from an integrated gradient-generation means to the separation conduit. A method is also provided for separating the components of a fluid sample using a mobile phase containing a gradient of a selected mobile-phase component, wherein the gradient is generated within a small volume of mobile phase.

摘要翻译： 本发明涉及用于分离流体样品的组分的微流体装置。 盖板布置在衬底的第一表面上，其与形成在第一表面中的微通道组合，限定用于分离流体样品的部件的分离管道。 与分离管道流体连通的入口允许将包含所选流动相组分的梯度的流动相从积分的梯度产生装置引入分离导管。 还提供了一种用于使用包含所选流动相成分的梯度的流动相分离流体样品的组分的方法，其中在少量流动相中产生梯度。

公开(公告)号：US20060097151A1

公开(公告)日：2006-05-11

申请号：US10982189

申请日：2004-11-05

申请人： Karen Seaward ,  Hongfeng Yin ,  Kevin Killeen ,  Daniel Sobek ,  Daniel Roitman

发明人： Karen Seaward ,  Hongfeng Yin ,  Kevin Killeen ,  Daniel Sobek ,  Daniel Roitman

IPC分类号： H01J49/04

CPC分类号： H01J49/165

摘要： An electrospray device for a mass spectrometry system is described. The electrospray device comprises a body portion and a tip portion extending from the body portion. The tip portion comprises a polymeric material. The electrospray device also comprises a hydrophobic coating substantially selectively covering the tip portion. The hydrophobic coating is electrically nonconductive.

摘要翻译： 描述了用于质谱系统的电喷雾装置。 电喷雾装置包括主体部分和从主体部分延伸的尖端部分。 尖端部分包括聚合材料。 电喷雾装置还包括基本上选择性地覆盖尖端部分的疏水涂层。 疏水涂层是不导电的。