-
公开(公告)号：US09789161B2
公开(公告)日：2017-10-17
申请号：US11414689
申请日：2006-04-28
申请人： Josee Roy , Susan J. Drapeau , Jeffrey C. Marx
发明人： Josee Roy , Susan J. Drapeau , Jeffrey C. Marx
CPC分类号： A61K38/1825 , A61K38/185 , A61K38/1858 , A61K38/2093 , A61K38/212
摘要： The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated disc. Disruption of neuronal elements in the disk includes destroying nerve endings without substantially affecting the central body of the nerve, suppressing activation of the nerve endings, and inhibiting the growth of nerve endings into the disk. Disruption of vascular elements includes causing the vascular extensions to retract from the disk, or suppressing the formation of such extensions. The therapeutic agent may be administered locally via an interbody pump, a bolus or a depot, or may be administered systemically.
-
公开(公告)号：US08916611B2
公开(公告)日：2014-12-23
申请号：US11413363
申请日：2006-04-28
申请人： Josee Roy , Susan J. Drapeau , Jeffrey C. Marx
发明人： Josee Roy , Susan J. Drapeau , Jeffrey C. Marx
IPC分类号： A61K31/185 , A61K31/115 , A61K31/045 , A61K31/737 , A61K31/485 , A61K31/655 , A61K31/56 , A61K38/16 , A61K31/11 , A61K31/225 , A61K36/31 , A61K38/48 , A61K31/125 , A61K36/9066 , A61K31/4709
CPC分类号： A61K38/4893 , A61K31/11 , A61K31/125 , A61K31/225 , A61K31/4709 , A61K31/485 , A61K31/496 , A61K31/5415 , A61K31/55 , A61K31/56 , A61K31/65 , A61K31/655 , A61K31/737 , A61K33/02 , A61K36/31 , A61K36/9066 , A61K38/168 , A61K38/4886 , C12Y304/24069
摘要： The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated disc. Disruption of neuronal elements in the disk includes destroying nerve endings without substantially affecting the central body of the nerve, suppressing activation of the nerve endings, and inhibiting the growth of nerve endings into the disk. Disruption of vascular elements includes causing the vascular extensions to retract from the disk, or suppressing the formation of such extensions. The therapeutic agent may be administered locally via an interbody pump, a bolus or a depot, or may be administered systemically.
摘要翻译： 本发明提供了一种通过施用破坏椎间盘中的神经元和/或血管元件（通常是退化的椎间盘）的治疗剂来减轻椎间盘突出症的方法。 磁盘中的神经元元件的破坏包括破坏神经末梢，而不会显着影响神经的中枢体，抑制神经末梢的激活，并抑制神经末梢进入椎间盘的生长。 血管元件的破坏包括使血管延伸部从圆盘缩回，或抑制这种延伸部的形成。 治疗剂可以通过体内泵，推注或贮库局部给药，或者可以全身给药。
-
公开(公告)号：US20080097229A1
公开(公告)日：2008-04-24
申请号：US11511701
申请日：2006-08-29
申请人： Josee Roy , Susan J. Drapeau , Jeffrey C. Marx , Sean M. Haddock
发明人： Josee Roy , Susan J. Drapeau , Jeffrey C. Marx , Sean M. Haddock
CPC分类号： A61L27/50 , A61F2002/30075 , A61F2002/444 , A61F2210/0061 , A61L27/14 , A61L2430/38
摘要： Early treatment for a degenerated disc includes identifying a non-ruptured, dehydrated disc. A hygroscopic agent is then selected. This agent should pull water towards itself and have a hygroscopic compound with a molecular weight of at least 400 Daltons. Additionally, it may be desirable to selected hygroscopic compounds that are anionic or electrically neutral. The hygroscopic agent is then injected into the nucleus pulposus of the disc without any prior removal of the nucleus pulposus material. Because the surrounding disc structure allows for the passive diffusion of water into the nucleus pulposus, the hygroscopic agent will draw water into the nucleus pulposus, thus promoting tissue hydration within the disc. The hygroscopic agent may also include a biological agent and/or an imaging agent.
摘要翻译： 退化椎间盘的早期治疗包括鉴定未破裂的脱水椎间盘。 然后选择吸湿剂。 该试剂应将水拉向自身并具有分子量至少为400道尔顿的吸湿性化合物。 另外，可能需要选择阴离子或电中性的吸湿化合物。 然后将吸湿剂注射到盘的髓核中，而无需先前去除髓核成分材料。 因为周围的圆盘结构允许水被钝化地扩散到髓核中，吸湿剂会将水吸入髓核，从而促进椎间盘内的组织水合作用。 吸湿剂还可以包括生物制剂和/或成像剂。
-
公开(公告)号：US08252738B2
公开(公告)日：2012-08-28
申请号：US11875267
申请日：2007-10-19
CPC分类号： A61L27/54 , A61F2002/2817 , A61F2002/4445 , A61F2002/445 , A61K9/0024 , A61K38/1875 , A61L2300/252 , A61L2300/258 , A61L2300/414 , C12N5/0602 , C12N2501/105 , C12N2501/155 , C12N2501/165 , C12N2501/60 , C12N2501/998 , C12N2510/00 , A61K2300/00
摘要： Methods of changing a phenotype of a cell are provided. The methods comprise increasing an amount of an amino acid sequence which is at least 70% identical to an amino acid sequence encoding an LMP protein or a fragment thereof in a cell. The cells may be contacted by either a composition comprising a nucleic acid sequence encoding the amino acid sequence which is at least 70% identical to the amino acid sequence encoding an LMP or its fragment or by a composition comprising acid sequence which is at least 70% identical to the amino acid sequence encoding an LMP or its fragment or any combination thereof. The cells may be contacted either in vivo or ex-vivo.
摘要翻译： 提供改变细胞表型的方法。 所述方法包括增加与细胞中编码LMP蛋白或其片段的氨基酸序列至少70％相同的氨基酸序列的量。 细胞可以由包含编码与编码LMP或其片段的氨基酸序列至少70％相同的氨基酸序列的核酸序列或包含至少70％的酸序列的组合物的组合物接触， 与编码LMP或其片段的氨基酸序列或其任何组合相同。 细胞可以在体内或体外接触。
-
公开(公告)号：US20090105117A1
公开(公告)日：2009-04-23
申请号：US11875267
申请日：2007-10-19
CPC分类号： A61L27/54 , A61F2002/2817 , A61F2002/4445 , A61F2002/445 , A61K9/0024 , A61K38/1875 , A61L2300/252 , A61L2300/258 , A61L2300/414 , C12N5/0602 , C12N2501/105 , C12N2501/155 , C12N2501/165 , C12N2501/60 , C12N2501/998 , C12N2510/00 , A61K2300/00
摘要： Methods of changing a phenotype of a cell are provided. The methods comprise increasing an amount of an amino acid sequence which is at least 70% identical to an amino acid sequence encoding an LMP protein or a fragment thereof in a cell. The cells may be contacted by either a composition comprising a nucleic acid sequence encoding the amino acid sequence which is at least 70% identical to the amino acid sequence encoding an LMP or its fragment or by a composition comprising acid sequence which is at least 70% identical to the amino acid sequence encoding an LMP or its fragment or any combination thereof. The cells may be contacted either in vivo or ex-vivo.
摘要翻译： 提供改变细胞表型的方法。 所述方法包括增加与细胞中编码LMP蛋白或其片段的氨基酸序列至少70％相同的氨基酸序列的量。 细胞可以由包含编码与编码LMP或其片段的氨基酸序列至少70％相同的氨基酸序列的核酸序列或包含至少70％的酸序列的组合物的组合物接触， 与编码LMP或其片段的氨基酸序列或其任何组合相同。 细胞可以在体内或体外接触。
-
6.发明申请Devices and methods for detection of markers of axial pain with or without radiculopathy 审中-公开用于检测具有或不具有神经根病变的轴向疼痛标记物的装置和方法公开(公告)号：US20070287991A1
公开(公告)日：2007-12-13
申请号：US11449530
申请日：2006-06-08
申请人： William F. McKay , Jeffrey M. Gross , Hai Trieu , Josee Roy , Susan J. Drapeau , Michael J. Schendel , Andrew J. Lowenthal Walsh
发明人： William F. McKay , Jeffrey M. Gross , Hai Trieu , Josee Roy , Susan J. Drapeau , Michael J. Schendel , Andrew J. Lowenthal Walsh
IPC分类号： A61K9/22
CPC分类号： A61B5/14546 , A61B5/0031 , A61B5/0071 , A61B5/0084 , A61B5/01 , A61B5/032 , A61B5/14539 , A61B5/4514 , A61B5/4561 , A61B5/4824 , A61B5/4896 , A61B5/6848 , G01N33/54366 , G01N33/6896 , G01N2800/2842
摘要： The invention provides devices and related methods and composition useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening test compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degenerating disc include markers of neuronal, vascular, immune and matrix elements.
摘要翻译： 本发明提供了用于诊断和监测具有或不具有神经根病变的轴向疼痛的疼痛发生器的装置和相关方法和组合，以及用于筛选潜在地可用于治疗或不发生神经根病变的轴向疼痛的测试化合物的方法。 或者，可以在发生病理性疼痛状况之前监测和治疗退化的椎间盘。 退行性椎间盘的疼痛标志物和标志物包括神经元，血管，免疫和基质元件的标记物。
-
公开(公告)号：US09757476B2
公开(公告)日：2017-09-12
申请号：US11449309
申请日：2006-06-08
申请人： William F. McKay , Jeffrey M. Gross , Hai Trieu , Josee Roy , Susan J. Drapeau , Michael J. Schendel , Andrew J. Lowenthal Walsh
发明人： William F. McKay , Jeffrey M. Gross , Hai Trieu , Josee Roy , Susan J. Drapeau , Michael J. Schendel , Andrew J. Lowenthal Walsh
IPC分类号： A61K49/00
CPC分类号： A61K49/0004 , A61K49/00
摘要： The invention provides methods and composition developed to be used with imaging techniques and useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening therapeutic compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degeneration include markers of neuronal, vascular, immune and matrix elements.
-
公开(公告)号：US07960098B2
公开(公告)日：2011-06-14
申请号：US11777093
申请日：2007-07-12
申请人： Josee Roy , Susan J. Drapeau , Daniel A. Shimko
发明人： Josee Roy , Susan J. Drapeau , Daniel A. Shimko
IPC分类号： A01N1/00
摘要： Disclosed are methods for the preservation and storage of living biological tissues, organs, and populations of isolated cells. Also disclosed are compositions and methods to permit biological samples (including e.g., cells, cell cultures, tissues, and organs) to be harvested from suitable donor animals, stored for prolonged periods under refrigerated, cryogenic, or near-freezing, and then transported and implanted into a site within the body of a selected recipient animal, all without significant loss of cellular viability, tissue integrity, and/or biochemical function of the stored biological sample.
摘要翻译： 公开了用于保存和储存活的生物组织，器官和分离细胞群体的方法。 还公开了允许从合适的供体动物收获生物样品（包括例如细胞，细胞培养物，组织和器官）的组合物和方法，在冷藏，低温或近冷冻下长时间储存，然后运输和 植入选定受体动物体内的部位，所有这些都不会显着损失存储的生物样品的细胞活力，组织完整性和/或生物化学功能。
-
9.发明授权Method for enhancing the viability of mammalian cells, tissues and organs using a solution comprising two low molecular weight PEGs 有权使用包含两种低分子量PEG的溶液增强哺乳动物细胞，组织和器官的存活力的方法公开(公告)号：US07892724B2
公开(公告)日：2011-02-22
申请号：US11777167
申请日：2007-07-12
申请人： Daniel A. Shimko , Scott Noel , Susan J. Drapeau , Josee Roy
发明人： Daniel A. Shimko , Scott Noel , Susan J. Drapeau , Josee Roy
IPC分类号： A01N1/00
CPC分类号： A01N1/0226 , A01N1/02 , A01N1/021 , C12N5/0018 , C12N2500/30 , C12N2500/46 , C12N2500/60
摘要： Disclosed are compositions and methods for the preservation, storage, and transport of living biological tissues, organs, and populations of isolated cells. In particular, the disclosed compositions and processes permit mammalian cells, tissues, and organs to be harvested from suitable donor animals, stored for prolonged periods, and transported to the site of recipient implantation, all without significant loss of cell viability, biological activity, and/or tissue integrity.
摘要翻译： 公开了用于保存，储存和运输生物体组织，器官和分离细胞群体的组合物和方法。 特别地，所公开的组合物和方法允许哺乳动物细胞，组织和器官从合适的供体动物中收获，长时间储存并转运到受体植入部位，所有细胞，组织和器官都不会显着损失细胞活力，生物活性和 /或组织完整性。
-
公开(公告)号：US20090035250A1
公开(公告)日：2009-02-05
申请号：US11890154
申请日：2007-08-03
CPC分类号： A61K31/74 , A61K31/77 , A61K33/06 , A61K45/06 , A61K2300/00
摘要： Compositions, methods and kits to be used as a lubricant and for treatment of a cavity pathology including joint pathology are provided. The composition comprises therapeutically effective amounts of at least one bioactive agent, such as magnesium compound, at least one lubricating agent, such as hyaluronic acid, and at least one cell membrane repairing agent, such as polyethylene glycol. The components of these compositions may be administered by a direct application, an application through a cannula, an intra-articular injection, as a flush fluid during an arthroscopy of the affected area, as a post-arthroscopy injection, or as part of a lavage of the area affected by the intra-articular pathology. In addition, the composition of the present invention may be administered to the patient from a pump or a depot.
摘要翻译： 提供了用作润滑剂的组合物，方法和试剂盒以及用于治疗包括关节病理学在内的腔病理学。 组合物包含治疗有效量的至少一种生物活性剂，例如镁化合物，至少一种润滑剂，例如透明质酸，和至少一种细胞膜修复剂，例如聚乙二醇。 这些组合物的组分可以通过直接应用，通过插管施用，关节内注射，作为受影响区域的关节镜检查期间的冲洗液，作为关节内窥镜注射后或作为灌洗液的一部分施用 的受关节内病变影响的区域。 此外，本发明的组合物可以从泵或贮库给予患者。
-
-
-
-
-
-
-
-
-
搜索结果
92 条记录 (耗时 0.022 秒)
