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1.发明申请公开(公告)号：US20170198311A1
公开(公告)日：2017-07-13
申请号：US15279184
申请日：2016-09-28
CPC分类号： C12P5/007 , C12N1/12 , C12N1/14 , C12N1/20 , C12N9/1085 , C12N9/88 , C12N15/70 , C12P7/42 , C12Y203/01008 , C12Y205/01 , C12Y401/02009 , C12Y402/03027 , C12Y503/03002 , Y02P20/52
摘要： The invention provides for methods for the production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in cells via the heterologous expression of phosphoketolase enzymes.
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公开(公告)号：US20140127770A1
公开(公告)日：2014-05-08
申请号：US14148332
申请日：2014-01-06
IPC分类号： C12P5/00
摘要： The invention features methods producing isoprene and a co-product, such as ethanol, 1,3-propanediol, or hydrogen from cultured cells. The invention also provides compositions that include these cultured cells. The invention provides compositions comprising isoprene and ethanol, isoprene and 1,3-propanediol, and isoprene and hydrogen. Additionally, the invention provides methods of co-producing isoprene and ethanol, isoprene and 1,3-propanediol, and isoprene and hydrogen by culturing cells under conditions suitable for co-production of isoprene and ethanol, isoprene and 1,3-propanediol, and isoprene and hydrogen.
摘要翻译： 本发明的特征在于从培养细胞产生异戊二烯和共产物如乙醇，1,3-丙二醇或氢的方法。 本发明还提供包括这些培养细胞的组合物。 本发明提供了包含异戊二烯和乙醇，异戊二烯和1,3-丙二醇以及异戊二烯和氢的组合物。 另外，本发明提供了通过在适合共同生产异戊二烯和乙醇，异戊二烯和1,3-丙二醇的条件下培养细胞来共同生产异戊二烯和乙醇，异戊二烯和1,3-丙二醇以及异戊二烯和氢的方法，以及 异戊二烯和氢。
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公开(公告)号：US20140073026A1
公开(公告)日：2014-03-13
申请号：US14028342
申请日：2013-09-16
IPC分类号： C12P5/00
摘要： The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells. The invention provides isoprene compositions, such as compositions with increased amount of isoprene or increased purity. Additionally, the invention provides methods of producing isoprene by culturing cells under conditions suitable for isoprene production while maintaining cell viability and/or metabolic activity.
摘要翻译： 本发明的特征在于从培养细胞产生异戊二烯的方法。 本发明还提供包括这些培养细胞的组合物。 本发明提供异戊二烯组合物，例如具有增加的异戊二烯量或增加的纯度的组合物。 另外，本发明提供了通过在适合异戊二烯生产的条件下培养细胞同时维持细胞活力和/或代谢活性来生产异戊二烯的方法。
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公开(公告)号：US20180002727A1
公开(公告)日：2018-01-04
申请号：US15694193
申请日：2017-09-01
发明人： Zachary Q. BECK , Michael C. MILLER , Caroline M. PERES , Yuliya A. PRIMAK , Jeff P. PUCCI , Derek H. WELLS
CPC分类号： C12P5/007 , C12N9/0006 , C12N9/1025 , C12N9/1029 , C12N15/70 , C12N15/81 , C12P5/002 , C12P7/02 , C12P7/04 , C12P7/42 , C12Y101/01034 , C12Y203/01016 , C12Y203/0301 , Y02E50/343
摘要： The invention features compositions and methods for the increased production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in microorganisms via the heterologous expression of the mvaE and mvaS genes from the organisms Listeria grayi DSM 20601, Enterococcus faecium, Enterococcus gallinarum EG2, and Enterococcus casseliflavus.
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公开(公告)号：US20180273982A1
公开(公告)日：2018-09-27
申请号：US15873761
申请日：2018-01-17
发明人： Marguerite A. CERVIN , Gopal K. CHOTANI , Frank J. FEHER , Richard LA DUCA , Joseph C. MCAULIFFE , Andrei MIASNIKOV , Caroline M. PERES , Aaron S. PUHALA , Karl J. SANFORD , Fernando VALLE , Gregory M. WHITED
CPC分类号： C12P5/007 , C12N9/1022 , C12N9/1205 , C12N9/1229 , C12N9/88 , C12N9/90 , C12N15/52 , C12Y203/01009 , C12Y207/01036 , C12Y401/01033 , C12Y402/03027 , C12Y503/03002 , Y02E50/343
摘要： The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells.
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6.发明申请公开(公告)号：US20190153479A1
公开(公告)日：2019-05-23
申请号：US16200485
申请日：2018-11-26
发明人： Zachary Q. BECK , Michael C. MILLER , Caroline M. PERES , Yuliya A. PRIMAK , Jeff P. PUCCI , Derek H. WELLS
IPC分类号： C12P5/00 , C12P5/02 , C12N9/04 , C12N15/70 , C12P7/42 , C12P7/04 , C12P7/02 , C12N9/88 , C12N9/18 , C12N9/12 , C12N9/10 , C12N9/02
摘要： The invention features compositions and methods for the increased production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in microorganisms by engineering a microorganism for increased carbon flux towards mevalonate production in the following enzymatic pathways: (a) citrate synthase, (b) phosphotransacetylase, (c) acetate kinase, (d) lactate dehydrogenase, (e) malic enzyme, and (f) pyruvate dehydrogenase such that one of more of the enzyme activity is modulated. In addition, production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids can be further enhanced by the heterologous expression of the mvaE and mvaS genes (such as, but not limited to, mvaE and mvaS genes from the organisms Listeria grayi DSM 20601, Enterococcus faecium, Enterococcus gallinarum EG2, and Enterococcus casseliflavus).
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公开(公告)号：US20130164808A1
公开(公告)日：2013-06-27
申请号：US13725929
申请日：2012-12-21
申请人： Danisco US Inc.
发明人： Joseph C. MCAULIFFE , Rachel E. MUIR , Alex T. NIELSEN , Caroline M. PERES , Dmitrii V. VAVILINE , Derek H. WELLS
IPC分类号： C12P5/00
CPC分类号： C12P5/007 , C12N9/1085 , C12N9/88 , C12Y205/01001 , C12Y402/03027 , Y02P20/52
摘要： This invention relates to recombinant microorganisms capable of producing isoprene and isoprene production with the use of such recombinant microorganism with good efficiency. In this invention, functional activity of the ispA gene is altered to reduce the production of isoprenoid molecules in recombinant cells engineered to produce isoprene or in cells otherwise susceptible to isoprenoid accumulation during fermentation. This decreased ispA gene functional activity enables enhanced synthesis of isoprene in a host microorganism.
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公开(公告)号：US20130295633A1
公开(公告)日：2013-11-07
申请号：US13888248
申请日：2013-05-06
申请人： Danisco US Inc.
IPC分类号： C12P5/00
CPC分类号： C12N15/52 , C12N15/635 , C12N15/70 , C12P5/007 , C12P7/42
摘要： Provided herein are improved compositions and methods for the increased production of isoprene. Also provided herein are improved compositions and methods for the increased production of heterologous polypeptides capable of biological activity.
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