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公开(公告)号：US20140067246A1
公开(公告)日：2014-03-06
申请号：US13600398
申请日：2012-08-31
IPC分类号： G06F7/00
CPC分类号： B61L3/006 , B60L2200/26 , B61L15/0027 , B61L27/0022 , B61L27/0027
摘要： A system includes a vehicle control module, an operating information module, and a fuel analysis module. The vehicle control module is configured to obtain a trip plan for the vehicle. The operating information module is configured to be disposed on-board the vehicle and to autonomously obtain operating information describing one or more of tractive events or braking events performed during the trip. The fuel analysis module is configured to be disposed on-board the vehicle, to receive the operating information from the operating information module, and to autonomously determine a fuel consumption for at least a portion of the trip using the operating information received from the operating information module.
摘要翻译： 一种系统包括车辆控制模块，操作信息模块和燃料分析模块。 车辆控制模块被配置为获得车辆的行程计划。 操作信息模块被配置为布置在车辆上并且自主地获得描述在行程期间执行的牵引事件或制动事件中的一个或多个的操作信息。 燃料分析模块被配置为布置在车辆上，以从操作信息模块接收操作信息，并且使用从操作信息接收的操作信息自主地确定行程的至少一部分的燃料消耗 模块。
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公开(公告)号：US08930126B2
公开(公告)日：2015-01-06
申请号：US13600398
申请日：2012-08-31
CPC分类号： B61L3/006 , B60L2200/26 , B61L15/0027 , B61L27/0022 , B61L27/0027
摘要： A system includes a vehicle control module, an operating information module, and a fuel analysis module. The vehicle control module is configured to obtain a trip plan for the vehicle. The operating information module is configured to be disposed on-board the vehicle and to autonomously obtain operating information describing one or more of tractive events or braking events performed during the trip. The fuel analysis module is configured to be disposed on-board the vehicle, to receive the operating information from the operating information module, and to autonomously determine a fuel consumption for at least a portion of the trip using the operating information received from the operating information module.
摘要翻译： 一种系统包括车辆控制模块，操作信息模块和燃料分析模块。 车辆控制模块被配置为获得车辆的行程计划。 操作信息模块被配置为布置在车辆上并且自主地获得描述在行程期间执行的牵引事件或制动事件中的一个或多个的操作信息。 燃料分析模块被配置为布置在车辆上，以从操作信息模块接收操作信息，并且使用从操作信息接收的操作信息自主地确定行程的至少一部分的燃料消耗 模块。
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公开(公告)号：US09330910B2
公开(公告)日：2016-05-03
申请号：US13882631
申请日：2011-10-31
申请人： Yi Chen , G. Logan Liu
发明人： Yi Chen , G. Logan Liu
IPC分类号： H01L21/02 , H01L29/06 , B82Y30/00 , B82Y40/00 , H01L31/0236 , H01L31/0352 , H01L31/18 , B82Y20/00
CPC分类号： H01L21/02612 , B82Y20/00 , B82Y30/00 , B82Y40/00 , H01L29/0665 , H01L31/02363 , H01L31/035209 , H01L31/035227 , H01L31/1804 , Y02E10/547 , Y02P70/521
摘要： A method of forming an array of nanostructures includes forming a plurality of seed points on a surface of a substrate, and growing masks from the seed points to create masked regions of the substrate underlying the masks. A remainder of the substrate comprises an unmasked region. Each mask and masked region increase in size with growth time while the unmasked region of the substrate decreases in size. During the growing, the unmasked region is etched to remove material from the substrate in a depth direction, and, simultaneously, unetched structures are formed from the masked regions of the substrate underlying the masks. Each of the unetched structures has a lateral size that increases with depth.
摘要翻译： 形成纳米结构阵列的方法包括在衬底的表面上形成多个种子点，以及从种子点生长掩模以产生掩模下面的衬底的掩蔽区域。 衬底的其余部分包括未掩模区域。 每个掩模和掩模区域随着生长时间而增大，而衬底的未掩模区域的尺寸减小。 在生长期间，蚀刻未掩模区域以在深度方向上从衬底去除材料，并且同时从掩模下面的衬底的掩蔽区域形成未蚀刻的结构。 每个未蚀刻的结构具有随深度增加的横向尺寸。
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6.发明授权Camptothecin compound containing stable 7-membered lactone ring, preparation method and use 有权喜树碱化合物含有稳定的7元内酯环，制备方法和用途公开(公告)号：US09115150B2
公开(公告)日：2015-08-25
申请号：US14112583
申请日：2012-04-13
申请人： Wei Lv , Shanbao Yu , Yu Luo , Yi Chen , Jian Ding
发明人： Wei Lv , Shanbao Yu , Yu Luo , Yi Chen , Jian Ding
IPC分类号： C07D491/22
CPC分类号： C07D491/22
摘要： Provided are a camptothecin compound containing 7-membered lactone ring, as shown in general formula I, and pharmaceutically acceptable salt thereof, as well as the preparation method and use thereof. In general formula I, R1 is H, a C1˜C3 alkyl, acetyl or propionyl; R2 is H, a C1˜C6 alkyl, a C3˜C6 cycloalkyl, piperidyl; or a C1˜C6 alkyl substituted by an amino; R3 is H, a C1˜C3 alkyl, or a C1˜C6 alkyl substituted by an amino; R4 is H, a hydroxyl, or a C1˜C6 alkoxy; R5 is H, or a C1˜C6 alkoxyl; or R4 and R5 are linked to each other to form —OCH2O— or —OCH2CH2O—. The compound has good anti-tumor activity, and can be clinically used via oral administration, intravenous injection, and intramuscular injection, among others.
摘要翻译： 提供了如通式I所示的含有7-元内酯环的喜树碱化合物及其药学上可接受的盐以及其制备方法和用途。 在通式I中，R 1是H，C 1 -C 3烷基，乙酰基或丙酰基; R2是H，C1〜C6烷基，C3〜C6环烷基，哌啶基; 或被氨基取代的C 1-6烷基; R3是H，C1〜C3烷基或被氨基取代的C1〜C6烷基; R4是H，羟基或C1〜C6烷氧基; R5是H或C1〜C6烷氧基; 或R 4和R 5彼此连接形成-OCH 2 O-或-OCH 2 CH 2 O-。 该化合物具有良好的抗肿瘤活性，可以通过口服给药，静脉内注射和肌内注射等临床使用。
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公开(公告)号：US20150183747A1
公开(公告)日：2015-07-02
申请号：US14345562
申请日：2012-09-14
申请人： Yu Chen , Lan Yang , Feiyu Feng , Qiufu Ge , Dianwu Guo , Yi Chen
发明人： Yu Chen , Lan Yang , Feiyu Feng , Qiufu Ge , Dianwu Guo , Yi Chen
IPC分类号： C07D235/16 , A61K47/40
CPC分类号： C07D235/16 , A61K9/0019 , A61K9/19 , A61K31/16 , A61K31/4184 , A61K47/40 , A61K47/6951 , Y02A50/414
摘要： The present invention is directed to pharmaceutical compositions comprising: (a) a cyclopolysaccharide and (b) a compound of Formula (I) or its pharmaceutical acceptable salt: wherein X1, X2, Q, Z, and m are defined herein. Also disclosed is a method for treating a neoplastic disease or an immune disease with these compositions.
摘要翻译： 本发明涉及药物组合物，其包含：（a）环多糖和（b）式（I）化合物或其药学上可接受的盐：其中X 1，X 2，Q，Z和m如本文所定义。 还公开了用这些组合物治疗肿瘤疾病或免疫疾病的方法。
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公开(公告)号：US08980909B2
公开(公告)日：2015-03-17
申请号：US13977413
申请日：2012-01-06
IPC分类号： A61K31/44 , A01N43/42 , C07D491/22 , A61K31/4745 , A61K31/496 , A61K31/506 , A61K31/695 , A61K45/06 , C07F7/10
CPC分类号： C07D491/22 , A61K31/4745 , A61K31/496 , A61K31/506 , A61K31/695 , A61K45/06 , C07F7/10 , Y02A50/414
摘要： The disclosure includes hydroxamic compounds of Formula I: (Formula I) wherein Z, L, R1, R2, and R3 are defined herein. Also disclosed is a method for treating a neoplastic disease or an immune disease with these compounds.
摘要翻译： 本公开内容包括式I的异羟肟酸化合物：式（I）其中Z，L，R 1，R 2和R 3在本文中定义。 还公开了用这些化合物治疗肿瘤疾病或免疫疾病的方法。
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公开(公告)号：US08936510B1
公开(公告)日：2015-01-20
申请号：US13999479
申请日：2014-03-04
申请人： Yi Chen
发明人： Yi Chen
CPC分类号： A63F3/00157 , G07F17/323 , G07F17/326 , G07F17/329
摘要： A method to operate game of chance using a map of sites as playing surface with moving pieces called movers. There are ruled movements. A random draw of ruled movements move movers from sites to sites. Players bet on own selected movers moving to own selected sits by one or several draws of movements. The holder of a hanging bet earns credit to place free make-up bets. Calculation of the hanging or winning probability of every bet together with its hanging credit or winning payoff will be provided. An automatic computer/video version of the game is included.
摘要翻译： 使用称为移动器的移动部件的站点作为游戏面的操作游戏机会的方法。 有统治的运动。 随机绘制统治的动作将移动者从站点移动到站点。 玩家通过一个或多个动作画面，将自己选定的移动者投下自己的选择。 挂牌的持有人可以获得免费化妆赌注的信用。 将提供计算每次下注的挂牌或获胜概率及其挂牌或获胜回报。 包括游戏的自动计算机/视频版本。
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公开(公告)号：US08901135B2
公开(公告)日：2014-12-02
申请号：US13468234
申请日：2012-05-10
申请人： Yi Chen , Timothy D. Cushing , Jason A. Duquette , Felix Gonzalez Lopez De Turiso , Xiaolin Hao , Xiao He , Brian Lucas , Lawrence R. McGee , Andreas Reichelt , Robert M. Rzasa , Jennifer Seganish , Youngsook Shin , Dawei Zhang
发明人： Yi Chen , Timothy D. Cushing , Jason A. Duquette , Felix Gonzalez Lopez De Turiso , Xiaolin Hao , Xiao He , Brian Lucas , Lawrence R. McGee , Andreas Reichelt , Robert M. Rzasa , Jennifer Seganish , Youngsook Shin , Dawei Zhang
IPC分类号： C07D487/04 , C07D473/34 , C07D473/30
CPC分类号： C07D487/04 , C07D471/04 , C07D473/30 , C07D473/34
摘要： Substituted bicyclic heteroaryls having the following formula where the variables are as defined herein, and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110□ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
摘要翻译： 具有下式的取代的双环杂芳基，其中变量如本文所定义，以及含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎性或不稳定性膀胱病，牛皮癣， 包括但不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血， 包括所有形式的超敏反应的过敏症状本发明还使得能够治疗依赖于p110□活性或与p110□活性相关的癌症的方法，包括但不限于白血病，例如急性骨髓性白血病（AML）Myelo-dysplastic sy （MDS）骨髓增生性疾病（MPD）慢性骨髓性白血病（CML）T细胞急性淋巴细胞性白血病（T-ALL）B细胞急性淋巴细胞性白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和 实体肿瘤，如乳腺癌。
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