Abstract:
Human antibodies which specifically bind to human CTLA-4, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
Abstract:
A method for deterministic directional discovery of neighbor devices by a device in a wireless network comprises dividing equally an access time to a discovery channel to predefined number of sector scanning periods (410), wherein each sector scanning period includes a predefined number of discovery sweep periods (430), and each discovery sweep period includes a predefined number of time slots (440); scanning the discovery channel in a single sector during a current sector scanning period (S310); transmitting a discovery frame towards each sector during each time slot of each discovery sweep period of the current sector scanning period (S320); checking if at least one response to a transmitted discovery frame has been received during the current sector scanning period (S330); and setting the device to scan the discovery channel in a next sector during a next sector scanning period, thereby sequentially accessing the predefined number of sector scanning periods (S35).
Abstract:
A method to operate simultaneous races providing racecourses (10) printed on bet slips and scheduling draws of random numbers for racer advancements. On a bet slip, the player marks one selectable spot for a racer to start and none to scratch a racer, and also selects which forthcoming draws will be applicable to advance racers. Make-up bets can be placed between advancements. Besides, a 1-race bet winner can earn cash payoff or non-cashable credit to wager like cash. The ticket holder of a hanging multi-race bet has the option to trade in hanging credit for placing other bets. How to calculate advancement probabilities, winner credits, hanging credits and specific house edge formulas for payoffs will be provided. An automatic computer/video version of the game is included.
Abstract:
A method to operate simultaneous races providing racecourses (10) printed on bet slips and scheduling draws of random numbers for racer advancements. On a bet slip, the player marks one selectable spot for a racer to start and none to scratch a racer, and also selects which forthcoming draws will be applicable to advance racers. Make-up bets can be placed between advancements. Besides, a 1-race bet winner can earn cash payoff or non-cashable credit to wager like cash. The ticket holder of a hanging multi-race bet has the option to trade in hanging credit for placing other bets. How to calculate advancement probabilities, winner credits, hanging credits and specific house edge formulas for payoffs will be provided. An automatic computer/video version of the game is included.
Abstract:
Imaging spectrometers can be used to generate hyperspectral images for medical diagnoses, contaminant detection, and food safety inspections, among other applications. An exemplary imaging spectrometer includes an integrated position sensing array that measures the relative positions of the interferometer components based on an interference pattern generated by illuminating the interferometer with a reference beam. Such an imaging spectrometer includes a processor that controls the interferometer component position by actuating a voice coil and several piezo-electric elements to align the components with respect to each other and to provide a desired optical path length mismatch between the interferometer arms. In some cases, the processor may use feedback and feed forward control, possibly based on the actuators' transfer functions, for more precise positioning. The processor may also implement adaptive and recursive spectral sampling to reduce the image acquisition period.
Abstract:
A system includes a vehicle control module, an operating information module, and a fuel analysis module. The vehicle control module is configured to obtain a trip plan for the vehicle. The operating information module is configured to be disposed on-board the vehicle and to autonomously obtain operating information describing one or more of tractive events or braking events performed during the trip. The fuel analysis module is configured to be disposed on-board the vehicle, to receive the operating information from the operating information module, and to autonomously determine a fuel consumption for at least a portion of the trip using the operating information received from the operating information module.
Abstract:
A method to operate non-pari-mutuel game of chance using a map of sites as playing surface with moving pieces called movers. The game rules a plurality of movements. A random draw of ruled movements moves movers from sites to sites, one round after another. Calculation of any possible movement outcome probabilities is provided. Players can bet on any one or more possible movement outcomes. The holder of a hanging bet earns credit to place free make-up bets. House edge functions with outcome probability as variable are suggested. An automatic computer/video version of the game is included.
Abstract:
Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
Abstract:
The present invention relates to a structurally novel [1,2,4]triazolo[4,3-b][1,2,4]triazine compounds represented by formula (I) or formula (II), pharmaceutically acceptable salts thereof, prodrugs thereof, hydrates or solvates thereof, and also relates to a preparation method of the compounds, a pharmaceutical composition including a therapeutically effective amount of the compounds, as well as the use thereof as protein tyrosine kinase inhibitors, particularly as c-Met inhibitors, in the preparation of medicaments for the prevention and/or treatment of diseases associated with c-Met abnormality.
Abstract:
A chip-scale packaging method, with bottom and side of a semiconductor chip encapsulated, includes the following steps: attaching backside of a thinned semiconductor wafer to a dicing tape; separating individual chips by cutting from front side of the wafer at scribe line but not cut through the dicing tape; flipping and attaching the wafer onto a top surface of a double-sided tape, then removing the dicing tape; attaching bottom surface of the double-sided tape on a supporting plate; filling the space between adjacent chips and covering the whole wafer backside with a molding material; flipping the whole structure and remove the supporting plate; placing solder balls at corresponding positions on electrodes of each chip and performing backflow treatment; finally separating individual chip packages by cutting through molding material at the space between adjacent chip packages with molding material encapsulating the bottom and side of each individual semiconductor chip.