公开(公告)号：US20200262921A1

公开(公告)日：2020-08-20

申请号：US15777369

申请日：2015-11-19

Applicant: Zeling Cai ,  Yi Chen

Inventor： Zeling Cai ,  Yi Chen

IPC: C07K16/28 ,  A61K39/395 ,  A61K39/00 ,  A61K39/29

Abstract: Human antibodies which specifically bind to human CTLA-4, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

公开(公告)号：US09967726B2

公开(公告)日：2018-05-08

申请号：US13696654

申请日：2011-04-26

Applicant: Yi Chen ,  Chun-Wei Hsu ,  Chun-Ting Chou

Inventor： Yi Chen ,  Chun-Wei Hsu ,  Chun-Ting Chou

IPC: H04B1/18 ,  H04W8/00 ,  H04W16/28 ,  H04W84/18

CPC classification number: H04W8/005 ,  H04W16/28 ,  H04W84/18

Abstract: A method for deterministic directional discovery of neighbor devices by a device in a wireless network comprises dividing equally an access time to a discovery channel to predefined number of sector scanning periods (410), wherein each sector scanning period includes a predefined number of discovery sweep periods (430), and each discovery sweep period includes a predefined number of time slots (440); scanning the discovery channel in a single sector during a current sector scanning period (S310); transmitting a discovery frame towards each sector during each time slot of each discovery sweep period of the current sector scanning period (S320); checking if at least one response to a transmitted discovery frame has been received during the current sector scanning period (S330); and setting the device to scan the discovery channel in a next sector during a next sector scanning period, thereby sequentially accessing the predefined number of sector scanning periods (S35).

公开(公告)号：US20160180654A1

公开(公告)日：2016-06-23

申请号：US14544291

申请日：2014-12-19

Applicant: Yi Chen

Inventor： Yi Chen

IPC: G07F17/32

CPC classification number: G07F17/3288 ,  G07F17/3244 ,  G07F17/3262 ,  G07F17/3269

Abstract: A method to operate simultaneous races providing racecourses (10) printed on bet slips and scheduling draws of random numbers for racer advancements. On a bet slip, the player marks one selectable spot for a racer to start and none to scratch a racer, and also selects which forthcoming draws will be applicable to advance racers. Make-up bets can be placed between advancements. Besides, a 1-race bet winner can earn cash payoff or non-cashable credit to wager like cash. The ticket holder of a hanging multi-race bet has the option to trade in hanging credit for placing other bets. How to calculate advancement probabilities, winner credits, hanging credits and specific house edge formulas for payoffs will be provided. An automatic computer/video version of the game is included.

Abstract translation: 一种操作同步比赛的方法，提供打印在赌注上的赛马场（10），并为赛车进步调度随机数的绘制。 在投注单上，玩家标记赛车开始的一个可选择的位置，而不是划伤赛车手，并且还选择哪个即将到来的抽奖将适用于提前赛车手。 化妆赌注可以放在进步之间。 此外，1-bet赌注赢家可以赚取现金回报或不可兑现的信用额，以现金方式下注。 挂牌多人投注的持票人可以选择交易挂牌以进行其他投注。 将提供如何计算进步概率，获胜者信用额度，挂单信用额和具体房屋边缘公积金。 包括游戏的自动计算机/视频版本。

公开(公告)号：US09361760B1

公开(公告)日：2016-06-07

申请号：US14544291

申请日：2014-12-19

Applicant: Yi Chen

Inventor： Yi Chen

IPC: G07F17/32

CPC classification number: G07F17/3288 ,  G07F17/3244 ,  G07F17/3262 ,  G07F17/3269

Abstract: A method to operate simultaneous races providing racecourses (10) printed on bet slips and scheduling draws of random numbers for racer advancements. On a bet slip, the player marks one selectable spot for a racer to start and none to scratch a racer, and also selects which forthcoming draws will be applicable to advance racers. Make-up bets can be placed between advancements. Besides, a 1-race bet winner can earn cash payoff or non-cashable credit to wager like cash. The ticket holder of a hanging multi-race bet has the option to trade in hanging credit for placing other bets. How to calculate advancement probabilities, winner credits, hanging credits and specific house edge formulas for payoffs will be provided. An automatic computer/video version of the game is included.

公开(公告)号：US20160066775A1

公开(公告)日：2016-03-10

申请号：US14933666

申请日：2015-11-05

Applicant: Ian W. Hunter ,  Yi Chen

Inventor： Ian W. Hunter ,  Yi Chen

IPC: A61B1/06 ,  G01J3/45 ,  G01J3/28

CPC classification number: A61B1/0638 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/1256 ,  G01J3/2823 ,  G01J3/45 ,  G01J3/453 ,  G01J3/4535

Abstract: Imaging spectrometers can be used to generate hyperspectral images for medical diagnoses, contaminant detection, and food safety inspections, among other applications. An exemplary imaging spectrometer includes an integrated position sensing array that measures the relative positions of the interferometer components based on an interference pattern generated by illuminating the interferometer with a reference beam. Such an imaging spectrometer includes a processor that controls the interferometer component position by actuating a voice coil and several piezo-electric elements to align the components with respect to each other and to provide a desired optical path length mismatch between the interferometer arms. In some cases, the processor may use feedback and feed forward control, possibly based on the actuators' transfer functions, for more precise positioning. The processor may also implement adaptive and recursive spectral sampling to reduce the image acquisition period.

Abstract translation: 成像光谱仪可用于生成用于医疗诊断，污染物检测和食品安全检查的高光谱图像，以及其他应用。 示例性成像光谱仪包括集成位置检测阵列，其基于通过用参考光束照射干涉仪产生的干涉图案来测量干涉仪部件的相对位置。 这种成像光谱仪包括处理器，其通过致动音圈和若干压电元件来控制干涉仪组件位置，以使组件相对于彼此对准并且提供干涉仪臂之间期望的光程长度失配。 在某些情况下，处理器可以使用反馈和前馈控制，可能基于执行器的传递功能来进行更精确的定位。 处理器还可以实现自适应和递归频谱采样以减少图像采集周期。

公开(公告)号：US08930126B2

公开(公告)日：2015-01-06

申请号：US13600398

申请日：2012-08-31

Applicant: David A. Eldredge ,  Yi Chen ,  Jerod Svidunovich ,  Timothy Robert Brown ,  John W. McElroy

Inventor： David A. Eldredge ,  Yi Chen ,  Jerod Svidunovich ,  Timothy Robert Brown ,  John W. McElroy

IPC: G06F19/00 ,  B61L3/00

CPC classification number: B61L3/006 ,  B60L2200/26 ,  B61L15/0027 ,  B61L27/0022 ,  B61L27/0027

Abstract: A system includes a vehicle control module, an operating information module, and a fuel analysis module. The vehicle control module is configured to obtain a trip plan for the vehicle. The operating information module is configured to be disposed on-board the vehicle and to autonomously obtain operating information describing one or more of tractive events or braking events performed during the trip. The fuel analysis module is configured to be disposed on-board the vehicle, to receive the operating information from the operating information module, and to autonomously determine a fuel consumption for at least a portion of the trip using the operating information received from the operating information module.

Abstract translation: 一种系统包括车辆控制模块，操作信息模块和燃料分析模块。 车辆控制模块被配置为获得车辆的行程计划。 操作信息模块被配置为布置在车辆上并且自主地获得描述在行程期间执行的牵引事件或制动事件中的一个或多个的操作信息。 燃料分析模块被配置为布置在车辆上，以从操作信息模块接收操作信息，并且使用从操作信息接收的操作信息自主地确定行程的至少一部分的燃料消耗 模块。

公开(公告)号：US20140221082A1

公开(公告)日：2014-08-07

申请号：US13815185

申请日：2013-02-07

Applicant: Yi Chen

Inventor： Yi Chen

IPC: A63F3/00

CPC classification number: A63F3/00157 ,  G07F17/323 ,  G07F17/326 ,  G07F17/329

Abstract: A method to operate non-pari-mutuel game of chance using a map of sites as playing surface with moving pieces called movers. The game rules a plurality of movements. A random draw of ruled movements moves movers from sites to sites, one round after another. Calculation of any possible movement outcome probabilities is provided. Players can bet on any one or more possible movement outcomes. The holder of a hanging bet earns credit to place free make-up bets. House edge functions with outcome probability as variable are suggested. An automatic computer/video version of the game is included.

Abstract translation: 使用称为移动器的移动片段，使用站点的地图作为游戏表面来操作机会的非pari-mutuel游戏的方法。 游戏规则多个动作。 随机绘制统治的动作，将移动者从站点移动到站点，一个接一个地。 提供任何可能的运动结果概率的计算。 玩家可以赌注任何一个或多个可能的运动结果。 挂牌的持有人可以获得免费化妆赌注的信用。 建议以结果概率为变量的房屋边缘功能。 包括游戏的自动计算机/视频版本。

公开(公告)号：US08765940B2

公开(公告)日：2014-07-01

申请号：US13377210

申请日：2010-06-25

Applicant: Matthew Brown ,  Yi Chen ,  Timothy David Cushing ,  Felix Gonzalez Lopez De Turiso ,  Xiao He ,  Todd J. Kohn ,  Julia Winslow Lohman ,  Vatee Pattaropong ,  Jennifer Seganish ,  Youngsook Shin ,  Jillian L. Simard

Inventor： Matthew Brown ,  Yi Chen ,  Timothy David Cushing ,  Felix Gonzalez Lopez De Turiso ,  Xiao He ,  Todd J. Kohn ,  Julia Winslow Lohman ,  Vatee Pattaropong ,  Jennifer Seganish ,  Youngsook Shin ,  Jillian L. Simard

IPC: C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D491/107 ,  C07D491/20 ,  C07D513/04

CPC classification number: C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D491/107 ,  C07D491/113 ,  C07D491/20 ,  C07D495/10 ,  C07D513/04

Abstract: Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

公开(公告)号：US20130324542A1

公开(公告)日：2013-12-05

申请号：US13992048

申请日：2011-12-08

Applicant: Wenhu Duan ,  Meiyu Geng ,  Fang Chen ,  Jing Ai ,  Yi Chen ,  Zhengsheng Zhan ,  Yongcong Lv ,  Ying Wang ,  Jian Ding

Inventor： Wenhu Duan ,  Meiyu Geng ,  Fang Chen ,  Jing Ai ,  Yi Chen ,  Zhengsheng Zhan ,  Yongcong Lv ,  Ying Wang ,  Jian Ding

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: The present invention relates to a structurally novel [1,2,4]triazolo[4,3-b][1,2,4]triazine compounds represented by formula (I) or formula (II), pharmaceutically acceptable salts thereof, prodrugs thereof, hydrates or solvates thereof, and also relates to a preparation method of the compounds, a pharmaceutical composition including a therapeutically effective amount of the compounds, as well as the use thereof as protein tyrosine kinase inhibitors, particularly as c-Met inhibitors, in the preparation of medicaments for the prevention and/or treatment of diseases associated with c-Met abnormality.

Abstract translation: 本发明涉及由式（I）或式（II）表示的结构上新的[1,2,4]三唑并[4,3-b] [1,2,4]三嗪化合物，其药学上可接受的盐，前体药物 其还涉及本发明化合物的制备方法，包含治疗有效量的化合物的药物组合物，以及其作为蛋白酪氨酸激酶抑制剂，特别是作为c-Met抑制剂的用途， 制备用于预防和/或治疗与c-Met异常有关的疾病的药物。

公开(公告)号：US08486803B2

公开(公告)日：2013-07-16

申请号：US13273168

申请日：2011-10-13

Applicant: Ping Huang ,  Ruisheng Wu ,  Lei Duan ,  Yi Chen ,  Yuping Gong

Inventor： Ping Huang ,  Ruisheng Wu ,  Lei Duan ,  Yi Chen ,  Yuping Gong

IPC: H01L21/30

CPC classification number: H01L23/3171 ,  H01L21/568 ,  H01L23/3114 ,  H01L24/19 ,  H01L24/96 ,  H01L2224/02379 ,  H01L2224/12105 ,  H01L2924/1306 ,  H01L2924/13091 ,  H01L2924/15788 ,  H01L2924/181 ,  H01L2924/18162 ,  H01L2924/00

Abstract: A chip-scale packaging method, with bottom and side of a semiconductor chip encapsulated, includes the following steps: attaching backside of a thinned semiconductor wafer to a dicing tape; separating individual chips by cutting from front side of the wafer at scribe line but not cut through the dicing tape; flipping and attaching the wafer onto a top surface of a double-sided tape, then removing the dicing tape; attaching bottom surface of the double-sided tape on a supporting plate; filling the space between adjacent chips and covering the whole wafer backside with a molding material; flipping the whole structure and remove the supporting plate; placing solder balls at corresponding positions on electrodes of each chip and performing backflow treatment; finally separating individual chip packages by cutting through molding material at the space between adjacent chip packages with molding material encapsulating the bottom and side of each individual semiconductor chip.

Abstract translation: 封装了半导体芯片的底部和侧面的芯片级封装方法包括以下步骤：将薄化的半导体晶片的背面安装到切割带上; 通过在切割线处切割晶片的正面而不切割切割带来分离各个芯片; 翻转并将晶片连接到双面胶带的顶表面上，然后移除切割胶带; 将双面胶带的底面附着在支撑板上; 填充相邻芯片之间的空间并用模制材料覆盖整个晶片背面; 翻转整个结构并拆下支撑板; 将焊球放置在每个芯片的电极上的相应位置，并执行回流处理; 最后通过在封装每个单独的半导体芯片的底部和侧面的成型材料之间切割相邻芯片封装之间的空间处的模制材料来分离单个芯片封装。