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    Methods and materials for observing apoptosis
    4.
    发明授权
    Methods and materials for observing apoptosis 有权
    观察细胞凋亡的方法和材料

    公开(公告)号：US08198033B2

    公开(公告)日：2012-06-12

    申请号：US12308542

    申请日：2007-06-20

    申请人： Cary D. Austin ,  David A. Lawrence ,  Avi Ashkenazi

    发明人： Cary D. Austin ,  David A. Lawrence ,  Avi Ashkenazi

    IPC分类号： G01N33/53 ,  G01N33/567 ,  G01N33/574 ,  G01N33/00

    CPC分类号： G01N33/574 ,  G01N2510/00

    摘要： The invention provides methods and materials for observing protein fragments generated during apoptosis in order to observe this process in mammalian cells. Embodiments of the invention can be used for example to observe apoptosis in order to examine the sensitivity of a mammalian cancer cell to apoptosis inducing agents.

    摘要翻译： 本发明提供了用于观察凋亡过程中产生的蛋白质片段的方法和材料，以便在哺乳动物细胞中观察该过程。 本发明的实施方案可用于例如观察细胞凋亡以检查哺乳动物癌细胞对凋亡诱导剂的敏感性。

    FGF-19 NUCLEIC ACIDS
    5.
    发明申请
    FGF-19 NUCLEIC ACIDS 审中-公开
    FGF-19核酸

    公开(公告)号：US20110207912A1

    公开(公告)日：2011-08-25

    申请号：US13013734

    申请日：2011-01-25

    申请人： David Botstein ,  Audrey Goddard ,  Austin L. Gurney ,  Kenneth J. Hillan ,  David A. Lawrence ,  Margaret Ann Roy

    发明人： David Botstein ,  Audrey Goddard ,  Austin L. Gurney ,  Kenneth J. Hillan ,  David A. Lawrence ,  Margaret Ann Roy

    IPC分类号： C07K14/50 ,  C07H21/04 ,  C12N15/63 ,  C12N1/19 ,  C12P21/02 ,  C12N5/10 ,  C12N1/21

    CPC分类号： C07K14/50 ,  C07K2317/24 ,  C07K2319/00

    摘要： The present invention is directed to novel polypeptides having homology to the PRO533 protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention. The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis and/or autocrine signaling. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act of predictors of the prognosis of tumor treatment. Furthermore, the compounds, compositions including antagonists and methods of the present invention are further expected to have therapeutic effect upon conditions characterized by FgF-19 modulation.

    摘要翻译： 本发明涉及与PRO533蛋白质和编码这些多肽的核酸分子具有同源性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的抗体，以及本发明多肽的制备方法 发明。 本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。 本发明基于在肿瘤细胞基因组中扩增的基因的鉴定。 预期这种基因扩增与基因产物的过度表达有关，并且有助于肿瘤发生和/或自分泌信号传导。 因此，由扩增的基因编码的蛋白质被认为是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。 此外，进一步预期本发明的化合物，包括拮抗剂和方法的组合物对于以FgF-19调节为特征的病症具有治疗作用。

    Treatment of filament yarns to provide spun-like characteristics and yarns and fabrics produced thereby
    7.
    发明授权
    Treatment of filament yarns to provide spun-like characteristics and yarns and fabrics produced thereby 失效
    处理长丝纱以提供纺丝特性，由此生产纱线和织物

    公开(公告)号：US07127784B2

    公开(公告)日：2006-10-31

    申请号：US11058478

    申请日：2005-02-15

    申请人： Andre M. Goineau ,  David A. Lawrence ,  Jimmy B. Henson ,  Renee G. Booths ,  C. Brian Williamson

    发明人： Andre M. Goineau ,  David A. Lawrence ,  Jimmy B. Henson ,  Renee G. Booths ,  C. Brian Williamson

    IPC分类号： D02J3/02

    CPC分类号： D02G3/32 ,  D02G3/34 ,  D02J3/02 ,  Y10T428/2913

    摘要： A process for forming a continuous filament yarn having the surface tactile character of a spun yarn. The process includes passing the cohesive yarn structure through the interior of a rotating sleeve member disposed in surrounding relation to the cohesive yarn structure. The rotating sleeve member includes an abrasive inner surface of diameter greater than the cohesive yarn structure and is adapted to contact the exterior surface of the cohesive yarn structure such that at least a portion of the elongate filaments disposed at the exterior of the cohesive yarn structure are broken. Terminal ends of the broken filaments define an arrangement of outwardly projecting hairs at discrete locations disposed substantially around the circumference of the cohesive yarn structure. An apparatus for carrying out the process is also provided.

    摘要翻译： 用于形成具有细纱的表面触觉特性的连续长丝纱的方法。 该方法包括使粘性纱线结构通过围绕与内聚纱结构相关的旋转套筒部件的内部。 所述旋转套筒构件包括直径大于所述内聚纱结构的研磨内表面，并且适于接触所述粘性纱线结构的外表面，使得设置在所述粘性纱线结构外部的细长丝的至少一部分为 破碎。 断丝的终端限定了基本上围绕着粘性纱线结构的圆周设置的离散位置的向外突出的毛发的布置。 还提供了一种用于执行该过程的装置。

    Methods and materials for observing apoptosis
    10.
    发明申请
    Methods and materials for observing apoptosis 有权
    观察细胞凋亡的方法和材料

    公开(公告)号：US20110244473A1

    公开(公告)日：2011-10-06

    申请号：US12308542

    申请日：2007-06-20

    申请人： Cary D. Austin ,  David A. Lawrence ,  Avi Ashkenazi

    发明人： Cary D. Austin ,  David A. Lawrence ,  Avi Ashkenazi

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/567

    CPC分类号： G01N33/574 ,  G01N2510/00

    摘要： The invention provides methods and materials for observing protein fragments generated during apoptosis in order to observe this process in mammalian cells. Embodiments of the invention can be used for example to observe apoptosis in order to examine the sensitivity of a mammalian cancer cell to apoptosis inducing agents.

    摘要翻译： 本发明提供了用于观察凋亡过程中产生的蛋白质片段的方法和材料，以便在哺乳动物细胞中观察该过程。 本发明的实施方案可用于例如观察细胞凋亡以检查哺乳动物癌细胞对凋亡诱导剂的敏感性。