公开(公告)号：US20130267887A1

公开(公告)日：2013-10-10

申请号：US13825495

申请日：2011-09-21

Applicant: Malik Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

Inventor： Malik Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

IPC: A61F9/007 ,  B29C53/02

CPC classification number: A61F9/00781 ,  B29C53/02

Abstract: A small shunt can be placed within the eye to aid in drainage of aqueous humor from the anterior chamber of the eye to a pocket between the conjunctiva and the sclera to be absorbed, or to secrete through the cornea or the sclera external to the eye for glaucoma or ocular hypertension treatment. This drainage can decrease the pressure of the eye and potentially modify the course of advancing glaucomatous optic neuropathy as it relates to eye pressure. The shunt is formed of a shape memory polymer material and deformed into a smaller form factor to reduce trauma to the eye resulting from the insertion of the shunt through the sclera to the anterior chamber. Once in situ, the shunt deploys in response to body heat or other external stimulus and expands to its original, larger form factor to provide a secure friction fit of the shunt within the scleral tissue and to enlarge the lumen of the shunt to allow for aqueous flow.

Abstract translation: 可以将小分流器放置在眼睛内以帮助房水从眼前房排出到结膜和巩膜之间的口袋中以被吸收，或通过眼睛外部的角膜或巩膜分泌 青光眼或高眼压症治疗。 这种引流可以降低眼睛的压力，并可能改变与眼压有关的青光眼性视神经病变进展。 分流器由形状记忆聚合物材料形成并变形成更小的形状因子，以减少由于将分流器穿过巩膜插入前房而引起的对眼睛的创伤。 一旦就地，分流器响应于身体热量或其他外部刺激部署，并扩展到其原始的更大的形状因子，以提供分流器在巩膜组织内的可靠的摩擦配合并且扩大分流器的内腔以允许水分 流。

公开(公告)号：US20130218178A1

公开(公告)日：2013-08-22

申请号：US13821907

申请日：2011-09-12

Applicant: Robin Shandas ,  Craig Joseph Lanning ,  Robyn Grace Yeon Glang ,  Bryan Andrew Rech ,  Naresh Mandava ,  Malik Kahook ,  Nageswara Rao Mandava

Inventor： Robin Shandas ,  Craig Joseph Lanning ,  Robyn Grace Yeon Glang ,  Bryan Andrew Rech ,  Naresh Mandava ,  Malik Kahook ,  Nageswara Rao Mandava

IPC: A61F2/00

CPC classification number: A61F2/0063 ,  C08J5/24 ,  C08J2300/12 ,  C08J2300/24

Abstract: Formulations of shape memory polymer (SMP) are integrated with several existing clinically available medical fabrics. The SMP portion of a SMP-integrated fabric can be fabricated in varying thicknesses with the minimum thickness determined by the thickness of the underlying fabric and up to almost any thickness. A large variety of patterns may be formed in SMP-integrated fabrics based upon how the shape memory polymer is integrated into the base fabric. Integration of the SMP with the base fabrics does not alter the shape memory functionality of the SMP. The design tools for controlling activation rate for traditional SMP materials thus apply to SMP-integrated fabrics. SMP-integrated fabrics may also be steam sterilized without loss of shape memory functionality. By using multiple formulations of SMP on a single piece of fabric, a large combination of material properties may be provided within a single SMP-integrated fabric device.

Abstract translation: 形状记忆聚合物（SMP）的制剂与几种现有的临床医用织物相结合。 SMP集成织物的SMP部分可以以不同的厚度制造，最小厚度由下面的织物的厚度确定并且几乎达到任何厚度。 基于形状记忆聚合物如何整合到基底织物中，可以在SMP集成织物中形成各种图案。 SMP与基础结构的集成不会改变SMP的形状记忆功能。 用于控制传统SMP材料激活速率的设计工具因此适用于SMP集成的面料。 SMP集成的织物也可以进行蒸汽灭菌，而不会损失形状记忆功能。 通过在单个织物上使用多种配方的SMP，可以在单个SMP集成织物装置内提供大量材料性质的组合。

公开(公告)号：US08911495B2

公开(公告)日：2014-12-16

申请号：US13257196

申请日：2010-03-16

Applicant: Michael B. Lyons ,  Julie Marie Trommeter ,  Naresh Mandava ,  Malik Kahook ,  Robin Shandas ,  James Fogelberg ,  Jeffrey Paul Castleberry

Inventor： Michael B. Lyons ,  Julie Marie Trommeter ,  Naresh Mandava ,  Malik Kahook ,  Robin Shandas ,  James Fogelberg ,  Jeffrey Paul Castleberry

IPC: A61F2/14 ,  A61F9/007 ,  A61M31/00 ,  A61L27/50 ,  A61L27/14 ,  A61L27/04 ,  A61M25/01 ,  A61M25/04 ,  A61M25/00 ,  A61F9/00

CPC classification number: A61F9/00772 ,  A61F9/0017 ,  A61F2210/0014 ,  A61L27/04 ,  A61L27/14 ,  A61L27/50 ,  A61L2400/16 ,  A61L2430/16 ,  A61M25/00 ,  A61M25/01 ,  A61M25/04 ,  A61M31/002

Abstract: An implantable ophthalmological device (10) in the form of a punctal plug or canalicular implant is configured for use at or near the nasolacrimal drainage system. In a deployed state, the device (10) may include an elongated body (25), an anchor (15) operably connected to the elongated body (25), a radially expanding occlusive feature disposed on an outer circumference of the elongated body (32), and a flange (30). The elongated body (25) may define a lumen (35) configured to receive a pharmacological treatment (55). The device (10) is made of a shape memory material such as a shape memory polymer.

Abstract translation: 鼻泪管或小管植入物形式的可植入眼科装置（10）被配置用于在鼻泪管排出系统处或附近使用。 在展开状态下，装置（10）可以包括细长主体（25），可操作地连接到细长主体（25）的锚固件（15），设置在细长主体（32）的外圆周上的径向扩张的闭塞特征 ）和凸缘（30）。 细长主体（25）可以限定被配置为接受药物治疗（55）的管腔（35）。 装置（10）由诸如形状记忆聚合物的形状记忆材料制成。

公开(公告)号：US20120116504A1

公开(公告)日：2012-05-10

申请号：US13257196

申请日：2010-03-16

Applicant: Michael B. Lyons ,  Julie Marie Trommeter ,  Naresh Mandava ,  Malik Kahook ,  Robin Shandas ,  James Fogelberg ,  Jeffrey Paul Castleberry

Inventor： Michael B. Lyons ,  Julie Marie Trommeter ,  Naresh Mandava ,  Malik Kahook ,  Robin Shandas ,  James Fogelberg ,  Jeffrey Paul Castleberry

IPC: A61F2/14

CPC classification number: A61F9/00772 ,  A61F9/0017 ,  A61F2210/0014 ,  A61L27/04 ,  A61L27/14 ,  A61L27/50 ,  A61L2400/16 ,  A61L2430/16 ,  A61M25/00 ,  A61M25/01 ,  A61M25/04 ,  A61M31/002

Abstract: An implantable ophthalmological device (10) in the form of a punctal plug or canalicular implant is configured for use at or near the nasolacrimal drainage system. In a deployed state, the device (10) may include an elongated body (25), an anchor (15) operably connected to the elongated body (25), a radially expanding occlusive feature disposed on an outer circumference of the elongated body (32), and a flange (30). The elongated body (25) may define a lumen (35) configured to receive a pharmacological treatment (55). The device (10) is made of a shape memory material such as a shape memory polymer.

Abstract translation: 鼻泪管或小管植入物形式的可植入眼科装置（10）被配置用于在鼻泪管排出系统处或附近使用。 在展开状态下，装置（10）可以包括细长主体（25），可操作地连接到细长主体（25）的锚固件（15），设置在细长主体（32）的外圆周上的径向扩张的闭塞特征 ）和凸缘（30）。 细长主体（25）可以限定被配置为接受药物治疗（55）的管腔（35）。 装置（10）由诸如形状记忆聚合物的形状记忆材料制成。

公开(公告)号：US08685089B2

公开(公告)日：2014-04-01

申请号：US13441754

申请日：2012-04-06

Applicant: Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

Inventor： Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

IPC: A61F2/16

CPC classification number: B29D11/023 ,  A61F2/14 ,  A61F2/142 ,  A61F2/16 ,  A61F2002/16905 ,  A61F2210/0014 ,  A61F2210/0019 ,  A61F2210/0023 ,  A61L27/16 ,  A61L27/50 ,  A61L2400/16 ,  A61L2430/16 ,  B29C61/003 ,  B29C61/06 ,  B29C69/025 ,  B29L2011/0016 ,  C08L33/08 ,  C08L33/10 ,  C08F2220/1825 ,  C08F2222/108 ,  C08F226/02 ,  C08F2220/302

Abstract: A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.

Abstract translation: 形状记忆聚合物（SMP）眼内透镜可以具有高于1.45的折射率，10℃至60℃之间的Tg，包括最小或不闪光，并且可见光的基本上100％的透射率 光谱。 然后将眼内透镜在高于SMP材料的Tg的温度下滚动。 将眼内装置在模具内径向压缩至直径小于或等于1.8mm，同时保持温度高于Tg。 压缩的眼内透镜装置可以通过在角膜或巩膜或其他解剖结构中小于2mm宽的切口插入。 透镜可以通过切口插入囊袋，睫状沟或其他腔。 SMP可以基本上实现大于或等于1.45的折射率值。

公开(公告)号：US09427493B2

公开(公告)日：2016-08-30

申请号：US14026832

申请日：2013-09-13

Applicant: Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech ,  Michael D. Lowery ,  Daniel Urbaniak

Inventor： Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech ,  Michael D. Lowery ,  Daniel Urbaniak

IPC: A61L27/16 ,  A61K6/083 ,  A61L27/50 ,  B29D11/02 ,  B29C61/00 ,  B29C61/06 ,  B29L11/00 ,  A61F2/14 ,  A61F2/16

CPC classification number: A61L27/16 ,  A61F2/14 ,  A61F2/142 ,  A61F2/16 ,  A61F2/1659 ,  A61F9/007 ,  A61F2002/1683 ,  A61F2002/169 ,  A61F2002/169053 ,  A61F2002/1696 ,  A61F2002/16965 ,  A61F2210/0014 ,  A61F2240/001 ,  A61L27/26 ,  A61L27/50 ,  A61L2400/16 ,  A61L2430/16 ,  B29C61/003 ,  B29C61/06 ,  B29C69/025 ,  B29D11/023 ,  B29K2995/0037 ,  B29L2011/0016 ,  B29L2031/7532 ,  C08L33/08 ,  C08L33/10

Abstract: A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.

Abstract translation: 形状记忆聚合物（SMP）眼内透镜可以具有高于1.45的折射率，10℃至60℃之间的Tg，包括最小或不闪光，并且可见光的基本上100％的透射率 光谱。 然后将眼内透镜在高于SMP材料的Tg的温度下滚动。 将眼内装置在模具内径向压缩至直径小于或等于1.8mm，同时保持温度高于Tg。 压缩的眼内透镜装置可以通过角膜或巩膜或其他解剖结构中的小于2mm宽的切口插入。 透镜可以通过切口插入囊袋，睫状沟或其他腔。 SMP可以基本上实现大于或等于1.45的折射率值。

公开(公告)号：US20140232025A1

公开(公告)日：2014-08-21

申请号：US13500884

申请日：2012-03-07

Applicant: Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

Inventor： Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

IPC: B29D11/02

CPC classification number: B29D11/023 ,  A61F2/14 ,  A61F2/142 ,  A61F2/16 ,  A61F2002/16905 ,  A61F2210/0014 ,  A61F2210/0019 ,  A61F2210/0023 ,  A61L27/16 ,  A61L27/50 ,  A61L2400/16 ,  A61L2430/16 ,  B29C61/003 ,  B29C61/06 ,  B29C69/025 ,  B29L2011/0016 ,  C08L33/08 ,  C08L33/10 ,  C08F2220/1825 ,  C08F2222/108 ,  C08F226/02 ,  C08F2220/302

Abstract: A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.

Abstract translation: 形状记忆聚合物（SMP）眼内透镜可以具有高于1.45的折射率，10℃至60℃之间的Tg，包括最小或不闪光，并且可见光的基本上100％的透射率 光谱。 然后将眼内透镜在高于SMP材料的Tg的温度下滚动。 将眼内装置在模具内径向压缩至直径小于或等于1.8mm，同时保持温度高于Tg。 压缩的眼内透镜装置可以通过角膜或巩膜或其他解剖结构中的小于2mm宽的切口插入。 透镜可以通过切口插入囊袋，睫状沟或其他腔。 SMP可以基本上实现大于或等于1.45的折射率值。

公开(公告)号：US20140172094A1

公开(公告)日：2014-06-19

申请号：US14026832

申请日：2013-09-13

Applicant: Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech ,  Michael D. Lowery ,  Daniel Urbaniak

Inventor： Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech ,  Michael D. Lowery ,  Daniel Urbaniak

IPC: A61L27/16 ,  A61L27/50

CPC classification number: A61L27/16 ,  A61F2/14 ,  A61F2/142 ,  A61F2/16 ,  A61F2/1659 ,  A61F9/007 ,  A61F2002/1683 ,  A61F2002/169 ,  A61F2002/169053 ,  A61F2002/1696 ,  A61F2002/16965 ,  A61F2210/0014 ,  A61F2240/001 ,  A61L27/26 ,  A61L27/50 ,  A61L2400/16 ,  A61L2430/16 ,  B29C61/003 ,  B29C61/06 ,  B29C69/025 ,  B29D11/023 ,  B29K2995/0037 ,  B29L2011/0016 ,  B29L2031/7532 ,  C08L33/08 ,  C08L33/10

Abstract: A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45

Abstract translation: 形状记忆聚合物（SMP）眼内透镜可以具有高于1.45的折射率，10℃至60℃之间的Tg，包括最小或不闪光，并且可见光的基本上100％的透射率 光谱。 然后将眼内透镜在高于SMP材料的Tg的温度下滚动。 将眼内装置在模具内径向压缩至直径小于或等于1.8mm，同时保持温度高于Tg。 压缩的眼内透镜装置可以通过角膜或巩膜或其他解剖结构中的小于2mm宽的切口插入。 透镜可以通过切口插入囊袋，睫状沟或其他腔。 SMP可以基本上实现大于或等于1.45的折射率值

公开(公告)号：US20120232651A1

公开(公告)日：2012-09-13

申请号：US13441754

申请日：2012-04-06

Applicant: Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

Inventor： Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

IPC: A61F2/16

CPC classification number: B29D11/023 ,  A61F2/14 ,  A61F2/142 ,  A61F2/16 ,  A61F2002/16905 ,  A61F2210/0014 ,  A61F2210/0019 ,  A61F2210/0023 ,  A61L27/16 ,  A61L27/50 ,  A61L2400/16 ,  A61L2430/16 ,  B29C61/003 ,  B29C61/06 ,  B29C69/025 ,  B29L2011/0016 ,  C08L33/08 ,  C08L33/10 ,  C08F2220/1825 ,  C08F2222/108 ,  C08F226/02 ,  C08F2220/302

Abstract: A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.

Abstract translation: 形状记忆聚合物（SMP）眼内透镜可以具有高于1.45的折射率，10℃至60℃之间的Tg，包括最小或不闪光，并且可见光的基本上100％的透射率 光谱。 然后将眼内透镜在高于SMP材料的Tg的温度下滚动。 将眼内装置在模具内径向压缩至直径小于或等于1.8mm，同时保持温度高于Tg。 压缩的眼内透镜装置可以通过在角膜或巩膜或其他解剖结构中小于2mm宽的切口插入。 透镜可以通过切口插入囊袋，睫状沟或其他腔。 SMP可以基本上实现大于或等于1.45的折射率值。

公开(公告)号：US20120232648A1

公开(公告)日：2012-09-13

申请号：US13441764

申请日：2012-04-06

Applicant: Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

Inventor： Malik Y. Kahook ,  Naresh Mandava ,  Robin Shandas ,  Bryan Rech

IPC: A61F2/16 ,  A61F2/14

CPC classification number: B29D11/023 ,  A61F2/14 ,  A61F2/142 ,  A61F2/16 ,  A61F2002/16905 ,  A61F2210/0014 ,  A61F2210/0019 ,  A61F2210/0023 ,  A61L27/16 ,  A61L27/50 ,  A61L2400/16 ,  A61L2430/16 ,  B29C61/003 ,  B29C61/06 ,  B29C69/025 ,  B29L2011/0016 ,  C08L33/08 ,  C08L33/10 ,  C08F2220/1825 ,  C08F2222/108 ,  C08F226/02 ,  C08F2220/302

Abstract: A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.

Abstract translation: 形状记忆聚合物（SMP）眼内透镜可以具有高于1.45的折射率，10℃至60℃之间的Tg，包括最小或不闪光，并且可见光的基本上100％的透射率 光谱。 然后将眼内透镜在高于SMP材料的Tg的温度下滚动。 将眼内装置在模具内径向压缩至直径小于或等于1.8mm，同时保持温度高于Tg。 压缩的眼内透镜装置可以通过在角膜或巩膜或其他解剖结构中小于2mm宽的切口插入。 透镜可以通过切口插入囊袋，睫状沟或其他腔。 SMP可以基本上实现大于或等于1.45的折射率值。