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    Method of implanting a prosthesis device using bone cement in liquid form
    1.
    发明授权
    Method of implanting a prosthesis device using bone cement in liquid form 有权
    以液体形式使用骨粘固剂植入假体装置的方法

    公开(公告)号：US08940046B2

    公开(公告)日：2015-01-27

    申请号：US13249044

    申请日：2011-09-29

    申请人： David Blakemore ,  Keith Pennington ,  Shaun Pitts

    发明人： David Blakemore ,  Keith Pennington ,  Shaun Pitts

    IPC分类号： A61F2/28 ,  A61B17/88 ,  A61B19/00 ,  A61F2/32 ,  A61F2/38 ,  A61F2/40 ,  A61F2/42 ,  A61F2/44 ,  A61F2/46

    CPC分类号： A61B17/8836 ,  A61B17/8811 ,  A61B17/8827 ,  A61B17/8833 ,  A61B90/06 ,  A61B2017/8838 ,  A61F2/32 ,  A61F2/38 ,  A61F2/3804 ,  A61F2/3877 ,  A61F2/40 ,  A61F2/4202 ,  A61F2/44 ,  A61F2002/3895 ,  A61F2002/4631

    摘要： The present invention relates to a method of implanting a prosthesis device in a subject. In one embodiment, this method involves: (i) providing a prosthesis device to be attached to an exposed surface of a bone; (ii) applying bone cement in liquid form to a bone-implant interface region, the bone-implant interface region including a region between the exposed surface of the bone and an outer surface of the prosthesis device; and (iii) contacting the bone cement to the exposed surface of the bone and the outer surface of the prosthesis device under conditions effective to allow the bone cement to cure, thereby resulting in attachment of the prosthesis device to the bone of the subject. The present invention also relates to a kit for implanting a prosthesis device in a subject, a method of performing a joint arthroplasty surgical procedure, and other methods of using bone cement in liquid form.

    摘要翻译： 本发明涉及一种在受试者中植入假体装置的方法。 在一个实施例中，该方法包括：（i）提供要附接到骨的暴露表面的假体装置; （ii）将液体形式的骨粘固剂施用于骨 - 植入物界面区域，所述骨 - 植入物界面区域包括在所述暴露的骨表面和所述假体装置的外表面之间的区域; 和（iii）在有效地允许骨粘固剂固化的条件下，将骨粘固剂接触骨的露出表面和假体装置的外表面，从而导致假体装置附着到受试者的骨骼上。 本发明还涉及用于在受试者中植入假体装置的套件，执行关节置换手术的方法以及使用液体形式的骨水泥的其它方法。

    Tibial prosthesis
    2.
    发明授权
    Tibial prosthesis 有权
    胫骨假体

    公开(公告)号：US08100981B2

    公开(公告)日：2012-01-24

    申请号：US12393682

    申请日：2009-02-26

    申请人： Ron Clark ,  David Blakemore ,  Ross Mack

    发明人： Ron Clark ,  David Blakemore ,  Ross Mack

    IPC分类号： A61F2/38

    CPC分类号： A61F2/389 ,  A61F2002/30449 ,  A61F2002/3895 ,  A61F2220/005 ,  A61F2310/00353

    摘要： The present invention relates to a tibial prosthesis useful in knee replacement surgeries. The prosthesis includes one or more cement introduction ports which may be used to deliver and control delivery of bone cement to a prosthesis-bone interface after the prosthesis has been positioned on a resurfaced area of a tibia bone. The prosthesis is suitable for implantation using arthroscopic as well as open surgical procedures. The prosthesis may be used as a unicondylar implant in either compartment of the knee or in both compartments of the knee.

    摘要翻译： 本发明涉及一种可用于膝关节置换手术的胫骨假体。 假体包括一个或多个水泥引入口，其可以用于在假体已经被定位在胫骨骨的表面区域之后递送和控制骨水泥递送到假体 - 骨界面。 该假体适用于使用关节镜以及开放性外科手术进行植入。 假体可以用作膝盖的任一隔室或膝盖的两个隔室中的单髁植入物。

    Novel method for the stereoselective synthesis of cyclic amino acids
    4.
    发明申请
    Novel method for the stereoselective synthesis of cyclic amino acids 审中-公开
    用于立体选择性合成环状氨基酸的新方法

    公开(公告)号：US20060084825A1

    公开(公告)日：2006-04-20

    申请号：US10968430

    申请日：2004-10-19

    申请人： Justin Bryans ,  David Blakemore ,  Sophie Williams

    发明人： Justin Bryans ,  David Blakemore ,  Sophie Williams

    IPC分类号： C07C227/10

    CPC分类号： C07C229/28 ,  C07C227/32 ,  C07C2601/08

    摘要： The instant invention is a route to stereospecific 3-substituted 5-membered ring isomers of Formula (A). The final products are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), inflammation especially arthritis, sleep disorders, premenstrual syndrome, and hot flashes. The invention provides novel routes to synthesize stereoselectively analogs of gabapentin (Neurontin™) of Formulas (I), (II), (III), and (IV) wherein R is C1-C10 alkyl or C3 -C10 cycloalkyl and pharmaceutically acceptable salts thereof.

    摘要翻译： 本发明是式（A）的立体特异性3-取代的五元环异构体的途径。 最终产品可用作治疗癫痫，微弱发作，运动不良，颅内疾病，神经退行性疾病，抑郁症，焦虑症，恐慌症，疼痛，神经病理学障碍，胃肠道疾病如肠易激综合征（IBS），炎症，尤其是关节炎， 睡眠障碍，经前期综合征和潮热。 本发明提供了合成式（I），（II），（III）和（IV）的加巴喷丁（Neurontin TM）的立体选择性类似物的新途径，其中R是C 1 -C C 1 -C 10烷基或C 3 -C 10环烷基及其药学上可接受的盐。

    BUR GUIDE ATTACHMENT AND METHOD OF USE
    6.
    发明申请
    BUR GUIDE ATTACHMENT AND METHOD OF USE 失效
    BUR指南附件和使用方法

    公开(公告)号：US20120083788A1

    公开(公告)日：2012-04-05

    申请号：US13251359

    申请日：2011-10-03

    申请人： David Blakemore ,  Eric M. Lucas ,  Keith E. Pennington

    发明人： David Blakemore ,  Eric M. Lucas ,  Keith E. Pennington

    IPC分类号： A61B17/56

    CPC分类号： A61B17/1675 ,  A61B17/1764

    摘要： The invention provides a guide for controlling a surgical instrument, that includes a cutting member configured to resect a portion of anatomy and a sheath. The sheath may have a circular connecting portion with an inner diameter substantially the same as the outer diameter of the surgical instrument to receive the surgical instrument. The sheath may also include at least two distally extending arms connected to the circular connecting portion and a ring connected to the distal portion of the at least two distally extending arms. The sheath may also include a distally extending extension connected to the ring. The guide has a superiorly extending guard connected to the distal portion of the extension and a projection member positioned on a superior surface of the guard. The projection member includes a generally circular base and circular platform that has a diameter larger than the generally circular base.

    摘要翻译： 本发明提供了一种用于控制外科器械的指南，其包括构造成切除解剖部分和鞘的部分的切割构件。 护套可以具有圆形连接部分，其内径基本上与外科器械的外径相同以接收外科器械。 护套还可以包括连接到圆形连接部分的至少两个远端延伸的臂和连接到至少两个远端延伸臂的远端部分的环。 护套还可以包括连接到环的远侧延伸的延伸部。 引导件具有连接到延伸部的远端部分的上延伸防护件和位于护罩的上表面上的突出部件。 突出部件包括大致圆形的基部和圆形平台，其直径大于基本上圆形的基部。

    Tibial Prosthesis
    7.
    发明申请
    Tibial Prosthesis 有权
    胫骨假体

    公开(公告)号：US20090228112A1

    公开(公告)日：2009-09-10

    申请号：US12393682

    申请日：2009-02-26

    申请人： Ron Clark ,  David Blakemore ,  Ross Mack

    发明人： Ron Clark ,  David Blakemore ,  Ross Mack

    IPC分类号： A61F2/38

    CPC分类号： A61F2/389 ,  A61F2002/30449 ,  A61F2002/3895 ,  A61F2220/005 ,  A61F2310/00353

    摘要： The present invention relates to a tibial prosthesis useful in knee replacement surgeries. The prosthesis includes one or more cement introduction ports which may be used to deliver and control delivery of bone cement to a prosthesis-bone interface after the prosthesis has been positioned on a resurfaced area of a tibia bone. The prosthesis is suitable for implantation using arthroscopic as well as open surgical procedures. The prosthesis may be used as a unicondylar implant in either compartment of the knee or in both compartments of the knee.

    摘要翻译： 本发明涉及一种可用于膝关节置换手术的胫骨假体。 假体包括一个或多个水泥引入口，其可以用于在假体已经被定位在胫骨骨的表面区域之后递送和控制骨水泥递送到假体 - 骨界面。 该假体适用于使用关节镜以及开放性外科手术进行植入。 假体可以用作膝盖的任一隔室或膝盖的两个隔室中的单髁植入物。

    Bur guide attachment and method of use
    9.
    发明授权
    Bur guide attachment and method of use 失效
    Bur指南附件和使用方法

    公开(公告)号：US08608747B2

    公开(公告)日：2013-12-17

    申请号：US13251359

    申请日：2011-10-03

    申请人： David Blakemore ,  Eric M. Lucas ,  Keith E. Pennington

    发明人： David Blakemore ,  Eric M. Lucas ,  Keith E. Pennington

    IPC分类号： A61F5/00

    CPC分类号： A61B17/1675 ,  A61B17/1764

    摘要： The invention provides a guide for controlling a surgical instrument, that includes a cutting member configured to resect a portion of anatomy and a sheath. The sheath may have a circular connecting portion with an inner diameter substantially the same as the outer diameter of the surgical instrument to receive the surgical instrument. The sheath may also include at least two distally extending arms connected to the circular connecting portion and a ring connected to the distal portion of the at least two distally extending arms. The sheath may also include a distally extending extension connected to the ring. The guide has a superiorly extending guard connected to the distal portion of the extension and a projection member positioned on a superior surface of the guard. The projection member includes a generally circular base and circular platform that has a diameter larger than the generally circular base.

    摘要翻译： 本发明提供了一种用于控制外科器械的指南，其包括构造成切除解剖部分和鞘的部分的切割构件。 护套可以具有圆形连接部分，其内径基本上与外科器械的外径相同以接收外科器械。 护套还可以包括连接到圆形连接部分的至少两个远端延伸的臂和连接到至少两个远端延伸臂的远端部分的环。 护套还可以包括连接到环的远侧延伸的延伸部。 引导件具有连接到延伸部的远端部分的上延伸防护件和位于护罩的上表面上的突出部件。 突出部件包括大致圆形的基部和圆形平台，其直径大于基本上圆形的基部。

    Femoral prosthesis
    10.
    发明授权
    Femoral prosthesis 失效
    股骨假体

    公开(公告)号：US08226727B2

    公开(公告)日：2012-07-24

    申请号：US12393658

    申请日：2009-02-26

    申请人： Ron Clark ,  David Blakemore ,  Ross Mack

    发明人： Ron Clark ,  David Blakemore ,  Ross Mack

    IPC分类号： A61F2/38

    CPC分类号： A61F2/389 ,  A61F2002/30449 ,  A61F2002/3895 ,  A61F2220/005 ,  A61F2310/00353

    摘要： The present invention relates to a femoral prosthesis that includes a cement introduction port which may be used to facilitate delivery or introduction of bone cement into the prosthesis/bone interface after the prosthesis component has been placed on a resurfaced femur bone. The femoral prosthesis may have a keel with undercuts which are configured to assist in controlling the flow of bone cement during implantation and to improve stability of the prosthesis following implantation. The femoral prosthesis is suitable for implantation using arthroscopic, as well as open, surgical procedures. The present prostheses may be used as unicondylar implants in either compartment of the knee or in both compartments of the knee.

    摘要翻译： 本发明涉及一种股骨假体，其包括水泥引入口，其可以用于在假体部件已经放置在重新铺上的股骨上之后便于将骨水泥输送或引入假体/骨界面​​中。 股骨假体可以具有带有底切的龙骨，其被构造成有助于在植入期间控制骨水泥的流动并且在植入之后提高假体的稳定性。 股骨假体适用于使用关节镜和外科手术进行植入。 本假体可以用作膝盖的任一隔室或膝盖的两个隔室中的单髁植入物。