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21 条记录 (耗时 0.079 秒)

    Methods for Detecting and Treating the Early Onset of Aging-Related Conditions
    4.
    发明申请
    Methods for Detecting and Treating the Early Onset of Aging-Related Conditions 审中-公开
    检测和处理与老龄相关条件早期发生的方法

    公开(公告)号：US20080199865A1

    公开(公告)日：2008-08-21

    申请号：US11838490

    申请日：2007-08-14

    申请人： David C. Crossman ,  Gordon W. Duff ,  Sheila E. Francis ,  Katherine Stephensan ,  Kenneth S. Kornman

    发明人： David C. Crossman ,  Gordon W. Duff ,  Sheila E. Francis ,  Katherine Stephensan ,  Kenneth S. Kornman

    IPC分类号： C12Q1/68 ,  C12N5/00

    CPC分类号： C12Q1/6883 ,  C12Q2600/156

    摘要： Certain aspects of the invention relate to methods for determining a subject's susceptibility to the early onset or progression of aging-related conditions. In certain aspects the invention relates to accessing the genotype of a subject with respect to an allele of IL-1 pattern 1, pattern 2 and/or pattern 3. In other aspects, the invention relates to methods for selecting a therapeutic regimen, identifying age-related biomarkers, monitoring the progress of age-related conditions and identifying therapeutics for delaying or diminishing the onset of aging-related conditions.

    摘要翻译： 本发明的某些方面涉及确定受试者对老龄化相关病症的早期发病或进展的易感性的方法。 在某些方面，本发明涉及相对于IL-1模式1，模式2和/或模式3的等位基因获取对象的基因型。在其它方面，本发明涉及用于选择治疗方案的方法，鉴定年龄 相关的生物标志物，监测年龄相关病症的进展，并确定延缓或减少老化相关病症发作的治疗方法。

    Fetal testing for prediction of low birth weight
    9.
    发明授权
    Fetal testing for prediction of low birth weight 失效
    用于预测低出生体重的胎儿测试

    公开(公告)号：US06733967B1

    公开(公告)日：2004-05-11

    申请号：US09693555

    申请日：2000-10-20

    申请人： Kenneth S. Kornman ,  Gordon W. Duff ,  Steven Offenbacher

    发明人： Kenneth S. Kornman ,  Gordon W. Duff ,  Steven Offenbacher

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172

    摘要： Methods, assays and kits are disclosed for detecting a mother's or a fetus's susceptibility to an adverse pregnancy outcome such as low birth weight. The methods comprise obtaining a biological sample from a patient and determining the presence or absence of an IL-1 allele 2 of a marker that is associated with an adverse pregnancy outcome.

    摘要翻译： 公开了用于检测母亲或胎儿对不良妊娠结局如低出生体重的易感性的方法，测定和试剂盒。 所述方法包括从患者获得生物样品并确定与不良妊娠结局相关的标志物的IL-1等位基因2的存在或不存在。

    IL-1 Gene Cluster and Associated Inflammatory Polymorphisms and Haplotypes
    10.
    发明申请
    IL-1 Gene Cluster and Associated Inflammatory Polymorphisms and Haplotypes 有权
    IL-1基因簇和相关炎症多态性和单倍型

    公开(公告)号：US20090298063A1

    公开(公告)日：2009-12-03

    申请号：US12084181

    申请日：2006-10-25

    申请人： Kenneth S. Kornman ,  Kenneth Huttner ,  John Rogus

    发明人： Kenneth S. Kornman ,  Kenneth Huttner ,  John Rogus

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

    摘要： The invention provides methods and compositions relating to identification and use of genetic information from the IL-1 gene cluster—including the structure and organization of novel IL-1-like genes found within the IL-1 locus as well as polymorphisms and associated haplotypes within these genes. The invention thereby expands the repertoire of useful genetic information available from the IL-1 locus—which contains the previously-identified IL-1α, EL-1β and IL-1RN genes, for predicting IL-1 associated phenotypes (e.g. increased or decreased risks of inflammatory disease) and for treating IL-1 haplotype associated inflammatory phenotypes.

    摘要翻译： 本发明提供了与IL-1基因簇的遗传信息的鉴定和使用有关的方法和组合，包括在IL-1基因座内发现的新型IL-1样基因的结构和组织以及多态性和相关单体型 这些基因。 因此，本发明扩展了可用于预测IL-1相关表型的IL-1基因座（其含有先前鉴定的IL-1α，EL-1β和IL-1RN基因）的有用遗传信息的所有组成成分（例如增加或减少的风险 的炎性疾病）和用于治疗IL-1单倍型相关的炎症表型。