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    ULTRA-SENSITIVE DETECTION OF MOLECULES OR PARTICLES USING BEADS OR OTHER CAPTURE OBJECTS
    3.
    发明申请
    ULTRA-SENSITIVE DETECTION OF MOLECULES OR PARTICLES USING BEADS OR OTHER CAPTURE OBJECTS 有权
    使用珠子或其他捕获物体对分子或颗粒进行超敏感检测

    公开(公告)号：US20110212848A1

    公开(公告)日：2011-09-01

    申请号：US12731130

    申请日：2010-03-24

    申请人： David C. Duffy ,  David M. Rissin ,  David R. Walt ,  David Fournier ,  Cheuk Kan

    发明人： David C. Duffy ,  David M. Rissin ,  David R. Walt ,  David Fournier ,  Cheuk Kan

    IPC分类号： C40B30/04 ,  C40B40/04

    CPC分类号： G01N33/54393 ,  G01N33/54306 ,  G01N33/54313

    摘要： The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components.

    摘要翻译： 本发明涉及用于检测流体样品中的分析物分子或颗粒的系统和方法，并且在某些情况下，确定流体样品中分子或颗粒的浓度的量度。 本发明的方法可以包括相对于多个捕获物体固定多个分析物分子或颗粒。 多个捕获对象的至少一部分可以在空间上分离成多个位置。 可以至少部分地确定包含相对于捕获对象固定的分析物分子的反应容器的数量，来测量流体样品中分析物分子的浓度。 在一些情况下，该测定可另外包括包括结合配体，前体标记试剂和/或酶组分的步骤。

    Ultra-sensitive detection of molecules or particles using beads or other capture objects
    4.
    发明授权
    Ultra-sensitive detection of molecules or particles using beads or other capture objects 有权
    使用珠粒或其他捕获物体对分子或颗粒进行超敏感检测

    公开(公告)号：US08236574B2

    公开(公告)日：2012-08-07

    申请号：US12731130

    申请日：2010-03-24

    申请人： David C. Duffy ,  David M. Rissin ,  David R. Walt ,  David Fournier ,  Cheuk Kan

    发明人： David C. Duffy ,  David M. Rissin ,  David R. Walt ,  David Fournier ,  Cheuk Kan

    IPC分类号： G01N33/543

    CPC分类号： G01N33/54393 ,  G01N33/54306 ,  G01N33/54313

    摘要： The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components.

    摘要翻译： 本发明涉及用于检测流体样品中的分析物分子或颗粒的系统和方法，并且在某些情况下，确定流体样品中分子或颗粒的浓度的量度。 本发明的方法可以包括相对于多个捕获物体固定多个分析物分子或颗粒。 多个捕获对象的至少一部分可以在空间上分离成多个位置。 可以至少部分地确定包含相对于捕获对象固定的分析物分子的反应容器的数量，来测量流体样品中分析物分子的浓度。 在一些情况下，该测定可另外包括包括结合配体，前体标记试剂和/或酶组分的步骤。

    Ultra-sensitive detection of molecules or particles using beads or other capture objects
    5.
    发明授权
    Ultra-sensitive detection of molecules or particles using beads or other capture objects 有权
    使用珠粒或其他捕获物体对分子或颗粒进行超敏感检测

    公开(公告)号：US09482662B2

    公开(公告)日：2016-11-01

    申请号：US13530979

    申请日：2012-06-22

    申请人： David C. Duffy ,  David M. Rissin ,  David R. Walt ,  David Fournier ,  Cheuk Kan

    发明人： David C. Duffy ,  David M. Rissin ,  David R. Walt ,  David Fournier ,  Cheuk Kan

    IPC分类号： G01N33/543

    CPC分类号： G01N33/54393 ,  G01N33/54306 ,  G01N33/54313

    摘要： The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components.

    摘要翻译： 本发明涉及用于检测流体样品中的分析物分子或颗粒的系统和方法，并且在某些情况下，确定流体样品中分子或颗粒的浓度的量度。 本发明的方法可以包括相对于多个捕获物体固定多个分析物分子或颗粒。 多个捕获对象的至少一部分可以在空间上分离成多个位置。 可以至少部分地确定包含相对于捕获对象固定的分析物分子的反应容器的数量，来测量流体样品中分析物分子的浓度。 在一些情况下，该测定可另外包括包括结合配体，前体标记试剂和/或酶组分的步骤。

    ULTRA-SENSITIVE DETECTION OF MOLECULES OR PARTICLES USING BEADS OR OTHER CAPTURE OBJECTS
    8.
    发明申请
    ULTRA-SENSITIVE DETECTION OF MOLECULES OR PARTICLES USING BEADS OR OTHER CAPTURE OBJECTS 有权
    使用珠子或其他捕获物体对分子或颗粒进行超敏感检测

    公开(公告)号：US20120277114A1

    公开(公告)日：2012-11-01

    申请号：US13531061

    申请日：2012-06-22

    申请人： David C. Duffy ,  David M. Rissin ,  David R. Walt ,  David Fournier ,  Cheuk Kan

    发明人： David C. Duffy ,  David M. Rissin ,  David R. Walt ,  David Fournier ,  Cheuk Kan

    IPC分类号： C40B30/04

    CPC分类号： G01N33/54393 ,  G01N33/54306 ,  G01N33/54313

    摘要： The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components.

    摘要翻译： 本发明涉及用于检测流体样品中的分析物分子或颗粒的系统和方法，并且在某些情况下，确定流体样品中分子或颗粒的浓度的量度。 本发明的方法可以包括相对于多个捕获物体固定多个分析物分子或颗粒。 多个捕获对象的至少一部分可以在空间上分离成多个位置。 可以至少部分地确定包含相对于捕获对象固定的分析物分子的反应容器的数量，来测量流体样品中分析物分子的浓度。 在一些情况下，该测定可另外包括包括结合配体，前体标记试剂和/或酶组分的步骤。

    Methods and systems for extending dynamic range in assays for the detection of molecules or particles
    10.
    发明授权
    Methods and systems for extending dynamic range in assays for the detection of molecules or particles 有权

    公开(公告)号：US08415171B2

    公开(公告)日：2013-04-09

    申请号：US12731136

    申请日：2010-03-24

    申请人： David M. Rissin ,  David Fournier ,  David C. Duffy

    发明人： David M. Rissin ,  David Fournier ,  David C. Duffy

    IPC分类号： G01N33/543

    CPC分类号： G01N21/6452 ,  G01N33/50

    摘要： Described herein are systems and methods for extending the dynamic range of assay methods and systems used for determining the concentration of analyte molecules or particles in a fluid sample. In some embodiments, a method comprises spatially segregating a plurality of analyte molecules in a fluid sample into a plurality of locations. At least a portion of the locations may be addressed to determine the percentage of said locations containing at least one analyte molecule. Based at least in part on the percentage, a measure of the concentration of analyte molecules in the fluid sample may be determined using an analog, intensity-based detection/analysis method/system and/or a digital detection/analysis method/system. In some cases, the assay may comprise the use of a plurality of capture objects.