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公开(公告)号：US6091168A
公开(公告)日：2000-07-18
申请号：US218653
申请日：1998-12-22
摘要： Losses in efficiency of operation of a dynamoelectric machine as a result of eddy current losses and poor coolant efficiency and/or disruption of the magnetic circuit in a rotor by coolant passages is avoided in a dynamoelectric machine including a stator (18) in which a rotor (16) is journaled. The rotor includes a stack (16) of thin laminations (17) made of a ferromagnetic material to define a rotor body. The rotor body includes a plurality of equally angularly spaced poles (58) separated by recesses (64). Coolant passages (76) located in the rotor at or just radially inward of the base (72) of each pole (58) and substantially radially outward of the rotational axis (56) of the rotor (14) to maximize cooling efficiency of the poles (58) without disrupting the magnetic circuit in the rotor. Slots (80) are placed in the tips (70) of the poles (58) of selected laminations (17) and extend generally radially inward to reduce eddy current losses.
摘要翻译： 在包括定子（18）的电动机中避免了由于涡流损失和冷却剂效率差和/或由冷却剂通道引起的转子中的磁路的破坏导致的电动机的操作效率的损失，其中转子 （16）记录。 转子包括由铁磁材料制成的薄的叠片（17）的叠层（16），以形成转子体。 转子主体包括由凹部（64）分开的多个等角度间隔的极（58）。 冷却剂通道（76）位于转子的每一极（58）的基部（72）处或位于转子的径向内侧，并且基本上位于转子（14）的旋转轴线（56）的径向外侧，以使极点的冷却效率最大化 （58），而不破坏转子中的磁路。 狭槽（80）被放置在所选择的叠片（17）的极（58）的尖端（70）中，并且大致径向向内延伸以减少涡流损耗。
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公开(公告)号：US09301929B2
公开(公告)日：2016-04-05
申请号：US13505819
申请日：2010-11-16
IPC分类号： C07D491/08 , A61K31/00 , C07D451/02
CPC分类号： A61K31/00 , C07D451/02 , C07D491/08
摘要： The present invention relates to Substituted Biaryl Derivatives, compositions comprising a Substituted Biaryl Derivative, and methods of using the Substituted Biaryl Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of GPR119 in a patient.
摘要翻译： 本发明涉及取代的芳基衍生物，包含取代的芳基衍生物的组合物，以及使用取代的二芳基衍生物用于治疗或预防肥胖症，糖尿病，代谢紊乱，心血管疾病或与GPR119的活性有关的障碍的方法 患者。
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3.发明授权Bicyclic heterocycle derivatives and their use as modulators of the activity of GPR119 有权双环杂环衍生物及其作为GPR119活性调节剂的用途公开(公告)号：US08907095B2
公开(公告)日：2014-12-09
申请号：US12739531
申请日：2008-10-20
IPC分类号： C07D221/02 , A61K31/439 , C07D451/14 , C07D491/08 , C07D495/08 , C07D471/08 , C07D451/06 , C07D487/08 , C07D401/14 , C07D498/08
CPC分类号： C07D451/06 , A61K31/439 , C07D401/14 , C07D451/14 , C07D471/08 , C07D487/08 , C07D491/08 , C07D495/08 , C07D498/08
摘要： The present invention relates to Bicyclic Heterocycle Derivatives, compositions comprising a Bicyclic Heterocycle Derivative, and methods of using the Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of GPR119 in a patient.
摘要翻译： 本发明涉及双环杂环衍生物，包含双环杂环衍生物的组合物，以及使用双环杂环衍生物治疗或预防肥胖症，糖尿病，代谢紊乱，心血管疾病或与GPR119活性相关的病症的方法 患者。
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公开(公告)号：US08829036B2
公开(公告)日：2014-09-09
申请号：US13420007
申请日：2012-03-14
申请人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voight , Corey O. Strickland , Elizabeth M. Smith , Andrew W. Stamford , William J. Greenlee , Robert D. Mazzola, Jr. , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoiang Liu , Tao Guo , Thuy X. E. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan , Jeffrey A. Misiaszek , Gaifa Lai , Jingqi Duo , Chuanxing Qu , Yuefei Shao
发明人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voight , Corey O. Strickland , Elizabeth M. Smith , Andrew W. Stamford , William J. Greenlee , Robert D. Mazzola, Jr. , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoiang Liu , Tao Guo , Thuy X. E. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan , Jeffrey A. Misiaszek , Gaifa Lai , Jingqi Duo , Chuanxing Qu , Yuefei Shao
IPC分类号： A61K31/4168 , A61K31/4178 , C07D403/06 , C07D233/88
CPC分类号： C07D233/88 , A61K31/4168 , A61K31/4178 , C07D239/22 , C07D401/06 , C07D401/10 , C07D403/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/10 , C07D417/14 , C07D495/10
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein each variable in Formula 1 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.
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公开(公告)号：US08673900B2
公开(公告)日：2014-03-18
申请号：US13128493
申请日：2009-11-12
申请人： Zhaoning Zhu , William J. Greenlee , Xianhai Huang , Jun Qin , Xiaoxiang Liu , Hongmei Li , Wei Zhou , Anandan Palani , Xiaohong Zhu , Monica L. Vicarel , Mihirbaran Mandal , Zhong-Yue Sun , Chad E. Bennett , Troy Michael McCracken , Gioconda V. Gallo
发明人： Zhaoning Zhu , William J. Greenlee , Xianhai Huang , Jun Qin , Xiaoxiang Liu , Hongmei Li , Wei Zhou , Anandan Palani , Xiaohong Zhu , Monica L. Vicarel , Mihirbaran Mandal , Zhong-Yue Sun , Chad E. Bennett , Troy Michael McCracken , Gioconda V. Gallo
IPC分类号： C07D471/04 , C07D498/04 , A61K31/5395
CPC分类号： C07D471/04 , C07D498/04
摘要： In many embodiments, the present invention provides novel heterocyclic compounds which are modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more disease associated with the central nervous system using such compounds or pharmaceutical compositions.
摘要翻译： 在许多实施方案中，本发明提供了新的杂环化合物，其为γ-分泌酶的调节剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备包含一种或多种此类化合物的药物制剂的方法，以及治疗方法， 使用这些化合物或药物组合物预防，抑制或改善与中枢神经系统相关的一种或多种疾病。
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6.发明授权4, 5, 6-trisubstituted pyrimidine derivatives as factor IXa inhibitors 有权4,5,6,6-三取代嘧啶衍生物作为因子IXa抑制剂公开(公告)号：US08609676B2
公开(公告)日：2013-12-17
申请号：US13388628
申请日：2010-08-03
申请人： Mariappan V. Chelliah , Samuel Chackalamannil , William J. Greenlee , Keith Eagan , Zhuyan Guo , Martin C. Clasby , Yan Xia , Charles L. Jayne , Michael Dwyer , Kartik M. Keertikar , Tin-Yau Chan , Li Wang
发明人： Mariappan V. Chelliah , Samuel Chackalamannil , William J. Greenlee , Keith Eagan , Zhuyan Guo , Martin C. Clasby , Yan Xia , Charles L. Jayne , Michael Dwyer , Kartik M. Keertikar , Tin-Yau Chan , Li Wang
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D239/34 , C07D239/47 , C07D239/52 , C07D401/12 , C07D403/04 , C07D403/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to novel heterocyclic compounds of Formulae (I): (Chemical formula should be inserted here as it appears on abstract in paper form) Formula (I) as disclosed herein, or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosed are pharmaceutical compositions comprising said compounds, and methods for using said compounds for treating or preventing a thromboembolic disorder.
摘要翻译： 本发明涉及式（I）的新型杂环化合物：（化学式应在此插入，如本文摘要中所示）本文公开的式（I），或其药学上可接受的盐，溶剂合物，酯，前药或 其立体异构体。 还公开了包含所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓栓塞性疾病的方法。
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公开(公告)号：US20130072468A1
公开(公告)日：2013-03-21
申请号：US13616825
申请日：2012-09-14
IPC分类号： A61K31/496 , A61K31/495 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D413/06 , A61K31/5377 , C07D417/06 , A61K31/506 , C07D487/04 , A61K31/397 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P3/04 , A61P3/10 , A61P1/00 , A61P1/08 , A61P1/12 , A61P13/00 , A61P15/08 , A61P29/00 , A61P9/10 , A61P31/00 , A61P35/00 , A61P3/00 , A61P1/16 , A61P9/00 , C07D241/04
CPC分类号： C07D403/10 , C07D241/04 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D407/04 , C07D413/06 , C07D417/06 , C07D487/04
摘要： Compounds of Formula (I): or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB1 receptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e.g., smoking cessation), gastrointestinal disorders, and cardiovascular conditions.
摘要翻译： 式（I）化合物或其药学上可接受的盐，溶剂合物或酯可用于治疗由CB1受体介导的疾病或病症，例如代谢综合征和肥胖症，神经炎症性疾病，认知障碍和精神病，成瘾（例如吸烟 停止），胃肠道疾病和心血管疾病。
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公开(公告)号：US20120276118A1
公开(公告)日：2012-11-01
申请号：US13420007
申请日：2012-03-14
申请人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voight , Corey O. Strickland , Elizabeth M. Smith , Andrew Stamford , William J. Greenlee , Robert D. Mazzola , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoxiang Liu , Tao Guo , Thuy X.E. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan , Jeffrey A. Misiaszek , Gaifa Lai , Jingqi Duo , Chuanxing Qu , Yuefei Shao
发明人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voight , Corey O. Strickland , Elizabeth M. Smith , Andrew Stamford , William J. Greenlee , Robert D. Mazzola , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoxiang Liu , Tao Guo , Thuy X.E. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan , Jeffrey A. Misiaszek , Gaifa Lai , Jingqi Duo , Chuanxing Qu , Yuefei Shao
IPC分类号： A61K39/395
CPC分类号： C07D233/88 , A61K31/4168 , A61K31/4178 , C07D239/22 , C07D401/06 , C07D401/10 , C07D403/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/10 , C07D417/14 , C07D495/10
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein each variable in Formula 1 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.
摘要翻译： 公开了式I化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂化物，其中式1中的每个变量如说明书中所定义; 以及包含式I化合物的药物组合物。还公开了抑制天冬氨酰蛋白酶的方法，特别是治疗心血管疾病，认知和神经退行性疾病的方法，以及抑制人类免疫缺陷病毒，plasmepins，组织蛋白酶D和 原生动物酶。 还公开了使用式I化合物与胆碱酯酶抑制剂或毒蕈碱m1激动剂或m2拮抗剂组合治疗认知或神经变性疾病的方法。
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公开(公告)号：US20120231018A1
公开(公告)日：2012-09-13
申请号：US13416140
申请日：2012-03-09
申请人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voigt , Corey O. Strickland , Elizabeth M. Smith , Andrew Stamford , William J. Greenlee , Robert D. Mozzola , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoxiang Liu , Tao Guo , Thuy X. E. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan , Jeffrey A. Misiaszek , Gaifa Lai , Jingqi Duo , Chuanxing Qu , Yuefei Shao
发明人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voigt , Corey O. Strickland , Elizabeth M. Smith , Andrew Stamford , William J. Greenlee , Robert D. Mozzola , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoxiang Liu , Tao Guo , Thuy X. E. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan , Jeffrey A. Misiaszek , Gaifa Lai , Jingqi Duo , Chuanxing Qu , Yuefei Shao
IPC分类号： A61K31/513 , A61P25/28 , A61P31/10 , A61P25/00 , A61P29/00 , A61K39/395 , A61P31/04 , A61P9/00 , A61P33/02
CPC分类号： C07D233/88 , A61K31/4168 , A61K31/4178 , C07D239/22 , C07D401/06 , C07D401/10 , C07D403/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/10 , C07D417/14 , C07D495/10
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein each variable in Formula 1 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.
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公开(公告)号：US20120214805A1
公开(公告)日：2012-08-23
申请号：US13504363
申请日：2010-10-28
IPC分类号： A61K31/5386 , A61K31/439 , C07D498/08 , A61P3/00 , C07D451/02 , A61P3/10 , A61P3/04 , A61K31/506 , C07D491/08
CPC分类号： C07D491/08 , C07D498/08
摘要： The present invention relates to Bridged Bicyclic Piperidine Derivatives, compositions comprising a Bridged Bi-cyclic Piperidine Derivative, and methods of using the Bridged Bicyclic Piperidine Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of GPR119 in a patient.
摘要翻译： 本发明涉及桥连双环哌啶衍生物，包含桥连双环哌啶衍生物的组合物，以及使用桥连双环哌啶衍生物治疗或预防肥胖，糖尿病，代谢紊乱，心血管疾病或与 GPR119在患者体内的活动。
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