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公开(公告)号:US06495528B1
公开(公告)日:2002-12-17
申请号:US09720390
申请日:2001-02-20
申请人: David George Allen , Chuen Chan , Richard Peter Charles Cousins , Brian Cox , Joanna Victoria Geden , Heather Hobbs , Suzanne Elaine Keeling , Alison Judith Redgrave , Thomas Davis Roper, IV , Shiping Xie
发明人: David George Allen , Chuen Chan , Richard Peter Charles Cousins , Brian Cox , Joanna Victoria Geden , Heather Hobbs , Suzanne Elaine Keeling , Alison Judith Redgrave , Thomas Davis Roper, IV , Shiping Xie
IPC分类号: A61L3170
CPC分类号: C07H19/16 , A61K31/7076 , C07H7/06 , Y10S514/885
摘要: A series of 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives with broad anti-inflammatory properties which inhibit leukocyte recruitment and activation and which are agonists of the adenosine 2a receptor are described.
摘要翻译: 描述了一系列具有抑制白细胞募集和活化并且是腺苷2a受体激动剂的广泛抗炎性质的2-(嘌呤-9-基) - 四氢呋喃-3,4-二醇衍生物。
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公开(公告)号:US06534486B1
公开(公告)日:2003-03-18
申请号:US09720193
申请日:2001-02-28
申请人: David George Allen , Chuen Chan , Caroline Mary Cook , Richard Peter Charles Cousins , Brian Cox , Hazel Joan Dyke , Frank Ellis , Joanna Victoria Geden , Heather Hobbs , Suzanne Elaine Keeling , Alison Judith Redgrave , Stephen Swanson , Caroline Whitworth , David Bays
发明人: David George Allen , Chuen Chan , Caroline Mary Cook , Richard Peter Charles Cousins , Brian Cox , Hazel Joan Dyke , Frank Ellis , Joanna Victoria Geden , Heather Hobbs , Suzanne Elaine Keeling , Alison Judith Redgrave , Stephen Swanson , Caroline Whitworth , David Bays
IPC分类号: A01N4304
CPC分类号: C07H19/16 , Y10S514/826 , Y10S514/851 , Y10S514/921 , Y10S514/925
摘要: A series of 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives with broad anti-inflammatory properties which inhibit leukocyte recruitment and activation and which are agonists of the adenosine 2a receptor are described.
摘要翻译: 描述了一系列具有抑制白细胞募集和活化并且是腺苷2a受体激动剂的广泛抗炎性质的2-(嘌呤-9-基) - 四氢呋喃-3,4-二醇衍生物。
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公开(公告)号:US06528494B2
公开(公告)日:2003-03-04
申请号:US10025678
申请日:2001-12-19
申请人: Brian Cox , Suzanne Elaine Keeling , David George Allen , Alison Judith Redgrave , Michael David Barker , Heather Hobbs , Thomas Davis Roper, IV , Joanna Victoria Geden
发明人: Brian Cox , Suzanne Elaine Keeling , David George Allen , Alison Judith Redgrave , Michael David Barker , Heather Hobbs , Thomas Davis Roper, IV , Joanna Victoria Geden
IPC分类号: A01N4304
CPC分类号: C07D473/00 , C07H19/16 , Y10S514/826 , Y10S514/851 , Y10S514/885 , Y10S514/921 , Y10S514/925
摘要: There are provided according to the invention novel compounds of formula I wherein R1, R2 and R3 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
摘要翻译: 根据本发明提供新的式I化合物,其中R 1,R 2和R 3如说明书中所述,其制备方法,含有它们的制剂及其在治疗炎性疾病中的应用。
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公开(公告)号:US06426337B1
公开(公告)日:2002-07-30
申请号:US09331526
申请日:1999-08-20
申请人: Brian Cox , Suzanne Elaine Keeling , David George Allen , Alison Judith Redgrave , Michael David Barker , Heather Hobbs , Thomas Davis Roper, IV , Joanna Victoria Geden
发明人: Brian Cox , Suzanne Elaine Keeling , David George Allen , Alison Judith Redgrave , Michael David Barker , Heather Hobbs , Thomas Davis Roper, IV , Joanna Victoria Geden
IPC分类号: A61K3170
CPC分类号: C07D473/00 , C07H19/16 , Y10S514/826 , Y10S514/851 , Y10S514/885 , Y10S514/921 , Y10S514/925
摘要: There are provided according to the invention novel compounds of formula (I) wherein R1, R2, and R3 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
摘要翻译: 根据本发明提供新的式(I)化合物,其中R 1,R 2和R 3如说明书中所述,其制备方法,含有它们的制剂及其在治疗炎性疾病中的用途。
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公开(公告)号:US08735390B2
公开(公告)日:2014-05-27
申请号:US13821585
申请日:2011-09-06
申请人: Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr , Robert David Willacy
发明人: Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr , Robert David Willacy
IPC分类号: A61K31/5377 , C07D413/14
CPC分类号: A61K31/5377 , C07D413/14
摘要: The present invention is directed to novel polymorphs and salts of a compound which is an inhibitor of kinase activity.
摘要翻译: 本发明涉及作为激酶活性抑制剂的化合物的新型多晶型物和盐。
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公开(公告)号:US20130165433A1
公开(公告)日:2013-06-27
申请号:US13821594
申请日:2011-09-06
申请人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Zoe Alicia Harrison , Katherine Louise Jones , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Christopher James Lunniss , Charlotte Jane Mitchell , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christopher Alan Paul Smethurst , Yoshiaki Washio
发明人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Zoe Alicia Harrison , Katherine Louise Jones , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Christopher James Lunniss , Charlotte Jane Mitchell , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christopher Alan Paul Smethurst , Yoshiaki Washio
IPC分类号: C07D413/14
CPC分类号: A61K31/5377 , A61K31/416 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5386 , C07D413/14
摘要: The present invention is directed to compounds for use in the treatment or prevention of influenza virus infection.
摘要翻译: 本发明涉及用于治疗或预防流感病毒感染的化合物。
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公开(公告)号:US20120053166A1
公开(公告)日:2012-03-01
申请号:US13254034
申请日:2010-03-05
申请人: Julie Nicole Hamblin , Zoe Alicia Harrison , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Christopher James Lunniss , Nigel James Parr
发明人: Julie Nicole Hamblin , Zoe Alicia Harrison , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Christopher James Lunniss , Nigel James Parr
IPC分类号: A61K31/5377 , A61K31/506 , A61K31/454 , A61K31/496 , C07D471/08 , A61K31/4995 , A61K31/538 , C07D417/14 , A61K31/541 , A61K31/553 , A61P11/00 , A61P37/08 , A61P37/00 , A61P29/00 , A61P9/00 , A61P35/00 , A61P25/28 , A61P1/18 , A61P13/12 , A61P7/02 , A61P15/08 , A61P37/06 , A61P25/00 , A61P11/06 , A61P17/00 , A61P1/00 , A61P9/10 , C07D413/14
CPC分类号: C07D413/14 , C07D487/04 , C07D487/08
摘要: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.
摘要翻译: 本发明涉及某些新化合物。 具体地,本发明涉及式(I)的化合物及其盐。 本发明的化合物是激酶活性的抑制剂,特别是PI3-激酶活性。
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8.6-(1H-indol-4-yl)-4-(5-{[4-1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazole hemi succinate salt, polymorphs and pharmaceutical compositions thereof 有权
标题翻译: 6-(1H-吲哚-4-基)-4-(5 - {[4-1-甲基乙基] -1-哌嗪基]甲基} -1,3-恶唑-2-基)-1H-吲唑半琥珀酸盐 ,多晶型物及其药物组合物公开(公告)号:US08993576B2
公开(公告)日:2015-03-31
申请号:US13879667
申请日:2011-10-25
申请人: Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr , Robert David Willacy
发明人: Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr , Robert David Willacy
IPC分类号: A61K31/496 , C07D413/14
CPC分类号: C07D413/14
摘要: The present invention is directed to a polymorph of a compound and salts of a compound and polymorphs thereof, which compound is an inhibitor of kinase activity.
摘要翻译: 本发明涉及一种化合物和化合物的盐及其多晶型物的多晶型物,该化合物是激酶活性的抑制剂。
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公开(公告)号:US08580797B2
公开(公告)日:2013-11-12
申请号:US12768777
申请日:2010-04-28
申请人: Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr
发明人: Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr
IPC分类号: A61K31/497 , C07D413/14
CPC分类号: A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/535 , A61K45/06 , C07B2200/13 , C07D413/14 , Y02A50/409
摘要: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.
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公开(公告)号:US20100280045A1
公开(公告)日:2010-11-04
申请号:US12768777
申请日:2010-04-28
申请人: Julie Nicole HAMBLIN , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr
发明人: Julie Nicole HAMBLIN , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr
IPC分类号: A61K31/497 , C07D413/14 , A61P11/00 , A61P31/12 , A61P37/00 , A61P29/00 , A61P9/00 , A61P7/00 , A61P1/18 , A61P13/12 , A61P35/00
CPC分类号: A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/535 , A61K45/06 , C07B2200/13 , C07D413/14 , Y02A50/409
摘要: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular Pl3-kinase activity.
摘要翻译: 本发明涉及某些新化合物。 具体地,本发明涉及式(I)的化合物及其盐。 本发明的化合物是激酶活性抑制剂,特别是PI3激酶活性。
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