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公开(公告)号:US06534486B1
公开(公告)日:2003-03-18
申请号:US09720193
申请日:2001-02-28
申请人: David George Allen , Chuen Chan , Caroline Mary Cook , Richard Peter Charles Cousins , Brian Cox , Hazel Joan Dyke , Frank Ellis , Joanna Victoria Geden , Heather Hobbs , Suzanne Elaine Keeling , Alison Judith Redgrave , Stephen Swanson , Caroline Whitworth , David Bays
发明人: David George Allen , Chuen Chan , Caroline Mary Cook , Richard Peter Charles Cousins , Brian Cox , Hazel Joan Dyke , Frank Ellis , Joanna Victoria Geden , Heather Hobbs , Suzanne Elaine Keeling , Alison Judith Redgrave , Stephen Swanson , Caroline Whitworth , David Bays
IPC分类号: A01N4304
CPC分类号: C07H19/16 , Y10S514/826 , Y10S514/851 , Y10S514/921 , Y10S514/925
摘要: A series of 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives with broad anti-inflammatory properties which inhibit leukocyte recruitment and activation and which are agonists of the adenosine 2a receptor are described.
摘要翻译: 描述了一系列具有抑制白细胞募集和活化并且是腺苷2a受体激动剂的广泛抗炎性质的2-(嘌呤-9-基) - 四氢呋喃-3,4-二醇衍生物。
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公开(公告)号:US06495528B1
公开(公告)日:2002-12-17
申请号:US09720390
申请日:2001-02-20
申请人: David George Allen , Chuen Chan , Richard Peter Charles Cousins , Brian Cox , Joanna Victoria Geden , Heather Hobbs , Suzanne Elaine Keeling , Alison Judith Redgrave , Thomas Davis Roper, IV , Shiping Xie
发明人: David George Allen , Chuen Chan , Richard Peter Charles Cousins , Brian Cox , Joanna Victoria Geden , Heather Hobbs , Suzanne Elaine Keeling , Alison Judith Redgrave , Thomas Davis Roper, IV , Shiping Xie
IPC分类号: A61L3170
CPC分类号: C07H19/16 , A61K31/7076 , C07H7/06 , Y10S514/885
摘要: A series of 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives with broad anti-inflammatory properties which inhibit leukocyte recruitment and activation and which are agonists of the adenosine 2a receptor are described.
摘要翻译: 描述了一系列具有抑制白细胞募集和活化并且是腺苷2a受体激动剂的广泛抗炎性质的2-(嘌呤-9-基) - 四氢呋喃-3,4-二醇衍生物。
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公开(公告)号:US06528494B2
公开(公告)日:2003-03-04
申请号:US10025678
申请日:2001-12-19
申请人: Brian Cox , Suzanne Elaine Keeling , David George Allen , Alison Judith Redgrave , Michael David Barker , Heather Hobbs , Thomas Davis Roper, IV , Joanna Victoria Geden
发明人: Brian Cox , Suzanne Elaine Keeling , David George Allen , Alison Judith Redgrave , Michael David Barker , Heather Hobbs , Thomas Davis Roper, IV , Joanna Victoria Geden
IPC分类号: A01N4304
CPC分类号: C07D473/00 , C07H19/16 , Y10S514/826 , Y10S514/851 , Y10S514/885 , Y10S514/921 , Y10S514/925
摘要: There are provided according to the invention novel compounds of formula I wherein R1, R2 and R3 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
摘要翻译: 根据本发明提供新的式I化合物,其中R 1,R 2和R 3如说明书中所述,其制备方法,含有它们的制剂及其在治疗炎性疾病中的应用。
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公开(公告)号:US06426337B1
公开(公告)日:2002-07-30
申请号:US09331526
申请日:1999-08-20
申请人: Brian Cox , Suzanne Elaine Keeling , David George Allen , Alison Judith Redgrave , Michael David Barker , Heather Hobbs , Thomas Davis Roper, IV , Joanna Victoria Geden
发明人: Brian Cox , Suzanne Elaine Keeling , David George Allen , Alison Judith Redgrave , Michael David Barker , Heather Hobbs , Thomas Davis Roper, IV , Joanna Victoria Geden
IPC分类号: A61K3170
CPC分类号: C07D473/00 , C07H19/16 , Y10S514/826 , Y10S514/851 , Y10S514/885 , Y10S514/921 , Y10S514/925
摘要: There are provided according to the invention novel compounds of formula (I) wherein R1, R2, and R3 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
摘要翻译: 根据本发明提供新的式(I)化合物,其中R 1,R 2和R 3如说明书中所述,其制备方法,含有它们的制剂及其在治疗炎性疾病中的用途。
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5.PYRROLOPYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS 审中-公开
标题翻译: 吡咯啉化合物,其制备方法及其作为药物的用途公开(公告)号:US20100179139A1
公开(公告)日:2010-07-15
申请号:US12602619
申请日:2008-05-29
申请人: Paul Bamborough , Michael David Barker , Sebastien Andre Campos , Richard Peter Charles Cousins , Paul Faulder , Heather Hobbs , Duncan Stuart Holmes , Michael John Johnston , John Liddle , Jeremy John Payne , John Martin Pritchard , Caroline Whitworth
发明人: Paul Bamborough , Michael David Barker , Sebastien Andre Campos , Richard Peter Charles Cousins , Paul Faulder , Heather Hobbs , Duncan Stuart Holmes , Michael John Johnston , John Liddle , Jeremy John Payne , John Martin Pritchard , Caroline Whitworth
IPC分类号: A61K31/437 , C07D471/04 , A61K31/506 , A61K31/541 , A61P11/02 , A61P11/06 , A61P11/00 , A61P29/00 , A61P19/10 , A61P31/18 , A61P25/00 , A61P3/10 , A61P9/10 , A61P25/28 , A61P35/00
CPC分类号: C07D471/04
摘要: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds according to formula (I): and salts thereof.The compounds of the invention are inhibitors of kinase activity, in particular IKK2 activity.
摘要翻译: 本发明涉及某些新化合物。 具体地,本发明涉及根据式(I)的化合物及其盐。 本发明的化合物是激酶活性的抑制剂,特别是IKK2活性。
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公开(公告)号:US20080176891A1
公开(公告)日:2008-07-24
申请号:US11858144
申请日:2007-09-20
申请人: Paul Bamborough , Michael David Barker , Sebastien Andre Campos , Richard Peter Charles Cousins , Paul Faulder , Heather Hobbs , Duncan Stuart Holmes , Michael John Johnston , John Liddle , Jeremy John Payne , John Martin Pritchard , Caroline Whitworth
发明人: Paul Bamborough , Michael David Barker , Sebastien Andre Campos , Richard Peter Charles Cousins , Paul Faulder , Heather Hobbs , Duncan Stuart Holmes , Michael John Johnston , John Liddle , Jeremy John Payne , John Martin Pritchard , Caroline Whitworth
IPC分类号: A61K31/437 , C07D221/04 , A61P29/00 , A61P19/02 , A61P11/06
CPC分类号: C07D471/04
摘要: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds according to formula (I): and salts thereof.The compounds of the invention are inhibitors of kinase activity, in particular IKK2 activity.
摘要翻译: 本发明涉及某些新化合物。 具体地,本发明涉及根据式(I)的化合物及其盐。 本发明的化合物是激酶活性的抑制剂,特别是IKK2活性。
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7.PYRROLO[2,3-B]PYRIDIN-4-YL-BENZENESULFONAMIDE COMPOUNDS AS 1KK2 INHIBITORS 审中-公开
标题翻译: 作为1KK2抑制剂的吡咯并[2,3-B]吡啶-4-基 - 苯甲酰胺化合物公开(公告)号:US20100035917A1
公开(公告)日:2010-02-11
申请号:US12442012
申请日:2007-09-20
申请人: Paul Bamborough , Michael David Barker , Sebastien Andre Campos , Richard Peter Charles Cousins , Paul Faulder , Heather Hobbs , Duncan Stuart Holmes , Michael John Johnston , John Liddle , Jeremy John Payne , John Martin Pritchard , Caroline Whitworth
发明人: Paul Bamborough , Michael David Barker , Sebastien Andre Campos , Richard Peter Charles Cousins , Paul Faulder , Heather Hobbs , Duncan Stuart Holmes , Michael John Johnston , John Liddle , Jeremy John Payne , John Martin Pritchard , Caroline Whitworth
IPC分类号: A61K31/437 , C07D471/04
CPC分类号: C07D471/04
摘要: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds according to Formula (1) and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular 1KK2 activity.
摘要翻译: 本发明涉及某些新化合物。 具体地,本发明涉及根据式(1)的化合物及其盐。 本发明的化合物是激酶活性的抑制剂,特别是1KK2的活性。
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公开(公告)号:US20080146606A1
公开(公告)日:2008-06-19
申请号:US11858143
申请日:2007-09-20
申请人: Paul Bamborough , Michael David Barker , Sebastien Andre Campos , Richard Peter Charles Cousins , Paul Faulder , Heather Hobbs , Duncan Stuart Holmes , Michael John Johnston , John Liddle , Jeremy John Payne , John Martin Pritchard , Caroline Whitworth
发明人: Paul Bamborough , Michael David Barker , Sebastien Andre Campos , Richard Peter Charles Cousins , Paul Faulder , Heather Hobbs , Duncan Stuart Holmes , Michael John Johnston , John Liddle , Jeremy John Payne , John Martin Pritchard , Caroline Whitworth
IPC分类号: A61K31/437 , C07D221/04 , A61P11/06 , A61P19/02 , A61P29/00
CPC分类号: C07D471/04
摘要: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds according to formula (I): and salts thereof.The compounds of the invention are inhibitors of kinase activity, in particular IKK2 activity.
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9.SUBSTITUTED PIPERAZINES, (1,4) DIAZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS 审中-公开
标题翻译: 替代哌嗪,(1,4)双嘧达嗪和2,5-DIAZABICYCLO(2.2.1)作为组胺H1和/或H3拮抗剂或组胺H3逆转拮抗剂的HEPTANES公开(公告)号:US20100075953A1
公开(公告)日:2010-03-25
申请号:US12562285
申请日:2009-09-18
申请人: Rachael Ancliff , Colin David Eldred , Ashley Paul Hancock , Thomas Daniel Heightman , Heather Hobbs , Simon Teanby Hodgson , David Matthew Wilson
发明人: Rachael Ancliff , Colin David Eldred , Ashley Paul Hancock , Thomas Daniel Heightman , Heather Hobbs , Simon Teanby Hodgson , David Matthew Wilson
IPC分类号: A61K31/496 , A61K31/55 , A61K31/551 , A61K31/541 , A61K31/538 , C07D403/12 , C07D405/14 , C07D417/12 , C07D401/12 , C07D401/14 , A61P11/00
CPC分类号: C07D213/81 , C07D209/42 , C07D211/46 , C07D213/50 , C07D213/64 , C07D215/40 , C07D215/46 , C07D215/50 , C07D239/28 , C07D243/08 , C07D265/36 , C07D277/62 , C07D285/06 , C07D295/088 , C07D295/185 , C07D295/192 , C07D295/215 , C07D295/26 , C07D307/79 , C07D307/85 , C07D311/84 , C07D317/68 , C07D333/38 , C07D405/06 , C07D487/08 , C07D491/04
摘要: The present invention relates to novel piperazine and azepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurodegenerative disorders including Alzheimer's disease.
摘要翻译: 本发明涉及具有药理活性的新颖的哌嗪和吖庚因衍生物,其制备方法,含有它们的组合物及其在治疗包括阿尔茨海默病的神经变性疾病中的用途。
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10.Substituted piperazines,(1,4) diaszepines, and 2,5-diazabicyclo (2.2.1)iieptanes as histamine h1 and/or h3 antagonists or histamine h3 reverse antagonists 失效
标题翻译: 作为组胺h1和/或h3拮抗剂或组胺h3反向拮抗剂的取代的哌嗪,(1,4)二氮杂和2,5-二氮杂双环(2.2.1)公开(公告)号:US20060025404A1
公开(公告)日:2006-02-02
申请号:US10531758
申请日:2003-10-14
申请人: Rachel Ancliff , Colin Eldred , Yvonne Fogden , Ashley Hancock , Thomas Heightman , Heather Hobbs , Simon Hodgson , Matthew Lindon , David Wilson
发明人: Rachel Ancliff , Colin Eldred , Yvonne Fogden , Ashley Hancock , Thomas Heightman , Heather Hobbs , Simon Hodgson , Matthew Lindon , David Wilson
IPC分类号: A61K31/551 , A61K31/496
CPC分类号: C07D213/81 , C07D209/42 , C07D211/46 , C07D213/50 , C07D213/64 , C07D215/40 , C07D215/46 , C07D215/50 , C07D239/28 , C07D243/08 , C07D265/36 , C07D277/62 , C07D285/06 , C07D295/088 , C07D295/185 , C07D295/192 , C07D295/215 , C07D295/26 , C07D307/79 , C07D307/85 , C07D311/84 , C07D317/68 , C07D333/38 , C07D405/06 , C07D487/08 , C07D491/04
摘要: The present invention relates to novel piperazine and azepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurodegenerative disorders including Alzheimer's disease.
摘要翻译: 本发明涉及具有药理活性的新颖的哌嗪和吖庚因衍生物,其制备方法,含有它们的组合物及其在治疗包括阿尔茨海默病的神经变性疾病中的用途。
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