公开(公告)号：US20060134064A1

公开(公告)日：2006-06-22

申请号：US11303728

申请日：2005-12-16

申请人： David Goldstein ,  Xian-Jun Qu ,  Pamela Russell ,  Jia-Lin Yang

发明人： David Goldstein ,  Xian-Jun Qu ,  Pamela Russell ,  Jia-Lin Yang

IPC分类号： A61K38/21 ,  A61K31/175 ,  A61K31/7048

CPC分类号： A61K31/175 ,  A61K31/7048 ,  A61K38/212 ,  A61K2300/00

摘要： The present invention provides a method for treating tumors or tumor metastases in a patient, comprising administering to the patient simultaneously or sequentially a therapeutically effective amount of an EGFR kinase inhibitor and IFNα combination, with or without additional agents or treatments, such as other anti-cancer drugs or radiation therapy. The invention also encompasses a pharmaceutical composition that is comprised of an EGFR kinase inhibitor and IFNα combination in combination with a pharmaceutically acceptable carrier. A preferred example of an EGFR kinase inhibitor that can be used in practicing this invention is the compound erlotinib HCl (also known as TARCEVA®).

摘要翻译： 本发明提供了一种用于治疗患者的肿瘤或肿瘤转移的方法，其包括向所述患者同时或依次施用治疗有效量的EGFR激酶抑制剂和IFNα组合，所述另外的药物或治疗剂， 癌症药物或放射治疗。 本发明还包括药物组合物，其由EGFR激酶抑制剂和IFNalpha组合与药学上可接受的载体组合组成。 可用于实施本发明的EGFR激酶抑制剂的优选实例是化合物厄洛替尼HCl（也称为TARCEVA）。

公开(公告)号：US08394796B2

公开(公告)日：2013-03-12

申请号：US13427081

申请日：2012-03-22

申请人： Georgette Castanedo ,  Bryan Chan ,  David Goldstein ,  Rama Kondru ,  Matthew Lucas ,  Wylie Palmer ,  Stephen Price ,  Brian Safina ,  Pascal Pierre Alexandre Savy ,  Eileen Mary Seward ,  Daniel P. Sutherlin ,  Zachary K. Sweeney

发明人： Georgette Castanedo ,  Bryan Chan ,  David Goldstein ,  Rama Kondru ,  Matthew Lucas ,  Wylie Palmer ,  Stephen Price ,  Brian Safina ,  Pascal Pierre Alexandre Savy ,  Eileen Mary Seward ,  Daniel P. Sutherlin ,  Zachary K. Sweeney

IPC分类号： A61K31/535

CPC分类号： C07D513/04 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

摘要： Formula I (Ia and Ib) compounds wherein (i) X1 is N and X2 is S, (ii) X1 is CR7 and X2 is S, (iii) X1 is N and X2 is NR2, or (iv) X1 is CR7 and X2 is O, including stereoisomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

摘要翻译： 式（I）和（Ib）化合物，其中（i）X1为N，X 2为S，（ii）X1为CR7，X2为S，（iii）X1为N，X2为NR2，或（iv）X1为CR7， X 2为O，包括立体异构体，互变异构体，代谢物及其药学上可接受的盐，可用于抑制PI3K的δ同种型，以及用于治疗由脂质激酶如炎症，免疫学和癌症介导的病症。 公开了使用式I化合物在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

公开(公告)号：US08158625B2

公开(公告)日：2012-04-17

申请号：US12787608

申请日：2010-05-26

申请人： Georgette Castanedo ,  David Goldstein ,  Rama Kondru ,  Matthew Lucas ,  Wylie Palmer ,  Stephen Price ,  Brian Safina ,  Pascal Pierre Alexandre Savy ,  Eileen Mary Seward ,  Daniel P. Sutherlin ,  Zachary K. Sweeney

发明人： Georgette Castanedo ,  David Goldstein ,  Rama Kondru ,  Matthew Lucas ,  Wylie Palmer ,  Stephen Price ,  Brian Safina ,  Pascal Pierre Alexandre Savy ,  Eileen Mary Seward ,  Daniel P. Sutherlin ,  Zachary K. Sweeney

IPC分类号： A61K31/535 ,  C07D413/14

CPC分类号： C07D495/04 ,  C07D487/04 ,  C07D513/04

摘要： Formula I (Ia and Ib) compounds wherein (i) X1 is N and X2 is S, (ii) X1 is CR7 and X2 is S, (iii) X1 is N and X2 is NR2, (iv) X1 is CR7 and X2 is O, or (v) X1 is CR7 and X2 is NR2, including stereoisomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

摘要翻译： 式（I）和（Ib）化合物，其中（i）X1为N，X2为S，（ii）X1为CR7，X2为S，（iii）X1为N，X2为NR2，（iv）X1为CR7和X2 是O，或（v）X1是CR7，X2是NR2，包括立体异构体，互变异构体，代谢物和药学上可接受的盐可用于抑制PI3K的δ同种型，以及用于治疗脂质激酶介导的疾病，例如炎症，免疫学 ，和癌症。 公开了使用式I化合物在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

公开(公告)号：US07975877B2

公开(公告)日：2011-07-12

申请号：US12182410

申请日：2008-07-30

申请人： Martin T. Garthaffner ,  Travis M. Garthaffner ,  George R. Scott ,  Jeremy J. Straight ,  James D. Evans ,  David Goldstein ,  Martin Heidorn

发明人： Martin T. Garthaffner ,  Travis M. Garthaffner ,  George R. Scott ,  Jeremy J. Straight ,  James D. Evans ,  David Goldstein ,  Martin Heidorn

IPC分类号： B65H3/08

CPC分类号： B65G47/848 ,  A24D3/0216 ,  A24D3/061 ,  B65G29/02 ,  B65G47/1428

摘要： A bead feeder for serially delivering beads to a downstream location comprises a bead supply wheel which rotates about a vertical axis. The bead supply wheel includes a bead supply bowl and a plurality of radially arranged channels below the bowl connected to rotate with the bowl. Discharge openings in the bowl are in alignment with the radially arranged channels to delivery beads to those channels, and a bead receiving pocket is positioned at the outer end of each channel. A transfer wheel picks up beads from the bead receiving pockets and transfers those beads to a delivery wheel by vacuum transfer and release. The delivery wheel serially delivers the beads to the downstream location.

摘要翻译： 用于将珠粒串行地输送到下游位置的珠粒进料器包括围绕垂直轴线旋转的胎圈供给轮。 胎圈供给轮包括一个胎圈供应碗和在碗下面的多个径向布置的通道，其连接成与碗一起旋转。 碗中的排放开口与径向布置的通道对准，以将输送珠移动到那些通道，并且胎圈接收袋位于每个通道的外端。 传送轮从胎圈接收袋中取出珠子，并通过真空转移和释放将这些珠粒转移到输送轮。 输送轮将珠子串联输送到下游位置。

公开(公告)号：US20100180017A1

公开(公告)日：2010-07-15

申请号：US12684091

申请日：2010-01-07

申请人： David Goldstein

发明人： David Goldstein

IPC分类号： G06F15/177 ,  G06F3/01

CPC分类号： H04L41/5067 ,  H04L67/34 ,  H04L67/36 ,  H04L69/18

摘要： A computer program product that provides a graphical user interface for configuring communication information for multiple network service providers on a computer system. The program product is operable to display a network communication scene that includes edit windows and selectable options for a user to view, enter, remove, and modify configuration information for at least one network service provider, and allows the user to enter information for establishing communication with the same network service provider using at least two different communication mediums, and from several different geographical locations.

摘要翻译： 一种计算机程序产品，其提供用于在计算机系统上为多个网络服务提供商配置通信信息的图形用户界面。 程序产品可操作以显示包括编辑窗口和可选择选项的网络通信场景，用于用户查看，输入，删除和修改至少一个网络服务提供商的配置信息，并且允许用户输入用于建立通信的信息 使用相同的网络服务提供商使用至少两种不同的通信介质，以及来自多个不同的地理位置。

公开(公告)号：US20090039102A1

公开(公告)日：2009-02-12

申请号：US12182410

申请日：2008-07-30

申请人： Martin T. Garthaffner ,  Travis M. Garthaffner ,  George R. Scott ,  Jeremy J. Straight ,  James D. Evans ,  David Goldstein ,  Martin Heidorn

发明人： Martin T. Garthaffner ,  Travis M. Garthaffner ,  George R. Scott ,  Jeremy J. Straight ,  James D. Evans ,  David Goldstein ,  Martin Heidorn

IPC分类号： B65G47/04

CPC分类号： B65G47/848 ,  A24D3/0216 ,  A24D3/061 ,  B65G29/02 ,  B65G47/1428

摘要： A bead feeder for serially delivering beads to a downstream location comprises a bead supply wheel which rotates about a vertical axis. The bead supply wheel includes a bead supply bowl and a plurality of radially arranged channels below the bowl connected to rotate with the bowl. Discharge openings in the bowl are in alignment with the radially arranged channels to delivery beads to those channels, and a bead receiving pocket is positioned at the outer end of each channel. A transfer wheel picks up beads from the bead receiving pockets and transfers those beads to a delivery wheel by vacuum transfer and release. The delivery wheel serially delivers the beads to the downstream location.

摘要翻译： 用于将珠粒串行地输送到下游位置的珠粒进料器包括围绕垂直轴线旋转的胎圈供给轮。 胎圈供给轮包括一个胎圈供应碗和在碗下面的多个径向布置的通道，其连接成与碗一起旋转。 碗中的排放开口与径向布置的通道对准，以将输送珠移动到那些通道，并且胎圈接收袋位于每个通道的外端。 传送轮从胎圈接收袋中取出珠子，并通过真空转移和释放将这些珠粒转移到输送轮。 输送轮将珠子串联输送到下游位置。

公开(公告)号：US20070135459A1

公开(公告)日：2007-06-14

申请号：US11651320

申请日：2007-01-09

申请人： Nolan Dewdney ,  David Goldstein

发明人： Nolan Dewdney ,  David Goldstein

IPC分类号： A61K31/519 ,  C07D487/02

CPC分类号： C07D471/04

摘要： Compounds having the formula (I) or (II), are useful as p38 kinase inhibitors, wherein R is an optionally substituted alkyl, cycloalkyl, or aryl; R6 is hydrogen or lower alkyl; R7 is hydrogen or a non-interfering substituent, and Q is a non-aromatic moiety as defined in the specification.

摘要翻译： 具有式（I）或（II）的化合物可用作p38激酶抑制剂，其中R是任选取代的烷基，环烷基或芳基; R 6是氢或低级烷基; R 7是氢或非干扰取代基，Q是说明书中定义的非芳族部分。

公开(公告)号：US20060269935A1

公开(公告)日：2006-11-30

申请号：US11377985

申请日：2006-03-17

申请人： Sarah Tate ,  Gianpiero Cavalleri ,  Stephanie Schorge ,  Sanjay Sisodiya ,  Nicholas Wood ,  David Goldstein

发明人： Sarah Tate ,  Gianpiero Cavalleri ,  Stephanie Schorge ,  Sanjay Sisodiya ,  Nicholas Wood ,  David Goldstein

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/172

摘要： A method for determining the dosage regime of a drug suitable for use in the treatment of a neurological condition in a subject, which method comprises typing the SCN1A gene of the subject. The method may be used to determine the dosage regime of an anti-epileptic drug (AED) in a subject. A subject may be treated in accordance with the dosage regime determined using such a method.

摘要翻译： 一种用于确定适合用于治疗受试者神经病症的药物的剂量方案的方法，所述方法包括分型受试者的SCN1A基因。 该方法可用于确定受试者中抗癫痫药（AED）的剂量方案。 可以根据使用这种方法确定的剂量方案来治疗受试者。

公开(公告)号：US20060252783A1

公开(公告)日：2006-11-09

申请号：US11486193

申请日：2006-07-13

申请人： David Goldstein ,  Ronald Hawley ,  Alfred Lui ,  Eric Sjogren

发明人： David Goldstein ,  Ronald Hawley ,  Alfred Lui ,  Eric Sjogren

IPC分类号： C07D487/14 ,  A61K31/519

CPC分类号： C07D471/14 ,  C07D487/14

摘要： The present invention discloses compounds corresponding to formula I: wherein A, Z, Z1, Y, R1 and R2 are as defined in the specification, as well as pharmaceutical formulations, methods of making and uses thereof.

公开(公告)号：US20060188861A1

公开(公告)日：2006-08-24

申请号：US11404961

申请日：2006-04-13

申请人： Michael Wood ,  Alice Vordan ,  David Goldstein ,  Mark Flowers ,  Joseph Miller ,  Michelle Fitts ,  Curtis Cole ,  Rick Adolf ,  Antonia Kohl ,  Carol Thies

发明人： Michael Wood ,  Alice Vordan ,  David Goldstein ,  Mark Flowers ,  Joseph Miller ,  Michelle Fitts ,  Curtis Cole ,  Rick Adolf ,  Antonia Kohl ,  Carol Thies

IPC分类号： G09B7/00

CPC分类号： A63F13/92 ,  A63F13/08 ,  A63F13/2145 ,  A63F13/95 ,  A63F2300/1075 ,  A63F2300/204 ,  A63F2300/206 ,  A63F2300/302 ,  G09B5/06 ,  G09B19/00 ,  H01M2/1022

摘要： An interactive, handheld apparatus is provided. The apparatus includes a housing, a display screen on the housing, an electronic position location system, a stylus for selecting images on the display screen, a directional control pad on the housing and a memory device. The electronic position location system includes a processor that is capable of determining a location of a selected region of the display screen. The memory device includes computer code for an educational game and is operatively coupled to the processor.