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公开(公告)号：US07141377B2
公开(公告)日：2006-11-28
申请号：US11043099
申请日：2005-01-27
CPC分类号： C12Q1/686 , C07H21/00 , C12Q1/6818 , C12Q1/6823 , C12Q1/6827 , C12Q1/703 , Y10S435/805 , Y10S435/81 , Y10S436/815 , C12Q2521/101 , C12Q2565/1015 , C12Q2531/113 , C12Q2521/319 , C12Q2535/131 , C12Q2521/325 , C12Q2537/157 , C12Q2561/101 , C12Q2525/186 , C12Q2525/131
摘要： A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for detection. This process is easily incorporated into a PCR amplification assay.
摘要翻译： 使用标记的寡核苷酸检测靶核酸的过程使用核酸聚合酶的5'至3'核酸酶活性从杂交双链体切割退火标记的寡核苷酸，并释放标记的寡核苷酸片段进行检测。 该方法容易地并入PCR扩增测定中。
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公开(公告)号：US5804375A
公开(公告)日：1998-09-08
申请号：US428941
申请日：1995-04-25
CPC分类号： C12Q1/686 , C07H21/00 , C12Q1/6818 , C12Q1/6823 , C12Q1/6827 , C12Q1/703 , Y10S435/805 , Y10S435/81 , Y10S436/815
摘要： A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5' to 3' nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for detection. This process is easily incorporated into a PCR amplification assay.
摘要翻译： 使用标记的寡核苷酸检测靶核酸的过程使用核酸聚合酶的5'至3'核酸酶活性从杂交双链体切割退火标记的寡核苷酸，并释放标记的寡核苷酸片段进行检测。 该方法容易地并入PCR扩增测定中。
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公开(公告)号：US07445900B2
公开(公告)日：2008-11-04
申请号：US11203461
申请日：2005-08-11
CPC分类号： C12Q1/686 , C07H21/00 , C12Q1/6818 , C12Q1/6823 , C12Q1/6827 , C12Q1/703 , Y10S435/805 , Y10S435/81 , Y10S436/815 , C12Q2521/101 , C12Q2565/1015 , C12Q2531/113 , C12Q2521/319 , C12Q2535/131 , C12Q2521/325 , C12Q2537/157 , C12Q2561/101 , C12Q2525/186 , C12Q2525/131
摘要： A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for detection. This process is easily incorporated into a PCR amplification, assay.
摘要翻译： 使用标记的寡核苷酸检测靶核酸的过程使用核酸聚合酶的5'至3'核酸酶活性从杂交双链体切割退火标记的寡核苷酸，并释放标记的寡核苷酸片段进行检测。 该方法容易地并入PCR扩增测定中。
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公开(公告)号：US20080171315A1
公开(公告)日：2008-07-17
申请号：US11203461
申请日：2005-08-11
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C07H21/00 , C12Q1/6818 , C12Q1/6823 , C12Q1/6827 , C12Q1/703 , Y10S435/805 , Y10S435/81 , Y10S436/815 , C12Q2521/101 , C12Q2565/1015 , C12Q2531/113 , C12Q2521/319 , C12Q2535/131 , C12Q2521/325 , C12Q2537/157 , C12Q2561/101 , C12Q2525/186 , C12Q2525/131
摘要： A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for detection. This process is easily incorporated into a PCR amplification, assay.
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公开(公告)号：US06214979B1
公开(公告)日：2001-04-10
申请号：US08934378
申请日：1997-09-19
IPC分类号： C07H2100
CPC分类号： C12Q1/686 , C07H21/00 , C12Q1/6818 , C12Q1/6823 , C12Q1/6827 , C12Q1/703 , Y10S435/805 , Y10S435/81 , Y10S436/815 , C12Q2521/101 , C12Q2565/1015 , C12Q2531/113 , C12Q2521/319 , C12Q2535/131 , C12Q2521/325 , C12Q2537/157 , C12Q2561/101 , C12Q2525/186 , C12Q2525/131
摘要： A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for detection. This process is easily incorporated into a PCR amplification assay.
摘要翻译： 使用标记的寡核苷酸检测靶核酸的过程使用核酸聚合酶的5'至3'核酸酶活性从杂交双链体切割退火标记的寡核苷酸，并释放标记的寡核苷酸片段进行检测。 该方法容易地并入PCR扩增测定中。
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6.发明授权Nucleic acid detection by the 5'-3'exonuclease activity of polymerases acting on adjacently hybridized oligonucleotides 失效通过作用于相邻杂交寡核苷酸的聚合酶的5'-3核酸外切酶活性检测核酸
公开(公告)号：US5487972A
公开(公告)日：1996-01-30
申请号：US961884
申请日：1993-01-05
CPC分类号： C12Q1/686 , C07H21/00 , C12Q1/6818 , C12Q1/6823 , C12Q1/6827 , C12Q1/703 , Y10S435/805 , Y10S435/81 , Y10S436/815
摘要： A process of detecting a target nucleic acid using labeled oligonucleotides which uses the 5' to 3' nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and thus releasing labeled oligonucleotide fragments for detection. This process is easily incorporated into a PCR amplification assay.
摘要翻译： 使用使用核酸聚合酶的5'至3'核酸酶活性的标记的寡核苷酸检测靶核酸的过程，以从杂交的双链体切割退火的标记寡核苷酸，从而释放用于检测的标记的寡核苷酸片段。 该方法容易地并入PCR扩增测定中。
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7.发明授权Homogeneous assay system using the nuclease activity of a nucleic acid polymerase 失效使用核酸聚合酶的核酸酶活性的均质测定系统
公开(公告)号：US5210015A
公开(公告)日：1993-05-11
申请号：US563758
申请日：1990-08-06
CPC分类号： C12Q1/686 , C07H21/00 , C12Q1/6818 , C12Q1/6823 , C12Q1/6827 , C12Q1/703 , Y10S435/805 , Y10S435/81 , Y10S436/815
摘要： The present invention is directed to a process of detecting a target nucleic acid using labeled oligonucleotides. This process uses the 5' to 3' nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for detection. This process is easily incorporated into a PCR amplification assay.
摘要翻译： 本发明涉及使用标记的寡核苷酸检测靶核酸的方法。 该方法使用核酸聚合酶的5'至3'核酸酶活性从杂交双链体切割退火标记的寡核苷酸并释放标记的寡核苷酸片段进行检测。 该方法容易地并入PCR扩增测定中。
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公开(公告)号：US06911336B2
公开(公告)日：2005-06-28
申请号：US09978248
申请日：2001-10-16
CPC分类号： C12N9/88 , C07K2319/00
摘要： The present invention discloses a novel polypeptide that contains an amino acid decarboxylase domain, and is a substrate for caspase-3. Nucleic acids that encode the novel polypeptide and antibodies to the polypeptide are also part of the present invention. Methods of using the polypeptide, the nucleic acids and antibodies are also provided.
摘要翻译： 本发明公开了一种含有氨基酸脱羧酶结构域的新型多肽，是胱天蛋白酶-3的底物。 编码新多肽的核酸和多肽的抗体也是本发明的一部分。 还提供了使用多肽，核酸和抗体的方法。
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公开(公告)号：US20110287001A1
公开(公告)日：2011-11-24
申请号：US13063307
申请日：2009-08-05
申请人： Pamela M. Holland , Julia C. Piasecki , Christopher A. Benetatos , Srinivas K. Chunduru , Mark A. McKinlay
发明人： Pamela M. Holland , Julia C. Piasecki , Christopher A. Benetatos , Srinivas K. Chunduru , Mark A. McKinlay
IPC分类号： A61K39/395 , A61P35/04 , A61K38/17
CPC分类号： A61K45/06 , A61K38/177 , A61K38/1793 , A61K39/39558 , A61K2039/505 , C07K16/241 , C07K16/2878 , C07K2317/76 , A61K2300/00
摘要： The invention provides methods for inducing apoptosis, comprising treatment of a patient with a TNFα inhibitor as well as with an IAP inhibitor and a TRAIL receptor agonist. The methods ameliorate the risk of unwanted effects, thereby resulting in an improved therapeutic index for IAP inhibitors in combination with a TRAIL receptor agonist.
摘要翻译： 本发明提供诱导凋亡的方法，包括用TNFα抑制剂以及IAP抑制剂和TRAIL受体激动剂治疗患者。 该方法改善不需要的作用的风险，从而导致IAP抑制剂与TRAIL受体激动剂组合改善的治疗指数。
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