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18 条记录 (耗时 0.018 秒)

    C-REACTIVE PROTEIN APHERESIS
    1.
    发明申请
    C-REACTIVE PROTEIN APHERESIS 审中-公开
    C-反应性蛋白质

    公开(公告)号：US20070225226A1

    公开(公告)日：2007-09-27

    申请号：US11690318

    申请日：2007-03-23

    申请人： David Hammond ,  Julie Lathrop

    发明人： David Hammond ,  Julie Lathrop

    IPC分类号： A61K38/16 ,  A61K38/10 ,  A61K38/08 ,  A61K38/06 ,  A61K38/05 ,  C07K14/16 ,  C07K7/08 ,  C07K7/06

    CPC分类号： A61K38/08 ,  A61M1/3486 ,  A61M1/3679 ,  C07K7/06

    摘要： The present invention provides ligands that can bind CRP with high affinity and high specificity. The present invention also provides a method of treating a condition of elevated CRP through apheresis, by reducing CRP level via its binding to a CRP-specific ligand ex vivo. Systems of performing apheresis to reduce CRP levels are also provided.

    摘要翻译： 本发明提供可以高亲和力和高特异性结合CRP的配体。 本发明还提供了一种通过分离术来治疗CRP升高的病症的方法，通过其离体结合到CRP特异性配体来降低CRP水平。 还提供了进行单采血药浓度降低CRP水平的系统。

    METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR PREVENTING TRAFFIC CONGESTION WITHIN A LONG TERM EVOLUTION (LTE) MULTI-USER EQUIPMENT (MULTI-UE) SIMULATOR DEVICE
    2.
    发明申请
    METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR PREVENTING TRAFFIC CONGESTION WITHIN A LONG TERM EVOLUTION (LTE) MULTI-USER EQUIPMENT (MULTI-UE) SIMULATOR DEVICE 有权
    用于在长时间演进（LTE）多用户设备（多UE）模拟器件中预防交通约束的方法，系统和计算机可读介质

    公开(公告)号：US20130235727A1

    公开(公告)日：2013-09-12

    申请号：US13418076

    申请日：2012-03-12

    申请人： Damon Lee Campbell ,  David Hammond ,  William Clarry Hough ,  Eric Hugh Wilke

    发明人： Damon Lee Campbell ,  David Hammond ,  William Clarry Hough ,  Eric Hugh Wilke

    IPC分类号： H04W28/12

    CPC分类号： H04L43/10 ,  H04L43/12 ,  H04L43/50 ,  H04W24/06

    摘要： Methods, systems, and computer readable media for preventing traffic congestion in a long term evolution (LTE) multi-user equipment (multi-UE) simulator device are disclosed. In one example, a method includes transmitting, from a first module to a second module over a shared bus, one of a plurality of LTE subframe signal portions at the beginning of a first transmission interval. The method further includes sending, from the first module to a third module over the shared bus, a trigger signal upon completing the transmission of the LTE signal portion. The method also includes forwarding, from the third module to the second module over the shared bus, decoded control information associated with at least one of the plurality of LTE subframe signal portions during an idle time period defined by the receipt of the trigger signal and the beginning of a second transmission interval.

    摘要翻译： 公开了用于防止长期演进（LTE）多用户设备（multi-UE）模拟器设备中的交通拥堵的方法，系统和计算机可读介质。 在一个示例中，一种方法包括在第一传输间隔开始时通过共享总线从第一模块向第二模块发送多个LTE子帧信号部分中的一个。 该方法还包括在完成LTE信号部分的传输时，通过共享总线从第一模块向第三模块发送触发信号。 该方法还包括通过共享总线从第三模块转发到第二模块，在由接收触发信号定义的空闲时间周期期间与多个LTE子帧信号部分中的至少一个相关联的解码控制信息， 第二个传输间隔的开始。

    Fluorescent substrates for Detecting organophosphatase enzyme activity
    3.
    发明申请
    Fluorescent substrates for Detecting organophosphatase enzyme activity 审中-公开
    荧光底物用于检测有机磷酸酶活性

    公开(公告)号：US20100255521A1

    公开(公告)日：2010-10-07

    申请号：US11648679

    申请日：2007-01-03

    申请人： Serguei Soukharev ,  David Hammond

    发明人： Serguei Soukharev ,  David Hammond

    IPC分类号： C12Q1/42 ,  C07F9/12

    CPC分类号： C07F9/65522 ,  C07F9/6561 ,  C12Q1/42

    摘要： Disclosed are compounds of the formula (I): wherein R3, R4, R5, R9, and R10 are selected from the group consisting of H and groups or atoms other than H, and R6 and R8 are halo or hydrogen; X1, X2, and X3 are independently O or S; provided that R9 and R10 are not simultaneously H, when all of X1, X2, and X3 are O; and of the formula (II) wherein R11-R14 are selected from the group consisting of H and groups or atoms other than H; X4-X9 are independently O or S; n and m are 0 or 1 but m and n cannot be 0 simultaneously; R15-R24 can be H or any substituent so long as the compound of formula II upon hydrolysis provides a fluorescent compound. These compounds are useful as substrates with high specificity for organophosphatase particularly human paraoxonase and bacterial organophosphorus hydrolase. Also disclosed is a method for detecting and/or measuring the paraoxonase activity in a fluid comprising contacting the fluid with a fluorescent substrate and measuring the fluorescence of the fluorescent product formed.

    摘要翻译： 公开了式（I）的化合物：其中R 3，R 4，R 5，R 9和R 10选自H和H以外的基团或原子，R 6和R 8是卤素或氢; X1，X2和X3独立地为O或S; 条件是当X1，X2和X3全部为O时，R9和R10不同时为H; 和式（II）的化合物，其中R11-R14选自H和H以外的基团或原子; X4-X9独立地为O或S; n和m是0或1，但m和n不能同时为0; R15-R24可以是H或任何取代基，只要在水解时式II化合物提供荧光化合物即可。 这些化合物可用作对有机磷酸酶特别是人类对氧磷酶和细菌有机磷水解酶具有高特异性的底物。 还公开了一种用于检测和/或测量流体中对氧磷酶活性的方法，包括使流体与荧光底物接触并测量形成的荧光产物的荧光。

    Methods for reducing the range in concentrations of analyte species in a sample
    5.
    发明申请
    Methods for reducing the range in concentrations of analyte species in a sample 审中-公开
    减少样品中分析物种浓度范围的方法

    公开(公告)号：US20060275923A1

    公开(公告)日：2006-12-07

    申请号：US11454795

    申请日：2006-06-19

    申请人： David Hammond

    发明人： David Hammond

    IPC分类号： C40B30/06 ,  C40B40/10

    CPC分类号： G01N33/6803

    摘要： The present invention relates to the fields of molecular biology, combinatorial chemistry and biochemistry. Particularly, the present invention describes methods and kits for dynamically reducing the variance between analyte taken from complex mixtures.

    摘要翻译： 本发明涉及分子生物学，组合化学和生物化学领域。 特别地，本发明描述了用于动态地减少从复杂混合物中取出的分析物之间的方差的方法和试剂盒

    Prion protein binding materials and methods of use
    7.
    发明申请
    Prion protein binding materials and methods of use 有权
    朊病毒蛋白结合材料及使用方法

    公开(公告)号：US20050014196A1

    公开(公告)日：2005-01-20

    申请号：US10817117

    申请日：2004-04-02

    申请人： Ruben Carbonell ,  Honglue Shen ,  Patrick Gurgel ,  Viterose Wiltshire-Lyerly ,  David Hammond ,  Steven Burton

    发明人： Ruben Carbonell ,  Honglue Shen ,  Patrick Gurgel ,  Viterose Wiltshire-Lyerly ,  David Hammond ,  Steven Burton

    IPC分类号： C12N20060101 ,  G01N33/53 ,  G01N33/68

    CPC分类号： G01N33/6896

    摘要： Prion protein binding materials and methods for using the binding materials to detect or remove a prion protein from a sample, such as a biological fluid or an environmental sample. The binding materials are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), recombinant prion protein (PrPr), and proteinase resistant prion protein (PrPres). Prions from various species, including humans and hamsters, are bound by the binding materials.

    摘要翻译： 朊病毒蛋白结合材料和使用结合材料从样品如生物流体或环境样品中检测或除去朊病毒蛋白的方法。 结合材料能够结合一种或多种形式的朊病毒蛋白，包括细胞朊蛋白（PrPc），感染性朊病毒蛋白（PrPsc），重组朊病毒蛋白（PrPr）和蛋白酶抗性朊病毒蛋白（PrPres）。 来自各种物种的朊病毒，包括人类和仓鼠，都受到结合物质的束缚。

    Methods, systems, and computer readable media for preventing traffic congestion within a long term evolution (LTE) multi-user equipment (multi-UE) simulator device
    8.
    发明授权
    Methods, systems, and computer readable media for preventing traffic congestion within a long term evolution (LTE) multi-user equipment (multi-UE) simulator device 有权
    用于防止长期演进（LTE）多用户设备（multi-UE）模拟器装置中的交通拥堵的方法，系统和计算机可读介质

    公开(公告)号：US09172626B2

    公开(公告)日：2015-10-27

    申请号：US13418076

    申请日：2012-03-12

    申请人： Damon Lee Campbell ,  David Hammond ,  William Clarry Hough ,  Eric Hugh Wilke

    发明人： Damon Lee Campbell ,  David Hammond ,  William Clarry Hough ,  Eric Hugh Wilke

    IPC分类号： H04L12/26 ,  H04W24/06

    CPC分类号： H04L43/10 ,  H04L43/12 ,  H04L43/50 ,  H04W24/06

    摘要： Methods, systems, and computer readable media for preventing traffic congestion in a long term evolution (LTE) multi-user equipment (multi-UE) simulator device are disclosed. In one example, a method includes transmitting, from a first module to a second module over a shared bus, one of a plurality of LTE subframe signal portions at the beginning of a first transmission interval. The method further includes sending, from the first module to a third module over the shared bus, a trigger signal upon completing the transmission of the LTE signal portion. The method also includes forwarding, from the third module to the second module over the shared bus, decoded control information associated with at least one of the plurality of LTE subframe signal portions during an idle time period defined by the receipt of the trigger signal and the beginning of a second transmission interval.

    摘要翻译： 公开了用于防止长期演进（LTE）多用户设备（multi-UE）模拟器设备中的交通拥堵的方法，系统和计算机可读介质。 在一个示例中，一种方法包括在第一传输间隔开始时通过共享总线从第一模块向第二模块发送多个LTE子帧信号部分中的一个。 该方法还包括在完成LTE信号部分的传输时，通过共享总线从第一模块向第三模块发送触发信号。 该方法还包括通过共享总线从第三模块转发到第二模块，在由接收触发信号定义的空闲时间周期期间与多个LTE子帧信号部分中的至少一个相关联的解码控制信息， 第二个传输间隔的开始。