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1.发明授权公开(公告)号：US08962757B2
公开(公告)日：2015-02-24
申请号：US12744824
申请日：2008-11-26
申请人： David I. Devore , Charles Roth
发明人： David I. Devore , Charles Roth
CPC分类号： C08F265/02 , A61K31/70 , A61K47/32 , C08G81/025
摘要： Innovative graft polymers designed for the efficient delivery of antisense molecules into biological cells and for maintaining the biological activity of these molecules while in serum and other aqueous environments are provided. Such polymers may comprise an anionic graft polymer comprising an anionic polymer backbone with pendant carboxylic acid groups and pendant chains comprising amphipathic or hydrophilic polymers covalently bonded to a portion of said pendant carboxylic acid groups. Antisense molecule delivery vectors comprising such polymers in combination with cationic agents for delivery of antisense molecules are also disclosed.
摘要翻译： 提供了设计用于将反义分子有效递送到生物细胞中并用于在血清和其它水性环境中维持这些分子的生物学活性的创新的接枝聚合物。 这样的聚合物可以包含阴离子接枝聚合物，其包含具有侧挂羧酸基团的阴离子聚合物主链和包含共价键合到所述侧挂羧酸基团的一部分的两亲性或亲水性聚合物的侧链。 还公开了包含这种聚合物与用于递送反义分子的阳离子试剂组合的反义分子递送载体。
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2.发明申请公开(公告)号：US20110021602A1
公开(公告)日：2011-01-27
申请号：US12744824
申请日：2008-11-26
申请人： David I. Devore , Charles Roth
发明人： David I. Devore , Charles Roth
IPC分类号： A61K31/713 , C08G73/02 , C12N15/63 , A61P35/00
CPC分类号： C08F265/02 , A61K31/70 , A61K47/32 , C08G81/025
摘要： Innovative graft polymers designed for the efficient delivery of antisense molecules into biological cells and for maintaining the biological activity of these molecules while in serum and other aqueous environments are provided. Such polymers may comprise an anionic graft polymer comprising an anionic polymer backbone with pendant carboxylic acid groups and pendant chains comprising amphipathic or hydrophilic polymers covalently bonded to a portion of said pendant carboxylic acid groups. Antisense molecule delivery vectors comprising such polymers in combination with cationic agents for delivery of antisense molecules are also disclosed.
摘要翻译： 提供了设计用于将反义分子有效递送到生物细胞中并用于在血清和其它水性环境中维持这些分子的生物学活性的创新的接枝聚合物。 这样的聚合物可以包含阴离子接枝聚合物，其包含具有侧挂羧酸基团的阴离子聚合物主链和包含共价键合到所述侧挂羧酸基团的一部分的两亲性或亲水性聚合物的侧链。 还公开了包含这种聚合物与用于递送反义分子的阳离子试剂组合的反义分子递送载体。
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3.发明授权Alkyl polyglycoside compositions having reduced viscosity and inhibited crystallization 失效具有降低的粘度和抑制结晶的烷基多糖苷组合物
公开(公告)号：US6110977A
公开(公告)日：2000-08-29
申请号：US95677
申请日：1998-06-10
申请人： Stephen F. Gross , Michael S. Wiggins , Ronald W. Broadbent , David I. Devore , Timothy C. Morris
发明人： Stephen F. Gross , Michael S. Wiggins , Ronald W. Broadbent , David I. Devore , Timothy C. Morris
CPC分类号： C08G65/24 , B01D19/04 , B01D19/0404 , B01D19/0431 , C08G65/2609 , C08G65/337
摘要： Products of the reaction of epichlorohydrin and compounds having the formula IIR.sub.3 (EO).sub.n (PO).sub.m OH (II)wherein R.sub.3 is an alkyl, alkenyl or arenyl group having from 4 to 22 carbon atoms; a substituted alkyl or alkenyl group having from 4 to 22 carbon atoms wherein; n is a number from 0 to 50 and m is a number from 0 to 10; wherein the mole ratio of epichlorohydrin to (II) is from about 0.60/1 to about 2/1 are extremely efficient defoamers for aqueous surfactant systems are effective as defoamers, viscosity reducers and crystallization preventives for aqueous surfactant solutions, particularly alkyl polyglycosides.
摘要翻译： 表氯醇与具有式IIR 3（EO）n（PO）mOH（II）的化合物的反应产物，其中R 3是具有4至22个碳原子的烷基，链烯基或异戊基; 具有4至22个碳原子的取代的烷基或烯基，其中： n为0〜50的数，m为0〜10的数。 其中表氯醇与（II）的摩尔比为约0.60 / 1至约2/1是用于水性表面活性剂体系的非常有效的消泡剂作为用于表面活性剂水溶液，特别是烷基多糖苷的消泡剂，降粘剂和结晶预防剂是有效的。
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公开(公告)号：US5503713A
公开(公告)日：1996-04-02
申请号：US270088
申请日：1994-07-01
摘要： A process for making a cellulosic pulp fiber web having increased wet strength comprising the steps of: (1) adding to an aqueous cellulosic pulp fiber slurry a water soluble cationic polymer consisting of polydimethyldiallylammonium chloride to form a first treated slurry; (2) adding to the first treated slurry an aminopolyamide-epichlorohydrin acid salt resin solution having an E/N ratio of from about 0.6 to about 2.0 so that the weight percent of the cationic polymer is from about 1% to about 35% based on the weight of the resin, thus forming a second treated slurry; and (3) forming a cellulosic pulp fiber web by dewatering the second treated slurry.
摘要翻译： 一种制备具有增加的湿强度的纤维素纸浆纤维网的方法，包括以下步骤：（1）向纤维素浆浆纤维浆料中加入由聚二甲基二烯丙基氯化铵组成的水溶性阳离子聚合物以形成第一处理浆料; （2）向第一处理浆料中加入E / N比为约0.6至约2.0的氨基多胺 - 表氯醇酸盐树脂溶液，使得阳离子聚合物的重量百分比为约1％至约35％，基于 树脂的重量，从而形成第二处理浆料; 和（3）通过使第二处理浆料脱水而形成纤维素纸浆纤维网。
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公开(公告)号：US5364927A
公开(公告)日：1994-11-15
申请号：US106097
申请日：1993-08-12
CPC分类号： D21H17/55 , C08G73/0286 , D21H17/00 , D21H21/20 , Y10T428/31504
摘要： A wet strength resin composition is comprised of an aminopolyamide-epichlorohydrin acid salt resin having a total organically bound chlorine of up to 0.7% by weight of the resin. The amount of total organically bound chlorine present is controlled by the process parameters.
摘要翻译： 湿强度树脂组合物由氨基聚酰胺 - 表氯醇酸盐树脂组成，其总有机结合氯高达树脂重量的0.7％。 总有机结合氯的存在量由工艺参数控制。
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6.发明授权Stable blends of cationic water-in-oil emulsion polymers and cationic aqueous solution polymers 失效阳离子油包水乳液聚合物和阳离子水溶液聚合物的稳定共混物
公开(公告)号：US5169540A
公开(公告)日：1992-12-08
申请号：US816902
申请日：1992-01-03
申请人： Bruce K. Fillipo , John F. Walko , David I. Devore
发明人： Bruce K. Fillipo , John F. Walko , David I. Devore
CPC分类号： C08J3/09 , C02F1/5227 , C02F1/54 , C08J2300/14
摘要： Novel, stable blends of cationic water-in-oil emulsion polymers with cationic polymers in aqueous solution are preparable through the use of stabilizing solvents and surfactants.
摘要翻译： 阳离子油包水乳液聚合物与阳离子聚合物在水溶液中的稳定共混物可以通过使用稳定溶剂和表面活性剂来制备。
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公开(公告)号：US06472440B2
公开(公告)日：2002-10-29
申请号：US09291866
申请日：1999-04-14
IPC分类号： B01D1904
CPC分类号： B01D19/0404 , B01D19/0427 , B01D19/0431 , C08G65/24 , C08G65/2609 , C08G65/337 , C11D1/662 , C11D1/72 , C11D1/722 , C11D1/8255 , C11D3/0026
摘要： Defoamers are the products of the reaction of epichlorohydrin and compounds having the formula II R3(EO)n(PO)mOH (II) wherein R3 is an alkyl, alkenyl or arenyl group having from 4 to 22 carbon atoms; a substituted alkyl or alkenyl group having from 4 to 22 carbon atoms wherein; n is a number from 0 to 50 and m is a number from 0 to 10; wherein the mole ratio of epichlorohydrin to (II) is from about 0.60/1 to about 2/1 are extremely efficient defoamers for aqueous surfactant systems. The defoamers are added to a surfactant in an amount sufficient to reduce or eliminate foam and have the advantage of being totally dispersible in water, are readily biodegradable, contain no organic solvents and do not affect the detergency of surfactants with which they are used because they are nonionic surfactants in themselves.
摘要翻译： 消泡剂是表氯醇与式II化合物反应的产物，其中R3是具有4-22个碳原子的烷基，链烯基或异氰酸酯基; 具有4至22个碳原子的取代的烷基或烯基，其中： n为0〜50的数，m为0〜10的数。 其中表氯醇与（II）的摩尔比为约0.60 / 1至约2/1是用于水性表面活性剂体系的非常有效的消泡剂。 消泡剂以足以减少或消除泡沫的量加入到表面活性剂中，并且具有完全分散在水中的优点，易于生物降解，不含有机溶剂，并且不影响使用它们的表面活性剂的去污力，因为它们 本身是非离子表面活性剂。
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8.发明授权Composition containing a polymethylalkyl siloxane for enhancing white liquor penetration into wood chips 失效含有聚甲基烷基硅氧烷的组合物，用于增强白液渗入木片
公开(公告)号：US6036817A
公开(公告)日：2000-03-14
申请号：US972007
申请日：1997-11-17
申请人： Marie-Esther Saint Victor , David I. Devore , Barbara Balos Bowker , John J. Palmer , Vincent T. Stine
发明人： Marie-Esther Saint Victor , David I. Devore , Barbara Balos Bowker , John J. Palmer , Vincent T. Stine
CPC分类号： D21C3/222
摘要： The efficiency by which pulp cooking liquor components penetrate the wood and enable lignin and resins to be removed from the cellulosic materials is increased by contacting wood chips and the like with a liquid mixture comprised of white liquor containing at least one surfactant selected from the group consisting of a polymethylalkylsiloxane; a co- and terpolymer of silicone and a polyhydric alcohol; an alkoxylated aryl phosphate; an alkoxylated branched alkyl phosphate; an alkoxylated branched alcohol; an alkyl polyglycoside, an alkoxylated alkyl polyglycoside; a mixture of alkali metal salts of alkyl aromatic sulfate, a sulfosuccinate and a silicone; and combinations thereof; for a residence time effective to extract resinous components without substantial degradation of cellulose and thereafter heating at least a portion of the resulting mixture and wood chips.
摘要翻译： 纸浆蒸煮液组分穿透木材并使木质素和树脂从纤维素材料中除去的效率通过将木屑等与含有至少一种表面活性剂的白液接触的液体混合物而增加，所述表面活性剂选自： 的聚甲基烷基硅氧烷; 硅酮和多元醇的共聚物和三元共聚物; 烷氧基化芳基磷酸酯; 烷氧基化支链烷基磷酸酯; 烷氧基化支化醇; 烷基多糖苷，烷氧基化烷基多糖苷; 烷基芳族硫酸盐，磺基琥珀酸盐和硅氧烷的碱金属盐的混合物; 及其组合; 用于在不显着降解纤维素的情况下提取树脂组分并随后加热至少一部分所得混合物和木屑的停留时间。
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公开(公告)号：US5382324A
公开(公告)日：1995-01-17
申请号：US68447
申请日：1993-05-27
摘要： Method for enhancing the strength of paper comprising the steps ofA) contacting paper fibers with a water slurry of at least one polymer which is a homopolymer and/or a random copolymer of an allylamine;B) forming a paper sheet from the paper fibers; andC) drying the paper sheet.
摘要翻译： 提高纸张强度的方法，包括以下步骤：A）使纸纤维与至少一种作为烯丙胺的均聚物和/或无规共聚物的聚合物的水浆料接触; B）从纸纤维形成纸片; 和C）干燥纸张。
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公开(公告)号：US5350796A
公开(公告)日：1994-09-27
申请号：US142642
申请日：1993-10-25
摘要： A composition for improving the wet strength of cellulosic fibrous webs is comprised of an aminopolyamide-epichlorohydrin acid salt resin having an E/N ratio of from about 0.6 to about 2.0 and from about 1% to about 35% of a water soluble cationic polymer based on the weight of the resin. The composition has a total organic chlorine content of from about 0.5% to 1.0% by weight based on the weight of the aminopolyamide-epichlorohydrin acid salt resin.
摘要翻译： 用于改善纤维素纤维网的湿强度的组合物由具有约0.6至约2.0的E / N比和约1％至约35％的水溶性阳离子聚合物基的氨基多胺 - 表氯醇酸盐树脂 关于树脂的重量。 该组合物的总有机氯含量为氨基聚酰胺 - 表氯醇酸盐树脂重量的约0.5％至1.0％。
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