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1.发明授权Method for making die boards, and materials and apparatus for practicing the method 有权制造模板的方法，以及用于实施该方法的材料和装置公开(公告)号：US07267511B2
公开(公告)日：2007-09-11
申请号：US11069366
申请日：2005-06-20
Applicant: Wolfgang M. Strobel , David J. Logan , David J. Gerber
Inventor： Wolfgang M. Strobel , David J. Logan , David J. Gerber
CPC classification number: B23P15/406 , B21D37/205 , B26F1/44 , B26F2001/4463 , Y10T82/10 , Y10T82/16016 , Y10T83/929 , Y10T83/9473 , Y10T83/9478 , Y10T407/1946 , Y10T407/195
Abstract: In a die board for cutting and/or creasing sheet-type work material, a base is provided that includes a first upper surface and a second lower surface. At least one slot extends along the first upper surface and includes a first slot section extending from said first upper surface at least part-way through the die board base. The at least one slot also includes a second slot section extending from said second lower surface at least part-way through the die board base. The first and second slot sections each have a width with at least one of the slot section widths being adapted to grip and retain at least one die-board rule.
Abstract translation: 在用于切割和/或压缩片状工作材料的模板中，设置有包括第一上表面和第二下表面的基底。 至少一个槽沿着第一上表面延伸并且包括从所述第一上表面至少部分地延伸穿过模板基座的第一槽部分。 所述至少一个狭槽还包括从所述第二下表面至少部分地延伸通过所述模板基座的第二槽部分。 第一和第二槽段各自具有宽度，其中至少一个槽段宽度适于夹持并保持至少一个模板板规则。
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公开(公告)号：US5443680A
公开(公告)日：1995-08-22
申请号：US105603
申请日：1993-08-12
Applicant: David J. Gerber
Inventor： David J. Gerber
CPC classification number: B44C3/126 , B44B9/00 , B44C3/123 , B44F11/04 , Y10T156/1754 , Y10T156/1759 , Y10T156/1766 , Y10T156/1771 , Y10T156/1788
Abstract: An apparatus for automatically creating a simulated mosaic controllably discharges tile pieces onto plate material and secures the tile pieces in place such that the plates with the tile pieces are freestanding permitting the plates themselves to be an ordered arrangement of sections of the mosaic once cemented to the substrate. Many different forms may be had for the plate material, including ones that are pressure or heat activatable to bond with the tile pieces or ones that are mechanically connectable.
Abstract translation: 一种用于自动创建模拟马赛克的装置可控制地将瓦片排放到板材上并将瓦片固定在适当的位置，使得具有瓦片的板是独立的，允许板本身是马赛克的一部分的有序排列，一旦胶合到 基质。 板材可能有许多不同的形式，包括压力或热可激活以与瓦片或可机械连接的块材料结合的形式。
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公开(公告)号：US20110172158A1
公开(公告)日：2011-07-14
申请号：US13049502
申请日：2011-03-16
Applicant: David J. Gerber , Maria Karayiorgou , Tsuyoshi Miyakawa , Susumu Tonegawa
Inventor： David J. Gerber , Maria Karayiorgou , Tsuyoshi Miyakawa , Susumu Tonegawa
CPC classification number: C12Q1/6883 , C12Q2600/136 , C12Q2600/156
Abstract: The present invention provides targets, methods, and reagents for the diagnosis and treatment of schizophrenia and related conditions. The invention provides methods for the diagnosis of schizophrenia and susceptibility to schizophrenia by detection of polymorphisms, mutations, variations, alterations in expression, etc., in calcineurin genes or calcineurin interacting genes, or polymorphisms linked to such genes. The invention provides oligonucleotides, arrays, and antibodies for detection of polymorphisms and variants. The invention provides transgenic mice having alterations in such genes. The invention also provides methods of treating schizophrenia by administering compounds that target these genes. The invention further provides screening methods for identifying such compounds and compounds obtained by performing the screens.
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公开(公告)号：US07935500B2
公开(公告)日：2011-05-03
申请号：US10400348
申请日：2003-03-26
Applicant: David J. Gerber , Maria Karayiorgou , Tsuyoshi Miyakawa , Susumu Tonegawa
Inventor： David J. Gerber , Maria Karayiorgou , Tsuyoshi Miyakawa , Susumu Tonegawa
CPC classification number: C12Q1/6883 , C12Q2600/136 , C12Q2600/156
Abstract: The present invention provides targets, methods, and reagents for the diagnosis and treatment of schizophrenia and related conditions. The invention provides methods for the diagnosis of schizophrenia and susceptibility to schizophrenia by detection of polymorphisms, mutations, variations, alterations in expression, etc., in calcineurin genes or calcineurin interacting genes, or polymorphisms linked to such genes. The invention provides oligonucleotides, arrays, and antibodies for detection of polymorphisms and variants. The invention provides transgenic mice having alterations in such genes. The invention also provides methods of treating schizophrenia by administering compounds that target these genes. The invention further provides screening methods for identifying such compounds and compounds obtained by performing the screens.
Abstract translation: 本发明提供用于诊断和治疗精神分裂症及相关病症的靶标，方法和试剂。 本发明通过检测钙调神经磷酸酶基因或钙调神经磷酸酶相互作用基因中的多态性，突变，变异，表达变化等，或与这些基因连锁的多态性，提供了诊断精神分裂症和精神分裂症易感性的方法。 本发明提供用于检测多态性和变体的寡核苷酸，阵列和抗体。 本发明提供了在这些基因中具有改变的转基因小鼠。 本发明还提供了通过施用靶向这些基因的化合物来治疗精神分裂症的方法。 本发明还提供了用于鉴定通过进行筛选获得的这些化合物和化合物的筛选方法。
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5.发明授权Method for making die boards and materials and apparatus for practicing the method 有权制造模板的方法及其实施方法的材料和装置公开(公告)号：US06913425B1
公开(公告)日：2005-07-05
申请号：US09558575
申请日：2000-04-26
Applicant: Wolfgang M. Strobel , David J. Logan , David J. Gerber
Inventor： Wolfgang M. Strobel , David J. Logan , David J. Gerber
CPC classification number: B23P15/406 , B21D37/205 , B26F1/44 , B26F2001/4463 , Y10T82/10 , Y10T82/16016 , Y10T83/929 , Y10T83/9473 , Y10T83/9478 , Y10T407/1946 , Y10T407/195
Abstract: In a die board for cutting and/or creasing sheet-type work material, a base is provided that includes a first upper surface and a second lower surface. At least one slot extends along the first upper surface and includes a first slot section extending from said first upper surface at least part-way through the die board base. The at least one slot also includes a second slot section extending from said second lower surface at least part-way through the die board base. The first and second slot sections each have a width with at least one of the slot section widths being adapted to grip and retain at least one die-board rule.
Abstract translation: 在用于切割和/或压缩片状工作材料的模板中，设置有包括第一上表面和第二下表面的基底。 至少一个槽沿着第一上表面延伸并且包括从所述第一上表面至少部分地延伸穿过模板基座的第一槽部分。 所述至少一个狭槽还包括从所述第二下表面至少部分地延伸通过所述模板基座的第二槽部分。 第一和第二槽段各自具有宽度，其中至少一个槽段宽度适于夹持并保持至少一个模板板规则。
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Patent Agency Ranking
公开(公告)号：US06634272B2
公开(公告)日：2003-10-21
申请号：US09948855
申请日：2001-09-07
Applicant: Wolfgang M. Strobel , David J. Logan , David J. Gerber
Inventor： Wolfgang M. Strobel , David J. Logan , David J. Gerber
IPC: B26D700
CPC classification number: B23P15/406 , B21D37/205 , B26F1/44 , B26F2001/4463 , Y10T82/10 , Y10T82/16016 , Y10T83/929 , Y10T83/9473 , Y10T83/9478 , Y10T407/1946 , Y10T407/195
Abstract: In a die board for cutting and/or creasing sheet-type work material, a base is provided that includes a first upper surface and a second lower surface. At least one slot extends along the first upper surface and includes a first slot section extending from said first upper surface at least part-way through the die board base. The at least one slot also includes a second slot section extending from said second lower surface at least part-way through the die board base. The first and second slot sections each have a width with at least one of the slot section widths being adapted to grip and retain at least one die-board rule.
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公开(公告)号：US5913992A
公开(公告)日：1999-06-22
申请号：US949811
申请日：1997-10-14
Applicant: David J. Gerber
Inventor： David J. Gerber
Abstract: An apparatus for automatically creating a simulated mosaic controllably discharges tile pieces onto plate material and secures the tile pieces in place such that the plates with the tile pieces are freestanding permitting the plates themselves to be an ordered arrangement of sections of the mosaic once cemented to the substrate. Many different forms may be had for the plate material, including ones that are pressure or heat activatable to bond with the tile pieces or ones that are mechanically connectable.
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公开(公告)号：US20120053084A1
公开(公告)日：2012-03-01
申请号：US13062459
申请日：2009-08-31
Applicant: David J. Gerber , Jeffrey R. Cottrell , Timothy A. Ryan , Jonathan M. Levenson
Inventor： David J. Gerber , Jeffrey R. Cottrell , Timothy A. Ryan , Jonathan M. Levenson
CPC classification number: G01N33/5058 , G01N33/542 , G01N33/6872 , G01N2500/10
Abstract: The present invention provides, in part, platforms for analyzing an aspect of synaptic vesicle cycling. According to other aspects, the invention provides neuronal cell culture platform and platforms for analyzing an aspect of synaptic vesicle cycling. According to other aspects, the invention provides methods of measuring an aspect of synaptic vesicle cycling in a plurality of cells. According to other aspects, the invention provides methods for identifying a test agent as a modulator of an aspect of synaptic vesicle cycling.
Abstract translation: 本发明部分提供用于分析突触小泡循环方面的平台。 根据其他方面，本发明提供了用于分析突触小泡循环方面的神经元细胞培养平台和平台。 根据其它方面，本发明提供了测量多个细胞中突触小泡循环方面的方法。 根据其它方面，本发明提供了用于鉴定作为突触小泡循环方面的调节剂的测试剂的方法。
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9.发明申请TARGETS, METHODS, AND REAGENTS FOR DIAGNOSIS AND TREATMENT OF SCHIZOPHRENIA 审中-公开用于诊断和治疗精神病药物的目标，方法和试剂公开(公告)号：US20110288027A1
公开(公告)日：2011-11-24
申请号：US13204245
申请日：2011-08-05
Applicant: David J. Gerber , Maria Karayiorgou , Tsuyoshi Miyakawa , Susumu Tonegawa
Inventor： David J. Gerber , Maria Karayiorgou , Tsuyoshi Miyakawa , Susumu Tonegawa
CPC classification number: C12Q1/6883 , C12Q2600/136 , C12Q2600/156
Abstract: The present invention provides targets, methods, and reagents for the diagnosis and treatment of schizophrenia and related conditions. The invention provides methods for the diagnosis of schizophrenia and susceptibility to schizophrenia by detection of polymorphisms, mutations, variations, alterations in expression, etc., in calcineurin genes or calcineurin interacting genes, or polymorphisms linked to such genes. The invention provides oligonucleotides, arrays, and antibodies for detection of polymorphisms and variants. The invention provides transgenic mice having alterations in such genes. The invention also provides methods of treating schizophrenia by administering compounds that target these genes. The invention further provides screening methods for identifying such compounds and compounds obtained by performing the screens.
Abstract translation: 本发明提供用于诊断和治疗精神分裂症及相关病症的靶标，方法和试剂。 本发明通过检测钙调神经磷酸酶基因或钙调神经磷酸酶相互作用基因中的多态性，突变，变异，表达变化等，或与这些基因连锁的多态性，提供了诊断精神分裂症和精神分裂症易感性的方法。 本发明提供用于检测多态性和变体的寡核苷酸，阵列和抗体。 本发明提供了在这些基因中具有改变的转基因小鼠。 本发明还提供了通过施用靶向这些基因的化合物来治疗精神分裂症的方法。 本发明还提供了用于鉴定通过进行筛选获得的这些化合物和化合物的筛选方法。
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公开(公告)号：US06689035B1
公开(公告)日：2004-02-10
申请号：US09547259
申请日：2000-04-11
Applicant: David J. Gerber
Inventor： David J. Gerber
IPC: B31B188
CPC classification number: G06Q30/02 , B41J15/04 , G06F17/50 , G06F2217/38
Abstract: A comprehensive model design environment for creating a comprehensive model having a graphical design and a structural design includes at least two design stations and a database. Each design station comprises a graphical. design module for generating signals indicative of the graphical design and a structural design module for generating signals indicative of the structural design. The database receives the graphical design and the structural design signals, and generates in accordance therewith an ordered set of signals corresponding to the graphical design and the structural design. Each of several parties which collaborate in designing a package may access the database, greatly reducing design time.
Abstract translation: 用于创建具有图形设计和结构设计的综合模型的综合模型设计环境至少包括两个设计站和数据库。 每个设计站都包含图形。 用于产生指示图形设计的信号的设计模块和用于产生指示结构设计的信号的结构设计模块。 数据库接收图形设计和结构设计信号，并根据图形设计和结构设计产生一组有序的信号。 协作设计包的几个方面的每一个可以访问数据库，大大减少了设计时间。
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