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公开(公告)号：US08301241B2
公开(公告)日：2012-10-30
申请号：US12835308
申请日：2010-07-13
申请人： David J. Ternes , Kenneth L. Baker
发明人： David J. Ternes , Kenneth L. Baker
IPC分类号： A61N1/00
CPC分类号： A61N1/36139 , A61B5/024 , A61N1/3605 , A61N1/36053 , A61N1/36114 , A61N1/36146 , A61N1/37211 , A61N1/37288 , G06F19/00 , G06F19/3418 , G06F19/3481 , G16H20/10 , G16H40/63 , G16H40/67
摘要： A system embodiment for stimulating a neural target comprises a neural stimulator, a pace detector, and a controller. The neural stimulator is electrically connected to at least one electrode, and is configured to deliver a neural stimulation signal through the at least one electrode to stimulate the neural target. The pace detector is configured to use at least one electrode to sense cardiac activity and distinguish paced cardiac activity in the sensed cardiac activity from non-paced cardiac activity in the sensed cardiac activity. The controller is configured to control a programmed neural stimulation therapy using the neural stimulator and using detected paced cardiac activity as an input for the neural stimulation therapy.
摘要翻译： 用于刺激神经目标的系统实施例包括神经刺激器，步速检测器和控制器。 神经刺激器电连接到至少一个电极，并且被配置为通过至少一个电极传递神经刺激信号以刺激神经靶标。 脚步检测器被配置为使用至少一个电极来感测心脏活动，并将感测到的心脏活动中的心跳活动与感觉到的心脏活动中的非节奏心脏活动区分开。 控制器被配置为使用神经刺激器来控制编程的神经刺激治疗，并使用检测到的起搏心脏活动作为神经刺激治疗的输入。
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公开(公告)号：US08548585B2
公开(公告)日：2013-10-01
申请号：US12962168
申请日：2010-12-07
IPC分类号： A61N1/00
CPC分类号： A61N1/36146 , A61B5/0028 , A61B5/4848 , A61B5/7207 , A61N1/37 , A61N1/37288
摘要： Various method embodiments detect a concurrent therapy, where the concurrent therapy includes a plurality of therapy pulses. Detecting the concurrent therapy includes detecting at least one electrical pulse, extracting at least one characteristic from the at least one electrical pulse, comparing the at least one characteristic of the detected pulse to at least one characteristic of therapy pulses, and detecting that the concurrent therapy is being applied if the at least one characteristic of the detected pulse favorably compares to the at least one characteristic of the therapy pulses.
摘要翻译： 各种方法实施例检测并行治疗，其中并发治疗包括多个治疗脉冲。 检测并行治疗包括检测至少一个电脉冲，从至少一个电脉冲中提取至少一个特征，将检测到的脉冲的至少一个特征与治疗脉冲的至少一个特征进行比较，以及检测并发治疗 如果检测到的脉冲的至少一个特性有利地与治疗脉冲的至少一个特性相比较，则被应用。
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公开(公告)号：US20130023957A1
公开(公告)日：2013-01-24
申请号：US13627551
申请日：2012-09-26
申请人： David J. Ternes , Kenneth L. Baker
发明人： David J. Ternes , Kenneth L. Baker
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61B5/024 , A61N1/3605 , A61N1/36053 , A61N1/36114 , A61N1/36146 , A61N1/37211 , A61N1/37288 , G06F19/00 , G06F19/3418 , G06F19/3481 , G16H20/10 , G16H40/63 , G16H40/67
摘要： A system embodiment for stimulating a neural target comprises a neural stimulator, a pace detector, and a controller. The neural stimulator is electrically connected to at least one electrode, and is configured to deliver a neural stimulation signal through the at least one electrode to stimulate the neural target. The pace detector is configured to use at least one electrode to sense cardiac activity and distinguish paced cardiac activity in the sensed cardiac activity from non-paced cardiac activity in the sensed cardiac activity. The controller is configured to control a programmed neural stimulation therapy using the neural stimulator and using detected paced cardiac activity as an input for the neural stimulation therapy.
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公开(公告)号：US20110015703A1
公开(公告)日：2011-01-20
申请号：US12835308
申请日：2010-07-13
申请人： David J. Ternes , Kenneth L. Baker
发明人： David J. Ternes , Kenneth L. Baker
CPC分类号： A61N1/36139 , A61B5/024 , A61N1/3605 , A61N1/36053 , A61N1/36114 , A61N1/36146 , A61N1/37211 , A61N1/37288 , G06F19/00 , G06F19/3418 , G06F19/3481 , G16H20/10 , G16H40/63 , G16H40/67
摘要： A system embodiment for stimulating a neural target comprises a neural stimulator, a pace detector, and a controller. The neural stimulator is electrically connected to at least one electrode, and is configured to deliver a neural stimulation signal through the at least one electrode to stimulate the neural target. The pace detector is configured to use at least one electrode to sense cardiac activity and distinguish paced cardiac activity in the sensed cardiac activity from non-paced cardiac activity in the sensed cardiac activity. The controller is configured to control a programmed neural stimulation therapy using the neural stimulator and using detected paced cardiac activity as an input for the neural stimulation therapy.
摘要翻译： 用于刺激神经目标的系统实施例包括神经刺激器，步速检测器和控制器。 神经刺激器电连接到至少一个电极，并且被配置为通过至少一个电极传递神经刺激信号以刺激神经靶标。 脚步检测器被配置为使用至少一个电极来感测心脏活动，并将感测到的心脏活动中的心跳活动与感觉到的心脏活动中的非节奏心脏活动区分开。 控制器被配置为使用神经刺激器来控制编程的神经刺激治疗，并使用检测到的起搏心脏活动作为神经刺激治疗的输入。
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公开(公告)号：US20110137360A1
公开(公告)日：2011-06-09
申请号：US12962168
申请日：2010-12-07
IPC分类号： A61N1/36
CPC分类号： A61N1/36146 , A61B5/0028 , A61B5/4848 , A61B5/7207 , A61N1/37 , A61N1/37288
摘要： Various method embodiments detect a concurrent therapy, where the concurrent therapy includes a plurality of therapy pulses. Detecting the concurrent therapy includes detecting at least one electrical pulse, extracting at least one characteristic from the at least one electrical pulse, comparing the at least one characteristic of the detected pulse to at least one characteristic of therapy pulses, and detecting that the concurrent therapy is being applied if the at least one characteristic of the detected pulse favorably compares to the at least one characteristic of the therapy pulses.
摘要翻译： 各种方法实施例检测并行治疗，其中并发治疗包括多个治疗脉冲。 检测并行治疗包括检测至少一个电脉冲，从至少一个电脉冲中提取至少一个特征，将检测到的脉冲的至少一个特征与治疗脉冲的至少一个特征进行比较，以及检测并发治疗 如果检测到的脉冲的至少一个特性有利地与治疗脉冲的至少一个特性相比较，则被应用。
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6.发明授权公开(公告)号：US07668595B2
公开(公告)日：2010-02-23
申请号：US11619391
申请日：2007-01-03
IPC分类号： A61N1/362
CPC分类号： A61N1/3702 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3688
摘要： A method of optimizing inter-site delay is disclosed for a cardiac rhythm management device that includes a dual chamber pacemaker, especially designed for treating congestive heart failure by pacing a plurality of sites. A microcontroller is operative to adjust the pacing mode and inter-site delay of the pacemaker so as to achieve optimum hemodynamic performance. Atrial cycle lengths measured during transient (immediate) time intervals following a change in the mode inter-site delay are signal processed and a determination can then be made as to which particular configuration yields the optimum performance. Performance is optimized when the patient is at rest and when the patient exercises so that a rate-adapted dynamic value of the optimum performance can be applied.
摘要翻译： 公开了一种用于心脏节律管理装置的优化站间延迟的方法，其包括双室起搏器，其特别设计用于通过起搏多个部位来治疗充血性心力衰竭。 微控制器可操作以调节起搏器的起搏模式和站间延迟，以达到最佳的血液动力学性能。 信号处理后的瞬时（即时）时间间隔内测量的心房周期长度被信号处理，然后可以确定哪个特定配置产生最佳性能。 当患者处于静止状态并且患者锻炼时优化性能，以便可以应用最佳性能的速率适应动态值。
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公开(公告)号：US06920355B2
公开(公告)日：2005-07-19
申请号：US10150297
申请日：2002-05-17
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3684
摘要： A hybrid cardiac pacemaker in which the operation of the device is controlled by hardware-based controller as supervised by a microprocessor-based controller. The hardware-based controller comprises a plurality of timers that expire when they reach timer limit values stored in registers updatable by the microprocessor, and a combinational logic array for causing the device to generate pace outputs in accordance with timer expirations and sense signals. The combinational logic array may operate the pacemaker in a number of programmed modes in accordance with a mode value stored in a mode control register by the microprocessor.
摘要翻译： 一种混合心脏起搏器，其中由基于微处理器的控制器监控的由基于硬件的控制器控制该设备的操作。 基于硬件的控制器包括多个定时器，当它们达到存储在可由微处理器更新的寄存器中的定时器限制值时，该定时器到期，以及组合逻辑阵列，用于使该设备根据定时器期满和感测信号产生步进输出。 组合逻辑阵列可以根据由微处理器存储在模式控制寄存器中的模式值，以多种编程模式操作起搏器。
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公开(公告)号：US08190256B2
公开(公告)日：2012-05-29
申请号：US12508317
申请日：2009-07-23
申请人： Jesse W. Hartley , Kent Lee , Quan Ni , Michael A. Querimit , Kenneth L. Baker , Ankur Garg , Kenneth L. Tobacman , Corey J. Miklos
发明人： Jesse W. Hartley , Kent Lee , Quan Ni , Michael A. Querimit , Kenneth L. Baker , Ankur Garg , Kenneth L. Tobacman , Corey J. Miklos
IPC分类号： A61N1/365
CPC分类号： A61B5/4812 , A61B5/4815 , A61N1/368 , A61N1/3688 , G06F19/00
摘要： Methods and systems are directed to delivering cardiac pacing therapy to a patient. A pacing therapy associated with one or more pacing parameters is delivered. Alternate cardiac pacing therapies associated with one or more alternate pacing parameters are transitioned to, based on a sleep/wake cycle of the patient. Interactions between the pacing parameters of the pacing therapy and the alternate pacing parameters are resolved. Resolving pacing parameters may be based on analysis of lower rate limits and/or lower rate hysteresis, for example.
摘要翻译： 方法和系统旨在向患者输送心脏起搏治疗。 提供与一个或多个起搏参数相关的起搏疗法。 与一个或多个替代起搏参数相关联的替代心脏起搏疗法基于患者的睡眠/唤醒周期而被转换。 起搏治疗起搏参数与替代起搏参数之间的相互作用得到解决。 例如，解析起搏参数可以基于较低速率限制和/或较低速率滞后的分析。
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9.发明授权公开(公告)号：US07177688B2
公开(公告)日：2007-02-13
申请号：US11018124
申请日：2004-12-21
IPC分类号： A61N1/18
CPC分类号： A61N1/3702 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3688
摘要： A method of optimizing inter-site delay is disclosed for a cardiac rhythm management device that includes a dual chamber pacemaker, especially designed for treating congestive heart failure by pacing a plurality of sites. A microcontroller is operative to adjust the pacing mode and inter-site delay of the pacemaker so as to achieve optimum hemodynamic performance. Atrial cycle lengths measured during transient (immediate) time intervals following a change in the mode inter-site delay are signal processed and a determination can then be made as to which particular configuration yields the optimum performance. Performance is optimized when the patient is at rest and when the patient exercises so that a rate-adapted dynamic value of the optimum performance can be applied.
摘要翻译： 公开了一种用于心脏节律管理装置的优化站间延迟的方法，其包括双室起搏器，其特别设计用于通过起搏多个部位来治疗充血性心力衰竭。 微控制器可用于调节起搏器的起搏模式和站间延迟，以达到最佳的血流动力学性能。 信号处理后的瞬时（即时）时间间隔内测量的心房周期长度被信号处理，然后可以确定哪个特定配置产生最佳性能。 当患者处于静止状态并且患者锻炼时优化性能，以便可以应用最佳性能的速率适应动态值。
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10.发明授权Reduction of left-ventricular offset interaction with tachyarrhythmia detection 有权减慢与心律失常检测的左心室偏移相互作用公开(公告)号：US06757562B2
公开(公告)日：2004-06-29
申请号：US10037444
申请日：2001-10-25
IPC分类号： A61N1362
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A device and method for improving tachyarrhythmia detection when the ventricles are resynchronized by delivering paces to both ventricles separated by a specified offset interval. Timing of escape intervals and tachyarrhythmia detection is based upon senses from one of the ventricles designated as a rate ventricle. A reversion pacing mode is provided in order to prevent tachyarrhythmia detection from being compromised when the rate ventricle is paced after the other ventricle.
摘要翻译： 通过向两个心室分配指定的偏移间隔来逐步重新同步心室，从而改善快速性心律失常检测的装置和方法。 逃避间隔和快速性心律失常检测的时间是基于指定为速率心室的心室之一的感觉。 提供回波起搏模式，以便当速率心室在另一脑室之后起搏时，防止快速性心律失常检测受到损害。
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