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    Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media
    2.
    发明授权
    Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media 有权
    用中性溶出介质溶解和过滤超极化剂的方法和装置

    公开(公告)号：US08763410B2

    公开(公告)日：2014-07-01

    申请号：US12106570

    申请日：2008-04-21

    申请人： David Brandon Whitt ,  Andrew Michael Leach ,  Peter Miller ,  Eric Telfeyan

    发明人： David Brandon Whitt ,  Andrew Michael Leach ,  Peter Miller ,  Eric Telfeyan

    IPC分类号： F25B19/00 ,  A61B5/055

    CPC分类号： G01R33/30 ,  G01R33/282 ,  G01R33/62

    摘要： Methods and apparatuses that facilitate dissolving a hyperpolarized agent within a polarizer and transporting it to a receiver is provided. The methods include delivering water to a hyperpolarized agent contained within a polarizer, forming a hyperpolarized aqueous solution, transporting the aqueous solution through a fluid path system out of the polarizer, filtering the aqueous solution through a partical size exclusion filter to a receiver, and modifying the pH of the filtered hyperpolarized aquous solution with a dissolution medium contained in the receiver. Also disclosed herein are apparatuses for dissolving a hyperpolarized agent comprising a vial for containing a hyperpolarized imaging agent therein, a dissolution fluid path, a delivery fluid path, a particle size exclusion filter, and a receiver connected to the particle size exclusion filter and positioned to receive the filtered aqueous solution of the hyperpolarized imaging agent.

    摘要翻译： 提供了有助于将偏振器内的超极化剂溶解并将其输送到接收器的方法和装置。 所述方法包括将水输送到偏振器内所含的超极化剂，形成超极化水溶液，将水溶液通过流体路径系统输送出偏振器，将水溶液通过部分尺寸排阻滤器过滤到接受器，并修改 过滤的超极化水溶液的pH值，其中溶解介质包含在接收器中。 本文还公开了用于溶解超极化剂的装置，其包含其中含有超极化成像剂的小瓶，溶解流体路径，输送流体路径，粒度排阻过滤器和连接到粒度排阻过滤器的接收器，并且定位成 接收过滤的超极化成像剂的水溶液。

    METHOD AND APPARATUS FOR THE DISSOLUTION AND FILTRATION OF A HYPERPOLARIZED AGENT WITH A NEUTRAL DISSOLUTION MEDIA
    3.
    发明申请
    METHOD AND APPARATUS FOR THE DISSOLUTION AND FILTRATION OF A HYPERPOLARIZED AGENT WITH A NEUTRAL DISSOLUTION MEDIA 有权
    用于中性溶解介质的高分子化合物的溶解和过滤的方法和装置

    公开(公告)号：US20090263325A1

    公开(公告)日：2009-10-22

    申请号：US12106570

    申请日：2008-04-21

    申请人： David Brandon Whitt ,  Andrew Michael Leach ,  Peter Miller ,  Eric Telfeyan

    发明人： David Brandon Whitt ,  Andrew Michael Leach ,  Peter Miller ,  Eric Telfeyan

    IPC分类号： A61K49/10 ,  B01J19/00

    CPC分类号： G01R33/30 ,  G01R33/282 ,  G01R33/62

    摘要： Methods and apparatuses that facilitate dissolving a hyperpolarized agent within a polarizer and transporting it to a receiver is provided. The methods include delivering water to a hyperpolarized agent contained within a polarizer, forming a hyperpolarized aqueous solution, transporting the aqueous solution through a fluid path system out of the polarizer, filtering the aqueous solution through a partical size exclusion filter to a receiver, and modifying the pH of the filtered hyperpolarized aquous solution with a dissolution medium contained in the receiver. Also disclosed herein are apparatuses for dissolving a hyperpolarized agent comprising a vial for containing a hyperpolarized imaging agent therein, a dissolution fluid path, a delivery fluid path, a particle size exclusion filter, and a receiver connected to the particle size exclusion filter and positioned to receive the filtered aqueous solution of the hyperpolarized imaging agent.

    摘要翻译： 提供了有助于将偏振器内的超极化剂溶解并将其输送到接收器的方法和装置。 所述方法包括将水输送到偏振器内所含的超极化剂，形成超极化水溶液，将水溶液通过流体路径系统输送出偏振器，将水溶液通过部分尺寸排阻滤器过滤到接受器，并修改 过滤的超极化水溶液的pH值，其中溶解介质包含在接收器中。 本文还公开了用于溶解超极化剂的装置，其包含其中含有超极化成像剂的小瓶，溶解流体路径，输送流体路径，粒度排阻过滤器和连接到粒度排阻过滤器的接收器，并且定位成 接收过滤的超极化成像剂的水溶液。

    Sensor systems and methods for quantification of physical parameters, chemical and biochemical volatile and nonvolatile compounds in fluids
    4.
    发明授权
    Sensor systems and methods for quantification of physical parameters, chemical and biochemical volatile and nonvolatile compounds in fluids 失效
    用于定量流体物理参数，化学和生物化学挥发性和非挥发性化合物的传感器系统和方法

    公开(公告)号：US07170609B2

    公开(公告)日：2007-01-30

    申请号：US10723534

    申请日：2003-11-24

    申请人： Radislav Alexandrovich Potyrailo ,  William Guy Morris ,  Scott Martell Boyette ,  Marc Brian Wisnudel ,  Andrew Michael Leach ,  Mary Lynn Stanley

    发明人： Radislav Alexandrovich Potyrailo ,  William Guy Morris ,  Scott Martell Boyette ,  Marc Brian Wisnudel ,  Andrew Michael Leach ,  Mary Lynn Stanley

    IPC分类号： G01N21/00

    CPC分类号： G01N21/5907 ,  G01N35/00069

    摘要： A system and method employing optical disc drives for quantitative analysis of physical, chemical and biochemical parameters are provided. The system including a disc drive for supporting and rotating an optical disc including at least one sensor spot; a light source for directing light onto the sensor spot; at least one optical pickup for detecting light transmitted from the sensor spot, the transmitted light being indicative of a concentration of a compound; and an analog-to-digital converter for quantifying an intensity of the transmitted light. The method comprising the steps of preparing the optical disc with a plurality of sensor spots, the sensor spots being responsive to a compound; exposing the optical disc to a fluid; measuring intensity of transmitted light from at least one of the plurality of sensor spots; and correlating the measured intensity of transmitted light to an amount of compound exposed to the optical disc.

    摘要翻译： 提供了一种使用光盘驱动器进行物理，化学和生物化学参数定量分析的系统和方法。 该系统包括用于支撑和旋转包括至少一个传感器点的光盘的盘驱动器; 用于将光引导到传感器点上的光源; 至少一个用于检测从传感器光点传输的光的光学拾取器，所述透射光指示化合物的浓度; 以及用于量化透射光强度的模拟 - 数字转换器。 该方法包括以下步骤：准备具有多个传感器点的光盘，所述传感器点响应于化合物; 将光盘暴露于流体; 测量来自所述多个传感器光点中的至少一个的透射光的强度; 并将测得的透射光强度与暴露于光盘的化合物的量相关联。

    Chemical and biological sensors, systems and methods based on radio frequency identification
    5.
    发明授权
    Chemical and biological sensors, systems and methods based on radio frequency identification 有权
    基于射频识别的化学和生物传感器，系统和方法

    公开(公告)号：US08318099B2

    公开(公告)日：2012-11-27

    申请号：US11259711

    申请日：2005-10-26

    申请人： Radislav Alexandrovich Potyrailo ,  William Guy Morris ,  Kenneth Brakeley Welles, II ,  Andrew Michael Leach ,  Andrew David Pris

    发明人： Radislav Alexandrovich Potyrailo ,  William Guy Morris ,  Kenneth Brakeley Welles, II ,  Andrew Michael Leach ,  Andrew David Pris

    IPC分类号： G01N27/00

    CPC分类号： G06K19/07749 ,  G01N27/3275 ,  G01N27/3278 ,  G06K19/0717 ,  Y10T436/11 ,  Y10T436/25375

    摘要： Embodiments of the invention include a wireless sensor, such as an RFID tag, that includes a substrate, an antenna disposed on the substrate, and an environmentally sensitive sensor material disposed over at least a portion of said substrate. Other embodiments an RFID tag and at least one antibody coupled to the RFID tag. The RFID tag includes a substrate, circuitry disposed on the substrate, and an antenna coupled to the substrate. The at least one antibody is capable of affecting the signals emanating from the RFID tag. Further embodiments include a detection system that includes a reader. Yet other embodiments include a method for detecting specific analytes. The method includes providing an RFID tag which emanates a first signal having a first frequency, and enabling the REID tag to emanate a second signal having a second frequency upon attraction of a specific analyte to the RFID tag.

    摘要翻译： 本发明的实施例包括诸如RFID标签的无线传感器，其包括基板，设置在基板上的天线以及设置在所述基板的至少一部分上的对环境敏感的传感器材料。 其他实施例是RFID标签和耦合到RFID标签的至少一个抗体。 RFID标签包括衬底，设置在衬底上的电路和耦合到衬底的天线。 所述至少一种抗体能够影响从RFID标签发出的信号。 另外的实施例包括包括读取器的检测系统。 其他实施方案包括用于检测特定分析物的方法。 该方法包括提供发射具有第一频率的第一信号的RFID标签，并且使得REID标签在将特定分析物吸引到RFID标签时能够发出具有第二频率的第二信号。

    Water hardness sensor system
    6.
    发明授权
    Water hardness sensor system 有权
    水硬度传感器系统

    公开(公告)号：US08147758B2

    公开(公告)日：2012-04-03

    申请号：US11473867

    申请日：2006-06-23

    申请人： Andrew Michael Leach

    发明人： Andrew Michael Leach

    IPC分类号： G01N21/00

    CPC分类号： G01N21/31 ,  G01N21/53 ,  G01N33/1853

    摘要： A sensor including a substrate and a sensing element disposed on a substrate is provided. The sensing element includes a sensing matrix in contact with a flow of water, an indicator for one or more chemical species in the flow of water, and a selectivity component that reacts reversibly with the one or more chemical species. The sensor also includes a light source configured to direct light through the substrate and the sensing element. The sensor further includes a light detector configured to receive transmitted light from the substrate and the sensing matrix and to generate a signal representative of selective wavelengths of the light indicative of the one or more chemical species in the flow of water.

    摘要翻译： 提供了包括基板和设置在基板上的感测元件的传感器。 感测元件包括与水流接触的感测矩阵，水流中的一种或多种化学物质的指示剂以及与一种或多种化学物质可逆地反应的选择性成分。 传感器还包括被配置为将光引导通过基板和感测元件的光源。 传感器还包括光检测器，其被配置为从基板和感测矩阵接收透射光，并且产生代表在水流中指示一种或多种化学物质的光的选择波长的信号。

    Appliance using a water hardness sensor system and method of operating the same
    7.
    发明申请
    Appliance using a water hardness sensor system and method of operating the same 有权
    电器采用水硬度传感器系统及其操作方法

    公开(公告)号：US20070295665A1

    公开(公告)日：2007-12-27

    申请号：US11473868

    申请日：2006-06-23

    申请人： Raul Eduardo Ayala ,  James Rulon Young Rawson ,  Todd Vincent Graves ,  Andrew Michael Leach

    发明人： Raul Eduardo Ayala ,  James Rulon Young Rawson ,  Todd Vincent Graves ,  Andrew Michael Leach

    IPC分类号： C02F1/42

    CPC分类号： C02F1/008 ,  C02F1/42 ,  C02F1/441 ,  C02F2209/005 ,  C02F2209/055 ,  C02F2209/40 ,  Y10S261/46

    摘要： An appliance using water including an incoming water valve is provided. The appliance also includes a sensor disposed in-line to an incoming flow of water received from the incoming water valve and is configured to sense a degree of hardness in the incoming flow of water. The sensor includes a substrate and a sensing element disposed on the substrate. The sensing element includes a sensing matrix, an indicator for one or more chemical species in a flow of water, and a selectivity component that reacts reversibly with the one or more chemical species in the water. The sensor also includes a light source configured to direct light through the substrate and the sensing matrix. The sensor further includes a light detector configured to receive transmitted light from the substrate and the sensing matrix and to generate a signal representative of selective wavelengths of the light indicative of the one or more chemical species in the flow of water. The appliance also includes a cleaning volume, a drain for the cleaning volume and an additive valve for an additive used for cleaning. The appliance further includes a controller configured to receive a signal indicative of hardness of the flow of water from the sensor and output it to control the incoming water valve, the additive valve and the drain on the cleaning volume.

    摘要翻译： 提供了一种使用包括进水阀在内的水的设备。 该器具还包括传感器，其与从入水阀接收的进入的水流成线配置，并且构造成感测进入的水流中的硬度。 传感器包括衬底和设置在衬底上的感测元件。 感测元件包括感测矩阵，水流中的一种或多种化学物质的指示剂以及与水中的一种或多种化学物质可逆地反应的选择性成分。 传感器还包括被配置为引导光通过基板和感测矩阵的光源。 传感器还包括光检测器，其被配置为从基板和感测矩阵接收透射光，并且产生代表在水流中指示一种或多种化学物质的光的选择波长的信号。 该器具还包括清洁体积，用于清洁体积的排水口和用于清洁的添加剂的添加阀。 该器具还包括控制器，该控制器被配置为接收指示来自传感器的水流的硬度的信号并将其输出以控制进入的水阀，添加阀和清洁体积上的排水口。

    Apparatus and method for fully automated closed system pH measurement
    9.
    发明授权
    Apparatus and method for fully automated closed system pH measurement 有权
    全自动封闭系统pH测量的装置和方法

    公开(公告)号：US07610157B2

    公开(公告)日：2009-10-27

    申请号：US11858573

    申请日：2007-09-20

    申请人： Peter Miller ,  Andrew Michael Leach

    发明人： Peter Miller ,  Andrew Michael Leach

    IPC分类号： A61B5/05

    CPC分类号： G01N21/33 ,  G01N21/3577 ,  G01N2201/129

    摘要： The present invention provides an apparatus and method for a noninvasive optical determination of the pH of a substance in a compartment in a closed system comprising a compartment wherein a substance resides which is permeable to at least one wavelength of light, a light source and light detecting device configured to obtain spectral data for a substance for at least one wavelength, a processor adapted to determine the pH of the substance by correlating the spectral data with predetermined spectral data for a known substance at a known pH at the at least one wavelength, and wherein the processor is further configured to control the release of the substance from the compartment to its end use.

    摘要翻译： 本发明提供了一种无密封光学测定封闭系统中的隔室中的物质的pH的装置和方法，所述封闭系统包括隔室，其中物质存在，其可透过至少一个波长的光，光源和光检测 被配置为获得用于至少一个波长的物质的光谱数据的处理器，适于通过将光谱数据与在至少一个波长处的已知物质的已知物质的预定光谱数据相关联来确定物质的pH的处理器，以及 其中所述处理器还被配置为控制所述物质从所述隔室到其最终用途的释放。