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公开(公告)号：US07163938B2
公开(公告)日：2007-01-16
申请号：US10415756
申请日：2001-11-14
申请人： David Kent Herron , Sajan Joseph , Angela Lynn Marquart , John Joseph Masters , David Mendel , Gerald Floyd Smith , Philip Parker Waid , Michael Robert Wiley , Ying Kwong Yee
发明人： David Kent Herron , Sajan Joseph , Angela Lynn Marquart , John Joseph Masters , David Mendel , Gerald Floyd Smith , Philip Parker Waid , Michael Robert Wiley , Ying Kwong Yee
IPC分类号： A61P7/00 , A61K31/44 , A61K31/55 , C07D213/00 , C07D401/12
CPC分类号： C07D213/75 , C07D213/81 , C07D401/12 , C07D401/14
摘要： This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
摘要翻译： 本申请涉及如本文所定义的式I化合物（或其药学上可接受的盐），其药物组合物及其作为因子Xa抑制剂的用途，以及其制备方法及其中间体。
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公开(公告)号：US07160878B2
公开(公告)日：2007-01-09
申请号：US10332120
申请日：2001-07-18
申请人： David Kent Herron , Sajan Joseph , Angela Lynn Marquart , John Joseph Masters , David Mendel , Gerald Floyd Smith , Philip Parker Waid , Michael Robert Wiley , Ying Kwong Yee
发明人： David Kent Herron , Sajan Joseph , Angela Lynn Marquart , John Joseph Masters , David Mendel , Gerald Floyd Smith , Philip Parker Waid , Michael Robert Wiley , Ying Kwong Yee
IPC分类号： A61P7/02 , A61K31/55 , C07D243/08
CPC分类号： C07D401/14 , C07D237/24 , C07D403/04
摘要： This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
摘要翻译： 本申请涉及本文所定义的式（I）化合物（或其药学上可接受的盐），其药物组合物及其作为因子Xa抑制剂的用途，以及其制备方法及其中间体。
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公开(公告)号：US07449457B2
公开(公告)日：2008-11-11
申请号：US10497250
申请日：2002-12-02
申请人： David Kent Herron , Sajan Joseph , Angela Lynn Marquart , John Joseph Masters , David Mendel , Gerald Floyd Smith , Anne Louise Tebbe , Philip Parker Waid , Michael Robert Wiley , Ying Kwong Yee
发明人： David Kent Herron , Sajan Joseph , Angela Lynn Marquart , John Joseph Masters , David Mendel , Gerald Floyd Smith , Anne Louise Tebbe , Philip Parker Waid , Michael Robert Wiley , Ying Kwong Yee
IPC分类号： A61K31/54 , A61K31/44 , A61K31/535 , C07D417/00 , C07D413/00 , C07D401/00
CPC分类号： C07D213/81 , C07D213/82 , C07D401/12 , C07D401/14 , C07D453/02
摘要： This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
摘要翻译： 本申请涉及本文所定义的式（I）化合物（或其药学上可接受的盐），其药物组合物及其作为因子Xa抑制剂的用途，以及其制备方法及其中间体。
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公开(公告)号：US07700628B2
公开(公告)日：2010-04-20
申请号：US11719415
申请日：2005-11-10
申请人： Ankush Baburao Argade , Theodore Goodson, Jr. , David Kent Herron , Sajan Joseph , Salvatore Donato Lepore , Angela Lynn Marquart , John Joseph Masters , David Mendel , Leander Merritt , Andrew Michael Ratz , Gerald Floyd Smith , Anne Louise Tebbe , Michael Robert Wiley , Ying Kwong Yee
发明人： Ankush Baburao Argade , Theodore Goodson, Jr. , David Kent Herron , Sajan Joseph , Salvatore Donato Lepore , Angela Lynn Marquart , John Joseph Masters , David Mendel , Leander Merritt , Andrew Michael Ratz , Gerald Floyd Smith , Anne Louise Tebbe , Michael Robert Wiley , Ying Kwong Yee
IPC分类号： C07D413/10 , C07D413/14 , C07D401/10 , C07D401/02 , C07D401/14 , C07D401/12 , C07D409/10 , C07D243/08 , C07D213/75 , A61K31/381 , A61K31/4402 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/5377 , A61K31/551
CPC分类号： C07D211/46 , C07C229/38 , C07D213/75 , C07D295/192 , C07D333/38 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D413/12 , C07D417/12
摘要： This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor. An example of a compound of formula (I) is (a).
摘要翻译： 本申请涉及如本文所定义的式（I）化合物（或其化合物或前药的药学上可接受的盐），其药物组合物及其作为因子Xa和/或凝血酶抑制剂的用途，以及 其制备方法及其中间体。 式（I）化合物的实例是（a）。
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公开(公告)号：US20090227566A1
公开(公告)日：2009-09-10
申请号：US11719415
申请日：2005-11-10
申请人： Ankush Baburao Argade , Theodore Goodson, JR. , David Kent Herron , Sajan Joseph , Salvatore Donato Lepore , Angela Lynn Marquart , John Joseph Masters , David Mendel , Leander Merritt , Andrew Michael Ratz , Gerald Floyd Smith , Anne Lousie Tebbe , Michael Robert Wiley , Ying Kwong Yee
发明人： Ankush Baburao Argade , Theodore Goodson, JR. , David Kent Herron , Sajan Joseph , Salvatore Donato Lepore , Angela Lynn Marquart , John Joseph Masters , David Mendel , Leander Merritt , Andrew Michael Ratz , Gerald Floyd Smith , Anne Lousie Tebbe , Michael Robert Wiley , Ying Kwong Yee
IPC分类号： A61K31/551 , A61K31/5377 , A61K31/445 , C07D243/08 , C07D413/12 , C07D401/12 , C07D211/98
CPC分类号： C07D211/46 , C07C229/38 , C07D213/75 , C07D295/192 , C07D333/38 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D413/12 , C07D417/12
摘要： This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor. An example of a compound of formula (I) is (a).
摘要翻译： 本申请涉及如本文所定义的式（I）化合物（或其化合物或前药的药学上可接受的盐），其药物组合物及其作为因子Xa和/或凝血酶抑制剂的用途，以及 其制备方法及其中间体。 式（I）化合物的实例是（a）。
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公开(公告)号：US06716855B2
公开(公告)日：2004-04-06
申请号：US10374124
申请日：2003-02-25
申请人： Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
发明人： Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
IPC分类号： A61K3144
CPC分类号： C07D295/135 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/14
摘要： This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：US06780878B2
公开(公告)日：2004-08-24
申请号：US10382614
申请日：2003-03-05
申请人： Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
发明人： Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
IPC分类号： C07D31202
CPC分类号： C07D295/135 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/14
摘要： This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：US06716839B2
公开(公告)日：2004-04-06
申请号：US10378108
申请日：2003-02-26
申请人： Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
发明人： Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
IPC分类号： A61K315377
CPC分类号： C07D295/135 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/14
摘要： This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：US06635657B1
公开(公告)日：2003-10-21
申请号：US09857751
申请日：2001-06-08
申请人： Douglas Wade Beight , Trelia Joyce Craft , Carl Penman Denny , Jeffry Bernard Franciskovich , Theodore Goodson , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
发明人： Douglas Wade Beight , Trelia Joyce Craft , Carl Penman Denny , Jeffry Bernard Franciskovich , Theodore Goodson , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
IPC分类号： A61K314545
CPC分类号： C07D213/75 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
摘要翻译： 本申请涉及如本文所定义的式I化合物（或其药学上可接受的盐），其药物组合物及其作为因子Xa抑制剂的用途，以及其制备方法及其中间体。
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公开(公告)号：US07129245B2
公开(公告)日：2006-10-31
申请号：US10629817
申请日：2003-07-29
申请人： Douglas Wade Beight , Trelia Joyce Craft , Carl Penman Denny , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Pi{hacek over (n)}elro-Nú{hacek over (n)}ez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
发明人： Douglas Wade Beight , Trelia Joyce Craft , Carl Penman Denny , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Pi{hacek over (n)}elro-Nú{hacek over (n)}ez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
IPC分类号： A61K31/506 , C07D239/04
CPC分类号： C07D213/75 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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