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公开(公告)号:US5697739A
公开(公告)日:1997-12-16
申请号:US466853
申请日:1995-06-06
CPC分类号: B23Q5/045 , B23Q11/1023 , B23Q2220/008 , Y10T409/308232 , Y10T409/308456 , Y10T409/309296
摘要: An angle spindle attachment for a vertically movable spindle unit is provided for rotating a cutting tool in a generally horizontal orientation. The attachment includes a spindle assembly having a drive train that is mechanically independent from the drive train of the vertically movable spindle unit, and a connector block for detachably connecting the spindle assembly at a transverse angle with respect to the vertically movable spindle unit. The connector block may include an angular adjustment mechanism that allows the spindle assembly to be oriented at an angle above or below the horizontal, as well as a rotational adjustment assembly that allows the spindle assembly to be pivotally adjusted about the axis of rotation of the vertically movable spindle unit. The independent drive train of the spindle assembly may be either electrically, hydraulically, or pneumatically powered, and allows the cutting tool to be held more rigidly, operated with less eccentric movement, and turned at speeds that are not limited by the drive train of the vertically movable spindle unit.
摘要翻译: 提供用于可垂直移动的主轴单元的角度主轴附件,用于以大致水平的方向旋转切削工具。 附件包括具有机械地独立于可垂直移动的主轴单元的传动系的传动系的主轴组件和用于相对于可垂直移动的主轴单元以横向角度可拆卸地连接主轴组件的连接器块。 连接器块可以包括角度调节机构,其允许主轴组件以水平面上方或下方的角度定向,以及旋转调节组件,其允许主轴组件围绕竖直方向的旋转轴线枢转调节 可动主轴单元。 主轴组件的独立驱动系统可以是电动的,液压的或气动的,并且允许切割工具被更加坚固地保持,以较少的偏心运动来操作,并以不受传动系的限制的速度转动 垂直移动主轴单元。
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2.
公开(公告)号:US5460388A
公开(公告)日:1995-10-24
申请号:US191231
申请日:1994-02-03
CPC分类号: B23B31/202 , B23B31/001 , B23B2231/2005 , B23B2250/12 , Y10T279/17299 , Y10T279/17504 , Y10T279/17581 , Y10T409/30952
摘要: A toolholder 1 of the type including a collet 5 integrally formed with a shank 3 is provided with an interface between a locknut 7 and collet 13 which substantially reduces the torque required to turn the locknut 7 into a position which radially collapses the collet segments 17. In this interface, one of either the inner locknut surface 23 or the outer surfaces of the collet segments 17 includes an engaging portion 56 for wedgingly flexing the collet segments 17 inwardly when the locknut is turned, and a non-engaging portion 58 disposed between the engaging portion 56 and the shank mounted ends of the collet segments 17. The non-engaging portion 58 reduces the torque required to turn the locknut 7 by reducing the binding forces that would otherwise occur between the ends of the collet segments 17 and the inner locknut surface 23. To further reduce torque, the collet portion interconnecting the collet segments 17 with the shank 3 of the toolholder is rendered thinner by the provision of circumferential grooves 72, 76 that make the collet segments 17 more flexible. Sealing rings 66, 74, 81 are seated in grooves 68, 72, 76 present in the interior defined by the collet segments 17 in order to prevent errant flows of coolant or debris from collecting between the collet segments 17 and the tool shank 9 gripped thereby.
摘要翻译: 包括与柄3一体形成的夹头5的刀架1在锁紧螺母7和夹头13之间设置有一个接口,该接合件基本上减小了将锁紧螺母7转动到使夹紧部分17径向塌缩的位置所需的扭矩。 在该界面中,内锁紧螺母表面23或夹头段17的外表面中的一个包括用于在锁紧螺母转动时将夹头段17向内楔入地弯曲的接合部分56以及布置在 接合部分56和夹头段17的柄安装的端部。非接合部分58通过减小否则将在夹头段17的端部和内部锁紧螺母之间发生的结合力来减小转动锁紧螺母7所需的扭矩 为了进一步减小扭矩,将夹头段17与刀架的柄3互连的夹头部分通过提供 使得夹头段17更柔性的圆周凹槽72,76。 密封环66,74,81位于由夹头段17限定的内部中的凹槽68,72,76中,以防止冷却剂或碎屑的错误流动收集在夹头段17和夹持的工具柄9之间 。
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公开(公告)号:US09074336B2
公开(公告)日:2015-07-07
申请号:US13796953
申请日:2013-03-12
申请人: David L. Lewis
发明人: David L. Lewis
IPC分类号: E02D27/00
CPC分类号: E02D27/013 , E02D27/00 , E02D2200/1664 , E02D2250/0023 , E04G13/00
摘要: A permanent frost protected shallow foundation footing for a building is assembled from a plurality of form parts arranged in a chain that is partially below ground level to form a foundation perimeter. The form parts are made of a lightweight material such as insulating foam material shaped as an elongated sectional unit with an overhang part overhanging a cavity part of an interior cavity. The interior cavity has an opening for receiving a concrete pour concurrent with a concrete pour of a floor. Open ends of the assembled sectional units abut each other in end-to-end alignment to form an elongated cavity inside the perimeter chain of form parts that is filled with concrete. The overhang part may have a foot shape that fits inside the interior cavity of another form part that may also have a foot shape for compact storage or transport prior to assembly.
摘要翻译: 用于建筑物的永久防霜保护的浅基础基础从布置在部分地下水平的链条中的多个形式部件组装以形成基础周边。 形状部件由轻质材料制成,例如形状为细长截面单元的绝缘泡沫材料,其具有悬垂在内部空腔的空腔部分上的突出部分。 内部空腔具有用于接收混凝土浇注的开口,同时具有地板的混凝土浇筑。 组装的截面单元的开口端部以端对端的对准方式彼此邻接,以在填充有混凝土的成形部件的周边链条中形成细长的空腔。 突出部分可以具有适合在另一形状部分的内腔内的脚形,其也可以具有足部形状,用于在组装之前进行紧凑的存储或运输。
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公开(公告)号:US09011919B2
公开(公告)日:2015-04-21
申请号:US13615938
申请日:2012-09-14
申请人: David B. Rozema , David L. Lewis , Darren H. Wakefield , Torsten Hoffmann , Eric Kitas , Peter Mohr , Philipp Hadwiger , Wilma Thuer , Linda Valis
发明人: David B. Rozema , David L. Lewis , Darren H. Wakefield , Torsten Hoffmann , Eric Kitas , Peter Mohr , Philipp Hadwiger , Wilma Thuer , Linda Valis
IPC分类号: A61K9/14 , C07H21/02 , C07K1/00 , A61K47/32 , A61K9/08 , A61K48/00 , C12N15/11 , C12N15/87 , A61K47/48
CPC分类号: C12N15/113 , A61K9/08 , A61K31/713 , A61K47/32 , A61K47/549 , A61K47/60 , A61K47/65 , A61K48/0041 , C12N15/111 , C12N15/87 , C12N2310/14 , C12N2310/141 , C12N2310/3515 , C12N2320/32
摘要: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.
摘要翻译: 本发明涉及用于将体内RNA干扰(RNAi)多核苷酸靶向递送至肝细胞的组合物。 靶向RNAi多核苷酸与共靶向递送聚合物一起施用。 递送聚合物提供膜穿透功能,用于将RNAi多核苷酸从细胞外部移动到细胞内。 可逆修饰提供对递送聚合物的生理反应性。
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5.
公开(公告)号:US08640501B2
公开(公告)日:2014-02-04
申请号:US12080974
申请日:2008-04-08
申请人: Robin L. Flynn , David L. Lewis
发明人: Robin L. Flynn , David L. Lewis
IPC分类号: C03B11/00
摘要: A neck ring for molding a glass container neck finish that includes at least one closure attachment feature. The neck ring includes two semi-annular bi-metal neck ring halves, each consisting essentially of a neck ring insert of wear-resistant metal construction, and a neck ring body of heat-conductive metal construction different from said wear-resistant metal construction and formed around said neck ring insert so as to embed it in said neck ring body. Each of said neck ring halves has a glass-contacting cavity face that includes a first surface portion formed by said inserts for molding the at least one closure attachment feature on the neck finish, and a second surface portion formed by said bodies for molding portions of the neck finish excluding the at least one closure attachment feature.
摘要翻译: 用于模制玻璃容器颈部的颈环,其包括至少一个闭合附接特征。 颈环包括两个半环形双金属颈环半部,每个半环形二环颈部半部分基本上由耐磨金属结构的颈环插入件和不同于所述耐磨金属结构的导热金属结构的颈环体和 形成在所述颈环插入件周围,以便将其嵌入所述颈环体中。 每个所述颈环半部具有玻璃接触腔体表面,其包括由所述插入件形成的第一表面部分,所述第一表面部分用于模制颈部末端处的至少一个封闭附接特征,以及由所述主体形成的第二表面部分,用于模制部分 不包括至少一个闭合件附接特征的颈部完成。
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公开(公告)号:US08137695B2
公开(公告)日:2012-03-20
申请号:US11840468
申请日:2007-08-17
申请人: David B. Rozema , James E. Hagstrom , Jason Klein , David L. Lewis , Sean D. Monahan , Darren H. Wakefield , Jon A. Wolff , So Wong
发明人: David B. Rozema , James E. Hagstrom , Jason Klein , David L. Lewis , Sean D. Monahan , Darren H. Wakefield , Jon A. Wolff , So Wong
CPC分类号: C12N15/87 , A01K2217/058 , A01K2267/0362 , A61K47/58 , A61K48/0041
摘要: The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.
摘要翻译: 本发明涉及可用于将多核苷酸或其它细胞不可渗透分子递送至哺乳动物细胞的化合物,组合物和方法。 描述了将靶向,抗调理作用,抗聚集和转染活性结合到小的生物相容性体内递送载体中的多偶联体系。 连接组成部分的多个可逆连接的使用提供了生理响应活性调节。
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公开(公告)号:US20110271626A1
公开(公告)日:2011-11-10
申请号:US13101331
申请日:2011-05-05
申请人: David L. Lewis
发明人: David L. Lewis
IPC分类号: E04B1/78
CPC分类号: E04D13/1625 , E04B1/7654 , E04B2001/7691
摘要: A thermal barrier is formed into a hat-shape by folding sections of an extended length of board formed for assembly and insertion as a barrier to thermal radiation into a space between two joists or studs of a floor, wall, roof, or ceiling of a building for completely covering the space while also covering protruding edges of the joists or studs so as to reduce thermal energy transfer through the joists or studs themselves. A thermal barrier assembly is shown with an outer reflective surface and is also shown for assembly into a form having an inner enclosure for enclosing an inner thermal barrier also having a reflective surface for reducing thermal radiation transfer by reflection and protected from dust by virtue of the enclosure.
摘要翻译: 通过将形成的用于组装和插入的延伸长度的板的部分折叠成热辐射的屏障,将热障形成折叠成一个地板,墙壁,屋顶或天花板的两个托梁或螺柱之间的空间,形成帽子形状 用于完全覆盖空间的同时还覆盖托梁或螺柱的突出边缘,以便减少通过托梁或螺柱本身的热能传递。 热屏障组件被示出具有外部反射表面,并且还示出为用于组装成具有用于封闭内部热障壁的形式的形式,其还具有反射表面,用于通过反射减少热辐射传递并且通过反射表面防止灰尘 外壳。
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公开(公告)号:US20080273435A1
公开(公告)日:2008-11-06
申请号:US11689741
申请日:2007-03-22
申请人: Darko Kirovski , Estrada T. Colon , David L. Lewis , Thomas Patrick Powell , Deepak Vijaywargiay
发明人: Darko Kirovski , Estrada T. Colon , David L. Lewis , Thomas Patrick Powell , Deepak Vijaywargiay
IPC分类号: G11B7/085
CPC分类号: H04L9/3247 , G11B20/00086 , G11B20/00123 , H04L2209/30 , H04L2209/603
摘要: The claimed subject matter relates to architectures and/or mechanisms that can facilitate issuing, embedding and verification of an optical DNA (o-DNA) signature. A first mechanism is provided for obtaining a set of manufacturing errors inherent in an optical media instance. These errors can be encoded into the o-DNA that can be cryptographically signed with a private key, then embedded into the source optical media instance. A second mechanism is provided that can decrypt the o-DNA with a public key and compare the authenticated errors to the observed errors to ascertain whether the optical media instance is authentic as opposed to a forgery or counterfeit.
摘要翻译: 所要求保护的主题涉及可以促进光学DNA(o-DNA)签名的发布,嵌入和验证的架构和/或机制。 提供了一种用于获得光学介质实例中固有的一组制造误差的第一机构。 这些错误可以编码到可以使用私钥进行加密签名的o-DNA中,然后嵌入到源光学媒体实例中。 提供了可以使用公开密钥来解密o-DNA的第二种机制,并将认证的错误与观察到的错误进行比较,以确定光学媒体实例是否与伪造或伪造相反是真实的。
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公开(公告)号:US07101995B2
公开(公告)日:2006-09-05
申请号:US10157674
申请日:2002-05-28
申请人: David L. Lewis , James E. Hagstrom , Hans Herweijer , Aaron G. Loomis , Sean D. Monahan , Jon A. Wolff
发明人: David L. Lewis , James E. Hagstrom , Hans Herweijer , Aaron G. Loomis , Sean D. Monahan , Jon A. Wolff
CPC分类号: C12N15/1137 , A61K31/58 , A61K31/74 , A61K38/00 , A61K48/00 , C12N15/111 , C12N15/88 , C12N2310/14 , C12N2320/32 , C12N2710/24111 , C12Y206/01002 , A61K2300/00
摘要: Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal cell or more particularly, a mammal cell.
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公开(公告)号:US5198114A
公开(公告)日:1993-03-30
申请号:US306104
申请日:1989-02-06
申请人: David L. Lewis , Gene E. Michaels
发明人: David L. Lewis , Gene E. Michaels
CPC分类号: C02F3/34 , A01K63/045 , C02F1/283
摘要: A water filter provides good tasting, potable water without chemical biocides. A water filter utilizing activated carbon to rid the water of undesirable chemicals and the like has dolomite added to the activated carbon. The dolomite acts as a nutrient for harmless bacteria and thereby promotes the growth of the harmless bacteria to the exclusion of harmful bacteria. Dolomite produces a slight alkalinity for improved taste, provides magnesium and calcium as dietary supplements, and encourages the growth of bacteria that produce no undesirable metabolites.
摘要翻译: 水过滤器提供良好的品尝,饮用水没有化学杀菌剂。 利用活性炭除去不希望有的化学品等的水的滤水器将白云石加入到活性炭中。 白云岩作为无害细菌的营养物,从而促进无害细菌的生长,排除有害细菌。 白云石产生轻微的碱度以改善味道,提供镁和钙作为膳食补充剂,并鼓励不产生不需要的代谢物的细菌的生长。
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