公开(公告)号：US07613133B2

公开(公告)日：2009-11-03

申请号：US10379801

申请日：2003-03-06

申请人： David M Pullen ,  Richard Schwartz ,  Kevin E O'Neal ,  John McQueen

发明人： David M Pullen ,  Richard Schwartz ,  Kevin E O'Neal ,  John McQueen

IPC分类号： H04L12/28

CPC分类号： H04L47/2433 ,  H04L12/2801 ,  H04L47/10 ,  H04L47/15 ,  H04L47/32 ,  H04L47/50 ,  H04L47/625 ,  H04L49/90

摘要： A system and method for processing information transport elements, such as ethernet packets, at interfaces to a forwarder. Modules that implement processing logic are allocated per interface and per direction (i.e., inbound or outbound). At any given interface, a series of modules would be used to process inbound packets; likewise, a set of modules would be used to process outbound packets. For inbound packets, the modules allocated for inbound processing are executed when the packet is received from the interface, before sending the packet on to the forwarder. For packets that are outbound from the forwarder, the modules allocated for outbound processing are applied when the packet is sent by the forwarder, prior to any other processing, e.g., queuing to hardware. To assign modules to different interfaces at a forwarder, a registration process is performed during the system start-up process, or dynamically at runtime. For any given interface and direction, modules can be prioritized, so that a packet is processed sequentially in a specific order, one module after the other.

摘要翻译： 一种用于在与转发器的接口处理诸如以太网分组之类的信息传输元件的系统和方法。 根据接口和每个方向（即入站或出站）分配实现处理逻辑的模块。 在任何给定的接口，一系列模块将用于处理入站数据包; 同样，一组模块将用于处理出站数据包。 对于入站数据包，在将数据包发送到转发器之前，从接口接收到数据包时，执行分配用于入站处理的模块。 对于从转发器出站的数据包，在进行任何其他处理（例如排队到硬件）之前，当转发器发送数据包时，分配用于出站处理的模块被应用。 要在转发器处将模块分配给不同的接口，在系统启动过程中或在运行时动态执行注册过程。 对于任何给定的接口和方向，可以对模块进行优先级排序，以便以特定顺序顺序处理数据包，一个接一个地进行处理。

公开(公告)号：US07715393B2

公开(公告)日：2010-05-11

申请号：US10448028

申请日：2003-05-30

申请人： David M Pullen ,  Richard Schwartz ,  Kevin E O'Neal ,  John McQueen

发明人： David M Pullen ,  Richard Schwartz ,  Kevin E O'Neal ,  John McQueen

IPC分类号： H04L12/28

CPC分类号： H04L47/2433 ,  H04L12/2801 ,  H04L47/10 ,  H04L47/15 ,  H04L47/32 ,  H04L47/50 ,  H04L47/625 ,  H04L49/90

摘要： A system and method for processing information transport elements, such as ethernet packets, at interfaces to a forwarder. Modules that implement processing logic are allocated per interface and per direction (i.e., inbound or outbound). At any given interface, a series of modules would be used to process inbound packets; likewise, a set of modules would be used to process outbound packets. For inbound packets, the modules allocated for inbound processing are executed when the packet is received from the interface, before sending the packet on to the forwarder. For packets that are outbound from the forwarder, the modules allocated for outbound processing are applied when the packet is sent by the forwarder, prior to any other processing, e.g., queuing to hardware. To assign modules to different interfaces at a forwarder, a registration process is performed during the system start-up process, or dynamically at runtime. For any given interface and direction, modules can be prioritized, so that a packet is processed sequentially in a specific order, one module after the other.

摘要翻译： 一种用于在与转发器的接口处理诸如以太网分组之类的信息传输元件的系统和方法。 根据接口和每个方向（即入站或出站）分配实现处理逻辑的模块。 在任何给定的接口，一系列模块将用于处理入站数据包; 同样，一组模块将用于处理出站数据包。 对于入站数据包，在将数据包发送到转发器之前，从接口接收到数据包时，执行分配用于入站处理的模块。 对于从转发器出站的数据包，在进行任何其他处理（例如排队到硬件）之前，当转发器发送数据包时，分配用于出站处理的模块被应用。 要在转发器处将模块分配给不同的接口，在系统启动过程中或在运行时动态执行注册过程。 对于任何给定的接口和方向，可以对模块进行优先级排序，以便以特定顺序顺序处理数据包，一个接一个地进行处理。

公开(公告)号：US08504708B2

公开(公告)日：2013-08-06

申请号：US12829145

申请日：2010-07-01

申请人： Gordon Yong Li ,  Xuemin Chen ,  John McQueen ,  Sam Anderson ,  Pierre Couilaud ,  Richard Schwartz

发明人： Gordon Yong Li ,  Xuemin Chen ,  John McQueen ,  Sam Anderson ,  Pierre Couilaud ,  Richard Schwartz

IPC分类号： G06F15/16

CPC分类号： H04L41/0813 ,  H04L12/281 ,  H04L12/2834 ,  H04L12/2898 ,  H04L41/0816 ,  H04L65/1026 ,  H04L65/605

摘要： A common IP layer client device interface within an IP multimedia gateway (IMG) is configured to connect client devices to broadband IP networks such as the Internet based on determined device capabilities. Broadband IP network interfaces within the IMG are configured to enable communication between the IMG and broadband IP networks based on the determined device capabilities. Content provided by various service managers are communicated with the client devices utilizing the common IP layer client device interface and the configured network interfaces. Network capabilities may be determined during the device and network discovery. Protocol translation, media transcoding and/or dynamic device configuration may be performed based on the determined device capabilities, and based on the determined network capabilities. The IMG may adjust system timing and manage power consumptions for service deployment over corresponding client devices. Information may be routed or distributed by the IMRG among the client devices when needed.

公开(公告)号：US20120005360A1

公开(公告)日：2012-01-05

申请号：US12829145

申请日：2010-07-01

申请人： Gordon Yong Li ,  Xuemin Chen ,  John McQueen ,  Sam Anderson ,  Pierre Couilaud ,  Richard Schwartz

发明人： Gordon Yong Li ,  Xuemin Chen ,  John McQueen ,  Sam Anderson ,  Pierre Couilaud ,  Richard Schwartz

IPC分类号： G06F15/16

CPC分类号： H04L41/0813 ,  H04L12/281 ,  H04L12/2834 ,  H04L12/2898 ,  H04L41/0816 ,  H04L65/1026 ,  H04L65/605

摘要： A common IP layer client device interface within an IP multimedia gateway (IMG) is configured to connect client devices to broadband IP networks such as the Internet based on determined device capabilities. Broadband IP network interfaces within the IMG are configured to enable communication between the IMG and broadband IP networks based on the determined device capabilities. Content provided by various service managers are communicated with the client devices utilizing the common IP layer client device interface and the configured network interfaces. Network capabilities may be determined during the device and network discovery. Protocol translation, media transcoding and/or dynamic device configuration may be performed based on the determined device capabilities, and based on the determined network capabilities. The IMG may adjust system timing and manage power consumptions for service deployment over corresponding client devices. Information may be routed or distributed by the IMRG among the client devices when needed.

摘要翻译： IP多媒体网关（IMG）中的公共IP层客户端设备接口被配置为基于确定的设备能力将客户端设备连接到诸如因特网的宽带IP网络。 IMG中的宽带IP网络接口被配置为基于所确定的设备能力来实现IMG和宽带IP网络之间的通信。 使用公共IP层客户端设备接口和配置的网络接口，与客户端设备通信各种服务管理器提供的内容。 可以在设备和网络发现期间确定网络功能。 可以基于所确定的设备能力，并且基于所确定的网络能力来执行协议转换，媒体代码转换和/或动态设备配置。 IMG可以通过相应的客户端设备调整系统时间并管理服务部署的功耗。 当需要时，信息可以由客户端设备中的IMRG进行路由或分发。

公开(公告)号：US08846032B2

公开(公告)日：2014-09-30

申请号：US13595897

申请日：2012-08-27

申请人： Jonathan Liu ,  Richard Schwartz ,  Mark Thompson ,  Luis Maranga ,  Mridul Ghosh ,  Ajit Subramanian ,  Simon Sheng-Tsiung Hsu

发明人： Jonathan Liu ,  Richard Schwartz ,  Mark Thompson ,  Luis Maranga ,  Mridul Ghosh ,  Ajit Subramanian ,  Simon Sheng-Tsiung Hsu

IPC分类号： A61K39/145 ,  A01N65/00 ,  A61K39/00 ,  C12N5/02 ,  C07K17/00 ,  C12N7/00

CPC分类号： C12N7/00 ,  C12N2760/16151 ,  C12N2760/16152 ,  C12N2760/16251 ,  C12N2760/16252

摘要： The present invention relates to novel MDCK cells which can be to grow viruses, e.g., influenza viruses, in cell culture to higher titer than previously possible. The MDCK cells can be adapted to serum-free culture medium. The present invention further relates to cell culture compositions comprising the MDCK cells and cultivation methods for growing the MDCK cells. The present invention further relates to methods for producing influenza viruses in cell culture using the MDCK cells of the invention.

摘要翻译： 本发明涉及可以在细胞培养中将病毒（例如流感病毒）生长至比先前可能更高滴度的新型MDCK细胞。 MDCK细胞可适应于无血清培养基。 本发明还涉及包含MDCK细胞的细胞培养组合物和用于培养MDCK细胞的培养方法。 本发明还涉及使用本发明的MDCK细胞在细胞培养中生产流感病毒的方法。

公开(公告)号：US08748174B2

公开(公告)日：2014-06-10

申请号：US13355252

申请日：2012-01-20

申请人： Richard Schwartz ,  John Michael Berry ,  Ajit Subramanian ,  Xiao Shi

发明人： Richard Schwartz ,  John Michael Berry ,  Ajit Subramanian ,  Xiao Shi

IPC分类号： C12N5/00 ,  C12N7/08 ,  C12N5/02

CPC分类号： C12N7/00 ,  C12N5/0037 ,  C12N5/0043 ,  C12N2500/36 ,  C12N2500/76 ,  C12N2500/90 ,  C12N2501/11 ,  C12N2501/395 ,  C12N2510/02 ,  C12N2760/16151 ,  C12N2760/16161 ,  C12N2760/16251 ,  C12N2760/16261

摘要： The present invention provides novel MDCK-derived adherent non-tumorigenic cell lines that can be grown in the presence or absence of serum. The cell lines of the present invention are useful for the production of vaccine material (e.g., viruses). More specifically, the cell lines of the present invention are useful for the production of influenza viruses in general and ca/ts influenza viruses in particular. The invention further provides methods and media formulations for the adaptation and cultivation of MDCK cells such that they remain non-tumorigenic. Additionally, the present invention provides methods for the production of vaccine material (e.g., influenza virus) in the novel cell lines of the invention.

摘要翻译： 本发明提供可在血清存在或不存在的情况下生长的新型MDCK衍生的粘附性非致瘤细胞系。 本发明的细胞系可用于生产疫苗材料（例如病毒）。 更具体地说，本发明的细胞系通常用于生产流感病毒，尤其是流感病毒。 本发明还提供了用于适应和培养MDCK细胞的方法和培养基制剂，使得它们保持非致瘤性。 此外，本发明提供了在本发明的新型细胞系中生产疫苗材料（例如流感病毒）的方法。

公开(公告)号：US08336541B2

公开(公告)日：2012-12-25

申请号：US12592406

申请日：2009-11-24

申请人： John Schwartz ,  Richard Schwartz ,  Christopher L. Hogg

发明人： John Schwartz ,  Richard Schwartz ,  Christopher L. Hogg

IPC分类号： A61M11/00

CPC分类号： A61M16/0488 ,  A61B1/267 ,  A61M16/0418 ,  A61M16/0434

摘要： An endotracheal intubation device 10 is disclosed. The endotracheal intubation device 10 includes a stylet 100, an elongate rod 300 mounted within the stylet 100 and adapted to deform/curve the stylet 100 as well as an endotracheal tube 400 mounted thereto by contacting an inner wall of the endotracheal tube 400 via a slot 130 through which the rod 300 bows outwardly, and a handle 200 mounted to the stylet 100 and adapted to actuate the elongate rod 300 to deform/curve the stylet 100. The endotracheal intubation device 10 can be used on a patient by a medical professional to access the patient's trachea by inserting the endotracheal tube 400 into the patient. Upon insertion, the handle 200 is actuated to deform the stylet 100.

摘要翻译： 公开了一种气管内插管装置10。 气管内插管装置10包括探针装置100，安装在探针100内的细长杆300，并且适于使探针管100变形/弯曲，以及通过气管插管400的内壁经由插槽 130，杆300通过其向外弯曲;以及手柄200，其安装到探针100上并且适于致动细长杆300以使管心针100变形/弯曲。气管插管装置10可由医疗专业人员在患者身上使用 通过将气管插管400插入患者来进入病人的气管。 在插入时，手柄200被致动以使探针100变形。

公开(公告)号：US20120115206A1

公开(公告)日：2012-05-10

申请号：US13355252

申请日：2012-01-20

申请人： Richard Schwartz ,  John Michael Berry ,  Ajit Subramanian ,  Xiao Shi

发明人： Richard Schwartz ,  John Michael Berry ,  Ajit Subramanian ,  Xiao Shi

IPC分类号： C12N7/04 ,  C12N7/02

CPC分类号： C12N7/00 ,  C12N5/0037 ,  C12N5/0043 ,  C12N2500/36 ,  C12N2500/76 ,  C12N2500/90 ,  C12N2501/11 ,  C12N2501/395 ,  C12N2510/02 ,  C12N2760/16151 ,  C12N2760/16161 ,  C12N2760/16251 ,  C12N2760/16261

摘要： The present invention provides novel MDCK-derived adherent non-tumorigenic cell lines that can be grown in the presence or absence of serum. The cell lines of the present invention are useful for the production of vaccine material (e.g., viruses). More specifically, the cell lines of the present invention are useful for the production of influenza viruses in general and ca/ts influenza viruses in particular. The invention further provides methods and media formulations for the adaptation and cultivation of MDCK cells such that they remain non-tumorigenic. Additionally, the present invention provides methods for the production of vaccine material (e.g., influenza virus) in the novel cell lines of the invention.

摘要翻译： 本发明提供可在血清存在或不存在的情况下生长的新型MDCK衍生的粘附性非致瘤细胞系。 本发明的细胞系可用于生产疫苗材料（例如病毒）。 更具体地说，本发明的细胞系通常用于生产流感病毒，尤其是流感病毒。 本发明还提供了用于适应和培养MDCK细胞的方法和培养基制剂，使得它们保持非致瘤性。 此外，本发明提供了在本发明的新型细胞系中生产疫苗材料（例如流感病毒）的方法。

公开(公告)号：US20110196204A1

公开(公告)日：2011-08-11

申请号：US12931746

申请日：2011-02-09

申请人： Harsha Setty ,  Richard Schwartz ,  John Schwartz

发明人： Harsha Setty ,  Richard Schwartz ,  John Schwartz

IPC分类号： A61M16/04 ,  A61B1/04 ,  A61B1/06

CPC分类号： A61M16/04 ,  A61B1/00052 ,  A61B1/00154 ,  A61B1/0052 ,  A61B1/0056 ,  A61B1/0058 ,  A61B1/018 ,  A61B1/267 ,  A61M16/0418 ,  A61M16/0431 ,  A61M16/0488 ,  A61M2205/502

摘要： The disclosure generally relates to an endotracheal intubation device 100 including a channel element 120 that defines a first channel 122 and additional retaining structure that defines a second channel 140. The device 100 is reversibly movable between a first relaxed position A (e.g., a generally extended or straight position) and a second curved position B (e.g., an articulated, generally non-linear position) with an articulating means 160. An endotracheal tube 200 can be inserted into the second channel 140, and the intubation device 100 then can be used to intubate a patient P according to a disclosed intubation method.

摘要翻译： 本公开内容通常涉及气管插管装置100，其包括限定第一通道122的通道元件120和限定第二通道140的附加保持结构。装置100可在第一松弛位置A（例如，大体上延伸 或直线位置）和第二弯曲位置B（例如，铰接的，大致非线性位置）具有关节运动装置160.气管插管200可插入第二通道140中，然后可以使用插管装置100 根据所公开的插管方法插管患者P。

公开(公告)号：US20110137127A1

公开(公告)日：2011-06-09

申请号：US12928126

申请日：2010-12-03

申请人： John Schwartz ,  Richard Schwartz ,  Harsha Setty

发明人： John Schwartz ,  Richard Schwartz ,  Harsha Setty

IPC分类号： A61B1/267

CPC分类号： A61B1/267 ,  A61B1/00052 ,  A61B1/05 ,  A61B1/2673

摘要： A system and method are disclosed for using a laryngoscope blade with a camera and an endotracheal intubation device with a camera to enable simultaneous viewing of images from the two cameras on a display means such as an LCD display screen. The system enables accurate insertion and placement of an endotracheal tube in a patient with less risk to the patient.

摘要翻译： 公开了一种用于使用具有照相机的喉镜刀片和具有照相机的气管插管装置的系统和方法，以能够在诸如LCD显示屏的显示装置上同时观看来自两个照相机的图像。 该系统能够将患者的气管插管精确插入和放置在病人身上，风险较小。