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公开(公告)号：US5633279A
公开(公告)日：1997-05-27
申请号：US483042
申请日：1995-06-06
申请人： David Morgans, Jr. , David B. Smith , Francisco X. Talam as , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fern andez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , John W. Patterson , John C. Rohloff , Eric B. Sjogren , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
发明人： David Morgans, Jr. , David B. Smith , Francisco X. Talam as , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fern andez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , John W. Patterson , John C. Rohloff , Eric B. Sjogren , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
IPC分类号： A61K31/34 , A61K31/365 , A61K31/38 , A61K31/40 , A61K31/4025 , A61K31/42 , A61P17/00 , A61P29/00 , A61P35/00 , A61P37/06 , C07D307/83 , C07D307/88 , C07D405/06 , C07D405/10 , C07D407/06 , C07D407/10 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/12 , C07F9/655 , A61K31/445 , A61K31/535
CPC分类号： C07D405/06 , C07D307/88 , C07D407/06 , C07D409/06 , C07D413/06 , C07F9/65517
摘要： The disclosed hexenoic acid side-chain derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil, including immune, inflammatory, tumor, proliferative, viral or psoriatic disorders.
摘要翻译： 公开的霉酚酸的己烯酸侧链衍生物是治疗药物，其有利于治疗指示霉酚酸和/或霉酚酸酯的疾病状态，包括免疫，炎性，肿瘤，增殖性，病毒性或牛皮癣性疾病。
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公开(公告)号：US5538969A
公开(公告)日：1996-07-23
申请号：US452245
申请日：1995-05-26
申请人： David Morgans, Jr. , Eric B. Sjogren , David B. Smith , Francisco X. Talam as , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fern andez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , John W. Patterson , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
发明人： David Morgans, Jr. , Eric B. Sjogren , David B. Smith , Francisco X. Talam as , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fern andez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , John W. Patterson , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
IPC分类号： A61K31/34 , A61K31/365 , A61K31/38 , A61K31/40 , A61K31/4025 , A61P17/00 , A61P29/00 , A61P37/06 , C07D307/88 , C07D405/06 , C07D407/06 , C07D409/06 , A61K31/535 , C07D413/12
CPC分类号： C07D405/06 , C07D307/88 , C07D407/06 , C07D409/06
摘要： The disclosed derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil and other immunosuppressant agents.
摘要翻译： 公开的霉酚酸衍生物是治疗针对霉酚酸和/或霉酚酸酯和其它免疫抑制剂的疾病状态的治疗剂。
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公开(公告)号：US5493030A
公开(公告)日：1996-02-20
申请号：US198749
申请日：1994-02-18
申请人： David Morgans, Jr. , David B. Smith , Francisco X. Talamas , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fernandez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , John W. Patterson , John C. Rohloff , Eric B. Sjogren , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
发明人： David Morgans, Jr. , David B. Smith , Francisco X. Talamas , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fernandez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , John W. Patterson , John C. Rohloff , Eric B. Sjogren , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
IPC分类号： A61K31/34 , A61K31/365 , A61K31/38 , A61K31/40 , A61K31/4025 , A61K31/42 , A61P17/00 , A61P29/00 , A61P35/00 , A61P37/06 , C07D307/83 , C07D307/88 , C07D405/06 , C07D405/10 , C07D407/06 , C07D407/10 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/12 , C07F9/655 , C07D263/22
CPC分类号： C07D405/06 , C07D307/88 , C07D407/06 , C07D409/06 , C07D413/06 , C07F9/65517
摘要： The disclosed hexenoic acid side-chain derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil, including immune, inflammatory, tumor, proliferative, viral or psoriatic disorders.
摘要翻译： 公开的霉酚酸的己烯酸侧链衍生物是治疗剂，其用于治疗指示霉酚酸和/或霉酚酸酯的疾病状态，包括免疫，炎症，肿瘤，增殖性，病毒性或银屑病性疾病。
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4.发明授权
公开(公告)号：US5512568A
公开(公告)日：1996-04-30
申请号：US198732
申请日：1994-02-18
申请人： David Morgans, Jr. , Eric B. Sjogren , David B. Smith , Francisco X. Talamas , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fernandez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , John W. Patterson , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
发明人： David Morgans, Jr. , Eric B. Sjogren , David B. Smith , Francisco X. Talamas , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fernandez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , John W. Patterson , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
IPC分类号： A61K31/34 , A61K31/365 , A61K31/38 , A61K31/40 , A61K31/4025 , A61P17/00 , A61P29/00 , A61P37/06 , C07D307/88 , C07D405/06 , C07D407/06 , C07D409/06 , A61K31/535
CPC分类号： C07D405/06 , C07D307/88 , C07D407/06 , C07D409/06
摘要： The disclosed derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil and other immunosuppressant agents.
摘要翻译： 公开的霉酚酸衍生物是治疗针对霉酚酸和/或霉酚酸酯和其它免疫抑制剂的疾病状态的治疗剂。
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公开(公告)号：US5444072A
公开(公告)日：1995-08-22
申请号：US198725
申请日：1994-02-18
申请人： John W. Patterson , David Morgans, Jr. , David B. Smith , Francisco X. Talamas , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fernandez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , Eric B. Sjogren , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
发明人： John W. Patterson , David Morgans, Jr. , David B. Smith , Francisco X. Talamas , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fernandez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , Eric B. Sjogren , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
IPC分类号： C07D307/88 , A61K20060101 , A61K31/34 , A61K31/341 , A61K31/365 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/4025 , A61K31/445 , A61K31/535 , A61K31/54 , A61P17/00 , A61P29/00 , A61P35/00 , A61P37/06 , C07D20060101 , C07D307/83 , C07D405/02 , C07D405/06 , C07D405/10 , C07D405/12 , C07D407/06 , C07D407/10 , C07D407/12 , C07D409/06 , C07D409/10 , C07D413/00 , C07D413/12 , C07D417/00 , C07D417/12
CPC分类号： C07D307/83
摘要： The disclosed 6-substituted derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil.
摘要翻译： 所公开的麦考酚酸的6-取代衍生物是治疗药物，其有利于治疗针对霉酚酸和/或霉酚酸酯的疾病状态。
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公开(公告)号：US5536747A
公开(公告)日：1996-07-16
申请号：US435255
申请日：1995-05-05
申请人： John W. Patterson , David Morgans, Jr. , David B. Smith , Fancisco X. Talamas , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fernandez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , Eric B. Sjogren , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
发明人： John W. Patterson , David Morgans, Jr. , David B. Smith , Fancisco X. Talamas , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fernandez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , Eric B. Sjogren , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
IPC分类号： C07D307/88 , A61K20060101 , A61K31/34 , A61K31/341 , A61K31/365 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/4025 , A61K31/445 , A61K31/535 , A61K31/54 , A61P17/00 , A61P29/00 , A61P35/00 , A61P37/06 , C07D20060101 , C07D307/83 , C07D405/02 , C07D405/06 , C07D405/10 , C07D405/12 , C07D407/06 , C07D407/10 , C07D407/12 , C07D409/06 , C07D409/10 , C07D413/00 , C07D413/12 , C07D417/00 , C07D417/12
CPC分类号： C07D307/83
摘要： The disclosed 6-substituted derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil.
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7.发明授权
公开(公告)号：US5525602A
公开(公告)日：1996-06-11
申请号：US198741
申请日：1994-02-18
申请人： John W. Patterson , David Morgans, Jr. , Eric B. Sjogren , David B. Smith , Francisco X. Talamas , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fernandez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
发明人： John W. Patterson , David Morgans, Jr. , Eric B. Sjogren , David B. Smith , Francisco X. Talamas , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fernandez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
IPC分类号： A61K31/365 , A61K31/38 , A61K31/40 , A61K31/4025 , A61P17/00 , A61P29/00 , A61P35/00 , A61P37/06 , C07D307/88 , C07D405/06 , C07D407/06 , C07D409/06 , A61K31/535
CPC分类号： C07D307/88
摘要： The disclosed derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil and other immunosuppressant agents.
摘要翻译： 公开的霉酚酸衍生物是治疗针对霉酚酸和/或霉酚酸酯和其它免疫抑制剂的疾病状态的治疗剂。
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公开(公告)号：US5622948A
公开(公告)日：1997-04-22
申请号：US347915
申请日：1994-12-01
申请人： James P. Dunn , Chakk S. Ramesha , Jim W. Barnett , Denis J. Kertesz , Aaron B. Miller , David Morgans, Jr. , C. Elliott Sigal , Eric B. Sjogren , David B. Smith , Francisco X. Talamas
发明人： James P. Dunn , Chakk S. Ramesha , Jim W. Barnett , Denis J. Kertesz , Aaron B. Miller , David Morgans, Jr. , C. Elliott Sigal , Eric B. Sjogren , David B. Smith , Francisco X. Talamas
IPC分类号： C07D401/06 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/495 , A61K31/50 , A61P25/04 , A61P29/00 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14
CPC分类号： C07D403/06
摘要： Pyrrole pyridazine and pyridazinone compounds are described. These compounds are useful as anti-inflammatory agents in the treatment of inflammation and pain. The preparation of these compounds, their pharmaceutically acceptable salts, and pharmaceutical compositions containing these compounds, is also described.
摘要翻译： 描述了吡咯哒嗪和哒嗪酮化合物。 这些化合物可用作治疗炎症和疼痛的抗炎剂。 还描述了这些化合物的制备，其药学上可接受的盐和含有这些化合物的药物组合物。
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公开(公告)号：US5886178A
公开(公告)日：1999-03-23
申请号：US864708
申请日：1997-05-28
申请人： Darin A. Allen , James P. Dunn , Eric B. Sjogren , David B. Smith
发明人： Darin A. Allen , James P. Dunn , Eric B. Sjogren , David B. Smith
IPC分类号： A61K31/50 , A61P25/04 , A61P29/00 , C07D237/14 , C07D401/10 , C07D405/10 , C07D409/10 , C07D237/04
CPC分类号： C07D237/14
摘要： Compounds of formula I: ##STR1## where: R.sub.10 is a group represented by formula (A), (B), or (C): ##STR2## and the other substituents are as defined in the specification; and their pharmaceutically acceptable salts are inhibitors of prostaglandin G/H synthase and are anti-inflammatory and analgesic agents.
摘要翻译： 式I的化合物：其中：R 10是由式（A），（B）或（C）表示的基团：其中取代基如上定义 在规范中; 其药学上可接受的盐是前列腺素G / H合酶的抑制剂，并且是抗炎和止痛剂。
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公开(公告)号：US20100264194A1
公开(公告)日：2010-10-21
申请号：US12765330
申请日：2010-04-22
申请人： Zhifan F. Huang , Chad P. Boudreaux , Joseph C. Hueil , Dean B. Bruewer , Aron O. Zingman , David B. Smith , Geoffrey C. Hueil , Hector Chow , Mark R. Shaw
发明人： Zhifan F. Huang , Chad P. Boudreaux , Joseph C. Hueil , Dean B. Bruewer , Aron O. Zingman , David B. Smith , Geoffrey C. Hueil , Hector Chow , Mark R. Shaw
IPC分类号： A61B17/068
CPC分类号： A61B17/068 , A61B17/07207 , A61B2017/00318 , A61B2017/00734 , A61B2017/07214 , A61B2017/07285 , A61B2017/2913 , A61B2017/2916 , A61B2017/2923 , A61B2017/2927 , A61B2017/2929 , A61B2017/2943 , A61B2017/2946 , A61B2090/0811
摘要： A surgical instrument can comprise a channel configured to support a staple cartridge and, in addition, an anvil pivotable between open and closed positions relative to the channel. The surgical instrument can further comprise a cutting member configured to incise tissue positioned captured between the staple cartridge and the anvil and, in addition, means for stopping the cutting member prior to a distal end datum, wherein the distal end datum can be defined by the distal-most staple cavity in the staple cartridge. In such embodiments, the incision within the tissue may not extend beyond the portion of the tissue that has been stapled.
摘要翻译： 外科器械可以包括构造成支撑钉仓的通道，并且还包括相对于通道在可开启和关闭位置之间枢转的砧座。 外科器械还可以包括切割构件，其被配置为切割捕获在钉仓和砧座之间的组织，并且还包括用于在远端基准之前停止切割构件的装置，其中远端基准可以由 钉仓中最常见的缝隙腔。 在这样的实施例中，组织内的切口不能延伸超过已被装订的组织的部分。
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