-
1.发明申请Bio-Absorbable Micro-Clip And Applicator For Minimal Access Wound Closure 审中-公开生物可吸收的微型夹子和敷料器，用于最小的进入伤口闭合公开(公告)号：US20140188135A1
公开(公告)日：2014-07-03
申请号：US14124558
申请日：2012-06-11
申请人： David Pang Cheng Lau , Chee Kong Chui , Chin Boon Chng , Jun Quan Choo , Tao Yang , Swee Hin Teoh
发明人： David Pang Cheng Lau , Chee Kong Chui , Chin Boon Chng , Jun Quan Choo , Tao Yang , Swee Hin Teoh
CPC分类号： A61B17/083 , A61B17/0643 , A61B17/0644 , A61B17/0682 , A61B17/10 , A61B17/24 , A61B2017/00004 , A61B2017/00862
摘要： The present disclosure includes a bio-absorbable wound closure clip for wound closure without crushing of the tissue being closed. The bio-absorbable wound closure clip can be used in minimal access surgery as well as on tissue, such as mucosal tissue, where tactile feedback is reduced. Representative surgical instruments for applying the bio-absorbable wound closure clip and methods of using the same are also provided herein.
摘要翻译： 本公开内容包括用于伤口闭合的生物吸收性伤口闭合夹，而不破坏被关闭的组织。 生物可吸收伤口闭合夹可用于最小的手术以及组织，如粘膜组织，其中触觉反馈减少。 用于施用生物吸收性伤口闭合夹的代表性手术器械及其使用方法也在本文中提供。
-
公开(公告)号：US20110307073A1
公开(公告)日：2011-12-15
申请号：US13124161
申请日：2009-10-19
申请人： Swee Hin Teoh , Hae-Ryong Song , Soi Khoon Yew , Kelvin Hong Yap Koh , Ji Hoon Bae , Joon Ho Wang
发明人： Swee Hin Teoh , Hae-Ryong Song , Soi Khoon Yew , Kelvin Hong Yap Koh , Ji Hoon Bae , Joon Ho Wang
CPC分类号： A61F2/28 , A61F2/3094 , A61F2002/30062 , A61F2002/30235 , A61F2002/3024 , A61F2002/3092 , A61F2210/0004 , A61F2230/0069 , A61F2240/001 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/406 , A61L2300/414 , A61L2300/416 , A61L2300/426 , A61L2300/64 , C08L67/04
摘要： Bioresorbable scaffolds for bone engineering, such as repair of bone defects, particularly long bone defects, or augmentation of bone length are described. Scaffolds are porous and comprise multiple side channels. In one embodiment, scaffolds are made from layers of micro-filament meshes comprising polycaprolactone (PCL) or a PCL-composite sequentially laid in incremental 60 degrees of rotation to produce a 0/60/120 degree layering pattern, providing for the formation of interconnected pores. The scaffold can comprise a central channel filled, packed or infused with suitable agents such as bioactive agents. Furthermore, the scaffolds are stiff but yet fracture resistant and with sufficient bending, compressive and torsional strength suitable for bone engineering. The slow degradation of the scaffold is sufficient for the 3D matrix to maintain structure integrity and mechanical properties during the remodelling process.
摘要翻译： 描述了用于骨工程的生物可再吸收支架，例如修复骨缺损，特别是长骨缺损或增加骨长度。 支架是多孔的并且包括多个侧通道。 在一个实施方案中，支架由包含聚己内酯（PCL）或PCL-复合物的微细丝网层由顺序地以增量60度旋转顺序地铺设以产生0/60/120度分层图案，从而形成互连 毛孔 支架可以包括填充，包装或注入合适试剂如生物活性剂的中心通道。 此外，支架是刚性的但是具有抗断裂性，并且具有适于骨工程的足够的弯曲，压缩和扭转强度。 支架的缓慢降解足以使3D矩阵在重构过程中保持结构完整性和机械性能。
-
公开(公告)号：US07604987B2
公开(公告)日：2009-10-20
申请号：US11124618
申请日：2005-05-06
申请人： Dietmar W. Hutmacher , Swee Hin Teoh , Manoja Ranawake , Woon Shin Chong , Keng Soon Ting , Kay Chiang Chua , Than Myint , Chum Mok Puah , Toon Tien Foo , Jan-Thorsten Schantz
发明人： Dietmar W. Hutmacher , Swee Hin Teoh , Manoja Ranawake , Woon Shin Chong , Keng Soon Ting , Kay Chiang Chua , Than Myint , Chum Mok Puah , Toon Tien Foo , Jan-Thorsten Schantz
IPC分类号： C12M1/00
摘要： The invention relates to a bioreactor comprising a chamber for containing cells or tissue cultures within a culture medium. The bioreactor also comprises a detector capable of detecting a change in one or more metabolites associated with growth of the cell or tissue cultures within the chamber and a chamber drive capable of rotating the chamber at a first speed about a first axis and a second speed about a second axis, the second axis being disposed at an angle relative to the first axis. In use, the magnitude of the first speed and the second speed are independently variable of each other.
摘要翻译： 本发明涉及包含用于在培养基中含有细胞或组织培养物的室的生物反应器。 生物反应器还包括检测器，其能够检测与腔室内的细胞或组织培养物生长有关的一种或多种代谢物的变化，以及能够围绕第一轴线以第二速度围绕第一速度旋转腔室的腔室驱动器 第二轴线，第二轴线相对于第一轴线成一角度设置。 在使用中，第一速度和第二速度的大小彼此独立地变化。
-
4.发明授权公开(公告)号：US07968026B1
公开(公告)日：2011-06-28
申请号：US10828477
申请日：2004-04-20
IPC分类号： B29C47/06 , B29C35/00 , B29C41/02 , B29C67/00 , B29C67/20 , D04H1/16 , D01D5/088 , D01F1/02 , A61F2/28
CPC分类号： D01F6/625 , A61L27/18 , A61L27/46 , A61L27/58 , B33Y10/00 , B33Y70/00 , B33Y80/00 , C08L67/04
摘要： The invention relates to the use of Fused Deposition Modeling to construct three-dimensional (3D) bioresorbable scaffolds from bioresorbable polymers such as polycaprolactone (PCL), or from composites of bioresorbable polymers and ceramics, such as polycaprolactone/hydroxyapatite (PCL/HA). Incorporation of a bioresorbable ceramic to produce a hybrid/composite material support provides the desired degradation and resorption kinetics. Such a composite material improves the biocompatibility and hard tissue integration and allows for increased initial flash spread of serum proteins. The basic resorption products of the composite also avoids the formation of an unfavorable environment for hard tissue cells due to a decreased pH. The scaffolds have applications in tissue engineering, e.g., in tissue engineering bone and cartilage.
摘要翻译： 本发明涉及使用熔融沉积建模从生物可吸收聚合物如聚己内酯（PCL）或由生物可再吸收聚合物和陶瓷如聚己内酯/羟基磷灰石（PCL / HA）的复合材料构成三维（3D）生物可吸收支架。 掺入生物可吸收陶瓷以产生混合/复合材料载体提供所需的降解和再吸收动力学。 这种复合材料改善了生物相容性和硬组织整合，并且允许增加血清蛋白的初始快速扩散。 复合材料的基本吸收产物也避免了由于pH降低而对硬组织细胞形成不利环境。 支架可用于组织工程，例如在组织工程骨和软骨中。
-
公开(公告)号：US08702808B2
公开(公告)日：2014-04-22
申请号：US13124161
申请日：2009-10-19
申请人： Swee Hin Teoh , Hae-Ryong Song , Soi Khoon Yew , Kelvin Hong Yap Koh , Ji Hoon Bae , Joon Ho Wang
发明人： Swee Hin Teoh , Hae-Ryong Song , Soi Khoon Yew , Kelvin Hong Yap Koh , Ji Hoon Bae , Joon Ho Wang
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2/3094 , A61F2002/30062 , A61F2002/30235 , A61F2002/3024 , A61F2002/3092 , A61F2210/0004 , A61F2230/0069 , A61F2240/001 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/406 , A61L2300/414 , A61L2300/416 , A61L2300/426 , A61L2300/64 , C08L67/04
摘要： Bioresorbable scaffolds for bone engineering, such as repair of bone defects, particularly long bone defects, or augmentation of bone length are described. Scaffolds are porous and comprise multiple side channels. In one embodiment, scaffolds are made from layers of micro-filament meshes comprising polycaprolactone (PCL) or a PCL-composite sequentially laid in incremental 60 degrees of rotation to produce a 0/60/120 degree layering pattern, providing for the formation of interconnected pores. The scaffold can comprise a central channel filled, packed or infused with suitable agents such as bioactive agents. Furthermore, the scaffolds are stiff but yet fracture resistant and with sufficient bending, compressive and torsional strength suitable for bone engineering. The slow degradation of the scaffold is sufficient for the 3D matrix to maintain structure integrity and mechanical properties during the remodelling process.
摘要翻译： 描述了用于骨工程的生物可再吸收支架，例如修复骨缺损，特别是长骨缺损或增加骨长度。 支架是多孔的并且包括多个侧通道。 在一个实施方案中，支架由包含聚己内酯（PCL）或PCL-复合物的微细丝网层由顺序地以增量60度旋转顺序地铺设以产生0/60/120度分层图案，从而形成互连 毛孔 支架可以包括填充，包装或注入合适试剂如生物活性剂的中心通道。 此外，支架是刚性的但是具有抗断裂性，并且具有适于骨工程的足够的弯曲，压缩和扭转强度。 支架的缓慢降解足以使3D矩阵在重构过程中保持结构完整性和机械性能。
-
公开(公告)号：US08071007B1
公开(公告)日：2011-12-06
申请号：US10828467
申请日：2004-04-20
IPC分类号： B29C41/02
CPC分类号： D01F6/625 , A61L27/18 , A61L27/46 , A61L27/58 , B33Y10/00 , B33Y70/00 , B33Y80/00 , C08L67/04
摘要： The invention relates to the use of Fused Deposition Modeling to construct three-dimensional (3D) bioresorbable scaffolds from bioresorbable polymers such as polycaprolactone (PCL), or from composites of bioresorbable polymers and ceramics, such as polycaprolactone/hydroxyapatite (PCL/HA). Incorporation of a bioresorbable ceramic to produce a hybrid/composite material support provides the desired degradation and resorption kinetics. Such a composite material improves the biocompatibility and hard tissue integration and allows for increased initial flash spread of serum proteins. The basic resorption products of the composite also avoids the formation of an unfavorable environment for hard tissue cells due to a decreased pH. The scaffolds have applications in tissue engineering, e.g., in tissue engineering bone and cartilage.
-
公开(公告)号：US06730252B1
公开(公告)日：2004-05-04
申请号：US09957407
申请日：2001-09-20
IPC分类号： D01D5088
CPC分类号： D01F6/625 , A61L27/18 , A61L27/46 , A61L27/58 , B33Y10/00 , B33Y70/00 , B33Y80/00 , C08L67/04
摘要： The invention relates to the use of Fused Deposition Modeling to construct three-dimensional (3D) bioresorbable scaffolds from bioresorbable polymers such as polycaprolactone (PCL), or from composites of bioresorbable polymers and ceramics, such as polycaprolactone/hydroxyapatite (PCL/HA). Incorporation of a bioresorbable ceramic to produce a hybrid/composite material support provides the desired degradation and resorption kinetics. Such a composite material improves the biocompatibility and hard tissue integration and allows for increased initial flash spread of serum proteins. The basic resorption products of the composite also avoids the formation of an unfavorable environment for hard tissue cells due to a decreased pH. The scaffolds have applications in tissue engineering, e.g., in tissue engineering bone and cartilage.
摘要翻译： 本发明涉及使用熔融沉积建模从生物可吸收聚合物如聚己内酯（PCL）或由生物可再吸收聚合物和陶瓷如聚己内酯/羟基磷灰石（PCL / HA）的复合材料构成三维（3D）生物可吸收支架。 掺入生物可吸收陶瓷以产生混合/复合材料载体提供所需的降解和再吸收动力学。 这种复合材料改善了生物相容性和硬组织整合，并且允许增加血清蛋白的初始快速扩散。 复合材料的基本吸收产物也避免了由于pH降低而对硬组织细胞形成不利环境。 支架可用于组织工程，例如在组织工程骨和软骨中。
-
公开(公告)号：US5758253A
公开(公告)日：1998-05-26
申请号：US726732
申请日：1996-10-07
IPC分类号： B22F1/00 , A61F2/00 , A61L27/06 , A61L27/08 , A61L27/56 , C22C1/05 , C22C1/10 , C22C14/00 , B22F3/12
CPC分类号： C22C1/055 , A61L27/06 , A61L27/08 , A61L27/56 , A61F2310/00023 , A61F2310/00161 , Y10S264/36
摘要： A process for producing sintered titanium-graphite having improved wear resistance and low frictional characteristics is described. The said process which produces titanium-graphite composites having a triphasic structure with controlled porosity and a graphite lubricating film, comprises sintering a mixture of titanium and graphite powders in which the percentage of graphite may vary from 4 to 8 percent at temperatures from about 800.degree. C. to 1600.degree. C., for about 1/2 to 2 hours, under a compaction pressure of 0.17 to 0.62 MPa. The composites have applications in biomedical engineering and other fields of engineering due to their biocompatibility, strength and improved wear resistance.
摘要翻译： 描述了具有改进的耐磨性和低摩擦特性的生产烧结钛 - 石墨的方法。 所述制备具有可控孔隙率的三相结构和石墨润滑膜的钛 - 石墨复合材料的方法包括烧结钛和石墨粉末的混合物，其中石墨的百分比可以在约800℃的温度下变化4至8％ 在约0.17至0.62MPa的压实压力下，对于约+ E，fra 1/2 + EE至2小时。 由于复合材料具有生物相容性，强度和耐磨性，因此具有生物医学工程和其他工程领域的应用。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.03 秒)
