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公开(公告)号：US20110112040A1
公开(公告)日：2011-05-12
申请号：US12989829
申请日：2009-04-28
CPC分类号： A61K38/17
摘要： Compositions, systems and related methods for delivering a supercharged protein or a complex of a supercharged protein and therapeutic agent (e g, nucleic acid, peptide, small molecule) to cells are disclosed. Superpositively charged proteins may be associated with nucleic acids (which typically have a net negative charge) via electrostatic interactions. The systems and methods may involve altering the primary sequence of a protein in order to “supercharge” the protein (e g, to generate a superpositively-charged protein). The compositions may be used to treat proliferative diseases, infectious diseases, cardiovascular diseases, inborn errors in metabolism, genetic diseases, etc.
摘要翻译： 公开了用于将超荷电蛋白或超荷电蛋白和治疗剂（例如，核酸，肽，小分子）的复合物递送至细胞的组合物，系统和相关方法。 带正电荷的蛋白质可能通过静电相互作用与核酸（通常具有净负电荷）相关联。 所述系统和方法可以涉及改变蛋白质的一级序列以便“增加”蛋白质（例如产生超正电荷的蛋白质）。 该组合物可用于治疗增殖性疾病，感染性疾病，心血管疾病，代谢中的先天错误，遗传疾病等。
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公开(公告)号：US09221886B2
公开(公告)日：2015-12-29
申请号：US13318032
申请日：2010-04-28
IPC分类号： C12N15/09 , C12N9/96 , C12N5/00 , A61K38/43 , C07H21/04 , C07K1/00 , C07K14/435 , C07K7/06 , C07K7/08 , C07K14/00
CPC分类号： C07K14/43595 , C07K7/06 , C07K7/08 , C07K14/001 , C07K2319/01 , C12N5/0602 , C12N2501/40 , C12N2501/60 , C12N2740/13043
摘要： Compositions, preparations, systems, and related methods for delivering a supercharged protein, or a complex of a supercharged protein and an agent (e.g., nucleic acids, peptides, proteins, small molecules) to cells are provided. Such systems and methods include the use of supercharged proteins. For example, superpositively charged proteins may be associated with nucleic acids (which typically have a net negative charge) via electrostatic interactions. In some embodiments, such systems and methods involve altering the primary sequence of a protein in order to “supercharge” the protein (e.g., to generate a superpositively-charged protein). In some embodiments, complexes comprising supercharged proteins and one or more agents to be delivered are useful as therapeutic agents. In some embodiments, complexes and/or pharmaceutical compositions thereof are administered to a subject in need thereof. The inventive complexes or pharmaceutical compositions thereof may be used to treat proliferative diseases, infectious diseases, cardiovascular diseases, inborn errors in metabolism, genetic diseases, etc.
摘要翻译： 提供了将组合物，制剂，系统和用于将超荷电蛋白或者超荷电蛋白和药剂（例如核酸，肽，蛋白质，小分子）的复合物递送至细胞的相关方法。 这样的系统和方法包括使用超荷电蛋白。 例如，超正电荷的蛋白质可以通过静电相互作用与核酸（其通常具有净负电荷）相关联。 在一些实施方案中，这样的系统和方法包括改变蛋白质的一级序列以便“增加”蛋白质（例如，产生超正电荷的蛋白质）。 在一些实施方案中，包含超荷电蛋白和一种或多种待递送的试剂的复合物可用作治疗剂。 在一些实施方案中，将复合物和/或其药物组合物施用于有需要的受试者。 本发明的复合物或其药物组合物可用于治疗增殖性疾病，感染性疾病，心血管疾病，代谢中的先天错误，遗传疾病等。
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公开(公告)号：US20120100569A1
公开(公告)日：2012-04-26
申请号：US13318032
申请日：2010-04-28
CPC分类号： C07K14/43595 , C07K7/06 , C07K7/08 , C07K14/001 , C07K2319/01 , C12N5/0602 , C12N2501/40 , C12N2501/60 , C12N2740/13043
摘要： Compositions, preparations, systems, and related methods for delivering a supercharged protein, or a complex of a supercharged protein and an agent (e.g., nucleic acids, peptides, proteins, small molecules) to cells are provided. Such systems and methods include the use of supercharged proteins. For example, superpositively charged proteins may be associated with nucleic acids (which typically have a net negative charge) via electrostatic interactions. In some embodiments, such systems and methods involve altering the primary sequence of a protein in order to “supercharge” the protein (e.g., to generate a superpositively-charged protein). In some embodiments, complexes comprising supercharged proteins and one or more agents to be delivered are useful as therapeutic agents. In some embodiments, complexes and/or pharmaceutical compositions thereof are administered to a subject in need thereof. The inventive complexes or pharmaceutical compositions thereof may be used to treat proliferative diseases, infectious diseases, cardiovascular diseases, inborn errors in metabolism, genetic diseases, etc.
摘要翻译： 提供了将组合物，制剂，系统和用于将超荷电蛋白或者超荷电蛋白和药剂（例如核酸，肽，蛋白质，小分子）的复合物递送至细胞的相关方法。 这样的系统和方法包括使用超荷电蛋白。 例如，超正电荷的蛋白质可以通过静电相互作用与核酸（其通常具有净负电荷）相关联。 在一些实施方案中，这样的系统和方法包括改变蛋白质的一级序列以便“增加”蛋白质（例如，产生超正电荷的蛋白质）。 在一些实施方案中，包含超荷电蛋白和一种或多种待递送的试剂的复合物可用作治疗剂。 在一些实施方案中，将复合物和/或其药物组合物施用于有需要的受试者。 本发明的复合物或其药物组合物可用于治疗增殖性疾病，感染性疾病，心血管疾病，代谢中的先天错误，遗传疾病等。
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公开(公告)号：USD375711S
公开(公告)日：1996-11-19
申请号：US43945
申请日：1995-09-12
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公开(公告)号：US4862394A
公开(公告)日：1989-08-29
申请号：US8189
申请日：1987-01-28
摘要： A drop height recorder apparatus includes a housing suitable for packaging for shipment from an origin point to a destination point, a triaxial accelerometer provides three signals to corresponding high gain and low gain channels. The three high gain channel signals are full wave rectified to change any negative signals to positive signals for summing into a single high gain "zero G" (free-fall) channel. AN analog to digital converter is connected to the three low gain channels, the single high gain channel, and to auxiliary sensors for digitizing the analog signals. A recorder has a programmable controller connected to the ADC for setting the digital sampling rate. The digitized low gain channel signals are passed through a digital trigger threshold comparator for comparison with a reference signal for generating event detecting trigger signals on the way to a delay memory which also receives the digitized high gain zero G signal and auxiliary signals. In response to a trigger signal the programmable controller reads out of the delay memory preselected numbers of pre-trigger and post-trigger data as an event sample either for a data processing memory for processing the signals for desired information and storage in a storage memory or for a storage memory. A pre-selected number of event waveform signals together with time, date, and auxiliary data signals are stored in the storage memory. After recovery of the instrument, a personal computer can be attached for reading out the stored event waveforms from which the time of free-fall occurring during each event is determined and the drop height in inches computed. The personal computer is used prior to shipment to set the program parameters and operation modes in the programmable controller.
摘要翻译： 液滴高度记录仪装置包括适于从原点到目的地点装运的外壳，三轴加速度计提供三个信号到相应的高增益和低增益通道。 三个高增益通道信号被全波整流，以将任何负信号改变为正信号，用于求和到单个高增益“零G”（自由下降）通道。 AN模数转换器连接到三个低增益通道，单个高增益通道，以及辅助传感器，用于数字化模拟信号。 记录器具有连接到ADC的可编程控制器，用于设置数字采样率。 数字化的低增益通道信号通过数字触发阈值比较器，用于与参考信号进行比较，用于在还接收数字化的高增益零G信号和辅助信号的延迟存储器的路上产生事件检测触发信号。 响应于触发信号，可编程控制器读出延迟存储器预选数量的预触发和后触发数据作为事件样本，用于数据处理存储器，用于处理所需信息的信号和存储在存储存储器中，或者 用于存储存储器。 预先选择的事件波形信号以及时间，日期和辅助数据信号被存储在存储器中。 恢复仪器后，可以安装个人计算机，以读出存储的事件波形，从而确定每个事件期间发生自由落体的时间，并计算下降高度（以英寸为单位）。 出货前使用个人计算机，以便在可编程控制器中设置程序参数和操作模式。
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公开(公告)号：US06632377B1
公开(公告)日：2003-10-14
申请号：US09409798
申请日：1999-09-30
申请人： Vlasta Brusic , Daniel C. Edelstein , Paul M. Feeney , William Guthrie , Mark Jaso , Frank B. Kaufman , Naftali Lustig , Peter Roper , Kenneth Rodbell , David B. Thompson
发明人： Vlasta Brusic , Daniel C. Edelstein , Paul M. Feeney , William Guthrie , Mark Jaso , Frank B. Kaufman , Naftali Lustig , Peter Roper , Kenneth Rodbell , David B. Thompson
IPC分类号： C09K1300
CPC分类号： C09G1/02 , C09K13/04 , C23F3/00 , H01L21/3212
摘要： Copper or a copper alloy is removed by chemical-mechanical planarization (CMP) in a slurry of an oxidizer, an oxidation inhibitor, and an additive that appreciably regulates copper complexing with the oxidation inhibitor.
摘要翻译： 铜或铜合金通过化学机械平面化（CMP）在氧化剂，氧化抑制剂和显着调节与氧化抑制剂络合铜的添加剂的浆料中去除。
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公开(公告)号：US4153072A
公开(公告)日：1979-05-08
申请号：US840010
申请日：1977-10-06
申请人： David B. Thompson
发明人： David B. Thompson
CPC分类号： F16K17/10 , F16K17/00 , Y10T137/7723 , Y10T137/7734 , Y10T137/87217 , Y10T137/87225 , Y10T137/87233
摘要： A monitor-actuator pilot valve operable to close a safety valve in a fluid flow system reponsive to low line pressure or electrical failure. The safety valve is held open by pressure supplied into an actuator cylinder from the line protected by the safety valve. The pilot valve includes a first flow passage communicating with line pressure, a second flow passage communicating with the safety valve actuator cylinder, a third exhaust flow passage to the atmosphere, and a fourth flow passage to a fluid pressure reset. A valve assembly in the pilot valve responds to a low pressure in the first passage or electrical failure to connect the second and third passages for exhausting control pressure from the safety valve actuator cylinder to close the safety valve. An electromagnet on the pilot valve releases the valve assembly in response to a power failure allowing the safety valve to close. A reset assembly in the valve body manually or hydraulically operates the valve assembly reopening the pilot valve. The low pressure response mechanism is reset hydraulically or manually. The electrical response mechanism is reset only manually.
摘要翻译： 监视器 - 致动器先导阀，其可操作以关闭与低管路压力或电气故障相关的流体流动系统中的安全阀。 安全阀由通过安全阀保护的管线供应到致动器气缸中的压力保持打开。 先导阀包括与管路压力连通的第一流动通道，与安全阀致动器气缸连通的第二流动通道，到大气的第三排气流动通道和流体压力复位的第四流动通道。 先导阀中的阀组件响应于第一通道中的低压或电气故障以连接第二和第三通道，用于排出来自安全阀致动器气缸的控制压力以关闭安全阀。 先导阀上的电磁铁响应于停电而释放阀组件，允许安全阀关闭。 阀体中的复位组件手动或液压地操作阀组件重新打开先导阀。 液压或手动复位低压响应机构。 电气响应机制仅手动复位。
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公开(公告)号：US20080023604A1
公开(公告)日：2008-01-31
申请号：US10586195
申请日：2005-07-05
申请人： David Bottomley , David B. Thompson
发明人： David Bottomley , David B. Thompson
IPC分类号： A47B96/06
CPC分类号： A47B47/0008 , F16B12/50 , F16B17/004
摘要： A bracket for engaging one or more struts and a method of engaging the bracket and strut. The bracket comprises a body portion and one or more arm portions extending from the body portion. The arm portions include at least one pair of grooves that are adapted to releaseably engage complementary lips of the strut and at least one recessed region that is adapted to securely engage one or more crimped portions of the strut. A plurality of brackets and struts may be engaged to construct a frame.
摘要翻译： 用于接合一个或多个支柱的支架和接合支架和支柱的方法。 支架包括主体部分和从主体部分延伸的一个或多个臂部分。 臂部分包括适于可释放地接合支柱的互补唇缘的至少一对凹槽和适于牢固地接合支柱的一个或多个卷曲部分的至少一个凹陷区域。 多个支架和支柱可以被接合以构造框架。
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公开(公告)号：US06802484B1
公开(公告)日：2004-10-12
申请号：US10634353
申请日：2003-08-05
IPC分类号： A47K108
CPC分类号： A47G23/0225 , F16M11/041 , F16M13/00 , F16M13/022 , H04R1/08
摘要： An accessory holder designed to attach to a stand. The stand has a lower tube, a locking collet on the top of the lower tube, and a mast extending upward from the locking collet. The accessory holder has a top mount with a mast receiver that slips around the mast just over the top of the locking collet. The accessory holder also has a clip designed to slip around and engage the mast below the locking collet in the order to lock the holder to the stand. A variety of holding devices can be affixed to the accessory holder, including devices configured to hold an ashtray, a beverage, and a pick.
摘要翻译： 设计用于固定在支架上的附件支架。 支架具有下管，下管顶部的锁定夹头和从锁定夹头向上延伸的桅杆。 附件支架具有顶部安装件，其具有桅杆接收器，桅杆在锁定夹头的顶部之上滑动。 附件保持器还具有夹子，其设计用于在锁定夹头下方滑动并接合桅杆，以将支架锁定到支架上。 各种保持装置可以固定到附件保持器上，包括配置成容纳烟灰缸，饮料和拾取物的装置。
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公开(公告)号：US5185947A
公开(公告)日：1993-02-16
申请号：US737191
申请日：1991-07-29
IPC分类号： B41J29/15
CPC分类号： B41J29/15 , Y10T74/1547
摘要： A line-guide advancement mechanism for copyholders of the type for holding a document containing information to be transcribed and containing a linearly moveable line-guide for highlighting individual lines of information. The line-guide advancement unit is structured to be able to fixably attach to an existing copyholder (10) and a line-guide (46). The unit contains a drive mechanism (12) and an operator's foot pedal (20) which provide step-wise movement to the line-guide (46). The drive mechanism (12) can be adjusted via a knob (36) and vernier scale (74) to provide a wide range of spacings in the movement of the line-guide.
摘要翻译： 用于保存包含要转录的信息的文档的类型的线条引导器提升机构，并且包含用于突出显示各个信息线的可线性移动的线条引导件。 线路导引器提升单元被构造成能够固定地附接到现有的副座（10）和导线器（46）。 该单元包括驱动机构（12）和操作者的脚踏板（20），其向线引导件（46）提供逐步运动。 可以通过旋钮（36）和游标（74）来调节驱动机构（12），以在导轨的运动中提供宽范围的间隔。
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