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1.发明申请NOVEL CARBOXYLIC ACID ANALOGS AS GLYCOGEN SYNTHASE ACTIVATORS 审中-公开新型羧酸类似物作为GLYCOGEN SYNTHASE ACTIVATORS公开(公告)号：US20110136792A1
公开(公告)日：2011-06-09
申请号：US12908199
申请日：2010-10-20
IPC分类号： A61K31/198 , C07C233/48 , C07D295/185 , C07C271/22 , C07C311/19 , C07D233/90 , C07D213/82 , C07D213/81 , C07D307/24 , C07D279/02 , A61K31/5377 , A61K31/27 , A61K31/4164 , A61K31/455 , A61K31/4458 , A61K31/341 , A61P3/00 , A61K31/54 , A61P3/10
CPC分类号： C07C233/47 , C07C229/14 , C07C233/48 , C07C233/51 , C07C233/63 , C07C233/83 , C07C235/12 , C07C271/22 , C07C311/06 , C07C311/14 , C07C311/19 , C07C2601/02 , C07C2601/04 , C07D207/16 , C07D207/28 , C07D211/60 , C07D213/81 , C07D213/82 , C07D233/90 , C07D275/02 , C07D277/56 , C07D279/02 , C07D295/215 , C07D307/24 , C07D417/06
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症，例如II型糖尿病。
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2.发明授权公开(公告)号：US08039495B2
公开(公告)日：2011-10-18
申请号：US12905313
申请日：2010-10-15
IPC分类号： A61K31/426 , A61K31/40 , A61K31/198 , A61K31/18 , A61K31/41 , C07D207/16 , C07D403/04 , C07D277/56 , C07C235/42 , C07C311/51 , A61P3/10 , A61P3/00
CPC分类号： C07C235/42 , C07C311/51 , C07C2601/02 , C07D207/16 , C07D277/56 , C07D403/04
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症，例如II型糖尿病。
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3.发明申请BIPHENYL CARBOXYLIC ACIDS AND BIOISOSTERES AS GLYCOGEN SYNTHASE ACTIVATORS 失效作为GLYCOGEN SYNTHASE激活剂的联苯羧酸和生物活性成分公开(公告)号：US20110118322A1
公开(公告)日：2011-05-19
申请号：US12905313
申请日：2010-10-15
IPC分类号： A61K31/426 , C07D207/16 , A61K31/40 , C07C235/42 , A61K31/198 , C07C311/51 , A61K31/18 , C07D403/04 , A61K31/41 , C07D277/56 , A61P3/10 , A61P3/00
CPC分类号： C07C235/42 , C07C311/51 , C07C2601/02 , C07D207/16 , C07D277/56 , C07D403/04
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症，例如II型糖尿病。
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公开(公告)号：US07132425B2
公开(公告)日：2006-11-07
申请号：US10732838
申请日：2003-12-10
申请人： Shaoqing Chen , Wendy Lea Corbett , Kevin Richard Guertin , Nancy-Ellen Haynes , Robert Francis Kester , Francis A. Mennona , Steven Gregory Mischke , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar
发明人： Shaoqing Chen , Wendy Lea Corbett , Kevin Richard Guertin , Nancy-Ellen Haynes , Robert Francis Kester , Francis A. Mennona , Steven Gregory Mischke , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar
IPC分类号： A61K31/4965 , A61K31/44 , A01N43/40 , C07D401/00 , C07D241/02
CPC分类号： C07D213/75 , C07D213/76 , C07D213/78 , C07D241/20 , C07D241/26 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/04 , C07D413/04 , C07D417/06
摘要： The present invention provides a compound according to formula I where the substituent designations are provided in the specification. Pharmaceutical compositions comprising a compound according to formula I are also provided.
摘要翻译： 本发明提供了在说明书中提供了取代基名称的根据式I的化合物。 还提供了包含式I化合物的药物组合物。
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公开(公告)号：US07807674B2
公开(公告)日：2010-10-05
申请号：US12194643
申请日：2008-08-20
申请人： Nancy Ellen Haynes , Denis J. Kertesz , Sherrie Lynn Pietranico-Cole , Yimin Qian , Nathan Robert Scott , Sung-Sau So , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley
发明人： Nancy Ellen Haynes , Denis J. Kertesz , Sherrie Lynn Pietranico-Cole , Yimin Qian , Nathan Robert Scott , Sung-Sau So , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley
IPC分类号： C07D237/14 , C07D253/07 , A61K31/50 , A61K31/53 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10 , A61P9/00 , A61P35/00
CPC分类号： C07D237/14 , C07D237/16 , C07D237/18 , C07D403/10 , C07D403/12
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗诸如肥胖症，高脂血症，高胆固醇血症和糖尿病等疾病和疾病的疾病，并且可用于其它疾病如NASH，动脉粥样硬化，心血管疾病，甲状腺机能减退 ，甲状腺癌及其相关疾病和疾病。
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公开(公告)号：US07803816B2
公开(公告)日：2010-09-28
申请号：US11526523
申请日：2006-09-25
申请人： Steven Joseph Berthel , Shawn David Erickson , Nader Fotouhi , Robert Francis Kester , Kyungjin Kim , Steven Gregory Mischke , Yimin Qian , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Hong Wang
发明人： Steven Joseph Berthel , Shawn David Erickson , Nader Fotouhi , Robert Francis Kester , Kyungjin Kim , Steven Gregory Mischke , Yimin Qian , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Hong Wang
IPC分类号： A61K31/454 , C07D403/02
CPC分类号： C07D401/04 , C07D401/14 , C07D471/04
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of obesity, hyperphagia, anxiety, depression and related disorders and diseases.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗肥胖，食欲过盛，焦虑，抑郁和相关疾病和疾病。
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公开(公告)号：US20090005383A1
公开(公告)日：2009-01-01
申请号：US12194643
申请日：2008-08-20
申请人： Nancy-Ellen Haynes , Denis J. Kertesz , Sherrie Lynn Pietranico-Cole , Yimin Qian , Nathan Robert Scott , Sung-Sau So , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley
发明人： Nancy-Ellen Haynes , Denis J. Kertesz , Sherrie Lynn Pietranico-Cole , Yimin Qian , Nathan Robert Scott , Sung-Sau So , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley
IPC分类号： A61K31/50 , A61K31/53 , C07D403/10 , C07D237/14 , A61P3/00
CPC分类号： C07D237/14 , C07D237/16 , C07D237/18 , C07D403/10 , C07D403/12
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗诸如肥胖症，高脂血症，高胆固醇血症和糖尿病等疾病和疾病的疾病，并且可用于其它疾病如NASH，动脉粥样硬化，心血管疾病，甲状腺机能减退 ，甲状腺癌及其相关疾病和疾病。
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公开(公告)号：US07452882B2
公开(公告)日：2008-11-18
申请号：US11488870
申请日：2006-07-18
申请人： Nancy-Ellen Haynes , Denis J. Kertesz , Sherrie Lynn Pietranico-Cole , Yimin Qian , Nathan Robert Scott , Sung-Sau So , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley
发明人： Nancy-Ellen Haynes , Denis J. Kertesz , Sherrie Lynn Pietranico-Cole , Yimin Qian , Nathan Robert Scott , Sung-Sau So , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley
IPC分类号： A61K31/53 , C07D403/10 , C07D237/14 , C07D409/10 , A61P3/06
CPC分类号： C07D237/14 , C07D237/16 , C07D237/18 , C07D403/10 , C07D403/12
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗诸如肥胖症，高脂血症，高胆固醇血症和糖尿病等疾病和其它疾病和疾病的疾病，并且可用于其他疾病如NASH，动脉粥样硬化，心血管疾病，甲状腺机能减退 ，甲状腺癌及其相关疾病和疾病。
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公开(公告)号：US20100035864A1
公开(公告)日：2010-02-11
申请号：US12507890
申请日：2009-07-23
申请人： David Robert Bolin , Stuart Hayden , Yimin Qian
发明人： David Robert Bolin , Stuart Hayden , Yimin Qian
IPC分类号： A61K31/551 , C07D243/08 , A61P3/00
CPC分类号： C07D413/12 , C07D413/14
摘要： Provided herein are compounds of the formula (1): as well as pharmaceutically acceptable salts thereof wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type 11 diabetes mellitus and metabolic syndrome.
摘要翻译： 本文提供了式（1）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如肥胖症，11型糖尿病和代谢综合征。
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公开(公告)号：US08211884B2
公开(公告)日：2012-07-03
申请号：US12507890
申请日：2009-07-23
申请人： David Robert Bolin , Stuart Hayden , Yimin Qian
发明人： David Robert Bolin , Stuart Hayden , Yimin Qian
IPC分类号： A61P3/00 , A61K31/5513 , C07D413/02 , C07D413/14
CPC分类号： C07D413/12 , C07D413/14
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
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