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1.发明授权公开(公告)号：US08039495B2
公开(公告)日：2011-10-18
申请号：US12905313
申请日：2010-10-15
IPC分类号： A61K31/426 , A61K31/40 , A61K31/198 , A61K31/18 , A61K31/41 , C07D207/16 , C07D403/04 , C07D277/56 , C07C235/42 , C07C311/51 , A61P3/10 , A61P3/00
CPC分类号： C07C235/42 , C07C311/51 , C07C2601/02 , C07D207/16 , C07D277/56 , C07D403/04
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症，例如II型糖尿病。
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2.发明申请BIPHENYL CARBOXYLIC ACIDS AND BIOISOSTERES AS GLYCOGEN SYNTHASE ACTIVATORS 失效作为GLYCOGEN SYNTHASE激活剂的联苯羧酸和生物活性成分公开(公告)号：US20110118322A1
公开(公告)日：2011-05-19
申请号：US12905313
申请日：2010-10-15
IPC分类号： A61K31/426 , C07D207/16 , A61K31/40 , C07C235/42 , A61K31/198 , C07C311/51 , A61K31/18 , C07D403/04 , A61K31/41 , C07D277/56 , A61P3/10 , A61P3/00
CPC分类号： C07C235/42 , C07C311/51 , C07C2601/02 , C07D207/16 , C07D277/56 , C07D403/04
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症，例如II型糖尿病。
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3.发明申请NOVEL CARBOXYLIC ACID ANALOGS AS GLYCOGEN SYNTHASE ACTIVATORS 审中-公开新型羧酸类似物作为GLYCOGEN SYNTHASE ACTIVATORS公开(公告)号：US20110136792A1
公开(公告)日：2011-06-09
申请号：US12908199
申请日：2010-10-20
IPC分类号： A61K31/198 , C07C233/48 , C07D295/185 , C07C271/22 , C07C311/19 , C07D233/90 , C07D213/82 , C07D213/81 , C07D307/24 , C07D279/02 , A61K31/5377 , A61K31/27 , A61K31/4164 , A61K31/455 , A61K31/4458 , A61K31/341 , A61P3/00 , A61K31/54 , A61P3/10
CPC分类号： C07C233/47 , C07C229/14 , C07C233/48 , C07C233/51 , C07C233/63 , C07C233/83 , C07C235/12 , C07C271/22 , C07C311/06 , C07C311/14 , C07C311/19 , C07C2601/02 , C07C2601/04 , C07D207/16 , C07D207/28 , C07D211/60 , C07D213/81 , C07D213/82 , C07D233/90 , C07D275/02 , C07D277/56 , C07D279/02 , C07D295/215 , C07D307/24 , C07D417/06
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症，例如II型糖尿病。
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4.发明授权Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors 失效二氨基吡咯并喹唑啉化合物作为蛋白质酪氨酸磷酸酶抑制剂公开(公告)号：US07262297B2
公开(公告)日：2007-08-28
申请号：US10836507
申请日：2004-04-30
申请人： Steven Joseph Berthel , Adrian Wai-Hing Cheung , Kyungjin Kim , Kshitij Chhabilbhai Thakkar , Weiya Yun
发明人： Steven Joseph Berthel , Adrian Wai-Hing Cheung , Kyungjin Kim , Kshitij Chhabilbhai Thakkar , Weiya Yun
IPC分类号： C07D239/00 , C07D487/00
CPC分类号： C07D487/04
摘要： The invention relates to pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds which are useful for inhibiting protein tyrosine phosphatases, particularly PTP1B, and are useful for lowering blood glucose concentrations in mammals.
摘要翻译： 本发明涉及可用于抑制蛋白酪氨酸磷酸酶，特别是PTP1B的嘧啶并[5,4-e] [1,2,4]三嗪-5,7-二胺化合物，可用于降低哺乳动物的血糖浓度。
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公开(公告)号：US20090105477A1
公开(公告)日：2009-04-23
申请号：US12261138
申请日：2008-10-30
IPC分类号： C07D239/72
CPC分类号： C07D401/12 , C07D239/95 , C07D401/04 , C07D401/10 , C07D403/04 , C07D405/12 , C07D409/04 , C07D413/04
摘要： The present invention comprises aminoquinazoline compounds of the general formula I: wherein X is an unsubstituted or substituted phenyl, or is an unsubstituted or substituted 5 or 6 membered heteroaromatic ring. The compounds of the present invention are potent inhibitors of PTP1B. Accordingly, the invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.
摘要翻译： 本发明包括通式I的氨基喹唑啉化合物：其中X是未取代或取代的苯基，或是未取代或取代的5或6元杂芳族环。 本发明的化合物是PTP1B的有效抑制剂。 因此，本发明还包括治疗或预防PTP-1B介导的疾病（包括糖尿病，肥胖症和糖尿病相关疾病）的药物组合物和方法。
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公开(公告)号：US20090062276A1
公开(公告)日：2009-03-05
申请号：US12259737
申请日：2008-10-28
申请人： Steven Joseph Berthel , Adrian Wai-Hing Cheung , Kyungjin Kim , Shiming Li , Kshitij Chhabilbhai Thakkar , Weiya Yun
发明人： Steven Joseph Berthel , Adrian Wai-Hing Cheung , Kyungjin Kim , Shiming Li , Kshitij Chhabilbhai Thakkar , Weiya Yun
IPC分类号： A61K31/519 , C07D471/04 , A61P3/10 , A61K31/5377
CPC分类号： C07D471/04
摘要： The present invention comprises pyridopyrimidinediamine compounds of the general formula I: The compounds of the present invention are potent inhibitors of PTP1B. Accordingly, the invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.
摘要翻译： 本发明包括通式I的吡啶并嘧啶二胺化合物：本发明的化合物是PTP1B的有效抑制剂。 因此，本发明还包括治疗或预防PTP-1B介导的疾病（包括糖尿病，肥胖症和糖尿病相关疾病）的药物组合物和方法。
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公开(公告)号：US07132425B2
公开(公告)日：2006-11-07
申请号：US10732838
申请日：2003-12-10
申请人： Shaoqing Chen , Wendy Lea Corbett , Kevin Richard Guertin , Nancy-Ellen Haynes , Robert Francis Kester , Francis A. Mennona , Steven Gregory Mischke , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar
发明人： Shaoqing Chen , Wendy Lea Corbett , Kevin Richard Guertin , Nancy-Ellen Haynes , Robert Francis Kester , Francis A. Mennona , Steven Gregory Mischke , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar
IPC分类号： A61K31/4965 , A61K31/44 , A01N43/40 , C07D401/00 , C07D241/02
CPC分类号： C07D213/75 , C07D213/76 , C07D213/78 , C07D241/20 , C07D241/26 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/04 , C07D413/04 , C07D417/06
摘要： The present invention provides a compound according to formula I where the substituent designations are provided in the specification. Pharmaceutical compositions comprising a compound according to formula I are also provided.
摘要翻译： 本发明提供了在说明书中提供了取代基名称的根据式I的化合物。 还提供了包含式I化合物的药物组合物。
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公开(公告)号：US20100280021A1
公开(公告)日：2010-11-04
申请号：US12837558
申请日：2010-07-16
申请人： Steven Joseph Berthel , Adrian Wai-Hing Cheung , Kyungjin Kim , Shiming Li , Kshitij Chhabilbhai Thakkar , Weiya Yun
发明人： Steven Joseph Berthel , Adrian Wai-Hing Cheung , Kyungjin Kim , Shiming Li , Kshitij Chhabilbhai Thakkar , Weiya Yun
IPC分类号： A61K31/541 , C07D471/04 , A61K31/519 , A61K31/5377 , A61P3/10
CPC分类号： C07D471/04
摘要： The present invention comprises pyridopyrimidinediamine compounds of the general formula I: The compounds of the present invention are potent inhibitors of PTP1B. Accordingly, the invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.
摘要翻译： 本发明包括通式I的吡啶并嘧啶二胺化合物：本发明的化合物是PTP1B的有效抑制剂。 因此，本发明还包括治疗或预防PTP-1B介导的疾病（包括糖尿病，肥胖症和糖尿病相关疾病）的药物组合物和方法。
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公开(公告)号：US07807674B2
公开(公告)日：2010-10-05
申请号：US12194643
申请日：2008-08-20
申请人： Nancy Ellen Haynes , Denis J. Kertesz , Sherrie Lynn Pietranico-Cole , Yimin Qian , Nathan Robert Scott , Sung-Sau So , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley
发明人： Nancy Ellen Haynes , Denis J. Kertesz , Sherrie Lynn Pietranico-Cole , Yimin Qian , Nathan Robert Scott , Sung-Sau So , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley
IPC分类号： C07D237/14 , C07D253/07 , A61K31/50 , A61K31/53 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10 , A61P9/00 , A61P35/00
CPC分类号： C07D237/14 , C07D237/16 , C07D237/18 , C07D403/10 , C07D403/12
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗诸如肥胖症，高脂血症，高胆固醇血症和糖尿病等疾病和疾病的疾病，并且可用于其它疾病如NASH，动脉粥样硬化，心血管疾病，甲状腺机能减退 ，甲状腺癌及其相关疾病和疾病。
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公开(公告)号：US07803816B2
公开(公告)日：2010-09-28
申请号：US11526523
申请日：2006-09-25
申请人： Steven Joseph Berthel , Shawn David Erickson , Nader Fotouhi , Robert Francis Kester , Kyungjin Kim , Steven Gregory Mischke , Yimin Qian , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Hong Wang
发明人： Steven Joseph Berthel , Shawn David Erickson , Nader Fotouhi , Robert Francis Kester , Kyungjin Kim , Steven Gregory Mischke , Yimin Qian , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Hong Wang
IPC分类号： A61K31/454 , C07D403/02
CPC分类号： C07D401/04 , C07D401/14 , C07D471/04
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of obesity, hyperphagia, anxiety, depression and related disorders and diseases.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗肥胖，食欲过盛，焦虑，抑郁和相关疾病和疾病。
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